2010

1    Atanur SS; Birol I; Guryev V; Hirst M; Hummel O; Morrissey C; Behmoaras J; Fernandez-Suarez XM; Johnson MD; McLaren WM; Patone G; Petretto E; Plessy C; Rockland KS; Rockland C; Saar K; Zhao Y; Carninci P; Flicek P; Kurtz T; Cuppen E; Pravenec M; Huebner N; Jones SJ; Birney E; Aitman TJ. The genome sequence of the spontaneously hypertensive rat: analysis and functional significance. Genome Research 20 (6): 791-803 (2010)
2    Beckmann BM, Holinski-Feder E, Walter MC, Haserück N, Reithmann C, Hinterseer M, Wilde AA, Kääb S. Laminopathy presenting as familial atrial fibrillation. Int J Cardiol. 2010 May 14.
3    Ellinor PT, Lunetta KL, Glazer NL, Pfeufer A, Alonso A, Chung MK, Sinner MF, de Bakker PI, Mueller M, Lubitz SA, Fox E, Darbar D, Smith NL, Smith JD, Schnabel RB, Soliman EZ, Rice KM, Van Wagoner DR, Beckmann BM, van Noord C, Wang K, Ehret GB, Rotter JI, Hazen SL, Steinbeck G, Smith AV,Launer LJ, Harris TB, Makino S, Nelis M, Milan DJ, Perz S, Esko T, Köttgen A, Moebus S, Newton- Cheh C, Li M, Möhlenkamp S, Wang TJ, Kao WH, Vasan RS, Nöthen MM, MacRae CA, Stricker BH, Hofman A, Uitterlinden AG, Levy D, Boerwinkle E, Metspalu A, Topol EJ, Chakravarti A, Gudnason V, Psaty BM, Roden DM, Meitinger T, Wichmann HE, Witteman JC, Barnard J, Arking DE, Benjamin EJ, Heckbert SR, Kääb S. Common variants in KCNN3 are associated with lone atrial fibrillation. Nat Genet. 2010 Mar;42(3):240-4. Epub 2010 Feb 21
4    Frank D, Frauen R, Hanselmann C, Kuhn C, Will D, Gantenberg J, Füzesi L, Katus HA, Frey N. Lmcd1/Dyxin, a novel Z-disc associated LIM protein, mediates cardiac hypertrophy in vitro and in vivo. J Mol Cell Cardiol. 2010 Oct;49(4):673-82. Epub 2010 Jun 30.
5    Huber M, Völler H, Jakob S, Reibis R, Do V, Bolbrinker J, Schmieder RE, Wegscheider K, Kreutz R. Role of the angiotensin II type 2-receptor gene (+1675G/A) polymorphism on left ventricular hypertrophy and geometry in treated hypertensive patients. J Hypertens 2010;28:1221-1229
6    Joutel A; Monet-Lepretre M; Gosele C; Baron-Menguy C; Hammes A; Schmidt S; Lemaire-Carrette B; Domenga V; Schedl A; Lacombe P; Huebner N Cerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel disease. Journal of Clinical Investigation 120 (2): 433-445 (2010)
7    Knöll R, Kostin S, Klede S, Savvatis K, Klinge L, Stehle I, Gunkel S, Kotter S, Babicz K, Sohns M, Miocic S, Didie M, Knöll G, Zimmermann WH, Thelen P, Bickeboller H, Maier L, Schaper W, Schaper J, Kraft T, Tschope C, Linke WA, Chien KR. A Common MLP (Muscle LIM Protein) Variant Is Associated WithCardiomyopathy. Circ Res. 2010;106(4):695-704
8    Lehnart SE, Lederer WJ. An antidote for calcium leak: targeting molecular arrhythmia mechanisms. J Mol Cell Cardiol. 2010 Feb;48(2):279-82. Epub 2009 Nov 26. PMID: 19931542
9    Luedde M, Ehlermann P, Weichenhan D, Will R, Zeller R, Rupp S, Müller A, Steen H, Ivandic BT, Ulmer HE, Kern M, Katus HA, Frey N. Severe familial left ventricular non-compaction cardiomyopathy due to a novel troponin T (TNNT2) mutation. Cardiovasc Res. 2010 Jun 1;86(3):452-60. Epub 2010 Jan 18
