Publikationen

2013

135 Brand I., S. Fliegel, R. Spanagel, H.R. Noori.  Global Ethanol-Induced Enhancements of the Monoaminergic Neurotransmission: A Meta-Analysis, 2013.  Alcohol Clin Exp Res. 2013 Jun 28. doi: 10.1111/acer.12207. [Epub ahead of print]

134 Cacciaglia R, Nees F, Pohlack ST, Ruttorf M, Winkelmann T, Witt SH, Nieratschker V, Rietschel M, Flor H.  A risk variant for alcoholism in the NMDA receptor affects amygdala activity during fear conditioning in humans.  Biol Psychol. 2013 May 18. doi:pii: S0301-0511(13)00124-5. 10.1016/j.biopsycho.2013.05.006. [Epub ahead of print]

133 Charlet K, Schlagenhauf F, Richter A, Naundorf K, Dornhof L, Weinfurtner C, König F, Walaszek B, Schubert F, Müller CA, Gutwinski S, Seissinger A, Schmitz L, Walter H, Beck A, Gallinat J, Kiefer F, Heinz A.  Neural activation during processing of aversive faces predicts treatment outcome in alcoholism.  Addict Biol. 2013 Mar 7. doi: 10.1111/adb.12045. [Epub ahead of print]

132 Fliegel S., I. Brand, R. Spanagel, H.R. Noori. Ethanol-Induced Alterations of the Extracellular Amino Acid Concentrations: A Meta-Analysis, 2013 Alcohol Clin Exp Res [in press]

131 Haedel S, Wirth C, Rapp M, Gallinat J, Schubert F.  Effects of Age and Sex on the Concentrations of Glutamate and Glutamine in the Human Brain.  J Magn Reson Imaging. 2013 Apr 5. doi: 10.1002/jmri.24123. [Epub ahead of print]

130 Kienast T, Schlagenhauf F, Rapp M, Wrase J, Daig I, Buchholz HG, Smolka MN, Gründer G, Kumakura Y, Cumming P, Charlet K, Bartenstein P, Hariri A, Heinz A. Dopamine-modulated aversive emotion processing fails in alcohol-dependent patients.  Pharmacopsychiatry. 2013 Jun;46(4):130-6. doi: 10.1055/s-0032-1331747. Epub 2013 Jan 30.

129 Meinhardt MW, Hansson AC, Perreau-Lenz S, Bauder-Wenz C, Stählin O, Heilig M, Harper C, Drescher KU, Spanagel R, Sommer WH.  Rescue of Infralimbic mGluR2 Deficit Restores Control Over Drug-Seeking Behavior in Alcohol Dependence.  J Neurosci. 2013 Feb 13;33(7):2794-806.

128 Rietschel M, Treutlein J. The genetics of alcohol dependence.  Ann N Y Acad Sci. 2013 Apr;1282(1):39-70. doi: 10.1111/j.1749-6632.2012.06794.

127 Tozzi F, Teumer A, Munafò M, Rawal R, Kazeem G, Gerbaulet M, McArdle W, Chilcoat H, Döring A, Dahmen N, Mooser V, Nauck M, Ring SM, Rubio JP, Vollenweider P, Waeber G, John U, Völzke H, Homuth G, Freyberger HJ, Völker U, Davey-Smith G, Gieger C, Preisig M, Grabe HJ.  A genomewide association study of smoking relapse in four European population-based samples.  Psychiatr Genet. 2013 Mar 27. Pubmed PMID: 23542338

126 Van Eijk J, Demirakca T, Frischknecht U, Hermann D, Mann K, Ende G.   Rapid partial regeneration of brain volume during the first 14 days of abstinence from alcohol  Alcohol Clin Exp Res. 2013 Jan;37(1):67-74. doi: 10.1111/j.1530-0277.2012.01853.x. Epub 2012 Oct 16.

125 Vengeliene V, Noori H, Spanagel R.  The use of a novel Drinkometer system for assessing pharmacological treatment effects on alcohol consumption in rats.  Alcohol Clin Exp Res. 2013 Jan;37 Suppl 1:E322-8.

124 Wang X.D., Su Y.-A., Wagner K.V., Avrabos C., Scharf S.H., Hartmann J., Wolf M., Liebl C., Kuehne C., Wurst W., Holsboer F., Eder M., Deussing J.M., Mueller M.B., Schmidt M.V.  Nectin-3 Links CRHR1 Signaling to Stress-Induced Memory Deficits and Spine Loss.  Nat Neurosci. 2013 Jun;16(6):706-13. doi: 10.1038/nn.3395. Epub 2013 May 5 Nat Neurosci. Accepted

2012

123 Barkus C, Michael Feyder, Carolyn Graybeal, Tara Wright, Lisa Wiedholz, Alicia Izquierdo, Carly Kiselycznyk, Wolfram Schmitt, David J. Sanderson, J. Nicholas P. Rawlins, Lisa M. Saksida, Timothy J. Bussey, Rolf Sprengel, David Bannerman & Andrew Holmes  Do GluA1 knockout mice exhibit behavioral abnormalities relevant to the negative or cognitive symptoms of schizophrenia and schizoaffective disorder?   Neuropharmacology 62, 1263-1272.

122 Beck A, Wüstenberg T, Genauck A, Wrase J, Schlagenhauf F, Smolka MN, Mann K, Heinz A.  Effect of brain structure, brain function, and brain connectivity on relapse in alcohol-dependent patients. Arch Gen Psychiatry. 2012 Aug;69(8):842-52. doi: 10.1001/archgenpsychiatry.2011.2026.

121 Breu J, Touma C, Hölter SM, Knapman A, Wurst W, Deussing JM.  Urocortin 2 modulates aspects of social behaviour in mice.  Behav Brain Res. 2012 Aug 1;233(2):331-6.

120 Charlet K, Schlagenhauf F, Richter A, Naundorf K, Dornhof L, Weinfurtner C, König F, Walaszek B, Schubert F, Müller CA, Gutwinski S, Seissinger A, Schmitz L, Walter H, Beck A, Gallinat J, Kiefer F, Heinz A.Neural activation during processing of aversive faces predicts treatment outcome in alcoholism.  Addiction Biology [Epub ahead of print]

119 Charlet K, Schlagenhauf F, Richter A, Walter H, Beck A, Gallinat J, Kiefer F, Heinz A.  Neuronale Aktivierung während der Verarbeitung negativer Gesichtsausdrücke prädiziert Abstinenzdauer in alkoholabhängigen Patienten.  Sucht: Volume 58 (2012), Supplement 1, Page 114.                                                                                                                                                                                                                                                                                                                                                                                           
118 Clarke TK, Dempster E, Docherty SJ, Desrivieres S, Lourdsamy A, Wodarz N, Ridinger M, Maier W, Rietschel M, Schumann G.  Multiple polymorphisms in genes of the adrenergic stress system confer vulnerability to alcohol abuse.  Addict Biol. 2012 Jan;17(1):202-8. doi: 10.1111/j.1369-1600.2010.00263.

