Publikationen

 

2013

200 Antony P, Diederich N, Krüger R, Balling R. The hallmarks of Parkinson's disease.  FEBS J. 2013 May 11. doi: 10.1111/febs.12335. [Epub ahead of print]

199 Giesert F, Hofmann A, Bürger A, Zerle J, Kloos K, Hafen U, Ernst L, Zhang J, Vogt-Weisenhorn DM, Wurst W. Expression analysis of lrrk1, lrrk2 and lrrk2 splice variants in mice.  PLoS One. 2013 May 10;8(5):e63778. doi: 10.1371/journal.pone.0063778. Print 2013.

198 Gillardon F, Kremmer E, Froehlich T, Ueffing M, Hengerer B, Gloeckner CJ.  ATP-competitive LRRK2 inhibitors interfere with monoclonal antibody binding to the kinase domain of LRRK2 under native conditions.  J Neurosci Methods. 2013 Mar 30;214(1):62-8. doi: 10.1016/j.jneumeth.2012.12.015.

197 Heckman JA, Bardien S, Bozi M, Brice A, Brighina L , Van Broeckhoven C, Carr J, Chartier-Harlin MC, Dardiotis E , Dennis W. Dickson MD 2 , Diehl NN, Elbaz A , Ferrarese C , Ferraris A, Fiske B , Gibson J , Gibson R, Hadjigeorgiou GM,  Hattori N , Ioannidis JPA , Jasinska-Myga B, Jeon BS, Kim YJ, Klein C, Krüger R, Kyratzi  E, Lesage S, Lin CH, Lynch T,  Maraganore DMM, Mellick G, Mutez E,  Nilsson C, Opala G, Park SS, Puschmann A, Quattrone A, Sharma M,  Silburn PA,  Sohn  YA,  Stefanis L, Tadic J,  Theuns J, Tomiyama H , Uitti RJ, Valente EM,  van de Loo S, Vassilatis DK, Vilariño-Güell  C, White LR, Wirdefelt K, Wszolek ZK , Wu RM, Farrer MJ Ross OA on behalf of the Genetic Epidemiology Of Parkinson?s Disease (GEO-PD) consortium.  Population-specific frequencies for LRRK2 susceptibility variants.  Mov Disord (in press)

196 Holmans P, Moskvina V, Jones L, Sharma M; International Parkinson's Disease Genomics Consortium, Vedernikov A, Buchel F, Sadd M, Bras JM, Bettella F, Nicolaou N, Simón-Sánchez J, Mittag F, Gibbs JR, Schulte C, Durr A, Guerreiro R, Hernandez D, Brice A, Stefánsson H, Majamaa K, Gasser T, Heutink P, Wood NW, Martinez M, Singleton AB, Nalls MA, Hardy J, Morris HR, Williams NM.  A pathway-based analysis provides additional support for an immune-related genetic susceptibility to Parkinson's disease.  Human Molecular Genetics 2013 Mar 1;22(5):1039-49. doi: 10.1093/hmg/dds492.

195 Klebe S, Golmard JL, Nalls M, Saad M, Singleton A, Bras J, Hardy J, Simon-Sanchez J, Heutink P, Kuhlenbäumer G, Charfi R, Klein C, Hagenah J, Gasser T, Wurster I, Lesage S, Lorenz D, Deuschl G, Durif F, Pollak P, Damier P, Tison F, Durr A, Amouyel P, Lambert JC, Tzourio C, Maubaret C, Charbonnier-Beaupel F, Tahiri K, Vidailhet M, Martinez M, Brice A, Corvol JC.  Impact of COMT rs4680
on age at onset in Parkinson Disease.  J Neurol Neurosurg Psychiatry, Epub ahead of print.

194 Kragh CL, Fillon G, Gysbers A, Hansen HD, Neumann M, Richter-Landsberg C, Haass C, Zalc B, Lubetzki C, Gai WP, Halliday GM, Kahle PJ, Jensen PH.  FAS-dependent cell death in ?-synuclein transgenic oligodendrocyte models of multiple system atrophy.  PLoS One. 2013;8(1):e55243.

193 Kreiner G, Bierhoff H, Armentano M, Rodriguez Parkitna J, Bonfanti L, Grummt I, Schütz G, Parlato R.  A neuroprotective phase precedes striatal degeneration upon nucleolar stress Cell Death Differ. 2013 Jun 14. doi: 10.1038/cdd.2013.66. [Epub ahead of print].

192 Kumar K, Ramirez A, Göbel A, Kresojevic N, Svetel M, Lohmann K, Sue CM, Rolfs A, Mazzulli JR, Alcalay RN, Krainc D, Klein C, Kostic V, Grünewald A.  Glucocerebrosidase mutations in a Serbian Parkinson?s disease population.  Eur J Neurol 2013;20:402-405.

191 Merkl C, Saalfrank A, Riesen N, Kühn R, Pertek A, Eser S, Hardt MS, Kind A, Saur D, Wurst W, Iglesias A, Schnieke A.  Efficient generation of rat induced pluripotent stem cells using a non-viral inducible vector. PLoS One. 2013;8(1):e55170. doi: 10.1371/journal.pone.0055170. Epub 2013 Jan 31.

190 Müller SK, Bender A, Laub C, Högen T, Schlaudraff F, Liss B, Klopstock T, Elstner M.  Lewy body pathology is associated with mitochondrial DNA damage in Parkinson's disease.  Neurobiol Aging. 2013 Apr 6. pii: S0197-4580(13)00116-4. doi: 10.1016/j.neurobiolaging.2013.03.016.

189 Müller-Rischart AK, Pilsl A, Beaudette P, Patra M, Hadian K, Funke M, Peis R, Deinlein A, Schweimer C, Kuhn PH, Lichtenthaler SF, Motori E, Hrelia S, Wurst W, Trümbach D, Langer T, Krappmann D, Dittmar G, Tatzelt J, Winklhofer KF.  The E3 Ligase Parkin Maintains Mitochondrial Integrity by Increasing Linear Ubiquitination of NEMO.  Mol Cell. 2013 Mar 7;49(5):908-21.

188 Prinz A, Selesnew L, Liss B, Roeper J, Carlsson T.  Increased excitability of serotonin neurons in the dorsal raphe nucleus in the 6-OHDA mouse model of Parkinson's disease.  Experimental Neurology (Submitted).

187 Rakovic A, Shurkewitsch K, Seibler P, Grünewald A, Zanon A, Hagenah J, Krainc D, Klein C.  PTEN-induced putative kinase 1 (PINK1)-dependent ubiquitination of endogenous Parkin attenuates mitophagy: study in human primary fibroblasts and induced pluripotent stem (iPS) cell-derived neurons. J Biol Chem 2013;25;288:2223-2237.

186 Reinhardt P, Schmid B, Burbulla LF, Schöndorf DC, Wagner L, Glatza M, Höing S, Hargus G, Heck SA, Dhingra A, Wu G, Müller S, Brockmann K, Kluba T Maisel M, Krüger R, Berg D, Tsytsyura Y, Thiel CS, Psathaki K, Drexler H, Klingauf J, Kuhlmann T, Klewin M, Müller H, Gasser T, Schöler H, Sterneckert J.  Gene-correction in iPSCs uncovers multiple pathogenic changes associated with LRRK2 G2019S. Cell Stem Cell. 2013 Mar 7;12(3):354-67. doi: 10.1016/j.stem.2013.01.008.

185 Sharma M, Krüger R, Gasser T.  From Genome-wide association studies to next generation sequencing: Lessons from the past and planning for the future.  JAMA Neurol (in press)
184 Weiss D, Walach M, Meisner C, Fritz M, Scholten M, Breit S, Plewnia C, Bender B, Gharabaghi A, Wächter T, Krüger R.  Nigral stimulation for resistant axial motor impairment in Parkinson's disease? A randomized controlled trial.  Brain. 2013 Jul;136(Pt 7):2098-2108. Epub 2013 Jun 11.

183 Wrzodek C, Büchel F, Dräger A, Ruff M, and Zell, A.  Precise generation of systems biology models from KEGG pathways.  BMC Systems Biology, 2013. doi:10.1186/1752-0509-7-15.

182 Zhang L, Karsten P, Hamm S, Pogson JH, Lutz AK, Exner N, Haass C, Whitworth A, Winklhofer K, Schulz JB, Voigt A.  TRAP1 rescues PINK1 loss-of-function phenotypes.  Hum Mol Genet. 2013 Mar 21. [Epub ahead of print].

2012

181 Anders S, Sack B, Pohl A, Münte T, Pramstaller P, Klein C, Binkofski F.  Compensatory premotor activity during affective face processing in subclinical carriers of a single mutant Parkin allele.  Brain. 2012 Apr;135(Pt 4):1128-40. doi: 10.1093/brain/aws040. Epub 2012 Mar 20.

180 Auburger G, Klinkenberg M, Drost J, Marcus K, Morales-Gordo B, Kunz WS, Brandt U, Broccoli V, Reichmann H, Gispert S, Jendrach M. Primary Skin Fibroblasts as a Model of Parkinson's Disease. Mol Neurobiol. 2012 Feb 19. [Epub ahead of print]

179 Brockmann K, Hilker R, Pilatus U, Baudrexel S, Srulijes K, Magerkurth J, Hauser AK, Schulte C, Csoti I, Merten CD, Gasser T, Berg D, Hattingen E.  GBA-associated PD. Neurodegeneration, altered membrane metabolism, and lack of energy failure.  Neurology. 2012 Jul 17;79(3):213-20. doi: 10.1212/WNL.0b013e31825dd369.

178 Brosseron F, May C, Schoenebeck B, Tippler B, Woitalla D, Kauth M, Brockmann K, Meyer H E, Berg D, Bufe A, Marcus K. Stepwise isolation of human peripheral erythrocytes, T lymphocytes, and monocytes for blood cell proteomics.  Proteomics Clin Appl, 2012, 6:497-501.

177 Brüggemann N, Külper W, Hagenah J, Bauer P, Pattaro C, Tadic V, Lohnau T, Winkler S, Tonnies H, Sprenger A, Pramstaller P, Rolfs A, Siebert R, Riess O, Vieregge P, Lohmann K, Klein C.  Autosomal dominant Parkinson?s disease in a large German pedigree.  Acta Neurol Scand 2012;126:129-137.