10    Matthias Heinig, Enrico Petretto, Chris Wallace, Leonardo Bottolo, Maxime Rotival, Han Lu, Yoyo Li, Rizwan Sarwar, Sarah R. Langley, Anja Bauerfeind, Oliver Hummel, Young-Ae Lee, Svetlana Paskas, Carola Rintisch, Kathrin Saar, Jason Cooper, Rachel Buchan, Elizabeth E. Gray, Jason G. Cyster, Cardiogenics Consortium, Jeanette Erdmann, Christian Hengstenberg, Seraya Maouche, Willem H. Ouwehand, Catherine M. Rice, Nilesh J Samani, Heribert Schunkert, Alison H Goodall, Herbert Schulz, Helge Roider, Martin Vingron, Stefan Blankenberg, Thomas Münzel, Tanja Zeller, Silke Symczak, Andreas Ziegler, Laurence Tiret, Deborah J. Smyth, Michal Pravenec, Timothy J. Aitman, Francois Cambien, David Clayton, John A. Todd, Norbert Hubner, Stuart A. Cook. A conserved trans-acting regulatory locus underlies a proinflammatory gene expression network and susceptibility to autoimmune type 1 diabetes. Nature, Volume: 467, Pages: 460–464, Date published: 23 September 2010, DOI: doi:10.1038/nature09386
11    Meder B, Just S, Vogel B, Rudloff J, Gartner L, Dahme T, Huttner I, Zankl A, Katus HA, Rottbauer W. JunB-CBFß Signaling is essential to maintain sarcomeric Z-disc structure and when defective leads to heart failure. J Cell Sci. 2010 Jul 6. [Epub ahead of print]
12    Morgan H, Beck T, Blake A, Gates H, Adams N, Debouzy G, Leblanc S, Lengger C, Maier H, Melvin D, Meziane H, Richardson D, Wells S, White J,Wood J, The EUMODIC Consortiumy, Hrabé de Angelis M, Brown SDM,Hancock JM and Mallon A-M. EuroPhenome: a repository for high-throughputmouse phenotyping data. Nucleic Acids Res. 2010 Jan;38 (Database issue):D577-85. doi:10.1093/nar/gkp1007 Epub 2009 Nov 23
13    Pfeufer A, van Noord C, Marciante KD, Arking DE, Larson MG, Smith AV, Tarasov KV, Müller M, Sotoodehnia N, Sinner MF, Verwoert GC, Li M, Kao WH, Köttgen A, Coresh J, Bis JC, Psaty BM, Rice K, Rotter JI, Rivadeneira F, Hofman A, Kors JA, Stricker BH, Uitterlinden AG, van Duijn CM, BeckmannBM, Sauter W, Gieger C, Lubitz SA, Newton-Cheh C, Wang TJ, Magnani JW, Schnabel RB, Chung MK, Barnard J, Smith JD, Van Wagoner DR, Vasan RS, Aspelund T, Eiriksdottir G, Harris TB, Launer LJ, Najjar SS, Lakatta E, Schlessinger D, Uda M, Abecasis GR, Müller-Myhsok B, Ehret GB, Boerwinkle E, 28 Chakravarti A, Soliman EZ, Lunetta KL, Perz S, Wichmann HE, Meitinger T, Levy D, Gudnason V, Ellinor PT, Sanna S, Kääb S, Witteman JC, Alonso A, Benjamin EJ, Heckbert SR. Genome-wide association study of PR interval. Nat Genet. 2010 Feb;42(2):153-9. Epub 2010 Jan 10
14    Schoensiegel F, Ivandic B, Geis NA, Schrewe A, Katus HA, Bekeredjian R. High Throughput Echocardiography in Conscious Mice: Training and Primary Screens. Ultraschall Med. 2010 Feb 24. [Epub ahead of print]
15    Seeger TS, Frank D, Rohr C, Will R, Just S, Grund C, Lyon R, Luedde M, Koegl M, Sheikh F, Rottbauer W, Franke WW, Katus HA, Olson EN, Frey N. (2010). Myozap, a novel intercalated disc protein, activates serum response factor-dependent signaling and is required to maintain cardiac function in vivo. Circ Res. 106(5):880-90
16    Wang Y; Liska F; Gosele C; Sedova L; Kren V; Krenova D; Ivics Z; Huebner N; Izsvak Z A novel active endogenous retrovirus family contributes to genome variability in rat inbred strains. Genome Research 20 (1): 19-27 (2010)
17    Will R, Eden M, Just S, Hansen A, Eder A, Frank D, Kuhn C, Seeger TS, Oehl U, Wiemann S, Korn B, Koegl M, Rottbauer W, Eschenhagen T, Katus HA, Frey N. Myomasp/LRRC39, a heart- and muscle-specific protein, is a novel component of the sarcomeric M-band and is involved in stretch sensing. Circ Res. 2010 Sep 16. [Epub ahead of print]