117 Frank J, Cichon S, Treutlein J, Ridinger M, Mattheisen M, Hoffmann P, Herms S, Wodarz N, Soyka M, Zill P, Maier W, Mössner R, Gaebel W, Dahmen N, Scherbaum N, Schmäl C, Steffens M, Lucae S, Ising M, Müller-Myhsok B, Nöthen MM, Mann K, Kiefer F, Rietschel M.  Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster.  Addict Biol. 2012 Jan;17(1):171-80. doi: 10.1111/j.1369-1600.2011.00395.

116 Fusco S, Ripoli C, Podda MV, Ranieri SC, Leone L, Toietta G, McBurney MW, Schütz G, Riccio A, Grassi C, Galeotti T, Pani G.  A role for neuronal cAMP responsive-element binding (CREB)-1 in brain responses to calorie restriction.  Proc Natl Acad Sci USA. 2012; 109:621-626. E-pub 2011.

115 Graf C, Kuehne C, Panhuysen M, Puetz B, Weber P, Holsboer F, Wurst W, Deussing JM.  Corticotropin-releasing hormone regulates common target genes with divergent functions in corticotrope and neuronal cells.  Mol Cell Endocrinol. 2012 Oct 15;362(1-2):29-38.

114 Hermann D, Weber-Fahr W, Sartorius A, Hoerst M, Frischknecht U, Tunc-Skarka N, Perreau-Lenz S, Hansson AC, Krumm B, Kiefer F, Spanagel R, Mann K, Ende G, Sommer WH. Translational Magnetic Resonance Spectroscopy Reveals Excessive Central  Glutamate Levels During Alcohol Withdrawal in Humans and Rats.  Biol Psychiatry, 2012 Jun 1;71(11):1015-21. doi: 10.1016/j.biopsych.2011.07.034.

113 Karlsson RM, Adermark L, Molander A, Perreau-Lenz S, Singley E, Solomon M, Holmes A, Tanaka K, Lovinger DM, Spanagel R, Heilig M. Reduced alcohol intake and reward associated with impaired endocannabinoid signaling in mice with a deletion of the glutamate transporter GLAST.  Neuropharmacology. 2012 Aug;63(2):181-9.

112 Kühne C, Puk O, Graw J, Hrabe de Angelis M, Schütz G, Wurst W, Deussing JM.   Visualizing corticotropin-releasing hormone receptor type 1 expression and neuronal connectivities in the mouse using a novel multifunctional allele.  J Comp Neurol 2012; 520:3150-3180.

111 Laucht M, Blomeyer D, Buchmann AF, Treutlein J, Schmidt MH, Esser G, Jennen-Steinmetz C, Rietschel M, Zimmermann US, Banaschewski T.  Catechol-O-methyltransferase Val158 Met genotype, parenting practices and adolescent alcohol use: testing the differential susceptibility hypothesis.  J Child Psychol Psychiatry. 2012 Apr;53(4):351-9. doi: 10.1111/j.1469-7610.2011.02408.

110 Molander A, Vengeliene V, Heilig M, Wurst W, Deussing JM, Spanagel R. Brain-specific inactivation of the Crhr1 gene inhibits post-dependent and stress-induced alcohol intake, but does not affect relapse-like drinking.  Neuropsychopharmacology. 37:1047-56.

109 Mutschler J, Abbruzzese E, Witt SH, Dirican G, Nieratschker V, Frank J, Grosshans M, Rietschel M, Kiefer F.  Functional polymorphism of the dopamine ?-hydroxylase gene is associated with increased risk of disulfiram-induced adverse effects in alcohol-dependent patients.  J Clin Psychopharmacol. 2012 Aug;32(4):578-80. doi: 10.1097/JCP.0b013e31825ddbe6.

108 Nees F, Tzschoppe J, Patrick CJ, Vollstädt-Klein S, Steiner S, Poustka L, Banaschewski T, Barker GJ, Büchel C, Conrod PJ, Garavan H, Heinz A, Gallinat J, Lathrop M, Mann K, Artiges E, Paus T, Poline JB, Robbins TW, Rietschel M, Smolka MN, Spanagel R, Struve M, Loth E, Schumann G, Flor H; IMAGEN Consortium.  Determinants of early alcohol use in healthy adolescents: the differential contribution of neuroimaging and psychological factors.  Neuropsychopharmacology. 2012 Mar;37(4):986-95. doi: 10.1038/npp.2011.282.

107 Nieratschker V, Grosshans M, Frank J, Strohmaier J, von der Goltz C, El-Maarri O, Witt SH, Cichon S, Nöthen MM, Kiefer F, Rietschel M.  Epigenetic alteration of the dopamine transporter gene in alcohol-dependent patients is associated with age.  Addict Biol. 2012 Apr 16. doi: 10.1111/j.1369-1600.2012.00459.

106 Noori H.R.  Multi-Scale Modeling of Complex Neuronal Networks: a view Towards Striatal Pattern Formations J Biol Phys 38(4):597-606.

105 Noori H.R.  Mathematical Modeling of Neurochemical Responses to Alcohol, 2012 Alcohol Clin Exp Res, 36 Suppl 2: 20A.

104 Noori H.R., R. Spanagel, A. Hansson. Neurocircuitry for Modeling Drug Effects Addict Biol 17(5):827-864.

103 Noori H.R., S. Fliegel, I. Brand, R. Spanagel. The impact of Acetylcholinesterase Inhibitors on the Extracellular Concentrations in the Adult Rat Brain: A Meta- Analysis Synapse 66(10): 893-901.

102 Perreau-Lenz S., V. Vengeliene, H.R. Noori, E. Merlo-Pich, M. Corsi, C. Corti and R. Spanagel. Inhibition of the Casein-kinase-1-delta Prevents Relapse-Like Alcohol Drinking Behaviour Neuropsychopharm 37(9):2121-2131.

101 Piao X, Komazawa-Sakon S, Nishina T, Koike M, Piao JH, Ehlken H, Kurihara H, Hara M, Van Rooijen N, Schütz G, Uchiyama Y, Yagita H, Okumura K, He YW, Nakano H.  c-FLIP maintains tissue homeostasis by preventing apoptosis and programmed necrosis.  Sci Signal 2012; 5:ra93.

100 Racz I, Markert A, Mauer D, Stoffel-Wagner B, Zimmer A.  Long-term ethanol effects on acute stress responses: Modulation by dynorphin.  Addict Biol. 2012 Sep 21. doi: 10.1111/j.1369-1600.2012.00494.