176 Büchel F, Wrzodek C, Mittag F, Dräger A, Eichner J, Rodriguez N, Le Novère N, and Zell, A.  Qualitative translation of relations from BioPAX to SBML qual.  Bioinformatics, 2012. doi: 10.1093/bioinformatics/bts508.

175 Burbulla LF, Krüger R.  The use of primary fibroblasts to monitor mitochondrial phenotypes in the field of Parkinson's disease.  J Vis Exp 68. pii: 4228. doi: 10.3791/4228.

174 Butler E.K., Voigt, A., Lutz, A.K., Toegel, J.P., Gerhardt, E., Karsten, P., Falkenburger, B., Reinartz, A., Winklhofer, K.F., and Schulz, J.B. The Mitochondrial Chaperone Protein TRAP1 Mitigates ?-Synuclein Toxicity. PLoS Genetics, Feb;8(2):e1002488.

173 Dehorter N, Lozovaya N, Mdzomba BJ, Michel FJ, Lopez C, Tsintsadze V, Tsintsadze T, Klinkenberg M, Gispert S, Auburger G, Hammond C. Subthalamic lesion or levodopa treatment rescues giant GABAergic currents of PINK1-deficient striatum. J Neurosci. 2012 Dec 12;32(50):18047-53.

172 Exner N, Lutz AK, Haass C, Winklhofer KF.  Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences.  EMBO J. 2012 Jun 26;31(14):3038-62.

171 Fitzgerald JC, Camprubi MD, Dunn L, Wu HC, Ip NY, Kruger R, Martins LM, Wood NW, Plun-Favreau H. Phosphorylation of HtrA2 by cyclin dependent kinase 5 modulates its neuroprotective function.  Cell Death Differ 19: 257-266.

170 García J, Carlsson T, Döbrössy M, Nikkhah G, Winkler C.  Impact of dopamineversus serotonin cell transplantation for the development of graft-induceddyskinesia in a rat Parkinson model.  Brain Res. 2012 Aug 27;1470:119-29. doi:10.1016/j.brainres.2012.06.029.

169 Gispert S, Kurz A, Waibel S, Bauer P, Liepelt I, Geisen C, Gitler AD, Becker T, Weber M, Schulte C,  Berg D, Andersen PM, Krüger R, Riess O, Ludolph AC, Auburger G. The modulation of Amyotrophic Lateral Sclerosis risk by Ataxin-2 intermediate polyglutamine expansions is a specific effect.  Neurobiol Dis 45: 356-61.

168 Glasl, L., Kloos, K., Giesert, F., Roethig, A., Di Benedetto, B., Kühn, R., Zhang, J., Hafen, U., Julia Zerle, J., Hofmann, A., Winklhofer, K.F., Hölter, S.M., Vogt Weisenhorn, D.M., and Wurst, W.  Pink1-deficiency impairs gait, olfaction and serotonergic innervation of the olfactory bulb.  Exp Neurol, Jan 11 [Epub ahead of print].

167 Grünewald A, Arns B, Seibler P, Rakovic A, Münchau A, Ramirez A, Sue CM, Klein C.  ATP13A2 mutations impair mitochondrial function in fibroblasts from patients with Kufor-Rakeb syndrome.  Neurobiol Aging 2012.

166 Holmans P, Moskvina V, Jones L, Sharma M, The International Parkinson's Disease Genomics Consortium (IPDGC), Vedernikov A, Büchel F, Sadd M, Bras JM, Bettella F, Nicolaou N, Simón-Sánchez J, Mittag F, Gibbs JR, Schulte C, Durr A, Guerreiro R, Hernandez D, Brice A, Stefánsson H, Majamaa K, Gasser T, Heutink P, Wood NW, Martinez M, Singleton, AB, Nalls MA, Hardy J, Morris HR, and Williams NM.  A pathway-based analysis provides additional support for an immune-related genetic susceptibility to Parkinson's disease.  Human Molecular Genetics, December 2012. doi: 10.1093/hmg/dds492.

165 Keller MF, Saad M, Bras J, Bettella F, Nicolaou N, Simón-Sánchez J, Mittag F, Büchel F, Sharma M, Gibbs JR, Schulte C, Moskvina V, Durr A, Holmans P, Kilarski LL, Guerreiro R, Hernandez DG, Brice A, Ylikotila P, Stefánsson H, Majamaa K, Morris HR, Williams N, Gasser T, Heutink P, Wood NW, Hardy J, Martinez M, Singleton AB, Nalls MA; International Parkinson's Disease Genomics Consortium (IPDGC); Wellcome Trust Case Control Consortium 2 (WTCCC2).  Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease.  Hum Mol Genet. 2012 Nov 15;21(22):4996-5009. doi: 10.1093/hmg/dds335..

164 Klinkenberg M, Gispert S, Dominguez-Bautista JA, Braun I, Auburger G, Jendrach M. Restriction of trophic factors and nutrients induces PARKIN expression. Neurogenetics. 2012 Feb;13(1):9-21.

163 Klionski D, ?, Burbulla LF, ?,  Krüger R, ?, Zuckerbraun B (1269 authors listed). Guidelines for the use and interpretation of assays for monitoring autophagy.  Autophagy  8: 445-544.

162 Kumar KR, Lohmann K, Klein C.  Genetics of Parkinson disease and other movement disorders.  Curr Opin Neurol 2012;25:466-474.

161 Kurz A, May C, Schmidt O, Müller T, Stephan C, Meyer HE, Gispert S, Auburger G, Marcus K. A53T-alpha-synuclein-overexpression in the mouse nigrostriatal pathway leads to early increase of 14-3-3 epsilon and late increase of GFAP. J Neural Transm. 2012 Mar;119(3):297-312.

160 Mittag F, Büchel F, Saad M, Jahn A, Schulte C, Bochdanovits Z, Simón-Sánchez J, Nalls MA, Keller M, Hernandez D, Gibbs R, Lesage S, Brice A, Heutink P, Martinez M, Wood NW, Hardy J, Singleton AB, Zell A, Gasser T, and Sharma M.  Use of Support Vector Machines for Disease Risk Prediction in Genome-Wide Association Studies: Concerns and Opportunities.  Hum Mut, June 2012. doi:10.1002/humu.22161.

159 Palada V, Terzic J, Mazzulli J, Bwala G, Hagenah J, Peterlin B, Hung AY, Klein C, Krainc D.  Histamine N-methyltransferase Thr105Ile Polymorphism is associated with Parkinson's disease.  Neurobiol Aging 2012;33(4):836e1-3.

158 Pilsl, A. and Winklhofer, K.F. Parkin, PINK1 and mitochondrial integrity:Emerging concepts of mitochondrial dysfunction in Parkinson's Disease.  Acta Neuropathol., 123, 173-188.

157 Platt NJ, Gispert S, Auburger G, Cragg SJ. Striatal dopamine transmission is subtly modified in human A53T?-synuclein overexpressing mice. PLoS One. 2012;7(5):e36397.

156 Rannikko EH, Vesterager LB, Shaik JH, Weber SS, Cornejo Castro EM, Fog K, Jensen PH, Kahle PJ.  Loss of DJ-1 protein stability and cytoprotective function by Parkinson's disease-associated proline-158 deletion.  J Neurochem. 2012 Dec 14. [Epub ahead of print].

155 Robert G, Puissant A, Dufies M, Marchetti S, Jacquel A, Cluzeau T, Colosetti P, Belhacene N, Kahle PJ, Da Costa CA, Luciano F, Checler F, Auberger P.  The caspase 6 derived N-terminal fragment of DJ-1 promotes apoptosis via increased ROS production.  Cell Death Differ. 2012 Nov;19(11):1769-78.

154 Sartorius T, Lutz SZ, Hoene M, Waak J, Peter A, Weigert C, Rammensee HG, Kahle PJ, Häring HU, Hennige AM.  Toll-like receptors 2 and 4 impair insulin-mediated brain activity by interleukin-6 and osteopontin and alter sleep architecture.  FASEB J. 2012 May;26(5):1799-809.

153 Schell H, Boden C, Chagas AM, Kahle PJ.  Impaired c-Fos and polo-like kinase 2 induction in the limbic system of fear-conditioned ?-synuclein transgenic mice.  PLoS One. 2012;7(11):e50245.

152 Schiemann J, Schlaudraff F, Klose V, Bingmer M, Seino S, Magill PJ, Zaghloul KA, Schneider G, Liss B, Roeper J.  K-ATP channels in dopamine substantia nigra neurons control bursting and novelty-induced exploration.  Nature Neuroscience. 2012 Aug 19. doi:10.1038/nn.3185.

151 Sharma M,  Krüger R, Gasser T. LRRK2: Understanding the role of common and rare variants in Parkinson disease.  Mov Disord 20: 475.

150 Sharma M, C, Aasly J, Annesi G, Bentivoglio AR, Brice A, Brighina L, Djarmati A, Elbaz A, Farrer M, Ferrarese C, Gibson JM, Gispert S, Hattori N, Jasinska-Myga B, Klein C, Lesage S, Lynch T, , Mellick GD, Chartier-Harlin MC, de Nigris F, Opala G, Prigione A, Quattrone A, Roageva E, Ross O, Satake W, Silburn PA, Theuns J, Toda T, Tomiyama H, Wirdefeldt K, Wszolek Z, Gasser T, Maraganore DM and Krüger R on behalf of the Genetic Epidemiology of Parkinson disease (GEO-PD) consortium. Large scale replication and heterogeneity in Parkinson's disease genetic loci.  Neurology 79: 659-67.

149 Sharma M, Ioannidis JP, Aasly JO, Annesi G, Brice A, Bertram L, Bozi M, Barcikowska M, Crosiers D, Clarke CE, Facheris MF, Farrer M, Garraux G, Gispert S, Auburger G, Vilariño-Güell C, Hadjigeorgiou GM, Hicks AA, Hattori N, Jeon BS, Jamrozik Z, Krygowska-Wajs A, Lesage S, Lill CM, Lin JJ, Lynch T, Lichtner P, Lang AE, Libioulle C, Murata M, Mok V, Jasinska-Myga B, Mellick GD, Morrison KE, Meitnger T, Zimprich A, Opala G, Pramstaller PP, Pichler I, Park SS, Quattrone A, Rogaeva E, Ross OA, Stefanis L, Stockton JD, Satake W, Silburn PA, Strom TM, Theuns J, Tan EK, Toda T, Tomiyama H, Uitti RJ, Van Broeckhoven C, Wirdefeldt K, Wszolek Z, Xiromerisiou G, Yomono HS, Yueh KC, Zhao Y, Gasser T, Maraganore D, Krüger R; GEOPD consortium. A multi-centre clinico-genetic analysis of the VPS35 gene in Parkinson disease indicates reduced penetrance for disease-associated variants. J Med Genet 49: 721-726.