2009   

18    Benjamin EJ, Rice KM, Arking DE, Pfeufer A, van Noord C, Smith AV, Schnabel RB, Bis JC, Boerwinkle E, Sinner MF, Dehghan A, Lubitz SA, D'Agostino RB Sr, Lumley T, Ehret GB, Heeringa J, Aspelund T, Newton-Cheh C, Larson MG, Marciante KD, Soliman EZ, Rivadeneira F, Wang TJ, Eiríksdottir G, Levy D, Psaty BM, Li M, Chamberlain AM, Hofman A, Vasan RS, Harris TB, Rotter JI, Kao WH, Agarwal SK, Stricker BH, Wang K, Launer LJ, Smith NL, Chakravarti A, Uitterlinden AG, Wolf PA, Sotoodehnia N,Köttgen A, van Duijn CM, Meitinger T, Mueller M, Perz S, Steinbeck G, Wichmann HE, Lunetta KL, Heckbert SR, Gudnason V, Alonso A, Kääb S, Ellinor PT, Witteman JC. Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry. Nat Genet. 2009 Aug;41(8):879-81. Epub 2009 Jul 13
19    Dahme, T., H.A. Katus, and W. Rottbauer. (2009). Fishing for the genetic basis of cardiovascular disease. Dis Model Mech 2:18-22.
20    Dressel R, Guan K, Nolte J, Elsner L, Monecke S, Nayernia K, Hasenfuss G, Engel W. Multipotent adult germ-line stem cells, like other pluripotent stem cells, can be killed by cytotoxic T lymphocytes despite low expression of major histocompatibility complex class I molecules. Biol Direct 2009;4:31.
21    Feltrin E, Campanaro S, Diehl AD, Ehler E, Faulkner G, Fordham J, Gardin C, Harris M, Hill D, Knöll R, Laveder P, Mittempergher L, Nori A, Reggiani C, Sorrentino V, Volpe P, Zara I, Valle G, Deegan JNC. Muscle Research and Gene Ontology: New standards for improved data integration. BMC medical genomics. 2009 2(1):6.
22    Friedrichs F, Zugck C, Rauch GJ, Ivandic B, Weichenhan D, Müller-Bardorff M, Meder B, El Mokhtari NE, Regitz-Zagrosek V, Hetzer R, Schäfer A, Schreiber S, Chen J, Neuhaus I, Ji R, Siemers NO, Frey N, Rottbauer W, Katus HA, Stoll M. HBEGF, SRA1, and IK: Three co-segregating genes as determinants of cardiomyopathy. Genome Res. 2009 Mar;19(3):395-403
23    Fuchs H, Gailus-Durner V, Adler T, Aguilar Pimentel JA, Becker L, Bolle I, Brielmeier M, Calzada-Wack J, Dalke C, Ehrhardt N, Fasnacht N, Ferwagner B, Frischmann U, Hans W, Hölter SM, Hölzlwimmer G, Horsch M, Javaheri A, Kallnik M, Kling E, Lengger C, Maier H, Moßbrugger I, Mörth C, Naton B, Nöth U, Pasche B, Prehn C, Przemeck G, Puk O, Racz I, Rathkolb B, Rozman J, Schäble K, Schreiner R, Schrewe A, Sina C, Steinkamp R, Thiele F, Willershäuser M, Zeh R, Adamski J, Busch DH, Beckers J, Behrendt H, Daniel H, Esposito I, Favor J, Graw J, Heldmaier G, Höfler H, Ivandic B, Katus H, Klingenspor M, Klopstock T, Lengeling A, Mempel M, Müller W, Neschen S, Ollert M, Quintanilla-Martinez L, Rosenstiel P, Schmidt J, Schreiber S, Schughart K, Schulz H, Wolf E, Wurst W, Zimmer A, Hrabé de Angelis M. The German Mouse Clinic: a platform for systemic phenotype analysis of mouse models. Curr Pharm Biotechnol. 2009 Feb;10(2):236-43. PMID: 19199957
24    Goehringer C, Rutschow D, Bauer R, Schinkel S, Weichenhan D, Bekeredjian R, Straub V, Kleinschmidt JA, Katus HA, Müller OJ. Prevention of cardiomyopathy in delta-sarcoglycan knockout mice after systemic transfer of targeted adeno-associated viral vectors. Cardiovasc Res. 2009 Jun 1;82(3):404-10. Epub 2009 Feb 13.