99 Ridder S, Treutlein J, Nees F, Lang S, Diener S, Wessa M, Kroll A, Pohlack S, Cacciaglia R, Gass P, Schütz G, Schumann G, Flor H.  Brain activation during fear conditioning in humans depends on genetic variations related to functioning of the hypothalamic-pituitary-adrenal axis: first evidence from two independent subsamples.  Psychol Med. 2012 Mar 12:1-11. [Epub ahead of print].

98 Rieker C, Schober A, Bilbao A, Schütz G, Rodriguez Parkitna J.  Ablation of SRF in dopaminergic neurons exacerbates susceptibility towards MPTP-induced oxidative stress.  Eur J Neurosci. 2012; 35: 735-741. Epub 2012 February 23. Doi: 10.1111/j.1460-9568.2012.08003.

97 Rietschel M, Treutlein J.  The genetics of alcohol dependence.  Ann N Y Acad Sci. 2012 Nov 21. [Epub ahead of print].

96 Schonig, K., Weber, T., Frommig, A., Wendler, L., Pesold, B., Djandji, D., Bujard, H., and Bartsch, D.  Conditional Gene Expression Systems in the Transgenic Rat Brain.  BMC Biol 10, 77.

95 Spanagel R, Vengeliene V.  New Pharmacological Treatment Strategies for Relapse Prevention.  Curr Top Behav Neurosci. 2013;13:583-609.

94 Stacey D, Bilbao A, Maroteaux M, Jia T, Easton AC, Longueville S, Nymberg C, Banaschewski T, Barker GJ, Büchel C, Carvalho F, Conrod PJ, Desrivières S, Fauth-Bühler M, Fernandez-Medarde A, Flor H, Gallinat J, Garavan H, Bokde AL, Heinz A, Ittermann B, Lathrop M, Lawrence C, Loth E, Lourdusamy A, Mann KF, Martinot JL, Nees F, Palkovits M, Paus T, Pausova Z, Rietschel M, Ruggeri B, Santos E, Smolka MN, Staehlin O, Jarvelin MR, Elliott P, Sommer WH, Mameli M, Müller CP, Spanagel R, Girault JA, Schumann G; IMAGEN Consortium.  RASGRF2 regulates alcohol-induced reinforcement by influencing mesolimbic dopamine neuron activity and dopamine release.  Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):21128-33.

93 Vollstädt-Klein, Sabine, Sabine Loeber, Anne Richter, Martina Kirsch, Patrick Bach, Christoph von der Goltz, Derik Hermann, Karl Mann and Falk Kiefer.  Validating incentive salience with fMRI:  association between mesolimbic cue-reactivity and attentional bias in alcohol-dependent patients. Addiction Biology 17(4):807-816.

92 Wang XD, Labermaier C, Holsboer F, Wurst W, Deussing JM, Müller MB, Schmidt MV.  Early-life stress-induced anxiety-related behavior in adult mice partially requires forebrain corticotropin-releasing hormone receptor 1.  Eur J Neurosci. 2012 Jun 4. doi: 10.1111/j.1460-9568.2012.08148.x. [Epub ahead of print].

2011

91 Amin N, Byrne E, Johnson J, Chenevix-Trench G, Walter S, Nolte IM; kConFabInvestigators, Vink JM, Rawal R, Mangino M, Teumer A, Keers JC, Verwoert G,Baumeister S, Biffar R, Petersmann A, Dahmen N, Doering A, Isaacs A, Broer L,Wray NR, Montgomery GW, Levy D, Psaty BM, Gudnason V, Chakravarti A, Sulem P, Gudbjartsson DF, Kiemeney LA, Thorsteinsdottir U, Stefansson K, van Rooij FJ, Aulchenko YS, Hottenga JJ, Rivadeneira FR, Hofman A, Uitterlinden AG, Hammond CJ, Shin SY, Ikram A, Witteman JC, Janssens AC, Snieder H, Tiemeier H, Wolfenbuttel BH, Oostra BA, Heath AC, Wichmann E, Spector TD, Grabe HJ, Boomsma DI, Martin NG, van Duijn CM. Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM. Mol Psychiatry. 2011 Aug 30.

90 Chambers JC, Zhang W, Sehmi J, Li X, Wass MN, Van der Harst P, Holm H, Sanna S, Kavousi M, Baumeister SE, Coin LJ, Deng G, Gieger C, Heard-Costa NL, Hottenga JJ, Kühnel B, Kumar V, Lagou V, Liang L, Luan J, Vidal PM, Mateo Leach I, O'Reilly PF, Peden JF, Rahmioglu N, Soininen P, Speliotes EK, Yuan X, Thorleifsson G, Alizadeh BZ, Atwood LD, Borecki IB, Brown MJ, Charoen P, Cucca F, Das D, de Geus EJ, Dixon AL, Döring A, Ehret G, Eyjolfsson GI, Farrall M, Forouhi NG, Friedrich N, Goessling W, Gudbjartsson DF, Harris TB, Hartikainen AL, Heath S, Hirschfield GM, Hofman A, Homuth G, Hyppönen E, Janssen HL, Johnson T, Kangas AJ, Kema IP, Kühn JP, Lai S, Lathrop M, Lerch MM, Li Y, Liang TJ, Lin JP, Loos RJ, Martin NG, Moffatt MF, Montgomery GW, Munroe PB, Musunuru K, Nakamura Y, O'Donnell CJ, Olafsson I, Penninx BW, Pouta A, Prins BP, Prokopenko I, Puls R, Ruokonen A, Savolainen MJ, Schlessinger D, Schouten JN, Seedorf U, Sen-Chowdhry S, Siminovitch KA, Smit JH, Spector TD, Tan W, Teslovich TM, Tukiainen T, Uitterlinden AG, Van der Klauw MM, Vasan RS, Wallace C, Wallaschofski H, Wichmann HE, Willemsen G, Würtz P, Xu C, Yerges-Armstrong LM; Alcohol Genome-wide Association (AlcGen) Consortium; Diabetes Genetics Replication and Meta-analyses (DIAGRAM+) Study; Genetic Investigation of Anthropometric Traits (GIANT) Consortium; Global Lipids Genetics Consortium; Genetics of Liver Disease (GOLD) Consortium; International Consortium for Blood Pressure (ICBP-GWAS); Meta-analyses of Glucose and Insulin-Related Traits Consortium (MAGIC), Abecasis GR, Ahmadi KR, Boomsma DI, Caulfield M, Cookson WO, van Duijn CM, Froguel P, Matsuda K, McCarthy MI, Meisinger C, Mooser V, Pietiläinen KH, Schumann G, Snieder H, Sternberg MJ, Stolk RP, Thomas HC, Thorsteinsdottir U, Uda M, Waeber G, Wareham NJ, Waterworth DM, Watkins H, Whitfield JB, Witteman JC, Wolffenbuttel BH, Fox CS, Ala-Korpela M, Stefansson K, Vollenweider P, Völzke H, Schadt EE, Scott J, Järvelin MR, Elliott P, Kooner JS. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet

89 Charlet K, Naundorf K, Dornhof L, Schlagenhauf F, Beck A, Gallinat J, Heinz A. Altered implicit neuronal processing of negative emotional facial expressions in alcohol-dependent patients. European Neuropsychopharmacology. The Journal of the European College of Neuropsychopharmacology: Volume 21 (2011), Supplement 3, Page S317

88 Chen G, Carlson VC, Wang J, Beck A, Heinz A, Ron D, Lovinger DM, Buck KJ: Striatal Involvement in Human Alcoholism and Alcohol Consumption, and Withdrawal in Animal Models. Alcohol Clin Exp Res. 35(10):1739-48 (2011)

87 Clarke TK, Laucht M, Ridinger M, Wodarz N, Rietschel M, Maier W, Lathrop M, Lourdusamy A, Zimmermann US, Desrivieres S, Schumann G. KCNJ6 is associated with adult alcohol dependence and involved in gene × early life stress interactions in adolescent alcohol drinking. Neuropsychopharmacology. 2011 May;36(6):1142-8.

86 Dedic N, Touma C, Romanowski CP, Schieven M, Kühne C, Ableitner M, Lu A, Holsboer F, Wurst W, Kimura M, Deussing JM. Assessing Behavioural Effects of Chronic HPA Axis Activation Using Conditional CRH-Overexpressing Mice. Cell Mol Neurobiol. 2011 Dec 25. [Epub ahead of print]

85 Desrivières S, Pronko SP, Lourdusamy A, Ducci F, Hoffman PL, Wodarz N, Ridinger M, Rietschel M, Zelenika D, Lathrop M, Schumann G, Tabakoff B. Sex-specific role for adenylyl cyclase type 7 in alcohol dependence. Biol Psychiatry. 2011 Jun 1;69(11):1100-8.

84 Devigny C, Perez-Balderas F, Hoogeland B, Cuboni S, Wachtel R, Mauch CP, Webb KJ, Deussing JM, Hausch F. Biomimetic screening of class-B G protein-coupled receptors. J Am Chem Soc. 2011 Jun 15;133(23):8927-33. Epub 2011 May 23.

83 Domanskyi A, Geißler C, Vinnikov IA, Alter H, Schober A, Vogt MA, Gass P, Parlato R, Schütz G. Pten ablation in adult dopaminergic neurons is neuroprotective in mouse models of Parkinson´s disease. FASEB J. 2011; 25:2898-2910.

82 Dong L, Bilbao A, Laucht M, Henriksson R, Yakovleva T, Ridinger M, Desrivieres S, Clarke TK, Lourdusamy A, Smolka MN, Cichon S, Blomeyer D, Treutlein J, Perreau-Lenz S, Witt S, Leonardi-Essmann F, Wodarz N, Zill P, Soyka M, Albrecht U, Rietschel M, Lathrop M, Bakalkin G, Spanagel R, Schumann G. Effects of the circadian rhythm gene period 1 (per1) on psychosocial stress-induced alcohol drinking. American Journal of Psychiatry. 2011 Oct;168(10):1090-8. PubMed PMID: 21828288.

81 Fenzl T, Romanowski CP, Flachskamm C, Deussing JM, Kimura M. Wake-promoting effects of orexin: Its independent actions against the background of an impaired corticotropine-releasing hormone receptor system. Behav Brain Res. 2011 Sep 12;222(1):43-50. Epub 2011 Mar 21.

80 Frank J, Cichon S, Treutlein J, Ridinger M, Mattheisen M, Wodarz N, Soyka M, Zill P,  Maier W, Gaebel W, Dahmen N, Scherbaum N, Schmäl C, Priebe L, Steffens M, Müller-Myhsok B, Nöthen M, Mann K, Kiefer F, Rietschel M (2012). Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster. Addiction Biology 1:171-180

79 Grabe HJ, Mahler J, Witt SH, Schulz A, Appel K, Spitzer C, Stender J, Barnow S, Freyberger HJ, Teumer A, Völzke H, Rietschel M. A risk marker for alcohol dependence on chromosome 2q35 is related to neuroticism in the general population. Mol Psychiatry. 2011 Feb;16(2):126-8.

78 Heinz AJ, Beck A, Meyer-Lindenberg A, Sterzer P, Heinz A: Cognitive and neurobiological mechanisms of alcohol-related aggression. Nat Rev Neurosci. 12(7):400-13 (2011)

77 Helinski S, Spanagel R (2011). Publication trends in addiction research. Addict Biol 16:532-539

76 Hermann D, Weber-Fahr W, Sartorius A, Hoerst M, Frischknecht U, Tunc-Skarka N, Perreau-Lenz S, Hansson AC, Krumm B, Kiefer F, Spanagel R, Mann K, Ende G, Sommer WH (in press 2011). Translational Magnetic Resonance Spectroscopy Reveals Excessive Central Glutamate Levels During Alcohol Withdrawal in Humans and Rats. Biological Psychiatry. 2011 Sep 10. [Epub ahead of print]

75 Jakubcakova V, Flachskamm C, Deussing JM, Kimura M. Deficiency of corticotropin-releasing hormone type-2 receptor alters sleep responses to bacterial lipopolysaccharide in mice. Brain Behav Immun. 2011 Nov;25(8):1626-36. Epub 2011 Jun 17.

74 Kiefer F, Witt SH, Frank J, Richter A, Treutlein J, Lemenager T, Nöthen MM, Cichon S, Batra A, Berner M, Wodarz N, Zimmermann US, Spanagel R, Wiedemann K, Smolka MN, Heinz A, Rietschel M, Mann K.  *These authors contributed equally. Involvement of the atrial natriuretic peptide transcription factor GATA4 in alcohol dependence, relapse risk and treatment response to acamprosate. Pharmacogenomics J. 2011 Oct;11(5):368-74. doi: 10.1038/tpj.2010.51.;

73 Molander A, Vengeliene V, Heilig M, Wurst W, Deussing JM, Spanagel R. Brain-Specific Inactivation of the Crhr1 Gene Inhibits Post-Dependent and Stress-Induced Alcohol Intake, but Does Not Affect Relapse-Like Drinking. Neuropsychopharmacology. 2011 Nov 23. doi: 10.1038/npp.2011.297. [Epub ahead of print]

72 Noori, H. R. The effects of the acute administration of low-dosage ethanol on the phasic neurochemical oscillations of the basal ganglia. Math. Med. Biol., 2011, in press. Math Med Biol. 2011 May 4. [Epub ahead of print]

71 Parkitna, J.R., Solecki, W., Go?embiowska, K., Tokarski, K., Kubik, J., Go?da, S., Novak, M., Parlato, R., Hess, G., Sprengel, R., et al. (2011). Glutamate input to noradrenergic neurons plays an essential role in the development of morphine dependence and psychomotor sensitization. Int. J. Neuropsychopharmacol. 1?15.