148 Sharma M, Ioannidis JP, Aasly JO, Annesi G, Brice A, Van Broeckhoven C, Bertram L, Bozi M, Crosiers D, Clarke C, Facheris M, Farrer M, Garraux G, Gispert S, Auburger G, Vilariño-Güell C, Hadjigeorgiou GM, Hicks AA, Hattori N, Jeon B, Lesage S, Lill CM, Lin JJ, Lynch T, Lichtner P, Lang AE, Mok V, Jasinska-Myga B, Mellick GD, Morrison KE, Opala G, Pramstaller PP, Pichler I, Park SS, Quattrone A, Rogaeva E, Ross OA, Stefanis L, Stockton JD, Satake W, Silburn PA, Theuns J, Tan EK, Toda T, Tomiyama H, Uitti RJ, Wirdefeldt K, Wszolek Z, Xiromerisiou G, Yueh KC, Zhao Y, Gasser T, Maraganore D, Krüger R; GEO-PD Consortium. Large-scale replication and heterogeneity in Parkinson disease genetic loci. Neurology. 2012 Aug 14;79(7):659-67.

147 Simón-Sánchez J, Kilarski LL, Nalls MA, Martinez M, Schulte C, Holmans P; International Parkinson's Disease Genomics Consortium; Wellcome Trust Case Control Consortium, Gasser T, Hardy J, Singleton AB, Wood NW, Brice A, Heutink P, Williams N, Morris HR.  Cooperative genome-wide analysis shows increased homozygosity in early onset Parkinson's disease.  PLoS One. 2012;7(3):e28787. doi: 10.1371/journal.pone.0028787.

146 Taschenberger G, Garrido M, Tereshchenko Y, Bähr M, Zweckstetter M, Kügler S. Aggregation of ?Synuclein promotes progressive in vivo neurotoxicity in adult rat dopaminergic neurons. Acta Neuropathol. 2012 May;123(5):671-83.

145 Thier S, Lorenz D, Nothnagel M, Poremba C, Papengut F, Appenzeller S, Paschen S, Hofschulte F, Hussl AC, Hering S, Poewe W, Asmus F, Gasser T, Schöls L, Christensen K, Nebel A, Schreiber S, Klebe S, Deuschl G, Kuhlenbäumer G.  Polymorphisms in the glial glutamate transporter SLC1A2 are associated with essential tremor.  Neurology. 2012 Jul 17;79(3):243-8. doi: 10.1212/WNL.0b013e31825fdeed.

2011

144 Abramov AY, Gegg M, Grunewald A, Wood NW, Klein C, Schapira AH. Bioenergetic consequences of PINK1 mutations in Parkinson disease. PLoS One 2011; 6:e25622.

143 Baudrexel S, Witte T, Seifried C, von Wegner F, Beissner F, Klein JC, Steinmetz H, Deichmann R, Roeper J, Hilker R. Resting state fMRI reveals increased subthalamic nucleus-motor cortex connectivity in Parkinson's disease. Neuroimage. 2011 Apr 15;55(4):1728-38

142 Bingmer M, Schiemann J, Roeper J, Schneider G. Measuring burstiness and regularity in oscillatory spike trains. J Neurosci Methods. 2011 Oct 15;201(2):426-37. Epub 2011 Aug 18

141 Bouman L, Schlierf A, Lutz AK, Shan J, Deinlein A, Kast J, Galehdar Z, Palmisano V, Patenge N, Berg D, Gasser T, Augustin R, Trümbach D, Irrcher I, Park DS, Wurst W, Kilberg MS, Tatzelt J, Winklhofer KF. Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress. Cell Death Differ. 2011 May;18(5):769-82. Epub 2010 Nov 26.

140 Burbulla LF, Krüger R. (2011). Converging pathways of genes and environment in the pathogenesis of Parkinson?s disease. J Neurol Sci 306: 1-8

139 Butler EK, Voigt A, Lutz AK, Toegel JP, Gerhardt E, Karsten P, Falkenburger B, Reinartz A, Winklhofer KF, Schulz JB. The Mitochondrial Chaperone Protein TRAP1 Mitigates ?-Synuclein Toxicity. PLoS Genet 8(2): e1002488. doi:10.1371

138 Carlsson T, Schindler FR, Höllerhage M, Depboylu C, Arias-Carrión O, Schnurrbusch S, Rösler TW, Wozny W, Schwall GP, Groebe K, Oertel WH, Brundin P, Schrattenholz A, Höglinger GU. Systemic administration of neuregulin-1?1 protects dopaminergic neurons in a mouse model of Parkinson's disease. J Neurochem. 2011 Jun;117(6):1066-74. doi: 10.1111/j.1471-4159.2011.07284.x

137 Chertoff M, Di Paolo N, Schoeneberg A, Depino A, Ferrari C, Wurst W, Pfizenmaier K, Eisel U, Pitossi F. Neuroprotective and neurodegenerative effects of the chronic expression of tumor necrosis factor ? in the nigrostriatal dopaminergic circuit of adult mice. Exp Neurol. 2011 Feb;227(2):237-51. Epub 2010 Nov 17.

136 Cho MK, Kim HY, Fernandez CO, Becker S, Zweckstetter M. Conserved core of amyloid fibrils of wild type and A30P mutant ?-synuclein. Protein Sci. 2011 Feb;20(2):387-95.

135 Domanskyi A, Geißler C, Vinnikov IA, Alter H, Schober A, Vogt MA, Gass P, Parlato R, Schütz G. P. Pten ablation in adult dopaminergic neurons is neuroprotective in  Parkinson´s disease models. FASEB J. 2011; 25:2898-2910. Epub May 18, 2011.

134 Elbaz A, Ross OA, Ioannidis JP, Soto-Ortolaza AI, Moisan F, Aasly J, Annesi G, Bozi M, Brighina L, Chartier-Harlin MC, Destée A, Ferrarese C, Ferraris A, Gibson JM, Gispert S, Hadjigeorgiou GM, Jasinska-Myga B, Klein C, Krüger R, Lambert JC, Lohmann K, van de Loo S, Loriot MA, Lynch T, Mellick GD, Mutez E, Nilsson C, Opala G, Puschmann A, Quattrone A, Sharma M, Silburn PA, Stefanis L, Uitti RJ, Valente EM, Vilariño-Güell C, Wirdefeldt K, Wszolek ZK, Xiromerisiou G, Maraganore DM, Farrer MJ; Independent and joint effects of the MAPT and SNCA genes in Parkinson disease. Ann Neurol. 2011 May;69(5):778-92.

133 Fitzgerald JC, Wu SH, Dunn L, Krüger R, Martins LM, Wood NW, Plun-Favreau H. Phosphorylation of HtrA2 by cyclin dependent kinase 5 modulates its neuroprotective function. Cell Death Differ. 2012 Feb;19(2):257-66. doi: 10.1038/cdd.2011.90. Epub 2011 Jun 24

132 Fong CY, Rolfs A, Schwarzbraun T, Klein C, O'Callaghan FJ. Juvenile parkinsonism associated with heterozygous frameshift ATP13A2 gene mutation. Eur J Paediatr Neurol 2011.

131 Gajula Balija MB, Griesinger C, Herzig A, Zweckstetter M, Jäckle H. Pre-fibrillar ?-synuclein mutants cause Parkinson's disease-like non-motor symptoms in Drosophila. PLoS One. 2011;6(9):e24701. Epub 2011 Sep 8.

130 García J, Carlsson T, Döbrössy M, Nikkhah G, Winkler C. Impact of dopamine to serotonin cell ratio in transplants on behavioral recovery and L-DOPA-induced dyskinesia. Neurobiol Dis. 2011 Sep;43(3):576-87. Epub 2011 May 13. doi:10.1016/j.nbd.2011.05.004

129 García J, Carlsson T, Döbrössy M, Nikkhah G, Winkler C. Extent of pre-operative L-DOPA-induced dyskinesia predicts the severity of graft-induced dyskinesia after fetal dopamine cell transplantation. Exp Neurol. 2011 Dec;232(2):270-9. Epub 2011 Sep 17. doi:10.1016/j.expneurol.2011.09.017

128 Gasser T. Identifying PD-causing genes and genetic susceptibility factors: current approaches and future prospects. Progress in Brain research. Recent Advances in Parkinson's DiseasePart I: Basic Research

127 Grünewald A, Voges L, Rakovic A, Kasten M, Vandebona H, Hemmelmann C, Lohmann K, Orolicki S, Ramirez A, Schapira AHV, Pramstaller PP, Sue CM, Klein C. Mutant Parkin impairs mitochondrial function and morphology in human fibroblasts. PLoS One 2010; 5:e12962.