25    Guan K, Wolf F, Becker A, Engel W, Nayernia K, Hasenfuss G. Isolation and cultivation of stem cells from adult mouse testes. Nat Protocols. 2009;4:143-54
26    Gunkel S, Heineke J, Hilfiker-Kleiner D, Knöll R. MLP: a stress sensor goes nuclear. J Mol Cell Cardiol. 2009 47(4):423-425.
27    Gunkel S, Linke WA, Heineke J, Hilfiker-Kleiner D, Knöll R. Response to Gehmlich et al. Letter to the Editor of the Journal of Molecular and Cellular Cardiology Regarding MLP: A Stress Sensor Goes Nuclear. J Mol Cell Cardiol. 2009.
28    Hassel D, Dahme T, Erdmann J, Meder B, Huge A, Stoll M, Just S, Hess A, Ehlermann P, Weichenhan D, Grimmler M, Liptau H, Hetzer R, Regitz-Zagrosek V, Fischer C, Nürnberg P, Schunkert H, Katus HA, Rottbauer W. Nexilin mutations destabilize cardiac Z-disks and lead to dilated cardiomyopathy. Nat Med. 2009 Nov;15(11):1281-8. Epub 2009 Nov 1
29    Hippe, H.J., N.M. Wolf, I. Abu-Taha, R. Mehringer, S. Just, S. Lutz, F. Niroomand, E.H. Postel, H.A. Katus, W. Rottbauer, and T. Wieland. (2009). The interaction of nucleoside diphosphate kinase B with Gbetagamma dimers controls heterotrimeric G protein function. Proc Natl Acad Sci U S A 2009 106:16269-16274.
30    Knöll R. Dilatative Kardiomyopathie - eine aktuelle Bestandsaufnahme. Med Report. 2009(9):2.
31    Knöll R. Molekulargenetische Grundlagen der dilatativen Kardiomyopathie. Der Kardiologe. 2009:3:443-452
32    Kuhn C, Frank D, Will R, Jaschinski C, Frauen R, Katus HA, Frey N. DYRK1A is a novel negative regulator of cardiomyocyte hypertrophy. (2009) J Biol Chem 284(25): 17320-17327.
33    Lehmann LH, Schaeufele T, Buss SJ, Balanova M, Hartschuh W, Ehlermann P, Katus IMAGE CARDIO MED. A patient with LEOPARD syndrome and PTPN11 mutation. Circulation. 2009 Mar 10;119(9):1328-9
34    Luedde M, Flögel U, Knorr M, Grundt C, Hippe HJ, Brors B, Frank D, HaselmannU, Antony C, Voelkers M, Schrader J, Most P, Lemmer B, Katus HA, Frey N.Decreased contractility due to energy deprivation in a transgenic rat model ofhypertrophic cardiomyopathy. J Mol Med. 2009 Apr;87(4):411-22.
35    Meder B, Katus HA, Rottbauer W. Genetik der hypertrophischen Kardiomyopathie. Journal für Kardiologie 2009
36    Meder B, Katus HA, Rottbauer W. Leichte Kette mit schweren Folgen - Der Zebrafish als Modell genetischer Herzschwäche. GenomXpress 2009; 3.09
37    Meder, B., C. Laufer, D. Hassel, S. Just, S. Marquart, B. Vogel, A. Hess, M.C. Fishman, H.A. Katus, and W. Rottbauer. (2009). A single serine in the carboxyl terminus of cardiac essential myosin light chain-1 controls cardiomyocyte contractility in vivo. Circ Res 104:650-659
38    Palumbo V, Segat L, Padovan L, Amoroso A, Trimarco B, Izzo R, Lembo G, Zagrosek VR, Knöll R, Brancaccio M, Tarone G, Crovella S. Melusin gene (ITGB1BP2) nucleotide variations study in hypertensive and cardiopathic patients. BMC Med Genet. 2009;10:140.