70 Procaccini, C., Aitta-Aho, T., Jaako-Movits, K., Zharkovsky, A., Panhelainen, A., Sprengel, R., Linden, A.-M., and Korpi, E.R. (2011). Excessive novelty-induced c-Fos expression and altered neurogenesis in the hippocampus of GluA1 knockout mice. Eur J Neurosci 33, 161?174.

69 Refojo D, Schweizer M, Kuehne C, Ehrenberg S, Thoeringer C, Vogl AM, Dedic N, Schumacher M, von Wolff G, Avrabos C, Touma C, Engblom D, Schütz G, Nave KA, Eder M, Wotjak CT, Sillaber I, Holsboer F, Wurst W, Deussing JM. Glutamatergic and dopaminergic neurons mediate anxiogenic and anxiolytic effects of CRHR1. Science. 2011 Sep 30;333(6051):1903-7. Epub 2011 Sep 1.

68 Rieker C, Engblom D, Kreiner G, Domanskyi A, Schober A, Stotz S, Neumann M, Yuan X, Grummt I, Schütz G, and Parlato R. Nucleolar disruption in dopaminergic neurons leads to oxidative damage and parkinsonism through repression of mammalian target of rapamycin signaling.J Neurosci 2011; 31:453-460.

67 Sanderson, D.J., Hindley, E., Smeaton, E., Denny, N., Taylor, A., Barkus, C., Sprengel, R., Seeburg, P.H., and Bannerman, D.M. (2011a). Deletion of the GluA1 AMPA receptor subunit impairs recency-dependent object recognition memory. Learn Mem 18, 181?190.

66 Sanderson, D.J., Sprengel, R., Seeburg, P.H., and Bannerman, D.M. (2011b). Deletion of the GluA1 AMPA receptor subunit alters the expression of short-term memory. Learn Mem 18, 128?131.

65 Schumann G, Coin LJ, Lourdusamy A, Charoen P, Berger KH, Stacey D, Desrivières S, Aliev FA, Khan AA, Amin N, Aulchenko YS, Bakalkin G, Bakker SJ, Balkau B, Beulens JW, Bilbao A, de Boer RA, Beury D, Bots ML, Breetvelt EJ, Cauchi S, Cavalcanti-Proença C, Chambers JC, Clarke TK, Dahmen N, de Geus EJ, Dick D, Ducci F, Easton A, Edenberg HJ, Esk T, Fernández-Medarde A, Foroud T, Freimer NB, Girault JA, Grobbee DE, Guarrera S, Gudbjartsson DF, Hartikainen AL, Heath AC, Hesselbrock V, Hofman A, Hottenga JJ, Isohanni MK, Kaprio J, Khaw KT, Kuehnel B, Laitinen J, Lobbens S, Luan J, Mangino M, Maroteaux M, Matullo G, McCarthy MI, Mueller C, Navis G, Numans ME, Núñez A, Nyholt DR, Onland-Moret CN, Oostra BA, O'Reilly PF, Palkovits M, Penninx BW, Polidoro S, Pouta A, Prokopenko I, Ricceri F, Santos E, Smit JH, Soranzo N, Song K, Sovio U, Stumvoll M, Surakk I, Thorgeirsson TE, Thorsteinsdottir U, Troakes C, Tyrfingsson T, Tönjes A, Uiterwaal CS, Uitterlinden AG, van der Harst P, van der Schouw YT, Staehlin O, Vogelzangs N, Vollenweider P, Waeber G, Wareham NJ, Waterworth DM, Whitfield JB, Wichmann EH, Willemsen G, Witteman JC, Yuan X, Zhai G, Zhao JH, Zhang W, Martin NG, Metspalu A, Doering A, Scott J, Spector TD, Loos RJ, Boomsma DI, Mooser V, Peltonen L, Stefansson K, van Duijn CM, Vineis P, Sommer WH, Kooner JS, Spanagel R, Heberlein UA, Jarvelin MR, Elliott P. Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption. Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):7119-24. Epub 2011 Apr 6.

64 Staudinger M, Erk S, Walter H (2011). Dorsolateral prefrontal cortex modulates striatal reward encoding during reappraisal of reward anticipation. Cerebral Cortex 21(11):2578-88.

63 Stickel F, Buch S, Lau K, Meyer zu Schwabedissen H, Berg T, Ridinger M, Rietschel M, Schafmayer C, Braun F, Hinrichsen H, Günther R, Arlt A, Seeger M, Müller S, Seitz HK, Soyka M, Lerch M, Lammert F, Sarrazin C, Kubitz R, Häussinger D, Hellerbrand C, Bröring D, Schreiber S, Kiefer F, Spanagel R, Mann K, Datz C, Krawczak M, Wodarz N, Völzke H, Hampe J. Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasians. Hepatology. 2011 Jan;53(1):86-95. doi: 10.1002/hep.24017.

62 Taylor, A.M., Niewoehner, B., Seeburg, P.H., Sprengel, R., Rawlins, J.N.P., Bannerman, D.M., and Sanderson, D.J. (2011). Dissociations within short-term memory in GluA1 AMPA receptor subunit knockout mice. Behav Brain Res 224, 8?14.

61 Thoeringer CK, Henes K, Eder M, Dahlhoff M, Wurst W, Holsboer F, Deussing JM, Moosmang S, Wotjak CT. Consolidation of Remote Fear Memories Involves Corticotropin-Releasing Hormone (CRH) Receptor Type 1-Mediated Enhancement of AMPA Receptor GluR1 Signaling in the Dentate Gyrus. Neuropsychopharmacology. 2011 Oct 26. doi: 10.1038/npp.2011.256. [Epub ahead of print]

60 Trebicka J, Racz I, Siegmund SV, Cara E, Granzow M, Schierwagen R, Klein S, Wojtalla A, Hennenberg M, Huss S, Fischer HP, Heller J, Zimmer A, Sauerbruch T. Role of cannabinoid receptors in alcoholic hepatic injury: steatosis and fibrogenesis are increased in CB(2) receptor-deficient mice and decreased in CB(1) receptor knockouts. Liver Int. 2011 Jul;31(6):862-72.

59 Treutlein J, Rietschel M. Genome-wide association studies of alcohol dependence and substance use disorders. Curr Psychiatry Rep. 2011 Apr;13(2):147-55.

58 Vollstädt-Klein S,  Löber S, Kirsch M, Bach P, Richter A,  Bühler M, von der Goltz C, Hermann D, Mann K, Kiefer F. Effects of cue-exposure treatment on neutral cue reactivity in alcohol-dependence: a randomized trial. Biological Psychiatry, 2011, 69, 1060-1066.