126 Helling S, Shinde S, Brosseron F, Schnabel A, Mu?ller T, Meyer HE, Marcus K, Sellergren B.Ultratrace Enrichment of Tyrosine Phosphorylated Peptides on an Imprinted Polymer. Anal Chem. 2011 Feb 9. [Epub ahead of print] PMID:    21306124

125 Höglinger GU, Melhem NM, Dickson DW, Sleiman PM, Wang LS, Klei L, Rademakers R, de Silva R, Litvan I, Riley DE, van Swieten JC, Heutink P, Wszolek ZK, Uitti RJ, Vandrovcova J, Hurtig HI, Gross RG, Maetzler W, Goldwurm S, Tolosa E, Borroni B, Pastor P; PSP Genetics Study Group, Cantwell LB, Han MR, Dillman A, van der Brug MP, Gibbs JR, Cookson MR, Hernandez DG, Singleton AB, Farrer MJ, Yu CE, Golbe LI, Revesz T, Hardy J, Lees AJ, Devlin B, Hakonarson H, Müller U, Schellenberg GD. Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy. .Nat Genet. 2011;43:699-705

124 Krüger R, Sharma M, Riess O, Gasser T, van Broeckhoven C, Theuns J, Aasly J, Annesi G, Bentivoglio AR, Brice A, Elbaz A, Farrer M, Ferrarese C, Ferraris A, Hadjigeorgiou GM, Hattori N, Klein C, Lin JJ, Mellick GD, Opala G, Prigione A, Tan EK, Toda T, Valente EM, Wirdefeldt K, Wszolek Z, Maraganore DM for the Genetic Epidemiology of Parkinson disease  consortium. (2011) A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease. Neurobiol Aging 32:548.e9-548.e18

123 Krumova P, Meulmeester E, Garrido M, Tirard M, Hsiao HH, Bossis G, Urlaub H, Zweckstetter M, Kügler S, Melchior F, Bähr M, Weishaupt JH. Sumoylation inhibits alpha-synuclein aggregation and toxicity. J Cell Biol. 2011 Jul 11;194(1):49-60.

122 Kurz A, Rabbani N, Walter M, Bonin M, Thornalley P, Auburger G, Gispert S. Alpha-synuclein deficiency leads to increased glyoxalase I expression and glycation stress. Cell Mol Life Sci. 2011 Feb;68(4):721-33.

121 Lamberto GR, Torres-Monserrat V, Bertoncini CW, Salvatella X, Zweckstetter M, Griesinger C, Fernández CO. Toward the discovery of effective polycyclic inhibitors of alpha-synuclein amyloid assembly. J Biol Chem. 2011 Sep 16;286(37):32036-44. Epub 2011 Jul 27.

120 Lammel S, Ion DI, Roeper J, Malenka RC. Projection-specific modulation of dopamine neuron synapses by aversive and rewarding stimuli.Neuron. 2011 Jun 9;70(5):855-62

119 Maetzler W, Schmid SP, Wurster I, Liepelt I, Gaenslen A, Gasser T, Berg D. Reduced but not oxidized cerebrospinal fluid glutathione levels are lowered in Lewy body diseases. Mov Disord. 2011 Jan;26(1):176-8.

118 Meixner, A, Boldt, K, Van Troys, M, Askenazi, M, Gloeckner, CJ, Bauer, M, Marto, JA, Ampe, C, Kinkl, N, and Ueffing, M: A QUICK screen for Lrrk2 interaction partners--leucine-rich repeat kinase 2 is involved in actin cytoskeleton dynamics. Mol. Cell. Proteomics 2011 Jan. 1;10 (1), M110 001172. doi: 10.1074/mcp.M110.001172

117 Müller T, Schrötter A, Loosse C, Helling S, Stephan C, Ahrens M, Uszkoreit J, Eisenacher M, Meyer HE, Marcus K. Sense and nonsense of pathway analysis software in proteomics. J Proteome Res. 2011 ;10(12):5398-408. PMID:21978018

116 Nalls MA, Plagnol V, Hernandez DG, Sharma M, Sheerin UM, Saad M, Simón-Sánchez J, Schulte C, Lesage S, Sveinbjörnsdóttir S, Arepalli S, Barker R, Ben-Shlomo Y, Berendse HW, Berg D, Bhatia K, de Bie RM, Biffi A, Bloem B, Bochdanovits Z, Bonin M, Bras JM, Brockmann K, Brooks J, Burn DJ, Charlesworth G, Chen H, Chinnery PF, Chong S, Clarke CE, Cookson MR, Cooper M, Corvol JC, Counsell C, Damier P, Dartigues JF, Deloukas P, Deuschl G, Dexter DT, van Dijk KD, Dillman A, Durif F, Dürr A, Edkins S, Evans JR, Foltynie T, Gao J, Gardner M, Gibbs JR, Goate A, Gray E, Guerreiro R, Gústafsson Ó, Harris C, van Hilten JJ, Hofman A, Hollenbeck A, Hu M, Huang X, Huber H, Hudson G, Hunt SE, Huttenlocher J, Illig T, Jónsson PV, Lambert JC, Langford C, Lees A, Lichtner P, Limousin P, Lopez G, Lorenz D, McNeill A, Moorby C, Moore M, Morris HR, Morrison KE, Mudanohwo E, O'Sullivan S, Pearson J, Perlmutter JS, Pétursson H, Pollak P, Post B, Potter S, Ravina B, Revesz T, Riess O, Rivadeneira F, Rizzu P, Ryten M, Sawcer S, Schapira A, Scheffer H, Shaw K, Shoulson I, Sidransky E, Smith C, Spencer CC, Stefánsson H, Steinberg S, Stockton JD, Strange A, Talbot K, Tanner CM, Tashakkori-Ghanbaria A, Tison F, Trabzuni D, Traynor BJ, Utterlinden AG, Velseboer D, Vidailhet M, Walker R, van de Warrenburg B, Wickremaratchi M, Williams N, Williams-Gray CH, Winder-Rhodes S, Stefánsson K, Martinez M, Hardy J, Heutink P, Brice A, Gasser T, Singleton AB, Wood NW; International Parkinson Disease Genomics Consortium. Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. Lancet. 2011 Feb 19;377(9766):641-9.

115 Nuber S, Petrasch-Parwez E, Arias-Carrión O, Koch L, Kohl Z, Schneider J, Calaminus C, Dermietzel R, Samarina A, Boy J, Nguyen HP, Teismann P, Velavan TP, Kahle PJ, von Hörsten S, Fendt M, Krüger R, Riess O. Olfactory neuron-specific expression of A30P ?-synuclein exacerbates dopamine deficiency and hyperactivity in a novel conditional model of early Parkinson's disease stages. Neurobiol Dis 44:192-204

114 Piccoli G, Condliffe SB, Bauer M, Giesert F, Boldt K, De Astis S, Meixner A, Sarioglu H, Vogt-Weisenhorn DM, Wurst W, Gloeckner CJ, Matteoli M, Sala C, Ueffing M. LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool. J Neurosci. 2011 Feb 9;31(6):2225-37.

113 Plagnol V, Nalls MA, Bras JM, Hernandez DG, Sharma M, Sheerin UM, Saad M, Simón-Sánchez J, Schulte C, Lesage S, Sveinbjörnsdóttir S, Amouyel P, Arepalli S, Band G, Barker RA, Bellinguez C, Ben-Shlomo Y, Berendse HW, Berg D, Bhatia K, de Bie RM, Biffi A, Bloem B, Bochdanovits Z, Bonin M, Brockmann K, Brooks J, Burn DJ, Charlesworth G, Chen H, Chinnery PF, Chong S, Clarke CE, Cookson MR, Cooper JM, Corvol JC, Counsell C, Damier P, Dartigues JF, Deloukas P, Deuschl G, Dexter DT, van Dijk KD, Dillman A, Durif F, Dürr A, Edkins S, Evans JR, Foltynie T, Freeman C, Gao J, Gardner M, Gibbs JR, Goate A, Gray E, Guerreiro R, Gústafsson Ó, Harris C, Hellenthal G, van Hilten JJ, Hofman A, Hollenbeck A, Holton J, Hu M, Huang X, Huber H, Hudson G, Hunt SE, Huttenlocher J, Illig T, Jónsson PV, Langford C, Lees A, Lichtner P, Limousin P, Lopez G, Lorenz D, McNeill A, Moorby C, Moore M, Morris H, Morrison KE, Mudanohwo E, O'Sullivan SS, Pearson J, Pearson R, Perlmutter JS, Pétursson H, Pirinen M, Pollak P, Post B, Potter S, Ravina B, Revesz T, Riess O, Rivadeneira F, Rizzu P, Ryten M, Sawcer S, Schapira A, Scheffer H, Shaw K, Shoulson I, Sidransky E, de Silva R, Smith C, Spencer CC, Stefánsson H, Steinberg S, Stockton JD, Strange A, Su Z, Talbot K, Tanner CM, Tashakkori-Ghanbaria A, Tison F, Trabzuni D, Traynor BJ, Uitterlinden AG, Vandrovcova J, Velseboer D, Vidailhet M, Vukcevic D, Walker R, van de Warrenburg B, Weale ME, Wickremaratchi M, Williams N, Williams-Gray CH, Winder-Rhodes S, Stefánsson K, Martinez M, Donnelly P, Singleton AB, Hardy J, Heutink P, Brice A, Gasser T, Wood NW. International Parkinson's Disease Genomics Consortium (IPDGC); Wellcome Trust Case Control Consortium 2 (WTCCC2). A two-stage meta-analysis identifies several new loci for Parkinson's disease. PLoS Genet. 2011 Jun;7(6):e1002142.

112 Rakovic A, Grünewald A, Kottwitz J, Brüggemann N, Pramstaller PP, Lohmann K, Klein C. Mutations in PINK1 and Parkin impair ubiquitination of Mitofusins in human fibroblasts. PLoS One. 2011; 6(3):e16746.

111 Rieker C, Dev KK, Lehnhoff K, Barbieri S, Ksiazek I, Kauffmann S, Danner S, Schell H, Boden C, Ruegg MA, Kahle PJ, van der Putten H, Shimshek DR. Neuropathology in mice expressing mouse alpha-synuclein. PLoS One. 2011;6(9):e24834.

110 Rieker C, Engblom D, Kreiner G, Schober A, Stotz S, Neumann M, Yuan X, Grummt I, Schütz G, Parlato R. Nucleolar disruption in dopaminergic neurons leads to oxidative damage and parkinsonism through repression of mammalian target of rapamycin signaling. J Neurosci. 2011; 31:453-460.

109 Rolyan H, Scheffold A, Heinrich A, Begus-Nahrmann Y, Langkopf BH, Hölter SM, Vogt-Weisenhorn DM, Liss B, Wurst W, Lie DC, Thal DR, Biber K, Rudolph KL. Telomere shortening reduces Alzheimer's disease amyloid pathology in mice. Brain 2011; 134 (7): 2044-2056. doi: 10.1093/brain/awr133

108 Ros-Bernal F, Hunot S, Herrero MT, Parnadeau S, Corvol JC, Lu L, Alvarez-Fischer D, Carrillo-de Sauvage MA, Saurini F, Coussieu C, Kinugawa K, Prigent A, Höglinger G, Hamon M, Tronche F, Hirsch EC, Vyas S. Microglial glucocorticoid receptors play a pivotal role in regulating dopaminergic neurodegeneration in parkinsonism. Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6632-7. Epub 2011 Apr 5.