39    Pfeufer A, Sanna S, Arking DE, Müller M, Gateva V, Fuchsberger C, Ehret GB, Orrú M, Pattaro C, Köttgen A, Perz S, Usala G, Barbalic M, Li M, Pütz B, Scuteri A, Prineas RJ, Sinner MF, Gieger C, Najjar SS, Kao WH, Mühleisen TW, Dei M, Happle C, Möhlenkamp S, Crisponi L, Erbel R, Jöckel KH, NaitzaS, Steinbeck G, Marroni F, Hicks AA, Lakatta E, Müller-Myhsok B, Pramstaller PP, Wichmann HE, Schlessinger D, Boerwinkle E, Meitinger T, Uda M, Coresh J, Kääb S, Abecasis GR, Chakravarti A. Common variants at ten loci modulate the QT interval duration in the QTSCD Study Nat Genet. 2009Apr;41(4):407-14. Epub 2009 Mar 22
40    Scherer, D., D. Hassel, R. Bloehs, E. Zitron, K. von Lowenstern, C. Seyler, D. Thomas, F. Konrad, H.F. Burgers, G. Seemann, W. Rottbauer, H.A. Katus, C.A. Karle, and E.P. Scholz.Selective noradrenaline reuptake inhibitor atomoxetine directly blocks hERG currents. Br J Pharmacol 156:226-236. 2009.
41    Scholz, E.P., N. Niemer, D. Hassel, E. Zitron, H.F. Burgers, R. Bloehs, C. Seyler, D. Scherer, D. Thomas, S. Kathofer, H.A. Katus, W. Rottbauer, and C.A. Karle. (2009). Biophysical properties of zebrafish ether-a-go-go related gene potassium channels. Biochem Biophys Res Commun 381:159-164.
42    Sohns M, Rosenberger A, Bickeböller. Integration of a priori gene set information into genome-wide association studies. H. BMC Proc. 2009 Dec 15;3 Suppl 7:S95. PMID: 20018092
43    Streckfuss-Bömeke K, Vlasov A, Yin D, Hülsmann S, Nayernia K, Engel W, Hasenfuss G, Guan K. Generation of functional neurons and glia from multipotent adult mouse germline stem cells. Stem Cell Res. 2009;2:139-154
44    Tintle N, Lantieri F, Lebrec J, Sohns M, Ballard D, Bickeböller H. Inclusion of a priori information in genome-wide association analysis. Genet Epidemiol. 2009;33 Suppl 1:S74-80. PMID: 19924705.
45    Vogel, B., B. Meder, S. Just, C. Laufer, I. Berger, S. Weber, H.A. Katus, and W. Rottbauer. (2009). In-vivo characterization of human dilated cardiomyopathy genes in zebrafish. Biochem Biophys Res Commun 2009; 390:516-522.
46    Wendt N, Schulz A, Qadri F, Bolbrinker J, Kossmehl P, Winkler K, Stoll M, Vetter R, Kreutz R. Genetic analysis of salt-sensitive hypertension in Dahl rats reveals a link between cardiac fibrosis and high cholesterol. Cardiovasc Res 2009;15;81:618-626

2008   

47    Chen, Z., W. Huang, T. Dahme, W. Rottbauer, M.J. Ackerman, and X. Xu. (2008). Depletion of zebrafish essential and regulatory myosin light chains reduces cardiac function through distinct mechanisms. Cardiovasc Res 79:97-108.
48    Ehlermann P, Weichenhan D, Zehelein J, Steen H, Pribe R, Zeller R, Lehrke S, Zugck C, Ivandic BT, Katus HA. Adverse events in families with hypertrophic or dilated cardiomyopathy and mutations in the MYBPC3 gene. BMC Med Genet. 2008 Oct 28;9:95.
49    Geiger SK, Bär H, Ehlermann P, Wälde S, Rutschow D, Zeller R, Ivandic BT, Zentgraf H, Katus HA, Herrmann H, Weichenhan D. Incomplete nonsense-mediated decay of mutant lamin A/C mRNA provokes dilated cardiomyopathy and ventricular tachycardia. J Mol Med. 2008 Mar;86(3):281-9. Epub 2007 Nov 7.