57 Vollstädt-Klein S, Löber S, Richter A, Kirsch M, Bach P, von der Goltz C, Hermann D, Mann K, Kiefer F. Validating incentive salience with fMRI: association between mesolimbic cue-reactivity and attentional bias in alcohol-dependent patients. Addiction Biology, published online July 2011 (doi: 10.111/j.1369-1600.2011.00352.x).

56 von Wolff G, Avrabos C, Stepan J, Wurst W, Deussing JM, Holsboer F, Eder M. Voltage-sensitive dye imaging demonstrates an enhancing effect of corticotropin-releasing hormone on neuronal activity propagation through the hippocampal formation. J Psychiatr Res. 2011 Feb;45(2):256-61.

55 Wang XD, Chen Y, Wolf M, Wagner KV, Liebl C, Scharf SH, Harbich D, Mayer B, Wurst W, Holsboer F, Deussing JM, Baram TZ, Müller MB, Schmidt MV. Forebrain CRHR1 deficiency attenuates chronic stress-induced cognitive deficits and dendritic remodelling. Neurobiol Dis. 2011 Jun;42(3):300-10. Epub 2011 Feb 3.

54 Wang XD, Rammes G, Kraev I, Wolf M, Liebl C, Scharf SH, Rice CJ, Wurst W, Holsboer F, Deussing JM, Baram TZ, Stewart MG, Müller MB, Schmidt MV. Forebrain CRF? modulates early-life stress-programmed cognitive deficits. J Neurosci. 2011 Sep 21;31(38):13625-34.

53 Yu Z, Kastenmüller G, He Y, Belcredi P, Möller G, Prehn C, Mendes J, Wahl S,Roemisch-Margl W, Ceglarek U, Polonikov A, Dahmen N, Prokisch H, Xie L, Li Y,Wichmann HE, Peters A, Kronenberg F, Suhre K, Adamski J, Illig T, Wang-Sattler R. Differences between human plasma and serum metabolite profiles. PLoS One. 2011;6(7):e21230. Epub 2011 Jul 8

52 Zink M, Ferbert T, Frank ST, Seufert P, Gebicke-Haerter PJ, Spanagel R (2011). Perinatal exposure to alcohol disturbs spatial learning and glutamate transmission-related gene expression in the adult hippocampus. Eur J Neurosci. 34:457-68

2010

51 Abraham NM, Egger V, Shimshek DR, Renden R, Fukunaga I, Sprengel R, Seeburg PH, Klugmann M, Margrie TW, Schaefer AT, Kuner T. Synaptic inhibition in the olfactory bulb accelerates odor discrimination in mice. Neuron. 2010 Feb 11;65(3):399-411.

50 Barkus C, McHugh SB, Sprengel R, Seeburg PH, Rawlins JN, Bannerman DM. Hippocampal NMDA receptors and anxiety: at the interface between cognition and emotion. Eur J Pharmacol. 2010 Jan 10;626(1):49-56. Epub 2009 Oct 15. Review.

49 Bierut LJ, Agrawal A, Bucholz KK, Doheny KF, Laurie C, Pugh E, Fisher S, Fox L, Howells W, Bertelsen S, Hinrichs AL, Almasy L, Breslau N, Culverhouse RC, Dick DM, Edenberg HJ, Foroud T, Grucza RA, Hatsukami D, Hesselbrock V, Johnson EO, Kramer J, Krueger RF, Kuperman S, Lynskey M, Mann K, Neuman RJ, Nöthen MM, Nurnberger JI Jr, Porjesz B, Ridinger M, Saccone NL, Saccone SF, Schuckit MA, Tischfield JA, Wang JC, Rietschel M, Goate AM, Rice JP. Gene, Environment Association Studies Consortium. A genome-wide association study of alcohol dependence. Proc Natl Acad Sci U S A. 2010 Mar  16;107(11):5082-5087.

48 Charlet K, Wüstenberg T, Schneider-Hassloff H, Kensche M, Schott BH, Wrase J, Heinz A Improved long-term memory performance for reinforced reward-predicting stimuli ? a pilot study. Eur arch psychiatry clin neurosci 260 (suppl 1): S45, P23

47 Deussing JM, Breu J, Kühne C, Kallnik M, Bunck M, Glasl L, Yen YC, Schmidt MV, Zurmühlen R, Vogl AM, Gailus-Durner V, Fuchs H, Hölter SM, Wotjak CT, Landgraf R, de Angelis MH, Holsboer F, Wurst W. Urocortin 3 modulates social discrimination abilities via corticotropin-releasing hormone receptor type 2. J Neurosci. 2010 Jul 7;30(27):9103-16.

46 Drews E, Zimmer A. Modulation of alcohol and nicotine responses through the endogenous opioid system. Prog Neurobiol 90:1-15.

45 Grabe HJ, Mahler J, Witt SH, Schulz A, Appel K, Spitzer C, Stender J, Barnow S, Freyberger HJ, Teumer A, Völzke H, Rietschel M. A risk marker for alcohol dependence on chromosome 2q35 is related to neuroticism in the general population. Mol Psychiatry. 2010 Mar 30. [Epub ahead of print] PMID: 20351720

44 Inta D, Monyer H, Sprengel R, Meyer-Lindenberg A, Gass P. Mice with genetically altered glutamate receptors as models of schizophrenia: a comprehensive review. Neurosci Biobehav Rev. 2010 Mar;34(3):285-94. Epub 2009 Aug 3. Review.

43 Kiefer F, Witt SH, Frank J, Richter A, Treutlein J, Lemenager T, Berner M, Chichon S, Nöthen MN, Batra A, Wodarz N, Zimmermann U, Spanagel R, Wiedemann K, Smolka M, Heinz A, Rietschel M, Mann K. Involvement of the atrial natriuretic peptide transcription factor GATA4 in alcohol dependence, relapse risk, and treatment response to acamprosate. Pharmacogenomics J

42 Kiefer F. Neurobiologie und Genetik von Suchterkrankungen. Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz, Volume 53, Number 4, 284-288, DOI: 10.1007/s00103-010-1031-1.

41 Kimura M, Müller-Preuss P, Lu A, Wiesner E, Flachskamm C, Wurst W, Holsboer F, Deussing JM. Conditional corticotropin-releasing hormone overexpression in the mouse forebrain enhances rapid eye movement sleep. Mol Psychiatry. 2010 Feb;15(2):154-165.

40 Klär AA, Ballmaier M, Leopold K, Häke I, Schaefer M, Brühl R, Schubert F, Gallinat J. Interaction of hippocampal volume and N-acetylaspartate concentration deficits in schizophrenia: A combined MRI and 1H-MRS study.