107 Rösler TW, Depboylu C, Arias-Carrión O, Wozny W, Carlsson T, Höllerhage M, Oertel WH, Schrattenholz A, Höglinger GU. Biodistribution and brain permeability of the extracellular domain of neuregulin-1-?1. Neuropharmacology. 2011 Dec;61(8):1413-8. Epub 2011 Aug 31. doi:10.1016/j.neuropharm.2011.08.033

106 Ross OA, Soto-Ortolaza AI, Aasly JO, Abahuni N, Annesi G, Bacon J, Bardien S, Bozi M, Brice A, Brighina L, van Broeckhoven C,Carr J, Chartier-Harlin MC, Dardiotis E, Diehl N, Ferrarese C, Ferraris A, Friske B, Gibson JM, Gibson R, Hadjigeorgiou GM, Hattori N, Heckman MG, Jasinska-Myga, B, Jeon BS, Kim YJ, Klein C, Krüger R, Kyratzi E, Lesage S, Lin CH, Lynch T, Maraganore DM,  Mellick G, Nilsson C, Nuytemans K, Opala G, Sup Park S, Pedersen NL, Puschmann A, Quattrone A, Sharma M, Silburn PA, Sohn YH, Stefanis L, Tadic V, Tomiyama H, Uitti R, Valente EM, van de Loo S, Vassilatis D, Vilariño-Güell C, White LR, Wirdefelt K, Wszolek ZK, Wu RM and Farrer MJ on behalf of the Genetic Epidemiology Of Parkinson?s Disease (GEOPD) consortium. (2011) LRRK2 exonic variants and susceptibility to Parkinson?s disease. Lancet Neurology 10: 898-908

105 Seifried C, Weise L, Hartmann R, Gasser T, Baudrexel S, Szelényi A, van de Loo S, Steinmetz H, Seifert V, Roeper J, Hilker R. Intraoperative microelectrode recording for the delineation of subthalamic nucleus topography in Parkinson's disease. Brain Stimul. 2011 Jul 8

104 Sharma M, Maraganore DM, Ioannidis JP, Riess O, Aasly JO, Annesi G, Abahuni N, Bentivoglio AR, Brice A, Van Broeckhoven C, Chartier-Harlin MC, Destée A, Djarmati A, Elbaz A, Farrer M, Ferrarese C, Gibson JM, Gispert S, Hattori N, Jasinska-Myga B, Klein C, Lesage S, Lynch T, Lichtner P, Lambert JC, Lang AE, Mellick GD, De Nigris F, Opala G, Quattrone A, Riva C, Rogaeva E, Ross OA, Satake W, Silburn PA, Theuns J, Toda T, Tomiyama H, Uitti RJ, Wirdefeldt K, Wszolek Z, Gasser T, Krüger R; Genetic Epidemiology of Parkinson's Disease Consortium. Role of sepiapterin reductase gene at the PARK3 locus in Parkinson's disease. Neurobiol Aging. 2011 Nov;32(11):2108.e1-5.

103 Sperka T, Song Z, Morita Y, Nalapareddy K, Guachalla LM, Lechel A, Begus-Nahrmann Y, Burkhalter MD, Mach M, Schlaudraff F, Liss B, Ju Z, Speicher MR, Rudolph KL. Puma and p21 represent cooperating checkpoints limiting self-renewal and chromosomal instability of somatic stem cells in response to telomere dysfunction. Nat Cell Biol. 2011 Dec 4;14(1):73-9. doi: 10.1038/ncb2388.

102 Springer W, Kahle PJ. Regulation of PINK1-Parkin-mediated mitophagy. Autophagy. 2011 Mar 1;7(3):266-78.

101 Tozzi A, Costa C, Siliquini S, Tantucci M, Picconi B, Kurz A, Gispert S, Auburger G, Calabresi P. Mechanisms underlying altered striatal synaptic plasticity in old A53T-? synuclein overexpressing mice. Neurobiol Aging. 2011 Jun 16. [Epub ahead of print]

100 Unal-Cevik I, Gursoy-Ozdemir Y, Yemisci M, Lule S, Gurer G, Can A, Müller V, Kahle PJ, Dalkara T. Alpha-synuclein aggregation induced by brief ischemia negatively impacts neuronal survival in vivo: a study in [A30P]alpha-synuclein transgenic mouse. J Cereb Blood Flow Metab. 2011 Mar;31(3):913-23.

99 Wrzodek A, Dräger A, and Zell A. KEGGtranslator: visualizing and converting the KEGG PATHWAY database to various formats. Bioinformatics, 27(16):2314-2315, June 2011. doi:10.1093/bioinformatics/btr377

98 Zittel S, Kroeger J, van der Vegt JP, Siebner HR, Brüggemann N, Ramirez A, Behrens MI, Gerloff C, Bäumer T, Klein C, Münchau A. Motor pathway excitability in ATP13A2 mutation carriers: A transcranial magnetic stimulation study. Parkinsonism Relat Disord 2011.

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97 Babovic D, Jiang L, Gantois I, Lawrence AJ, Ferreri V, Schütz G, Waddington J.L, Drago J. Age-related behavioural phenotype and cellular characterization of mice with progressive ablation of D1 dopamine receptor-expressing cells. Behav Brain Res. 2010; 206:78-87. Epub 2009 Sep 4.

96 Behrens MI, Brüggemann N, Chana P, Venegas P, Kägi M, Parrao T, Orellana P, Garrido C, Rojas CV Hauke J, Hahnen E, Gonzalez R, Seleme N, Fernandez V, Schmidt A, Binkofski F, Kömpf D, Kubisch C, Hagenah J, Klein C, Ramirez A. Clinical spectrum of Kufor Rakeb Syndrome in the Chilean kindered with ATP13A2 mutations. Mov Disord, im Druck.

95 Berg D, Seppi K, Liepelt I, Schweitzer K, Wollenweber F, Wolf B, Dillmann U, Stockner H, Godau J, Kiechl S, Gaenslen A, Willeit J, Di Santo A, Maetzler W, Gasser T, Poewe W, Behnke S. Enlarged hyperechogenic substantia nigra is related to motor performance and olfaction in the elderly. Mov. Disord 25(10):1464-1469.

94 Bouman, L., Schlierf, A., Lutz, A.K., Shan, J., Deinlein , A., Kast, J., Galehdar, Z., Palmisano, V., Patenge, N., Berg, D., Gasser, T., Augustin, R., Trümbach, D., Irrcher, I., Park, D., Wurst, W., Kilberg, M.S., Tatzelt, J. and Winklhofer, K.F. Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress. Cell Death Differ., 2010 Nov 26 [Epub ahead of print].

93 Brüggemann N, Hagenah J, Reetz K, Schmidt A, Kasten M, Buchmann I, Eckerle S, Bähre M, Münchau A, Djarmati A, van der Vegt J, Siebner H, Binkofski F, Ramirez A, Behrens MI, Klein C. Recessively inherited parkinsonism: effect of ATP13A2 mutations on the clinical and neuroimaging phenotype. Arch Neurol, 2010.

92 Burbulla LF, Krebiehl G, Krüger R. Balance is the challgenge ? the impact of mitochondrial dynamics in Parkinson?s disease. Eur J Clin Invest 40(11):1048-60

91 Burbulla LF, Schelling C, Kato H, Rapaport D, Woitalla D, Schiesling C, Schulte C, Sharma M, Bauer P, Jung S, Nordheim A, Schöls L, Riess O, Krüger R. Dissecting the Role of the Mitochondrial Chaperone Mortalin in Parkinson?s Disease ? Functional Impact of Disease-Related Variants on Mitochondrial Homeostasis. Hum Mol Genet 19(22):4437-52

90 Carballo-Carbajal I, Weber-Endress S, Rovelli G, Chan D, Wolozin B, Klein CL, Patenge N, Gasser T, Kahle PJ. Leucine-rich repeat kinase 2 induces alpha-synuclein expression via the extracellular signal-regulated kinase pathway. Cell. Signal 22(5):821-827.

89 Cornejo Castro EM, Waak J, Weber SS, Fiesel FC, Oberhettinger P, Schütz M, Autenrieth IB, Springer W, Kahle PJ. Parkinson's disease-associated DJ-1 modulates innate immunity signaling in Caenorhabditis elegans. J Neural Transm. 2010 May;117(5):599-604.

88 Dietl P, Liss B, Felder E, Miklavc P, Wirtz H. Lamellar body exocytosis by cell stretch or purinergic stimulation: possible physiological roles, messengers and mechanisms. Cell Physiol Biochem. 2010;25(1):1-12. doi:10.1159/000272046

87 Dodel R, Spottke A, Gerhard A, Reuss A, Reinecker S, Schimke N, Trenkwalder C, Sixel-Döring F, Herting B, Kamm C, Gasser T, Sawires M, Geser F, Köllensperger M, Seppi K, Kloss M, Krause M, Daniels C, Deuschl G, Böttger S, Naumann M, Lipp A, Gruber D, Kupsch A, Du Y, Turkheimer F, Brooks DJ, Klockgether T, Poewe W, Wenning G, Schade-Brittinger C, Oertel WH, Eggert K. Minocycline 1-year therapy in multiple-system-atrophy: effect on clinical symptoms and [(11)C] (R)-PK11195 PET (MEMSA-trial). Mov. Disord 25(1):97-107.

86 Eggers C, Schmidt A, Hagenah J, Brüggemann N, Klein JC, Tadic V, Kertelge L, Binkofski F, Siebner H, Neumaier B, Fink GR, Hilder R, Klein C. Progression of subtle motor signs in PINK1 mutation carriers with mild dopaminergic deficit. Neurology, im Druck.