50    Hassel, D., E.P. Scholz, N. Trano, O. Friedrich, S. Just, B. Meder, D.L. Weiss, E. Zitron, S. Marquart, B. Vogel, C.A. Karle, G. Seemann, M.C. Fishman, H.A. Katus, and W. Rottbauer. Deficient zebrafish ether-a-go-go-related gene channel gating causes short-QT syndrome in zebrafish reggae mutants. Circulation. 117:866-875. 2008.
51    Hilfiker-Kleiner D, Knöll R. Disease-modifying mutations in familial hypertrophic cardiomyopathy: complexity from simplicity. Circulation. 2008 117(14):1775-1777.
52    Hubner N. The STAR Consortium, (2008) SNP and haplotype mapping for genetic analysis in the rat. Nat Genet. 40(5):560-566
53    Lange, M., B. Kaynak, U.B. Forster, M. Tonjes, J.J. Fischer, C. Grimm, J. Schlesinger, S. Just, I. Dunkel, T. Krueger, S. Mebus, H. Lehrach, R. Lurz, J. Gobom, W. Rottbauer, S. Abdelilah-Seyfried, and S. Sperling. (2008). Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex. Genes Dev 22:2370-2384.
54    Lehnart SE, Mongillo M, Bellinger A, Lindegger N, Chen BX, Hsueh W, Reiken S, Wronska A, Drew LJ, Ward CW, Lederer WJ, Kass RS, Morley G, Marks AR. Leaky Ca2+ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice. J Clin Invest. 2008;118(6):2230-45
55    Meder, B., H.A. Katus, and W. Rottbauer. (2008). Right into the heart of microRNA-133a. Genes Dev 22:3227-3231.
56    Monti J; Fischer J; Paskas S; Heinig M; Schulz H; Gösele C; Heuser A; Fischer R; Schmidt C; Schirdewan A; Gross V; Hummel O; Maatz H; Patone G; Saar K; Vingron M; Weldon SM; Lindpaintner K; Hammock BD; Rohde K; Dietz R; Cook SA; Schunck WH; Luft FC; Hubner N. Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease. Nature Genetics 40 (5): 529-537 (2008).
57    Nicolaou P, Knöll R, Haghighi K, Fan GC, Dorn GW, 2nd, Hasenfub G, Kranias EG. Human mutation in the anti-apoptotic heat shock protein 20 abrogates its cardioprotective effects. The Journal of biological chemistry. 2008 283(48):33465-33471.
58    Petretto E, Sarwar R, Grieve I, Lu H, Kumaran MK, Muckett PJ, Mangion J, Schroen B, Benson M, Punjabi PP, Prasad SK, Pennell DJ, Kiesewetter C, Tasheva ES, Corpuz LM, Webb MD, Conrad GW, Kurtz TW, Kren V, Fischer J, Hubner N, Pinto YM, Pravenec M, Aitman TJ, Cook SA. (2008) Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass. Nat Genet. 40(5):546-52.
59    Postel R, Vakeel P, Topczewski J, Knöll R, Bakkers J. Zebrafish integrin-linked kinase is required in skeletal muscles for strengthening the integrin-ECM adhesion complex. Dev Biol. 2008 318(1):92-101.
60    Pravenec M, Churchill PC, Churchill MC, Viklicky O, Kazdova L, Aitman TJ, Petretto E, Hubner N, Wallace CA, Zimdahl H, Zidek V, Landa V, Dunbar J, Bidani A, Griffin K, Qi N, Maxova M, Kren V, Mlejnek P, Wang J, Kurtz TW. (2008) Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension. Nat Genet. 40(8):952-4
61    Thum, T., C. Gross, J. Fiedler, T. Fischer, S. Kissler, M. Bussen, P. Galuppo, S. Just, W. Rottbauer, S. Frantz, M. Castoldi, J. Soutschek, V. Koteliansky, A. Rosenwald, M.A. Basson, J.D. Licht, J.T. Pena, S.H. Rouhanifard, M.U. Muckenthaler, T. Tuschl, G.R. Martin, J. Bauersachs, and S. Engelhardt. (2008). MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature 456:980-984.
62    Toischer K, Kögler H, Tenderich G, Grebe C, Seidler T, N. N, Jung K, Knöll R, Körfer R, Hasenfuss G. Elevated Afterload, Neuroendocrine Stimulation, and Human Heart Failure Increase BNP Levels and Inhibit Preload-Dependent SERCA Upregulation. Circulation Heart Failure. 2008; 1:265-271.