39 Konopka W, Kiryk A, Novak M, Herwerth M, Rodriguez Parkitna J, Wawrzyniak M, Kowarsch A, Michaluk P, Dzwonek J, Arnsperger T, Wilczynski G, Merkenschlager M, Theis FJ, Köhr G, Kaczmarek L, Schütz G. miRNA loss enhances learning and memory in mice. J Neurosci 2010; 30:14835-14842.

38 Kühn, S.; Schubert, F.; Gallinat, J. Reduced thickness in medial orbitofrontal cortex in smokers. Biological Psychiatry, 2010 Sept 25 (Epub ahead of print)

37 Liu JZ, Tozzi F, Waterworth DM, Pillai SG, Muglia P, Middleton L, BerrettiniW, Knouff CW, Yuan X, Waeber G, Vollenweider P, Preisig M, Wareham NJ, Zhao JH, Loos RJ, Barroso I, Khaw KT, Grundy S, Barter P, Mahley R, Kesaniemi A, McPherson R, Vincent JB, Strauss J, Kennedy JL, Farmer A, McGuffin P, Day R, Matthews K, Bakke P, Gulsvik A, Lucae S, Ising M, Brueckl T, Horstmann S, Wichmann HE, Rawal R, Dahmen N, Lamina C, Polasek O, Zgaga L, Huffman J, Campbell S, Kooner J, Chambers JC, Burnett MS, Devaney JM, Pichard AD, Kent KM, Satler L, Lindsay JM,Waksman R, Epstein S, Wilson JF, Wild SH, Campbell H, Vitart V, Reilly MP, Li M, Qu L, Wilensky R, Matthai W, Hakonarson HH, Rader DJ, Franke A, Wittig M, Schäfer A, Uda M, Terracciano A, Xiao X, Busonero F, Scheet P, Schlessinger D, St Clair D, Rujescu D, Abecasis GR, Grabe HJ, Teumer A, Völzke H, Petersmann A, John U, Rudan I, Hayward C, Wright AF, Kolcic I, Wright BJ, Thompson JR, Balmforth AJ, Hall AS, Samani NJ, Anderson CA, Ahmad T, Mathew CG, Parkes M, Satsangi J, Caulfield M, Munroe PB, Farrall M, Dominiczak A, Worthington J, Thomson W, Eyre S, Barton A; Wellcome Trust Case Control Consortium, Mooser V, Francks C, Marchini J. Meta- analysis and imputation refines the association of 15q25 withsmoking quantity. Nat Genet. 2010 May;42(5):436-40. Epub 2010 Apr 25. PubMed PMID: 20418889.

36 Mutschler J, Bilbao A, von der Goltz C, Demiralay C, Jahn H, Wiedemann K, Spanagel R, Kiefer F. Augmented stress-induced alcohol drinking and withdrawal in mice lacking functional natriuretic peptide A receptors. Alcohol Alcoholism 45:13-6

35 Noori H R, W. Jäger. Neurochemical oscillations in the basal ganglia, Bull. Math. Biol. 2010 Jan 72(1):133-47.

34 Novak M, Halbout B, O?Connor EC, Rodriguez Parkitna J, Su T, Chai M, Crombag HS, Bilbao A, Spanagel R, Stephens DN. Incentive learning underlying cocaine relapse requires mGluR5 receptors located on dopamine D1 receptor-expressing neurons. J Neurosci, 30:11973-82 (7.178)

33 Park SQ, Kahnt T, Beck A, Cohen MX, Dolan RJ, Wrase J, Heinz A. Prefrontal cortex fails to learn from reward prediction errors in alcohol dependence. J Neurosci. 30(22):7749-53.

32 Perreau-Lenz S, Sanchis-Segura C, Leonardi-Essmann F, Zghoul T, Schneider M,  Spanagel R. Development of morphine-induced tolerance and withdrawal: Involvement of the clock gene mPer2. Eur Neuropsychopharm in press

31 Rietschel M, Mattheisen M, Frank J, Treutlein J, Degenhardt F, Breuer R, Steffens M, Mier D, Esslinger C, Walter H, Kirsch P, Erk S, Schnell K, Herms S, Wichmann HE, Schreiber S, Jöckel KH, Strohmaier J, Roeske D, Haenisch B, Gross M, Hoefels S, Lucae S, Binder EB, Wienker TF, Schulze TG, Schmäl C, Zimmer A, Juraeva D, Brors B, Bettecken T, Meyer-Lindenberg A, Müller-Myhsok B, Maier W, Nöthen MM, Cichon S. Genome-wide association-, replication-, and neuroimaging study implicates HOMER1 in the etiology of major depression. Biol Psychiatry. 2010 Sep 15;68(6):578-85.

30 Rodriguez Parkitna J, Bilbao A, Rieker C, Engblom D, Peichota M, Nordheim A, Spanagel R*, Schütz G*. Loss of the Serum Response Factor in the dopamine system leads to hyperactivity. FASEB J Mar 11 [Epub ahead of print]

29 Romanowski CP, Fenzl T, Flachskamm C, Wurst W, Holsboer F, Deussing JM, Kimura M. Central deficiency of corticotropin-releasing hormone receptor type 1 (CRH-R1) abolishes effects of CRH on NREM but not on REM sleep in mice. Sleep. 2010 Apr 1;33(4):427-436

28 Schardt DM, Erk S, Nüsser C, Nöthen MM, Cichon S, Rietschel M, Treutlein J, Goschke T, Walter H. Volition diminishes genetically mediated amygdala hyperreactivity. Neuroimage. 2010 Nov 15;53(3):943-51. Epub 2009 Dec 5. pmid 19969089.

27 Schumann G, Loth E, Banaschewski T, Barker G, Buechel C, Conrod PJ, Dalley, JW, Flor H, Gallinat J, Garavan H, Heinz A, Itterman B, Lathrop M, Martinot JL, Mann K, Poline JB, Robbins TW, Rietschel M, Reed L, Smolka M, Spanagel R, Stephens DN, Stroehle A, Paus T, and the IMAGEN consortium. The IMAGEN study: Reinforcement-related behaviour in normal brain function and psychopathology. Mol Psychiatry, 15:1128-39 (15.049)

26 Spanagel R. Are metabotropic glutamate receptors promising targets for the treatment of alcoholism? Biol Psychiatry, 67:798-9 (8.926)

25 Spanagel R, Bartsch D, Brors B, Dahmen N, Deussing J, Eils R, Ende G, Gallinat J, Gebicke-Haerter P, Heinz A, Kiefer F, Jager W, Mann K, Matthaus F, Nothen M, Rietschel M, Sartorius A, Schutz G, Sommer WH, Sprengel R, Walter H, Wichmann E, Wienker T, Wurst W, Zimmer A. An integrated genome research network for studying the genetics of alcohol addiction. Addict Biol 15:369-379.