85 Elbaz A, Ross O, Ioannidis JPA, Soto-Ortolaza AI, Moisan F, Aasly J, Annesi G, Bozi M, Brighina L, Chartier-Harlin MC, Destée A, Ferrarese C, Ferraris A, Gibson JM, Gispert S, Hadjigeorgiou GM, Jasinska-Myga B, Klein C, Krüger R, Lambert JC, Lohmann K, van de Loo S, Loriot MA, Lynch T, Mellick G, Mutez E, Nilsson C, Opala G, Puschmann A,  Quattrone A, Sharma M, Silburn PA, Stefanis L, Uitti RJ, Valente EM, Vilariño-Güell C, Wirdefeldt K, Wszolek ZK, Xiromerisiou G, Maraganore DM, Farrer MJ on behalf of the Genetic Epidemiology Of Parkinson?s Disease (GEO-PD) consortium. Independent and joint effects of the MAPT and SNCA genes in Parkinson?s disease. Ann Neurol. 2010 Oct 29. doi: 10.1002/ana.22321. [Epub ahead of print]

84 Evangelou E, Maraganore DM, Annesi G, Brighina L, Brice A, Elbaz A, Ferrarese C, Hadjigeorgiou GM, Krueger R, Lambert JC, Lesage S, Markopoulou K, Mellick GD, Meeus B, Pedersen NL, Quattrone A, Van Broeckhoven C, Sharma M, Silburn PA, Tan EK, Wirdefeldt K, Ioannidis JP. Genetic Epidemiology of Parkinson's Disease (GEOPD) Consortium. (2010) Am J Med Genet B Neuropsychiatr Genet. 2010 Jan 5;153B(1):220-8.

83 Fett, M.E., Pilsl, A., Paquet, D., Haass, C, Tatzelt, J., Schmid, B. and Winklhofer, K.F. Parkin is protective against proteotoxic stress in a transgenic zebrafish model. PLoS One, 5(7): e11783.

82 Geisler S, Holmström KM, Skujat D, Fiesel FC, Rothfuss OC, Kahle PJ, Springer W. PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nat Cell Biol. 2010 Feb;12(2):119-31.

81 Geisler S, Holmström KM, Treis A, Skujat D, Weber SS, Fiesel FC, Kahle PJ, Springer W. The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations. Autophagy. 2010 Oct 1;6(7):871-8.

80 Gierthmühlen J, Schumacher S, Deuschl G, Fritzer E, Klein C, Baron R, Helmchen C. Somatosensory function in asymptomatic parkin mutation carriers. Eur J Neurol, im Druck.

79 Gloeckner CJ, Boldt K, von Zweydorf F, Helm S, Wiesent L, Sarioglu H, Ueffing M. Phosphopeptide analysis reveals two discrete clusters of phosphorylation inthe N-terminus and the Roc domain of the Parkinson-disease associated proteinkinase LRRK2. J Proteome Res. 2010 Apr 5;9(4):1738-45.  doi 10.1021/pr9008578

78 Haebig, K, Gloeckner, CJ, Miralles, MG, Gillardon, F, Schulte, C, Riess, O, Ueffing, M, Biskup, S, and Bonin, M. ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2. PLoS One 2010 Oct. 29; 5 (10), e13762. doi: 10.1371/journal.pone.0013762.

77 Hangen E, De Zio D, Bordi M, Zhu C, Dessen P, Caffin F, Lachkar S, Perfettini JL, Lazar V, Benard J, Fimia GM, Piacentini M, Harper F, Pierron G, Vicencio JM, Bénit P, de Andrade A, Höglinger G, Culmsee C, Rustin P, Blomgren K, Cecconi F, Kroemer G, Modjtahedi N. A brain-specific isoform of mitochondrial apoptosis-inducing factor: AIF2. Cell Death Differ. 2010;17:1155-66.

76 Irrcher, I., Aleyasin, H., Seifert, E.L., Hewitt, S.J., Chhabra, S., Phillips, M., Lutz, A.K., Rousseaux, M.W., Bevilacqua, L., Jahani-Asl, A., Callaghan, S., Maclaurin, J.G., Winklhofer, K.F., Rizzu, P., Rippstein, P., Kim, R.H., Chen, C.X., Fon, E.A., Slack, R.S., Harper, M.E., McBride, H.M., Mak, T.W. and Park, D.S. Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics. Hum Mol Genet, 19, 3734-3746.

75 Jeon J, Dencker D, Wörtwein G, Woldbye DPD, Cui Y, Davis AA, Levey AI, Schütz G, Sager TN, Mork A, Li C, Deng C-X, Fink-Jensen A, Wess J. A subpopulation of neuronal M4 muscarinic acetylcholine receptors plays a critical role in modulating dopamine-dependent behaviors. J Neurosci. 2010; 30:2396-2405.

74 Kamp, F., Exner, N, Lutz, A.K., Wender, N., Hegermann, J., Brunner, B., Nuscher, B., Bartels, T., Giese, A., Beyer, K., Eimer, S., Winklhofer, K.F., and Haass, C. Inhibition of Mitochondrial Fusion by a-Synuclein is rescued by PINK1, Parkin, and DJ-1. EMBO J, 29, 3571-3589.

73 Kasten M, Weichert C, Lohmann K, Klein C. Clinical and demographic characteristics of PINK1 mutation carriers ? A meta-analysis. Mov Disord, im Druck.

72 Kieper N, Holmström K, Ciceri D, Fiesel F, Wolburg H, Ziviani E, Whitworth A, Martins LM, Kahle PJ, Krüger R. Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1. Exp Cell Res (published online 13.01.2010)

71 Klebe S, Thier S, Lorenz D, Nothnagel M, Schreiber S, Klein C, Hagenah J, Kasten M, Berg D, Srulijes K, Gasser T, Deuschl G, Kuhlenbäumer G. LINGO1 is not associated with Parkinson's disease in German patients. Am. J. Med. Genet. B Neuropsychiatr. Genet 153B(6):1173

70 Klinkenberg M, Thurow N, Gispert S, Ricciardi F, Eich F, Prehn JH, Auburger G, Kögel D. Enhanced vulnerability of PARK6 patient skin fibroblasts to apoptosis induced by proteasomal stress. Neuroscience. 2010 Mar 17;166(2):422-34.

69 Krebiehl G, Ruckerbauer S, Burbulla L, Kieper N, Maurer B, Waak J, Wolburg H, Gizatullina Z, Gellerich F, Woitalla D, Riess O, Kahle PJ, Proikas-Cezanne T, Krüger R. Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson?s disease-associated protein DJ-1. PLoS One 5: e9367

68 Kurz A, Double KL, Lastres-Becker I, Tozzi A, Tantucci M, Bockhart V, Bonin M, García-Arencibia M, Nuber S, Schlaudraff F, Liss B, Fernández-Ruiz  J, Gerlach M, Wüllner U, Lüddens H, Calabresi P, Auburger G, Gispert S. A53T-alpha-Synuclein Overexpression Impairs Dopamine Signaling and Striatal Synaptic Plasticity in Old Mice. 2010 PLoS One. 5(7):1-15. doi:10.1371/journal.pone.0011464

67 Kurz A, Wöhr M, Walter M, Bonin M, Auburger G, Gispert S, Schwarting RK. Alpha-synuclein deficiency affects brain Foxp1 expression and ultrasonic vocalization.Neuroscience. 2010 Mar 31;166(3):785-95.

66 Liss B, Roeper J. A new tool for your novelty centre. J Physiol. 2010 Jun 15; 588(Pt 12):2013. doi:10.1113/jphysiol.2010.192203

65 Liviu Aron, Pontus Klein, Trang T. Pham, Edgar R. Kramer,Wolfgang Wurst, Rüdiger Klein. Pro-survival role for Parkinson?s associated gene DJ-1 revealed in trophically impaired dopaminergic neurons. PLOS Biol. 2010 Apr 6;8(4):e1000349.

64 Lücking CB, Lichtner P, Kramer ER, Gieger C, Illig T, Dichgans M, Berg D, Gasser T. Polymorphisms in the receptor for GDNF (RET) are not associated with Parkinson's disease in Southern Germany. Neurobiol. Aging 31(1):167-168.

63 Machner B, Klein C, Sprenger A, Baumbach P, Pramstaller P, Helmchen C, Heide W. Eye movement disorders are different in Parkin-linked and idiopathic early-onset Parkinson?s disease. Neurology, im Druck.

62 Maetzler W, Stoycheva V, Schmid B, Schulte C, Hauser A, Brockmann K, Melms A, Gasser T, Berg D. Neprilysin activity in cerebrospinal fluid is associated with dementia and amyloid-?42 levels in Lewy body disease. J. Alzheimers Dis 22(3):933-938.

61 Mai S, Klinkenberg M, Auburger G, Bereiter-Hahn J, Jendrach M. Decreased expression of Drp1 and Fis1 mediates mitochondrial elongation in senescent cells and enhances resistance to oxidative stress through PINK1. J Cell Sci. 2010 Mar 15;123(Pt 6):917-26.

60 Mollenhauer B, El-Agnaf OM, Marcus K, Trenkwalder C, Schlossmacher MG. Quantification of ?-synuclein in cerebrospinal fluid as a biomarker candidate: review of the literature and considerations for future studies. Biomark Med. 2010 Oct;4(5):683-99. PMID: 20945981

59 Nuber S, Franck T, Wolburg H, Schumann U, Casadei N, Fischer K, Calaminus C, Pichler BJ, Chanarat S, Teismann P, Schulz JB, Luft AR, Tomiuk J, Wilbertz J, Bornemann A, Krüger R, Riess O. Transgenic overexpression of the alpha-synuclein interacting protein synphilin-1 leads to behavioral and neuropathological alterations in mice. Neurogenetics. 2010 Feb;11(1):107-20.

58 Nuber S, Franck T, Wolburg H, Schumann U, Chanarat S, Teismann P, Schulz JB, Luft AR, Tomiuk J, Wilbertz J, Bornemann A, Krüger R,  Riess O. Overexpression of the alpha-synuclein interacting protein Synphilin-1 leads to behavioural and neuropathological alterations in transgenic mice. Neurogenetics 11:107-120

57 Pham TT, Giesert F, Röthig A, Floss T, Kallnik M, Weindl K, Hölter SM, Ahting U, Prokisch H, Becker L, Klopstock T, Hrabé de Angelis M, Beyer K, Görner K, Kahle PJ, Vogt Weisenhorn DM, and Wurst W. DJ-1-deficient mice show less TH-positive neurons in the ventral tegmental area and exhibit non-motoric behavioural impairments.Genes Brain Behav. 2010 Apr;9(3):305-17

56 Rakovic A, Grünewald A, Seibler P, Ramirez A, Kock N, Orolicki S, Lohmann K, Klein C. Effect of endogenous mutant and wild-type PINK1 on Parkin in fibroblasts from Parkinson disease patients. Hum Mol Genet 2010;19:3124-3137.

55 Seidel K, Schöls L, Nuber S, Petrasch-Parwez E, Gierga K, Wszolek Z, Dickson D, Gai WP, Bornemann A, Riess O, Rami A, den Dunnen WFA, Deller T, Rüb U, Krüger R. First appraisal of brain pathology owing to A30P mutant alpha-synuclein. Ann Neurol (published online 20.01.2010); DOI: 10.1002/ana.21966

54 Soehn AS, Franck T, Biskup S, Giaime E, Melle C, Rott R, Cebo D, Kalbacher H, Ott E, Pahnke J, Meitinger T, Krüger R, Gasser T, Berg D, von Eggeling F, Engelender S, Alves da Costa C, Riess O. Periphilin is a novel interactor of synphilin-1, a protein implicated in Parkinson's disease. Neurogenetics 11:203-215

53 Stamelou M, de Silva R, Arias-Carrion O, Boura E, Höllerhage M, Oertel WH, Müller U, Höglinger GU. Rational therapeutic approaches to progressive supranuclear palsy. Brain. 2010;133:1578-90.
52 Winklhofer, K.F. and Haass, C. Mitochondrial dysfunction in Parkinson's disease. Biochim Biophys Acta, 1802, 29-44.

51 Wrzodek C, Schröder A, Dräger A, Wanke D, Berendzen KW, Kronfeld M, Harter K, and Zell A. ModuleMaster: a new tool to decipher transcriptional regulatory networks. Biosystems. 2010 Jan; 99(1):79-81. doi 10.1016/j.biosystems.2009.09.005

2009

50 Begus-Nahrmann Y, Lechel A, Obenauf AC, Nalapareddy K, Peit E, Hoffmann E, Schlaudraff F, Liss B, Schirmacher P, Kestler H,Danenberg E, Barker N, Clevers H, Speicher MR, Rudolph KL. p53 deletion impairs clearance of chromosomal-instable stemcells in aging telomere-dysfunctional mice. Nature genetics. 2009 Oct; 41(10):1138-43. doi:10.1038/ng.426

49 Djarmati A, Hagenah J, Reetz K, Winkler S, Behrens MI, Pawlack H, Lohmann K, Ramirez A, Tadic V, Brüggemann N, Berg D, Siebner HR, Lang AE, Pramstaller PP, Binkofski F, Kostic VS, Volkmann J, Gasser T, Klein C. ATP13A2 variants in early-onset Parkinson?s disease patients and controls. Mov Disord 2009;24:2104-2111.

48 Dräger A, Planatscher H, Wouamba DM, Schröder A, Hucka M, Endler L, Golebiewski M, Müller W, and Zell A: SBML2LaTeX: Conversion of SBML files into human-readable reports, Bioinformatics 2009, (23 March 2009). doi:10.1186/1752-0509-3-67

47 Elstner M, Morris CM, Heim K, Lichtner P, Bender A, Mehta D, Schulte C, Sharma M, Hudson G, Goldwurm S, Giovanetti A, Zeviani M, Burn DJ, McKeith IG, Perry RH, Jaros E, Kruger R, Wichmann HE, Schreiber S, Campbell H, Wilson JF, Wright AF, Dunlop M, Pistis G, Toniolo D, Chinnery PF, Gasser T, Klopstock T, Meitinger T, Prokisch H, Turnbull DM. Single-cell expression profiling of dopaminergic neurons combined with association analysis identifies pyridoxal kinase as Parkinson's disease gene. Ann Neurol. 2009 Jun 18;66(6):792-8.

46 Fournier M, Vitte J, Garrigue J, Langui D, Dullin JP, Saurini F, Hanoun N, Perez-Diaz F, Cornilleau F, Joubert C, Ardila-Osorio H, Traver S, Duchateau R, Goujet-Zalc C, Paleologou K, Lashuel HA, Haass C, Duyckaerts C, Cohen-Salmon C, Kahle PJ, Hamon M, Brice A, Corti O. Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy. PLoS One. 2009 Aug 14;4(8):e6629.

45 Funke C, Soehn AS, Tomiuk J, Riess O, Berg D (2009) Genetic analysis of coding SNPs in blood-brain barrier transporter MDR1 in European Parkinson's disease patients. J Neural Transm 116(4):443-50

44 Funke C, Tomiuk J, Riess O, Berg D, Soehn AS (2009) Genetic analysis of heme oxygenase-1 (HO-1) in German Parkinson's disease patients.  J Neural Transm 116(7):853-9
43 Gasser T (2009) Molecular pathogenesis of Parkinson disease: insights from genetic studies. Expert Rev Mol Med 11:e22

42 Gispert S, Ricciardi F, Kurz A, Azizov M, Hoepken HH, Becker D, Voos W, Leuner K, Müller WE, Kudin AP, Kunz WS, Zimmermann A, Roeper J, Wenzel D, Jendrach M, García-Arencíbia M, Fernández-Ruiz J, Huber L, Rohrer H, Barrera M, Reichert AS, Rüb U, Chen A, Nussbaum RL, Auburger G.Parkinson phenotype in aged PINK1-deficient mice is accompanied by progressive mitochondrial dysfunction in absence of neurodegeneration. PLoS One. 2009 Jun 3;4(6):e5777.

41 Gloeckner CJ, Schumacher A, Boldt K, Ueffing M: The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro.  J Neurochem. 2009 May;109(4):959-68.  doi 10.1111/j.1471-4159.2009.06024.x

40 Jendrach M, Gispert S, Ricciardi F, Klinkenberg M, Schemm R, Auburger G.The mitochondrial kinase PINK1, stress response and Parkinsons disease. J Bioenerg Biomembr. 2009 Dec;41(6):481-6.
39 Kahle PJ, Waak J, Gasser T. DJ-1 and prevention of oxidative stress in Parkinson's disease and other age-related disorders. Free Radic Biol Med. 2009 Nov 15;47(10):1354-61.

38 Karpinar DP, Balija MB, Kügler S, Opazo F, Rezaei-Ghaleh N, Wender N, Kim HY, Taschenberger G, Falkenburger BH, Heise H, Kumar A, Riedel D, Fichtner L, Voigt A, Braus GH, Giller K, Becker S, Herzig A, Baldus M, Jäckle H, Eimer S, Schulz JB, Griesinger C, Zweckstetter M.Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson's disease models.EMBO J. 2009 Oct 21;28(20):3256-68. doi:10.1038/emboj.2009.257 PMID: 19745811

37 Kim HY, Cho MK, Kumar A, Maier E, Siebenhaar C, Becker S, Fernandez CO, Lashuel HA, Benz R, Lange A, Zweckstetter M. Structural properties of pore-forming oligomers of alpha-synuclein. J Am Chem Soc. 2009 Dec 2;131(47):17482-9.

36 Koch A, Lehmann-Horn K, Dächsel JC, Gasser T, Kahle PJ, Lücking CB. Proteasomal inhibition reduces parkin mRNA in PC12 and SH-SY5Y cells. Parkinsonism Relat Disord. 2009 Mar;15(3):220-5.

35 Kruger R, Sharma M, Riess O, Gasser T, Van Broeckhoven C, Theuns J, Aasly J, Annesi G, Bentivoglio AR, Brice A, Djarmati A, Elbaz A, Farrer M, Ferrarese C, Gibson JM, Hadjigeorgiou GM, Hattori N, Ioannidis JP, Jasinska-Myga B, Klein C, Lambert JC, Lesage S, Lin JJ, Lynch T, Mellick GD, de Nigris F, Opala G, Prigione A, Quattrone A, Ross OA, Satake W, Silburn PA, Tan EK, Toda T, Tomiyama H, Wirdefeldt K, Wszolek Z, Xiromerisiou G, Maraganore DM, for the Genetic Epidemiology of Parkinson's disease c. A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease. Neurobiol Aging. 2009 Dec 23.

34 Lutz AK, Exner N, Fett ME, Schlehe JS, Kloos K, Lämmermann K, Brunner B, Kurz-Drexler A, Vogel F, Reichert AS, Bouman L, Vogt-Weisenhorn D, Wurst W, Tatzelt J, Haass C, Winklhofer KF.Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation. J Biol Chem. 2009 Aug 21;284(34):22938-51. Epub 2009 Jun 22.

33 Madzar D, Schulte C, Gasser T. Screening for LRRK2 R1441 mutations in a cohort of PSP patients from Germany. Eur J Neurol. 2009 Nov;16(11):1230-2.
32 Morais VA, Verstreken P, Roethig A, Smet J, Snellinx A, Vanbrabant M, Haddad D, Frezza C, Mandemakers W, Vogt-Weisenhorn D, Van Coster R, Wurst W, Scorrano L, and De Strooper B.Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function. EMBO Mol Med. 2009 May;1(2):99-111.

31 Paquet D, Bhat R, Sydow A, Mandelkow EM, Berg S, Hellberg S, Fälting J, Distel M, Köster RW, Schmid B, Haass C. A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation. J Clin Invest. 2009 Apr 13.
30 Parlato R, Otto C, Tuckerman J, Stotz S, Kaden S, Gröne H-J, Unsicker K, Schütz G. Conditional inactivation of the glucocorticoid receptor gene in dopamin-?-hydroxylase cells impairs chromaffin cell survival. Endocrinology. 2009; 150:1775-1718. (2008 Nov 26 Epub ahead of print).

29 Pham TT, Giesert F, Röthig A, Floss T, Kallnik M, Weindl K, Hölter SM, Ahting U, Prokisch H, Becker L, Klopstock T, Hrabé de Angelis M, Beyer K, Görner K, Kahle PJ, Vogt Weisenhorn DM, Wurst W. DJ-1-deficient mice show less TH-positive neurons in the ventral tegmental area and exhibit non-motoric behavioural impairments. Genes Brain Behav. 2010 Apr;9(3):305-17. doi: 10.1111/j.1601-183X.2009.00559.x

28 Rakovic A, Stiller B, Djarmati A, Flaquer A, Freudenberg J, Toliat M-R, Linnebank M, Kostic V, Lohmann K, Paus S, Nürnberg P, Kubisch C, Klein C, Wüllner U, Ramirez A. Genetic association study of the P-type ATPase ATP13A2 in late onset Parkinson disease. Mov Disord 2009;24:429-433.

27 Scholz SW, Houlden H, Schulte C, Sharma M, Li A, Berg D, Melchers A, Paudel R, Gibbs JR, Simon-Sanchez J, Paisan-Ruiz C, Bras J, Ding J, Chen H, Traynor BJ, Arepalli S, Zonozi RR, Revesz T, Holton J, Wood N, Lees A, Oertel W, Wullner U, Goldwurm S, Pellecchia MT, Illig T, Riess O, Fernandez HH, Rodriguez RL, Okun MS, Poewe W, Wenning GK, Hardy JA, Singleton AB, Gasser T. SNCA variants are associated with increased risk for multiple system atrophy. Ann Neurol. 2009 Mar 18;65(5):610-4.

26 Schulte C, Synofzik M, Gasser T, Schols L. Ataxia with ophthalmoplegia or sensory neuropathy is frequently caused by POLG mutations. Neurology. 2009 Sep 15;73(11):898-900.
25 Sharma M, Lichtner P,  Krüger R, Berg D, Schulte C,  Illig T, Riess O, Gasser T. Further delineation of the association signal on chromosome 5 from the first whole genome association study in Parkinson's disease. Neurobiol Aging. 2009;30:706-9.

24 Sidransky E, Nalls MA, Aasly JO, Aharon-Peretz J, Annesi G, Barbosa ER, Bar-Shira A, Berg D, Bras J, Brice A, Chen CM, Clark LN, Condroyer C, De Marco EV, Durr A, Eblan MJ, Fahn S, Farrer MJ, Fung HC, Gan-Or Z, Gasser T, Gershoni-Baruch R, Giladi N, Griffith A, Gurevich T, Januario C, Kropp P, Lang AE, Lee-Chen GJ, Lesage S, Marder K, Mata IF, Mirelman A, Mitsui J, Mizuta I, Nicoletti G, Oliveira C, Ottman R, Orr-Urtreger A, Pereira LV, Quattrone A, Rogaeva E, Rolfs A, Rosenbaum H, Rozenberg R, Samii A, Samaddar T, Schulte C, Sharma M, Singleton A, Spitz M, Tan EK, Tayebi N, Toda T, Troiano AR, Tsuji S, Wittstock M, Wolfsberg TG, Wu YR, Zabetian CP, Zhao Y, Ziegler SG. Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease. N Engl J Med. 2009 Oct 22;361(17):1651-61.

23 Simon-Sanchez J, Schulte C, Bras JM, Sharma M, Gibbs JR, Berg D, Paisan-Ruiz C, Lichtner P, Scholz SW, Hernandez DG, Kruger R, Federoff M, Klein C, Goate A, Perlmutter J, Bonin M, Nalls MA, Illig T, Gieger C, Houlden H, Steffens M, Okun MS, Racette BA, Cookson MR, Foote KD, Fernandez HH, Traynor BJ, Schreiber S, Arepalli S, Zonozi R, Gwinn K, van der Brug M, Lopez G, Chanock SJ, Schatzkin A, Park Y, Hollenbeck A, Gao J, Huang X, Wood NW, Lorenz D, Deuschl G, Chen H, Riess O, Hardy JA, Singleton AB, Gasser T. Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nat Genet. 2009 Dec;41(12):1308-12.
22 Soehn AS, Pham TT, Schaeferhoff K, Floss T, Vogt-Weisenhorn DM, Wurst W, Bonin M, and Riess O. Periphilin Is Strongly Expressed in the Murine Nervous System and Is Indispensable for Murine Development. Genesis. 2009 Oct;47(10):697-707.

21 Supper J, Spangenberg L, Planatscher H, Dräger A, Schröder A, and Zell A: BowTieBuilder: modeling signal transduction pathways, BMC Systems Biology 2009, (30 June 2009). doi:10.1186/1752-0509-3-67
20 Tribl F, Asan E, Arzberger T, Tatschner T, Langenfeld E, Meyer HE, Bringmann G, Riederer P, Gerlach M, Marcus K.Identification of L-ferritin in neuromelanin granules of the human substantia nigra - a targeted proteomics approach. Mol Cell Proteomics. 2009 Aug;8(8):1832-8. doi:10.1074/mcp.M900006-MCP200
19 Waak J, Weber SS, Görner K, Schall C, Ichijo H, Stehle T, Kahle PJ. Oxidizable residues mediating protein stability and cytoprotective interaction of DJ-1 with apoptosis signal-regulating kinase 1. J Biol Chem. 2009 May 22;284(21):14245-57.

18 Waak J, Weber SS, Waldenmaier A, Görner K, Alunni-Fabbroni M, Schell H, Vogt-Weisenhorn D, Pham TT, Reumers V, Baekelandt V, Wurst W, Kahle PJ. Regulation of astrocyte inflammatory responses by the Parkinson's disease-associated gene DJ-1. FASEB J. 2009 Aug;23(8):2478-89. Epub 2009 Mar 10.

17 Wachter T, Weiss D, Breit S, Gasser T, Kruger R, Gharabaghi A (2009) Severe muscular fasciculations as an uncommon side-effect due to microdefect ofan extension wire in deep brain stimulation. Movement Disord 24(14):2161-2

16 Zimprich A, Schulte C, Reinthaler E, Haubenberger D, Balzar J, Lichtner P, El Tawil S, Edris S, Foki T, Pirker W, Katzenschlager R, Daniel G, Brucke T, Auff E, Gasser T. PARK11 gene (GIGYF2) variants Asn56Ser and Asn457Thr are not pathogenic for Parkinson's disease. Parkinsonism Relat Disord. 2009 Aug;15(7):532-4.

15 Zolles G, Wenzel D, Bildl W, Schulte U, Hofmann A, Mu?ller CS, Thumfart JO, Vlachos A, Deller T, Pfeifer A, Fleischmann BK,Roeper J, Fakler B, Klöcker N. Association with the auxiliary subunit PEX5R/Trip8b controls responsiveness of HCN channels tocAMP and adrenergic stimulation. Neuron. 2009 Jun 25; 62(6):814-25. doi:10.1016/j.neuron.2009.05.008

2008

14 Aguado C, Colón J, Ciruela F, Schlaudraff F, Cabañero MJ, Perry C, Watanabe M, Liss B, Wickman K, Luján R. Cell type-specific subunit composition of G protein-gated potassium channels in the cerebellum. J Neurochem. 2008 Apr;105(2):497-511. doi:10.1111/j.1471-4159.2007.05153.x

13 Andersson ER, Prakash N, Cajanek L, Minina E, Bryja V, Bryjova L, Yamaguchi TP, Hall AC, Wurst W, Arenas E. Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vivo. PLoS ONE. 2008;3(10):e3517. Epub 2008 Oct 27

12 Engblom D, Bilbao-Leis A, Sanchis-Segura C, Dahan L, Perreau-Lenz S, Balland M, Rodriguez Parkitna J, Lujan R, Halbout B, Mameli M, Parlato R, Sprengel R, Lüscher C, Schütz G, Spanagel R. Glutamate receptors on dopamine neurons control the persistence of cocaine-seeking. Neuron. 2008; 59:497-508

11 Gründemann J, Schlaudraff F, Haeckel O, Liss B. Elevated alpha-synuclein mRNA levels in individual UV-laser-microdissected dopaminergic substantia nigra neurons in idiopathic Parkinson's disease. Nucleic Acids Res. 2008 Apr;36(7):e38. doi:10.1093/nar/gkn084

10 Hasegawa T, Treis A, Patenge N, Fiesel FC, Springer W, Kahle PJ. Parkin protects against tyrosinase-mediated dopamine neurotoxicity by suppressing stress-activated protein kinase pathways. J Neurochem. 2008 Jun;105(5):1700-1715

9 Hoepken HH, Gispert S, Azizov M, Klinkenberg M, Ricciardi F, Kurz A, Morales-Gordo B, Bonin M, Riess O, Gasser T, Kögel D, Steinmetz H, Auburger G.Parkinson patient fibroblasts show increased alpha-synuclein expression. Exp Neurol. 2008 Aug;212(2):307-13.

8 Kruger R. (2008) LRRK2 in Parkinson?s disease ? drawing the curtain of penetrance. BMC Medicine 6: 30

7 Lammel S, Hetzel A, Häckel O, Jones I, Liss B, Roeper J. Unique properties of mesoprefrontal neurons within a dual mesocorticolimbic dopamine system. Neuron. 2008 Mar 13;57(5):760-73. doi:10.1016/j.neuron.2008.01.022

6 Liss B, Roeper J. Individual dopamine midbrain neurons: functional diversity and flexibility in health and disease. Brain Res Rev. 2008 Aug;58(2):314-21. doi:10.1016/j.brainresrev.2007.10.004

5 Radke S, Chander H, Schäfer P, Meiss G, Krüger R, Schulz JB, Germain D. (2008) Mitochondrial protein quality control by the proteasome involves ubiquitination and the protease Omi. J Biol Chem 283: 12681-12685

4 Tribl F, Meyer HE, Marcus K. Analysis of organelles within the nervous system: impact on brain and organelle functions. Expert Rev Proteomics. 2008 Apr;5(2):333-51. Review. PMID: 18466061

3 Tricarico D, Mele A, Liss B, Ashcroft FM, Lundquist AL, Desai RR, George AL Jr, Conte Camerino D. Reduced expression of Kir6.2/SUR2A subunits explains KATP deficiency in K+-depleted rats. Neuromuscul Disord. 2008 Jan; 18(1):74-80. doi:10.1016/j.nmd.2007.07.009

2 Tuin I, Voss U, Kessler K, Krakow K, Hilker R, Morales B, Steinmetz H, Auburger G.Sleep quality in a family with hereditary parkinsonism (PARK6). Sleep Med. 2008 Aug;9(6):684-8.

1 Veenstra T, Marcus K. Multidimensional advancement of neuroproteomics. Expert Rev Proteomics. 2008 Apr;5(2):149-51. PMID: 18466109