24 Thorgeirsson TE, Gudbjartsson DF, Surakka I, Vink JM, Amin N, Geller F, Sulem P, Rafnar T, Esko T, Walter S, Gieger C, Rawal R, Mangino M, Prokopenko I, MägiR, Keskitalo K, Gudjonsdottir IH, Gretarsdottir S, Stefansson H, Thompson JR, Aulchenko YS, Nelis M, Aben KK, den Heijer M, Dirksen A, Ashraf H, Soranzo N, Valdes AM, Steves C, Uitterlinden AG, Hofman A, Tönjes A, Kovacs P, Hottenga JJ, Willemsen G, Vogelzangs N, Döring A, Dahmen N, Nitz B, Pergadia ML, Saez B, De Diego V, Lezcano V, Garcia-Prats MD, Ripatti S, Perola M, Kettunen J, Hartikainen AL, Pouta A, Laitinen J, Isohanni M, Huei-Yi S, Allen M, Krestyaninova M, Hall AS, Jones GT, van Rij AM, Mueller T, Dieplinger B, Haltmayer M, Jonsson S,Matthiasson SE, Oskarsson H, Tyrfingsson T, Kiemeney LA, Mayordomo JI, Lindholt JS, Pedersen JH, Franklin WA, Wolf H, Montgomery GW, Heath AC, Martin NG, Madden PA, Giegling I, Rujescu D, Järvelin MR, Salomaa V, Stumvoll M, Spector TD, Wichmann HE, Metspalu A, Samani NJ, Penninx BW, Oostra BA, Boomsma DI, Tiemeier H, van Duijn CM, Kaprio J, Gulcher JR; ENGAGE Consortium, McCarthy MI, Peltonen L, Thorsteinsdottir U, Stefansson K. Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nat Genet. 2010 May;42(5):448-53. Epub 2010 Apr25. PubMed PMID: 20418888.

23 Trümbach D, Graf C, Pütz B, Kühne C, Panhuysen M, Weber P, Holsboer F, Wurst W, Welzl G, Deussing JM. Deducing corticotropin-releasing hormone receptor type 1 signaling networks from gene expression data by usage of genetic algorithms and graphical Gaussian models. BMC Syst Biol. 2010 Nov 19;4:159.

22 Tsolakidou A, Czibere L, Putz B, Trumbach D, Panhuysen M, Deussing JM, Wurst W, Sillaber I, Landgraf R, Holsboer F, Rein T. Gene expression profiling in the stress control brain region hypothalamic paraventricular nucleus reveals a novel gene network including Amyloid beta Precursor Protein. BMC Genomics. 2010 Oct 8;11:546.

21 Umhau JC, Momenan R, Schwandt ML, Singley E, Lifshitz M, Doty L, Adams LJ, Vengeliene V, Spanagel R, George DT, Hommer D, Heilig M. Effect of acamprosate on magnetic resonance spectroscopy measures of central glutamate in detoxified alcohol-dependent individuals: a randomized controlled experimental medicine study. Arch Gen Psychiatry, 67:1069-77 (14.273)

20 Vengeliene V, Leonardi-Essmann F, Marston H, Sommer W, Spanagel R. Glycine Transporter-1 Blockade Leads to Persistently Reduced Relapse-Like Alcohol Drinking in Rats. Biol Psychiatry, 68:704-11 (8.926)

19 von Engelhardt J, Mack V, Sprengel R, Kavenstock N, Li KW, Stern-Bach Y, Smit AB, Seeburg PH, Monyer H. CKAMP44: a brain-specific protein attenuating short-term synaptic plasticity in the dentate gyrus. Science 327:1518-1522.

2009

18 Beck A, Heinz A. Biologie der Alkoholabhängigkeit. Spectrum Psychiatrie 2009, 4: 10-13.

17 Drews E, Racz I, Lacava AD, Barth A, Bilkei-Gorzo A, Wienker TF, Zimmer A (2009) Quantitative trait loci contributing to physiological and behavioural ethanol responses after acute and chronic treatment. Int J Neuropsychopharmacol 13:155-169.

16 Fenzl T, Flachskamm C, Rossbauer M, Deussing JM, Kimura M. Circadian rhythms of basal orexin levels in the hypothalamus are not influenced by an impaired corticotropin-releasing hormone receptor type 1 system. Behav Brain Res. 2009 Oct 12;203(1):143-135.

15 Helander A, Böttcher M, Fehr C, Dahmen N, Beck O. Detection times for urinary ethyl glucuronide and ethyl sulfate in heavy drinkers during alcohol detoxification. Alcohol Alcohol. 2009 Jan-Feb;44(1):55-61. Epub 2008 Oct 29.PubMed PMID: 18971292.

14 Hirrlinger J, Scheller A, Hirrlinger PG, Kellert B, Tang W, Wehr MC, Goebbels S, Reichenbach A, Sprengel R, Rossner MJ, Kirchhoff F. Split-cre complementation indicates coincident activity of different genes in vivo. PLoS One. 2009;4(1):e4286. Epub 2009 Jan 27.

13 Mameli M, Halbout B, Creton C, Spanagel R, Lüscher C Cocaine-evoked synaptic plasticity: persistence in the VTA triggers adaptations in the nucleus accumbens. Nat Neurosci 12 (2009), 1036-1041

12 Matthäus F., Smith V.A., Fogtman A., Sommer W.H., Leonardi-Essmann F., Lourdusamy A., Reimers M.A., Spanagel R., Gebicke-Haerter P.J., Interactive molecular networks obtained by computer-aided conversion of microarray data from brains of alcohol-drinking rats. Pharmacopsychiatry. 2009; 42(Suppl. 1): S118-S128.

11 Perreau-Lenz S, Zghoul T, Rodriguez de Fonseca F, Spanagel R, Bilbao A (2009) Circadian regulation of ethanol sensitivity by the mPer2 gene. Addict Biol 14, 253-9

10 Schardt DM, Erk S, Nüsser C, Nöthen MM, Cichon S, Rietschel M, Treutlein J, Goschke T, Walter H. Volition diminishes genetically mediated amygdala hyperreactivity. NeuroImage Volume 53, Issue 3, 15 November 2010, Pages 943-951

9 Silberstein S, Vogl AM, Refojo D, Senin SA, Wurst W, Holsboer F, Deussing JM, Arzt E. Amygdaloid pERK1/2 in corticotropin-releasing hormone overexpressing mice under basal and acute stress conditions. Neuroscience. 2009 Mar 17;159(2):610-617.

8 Spanagel R; Alcoholism ? a systems approach from molecular physiology to behavior. Physiol Rev (2009) 89, 649-705

7 Tang W, Ehrlich I, Wolff SB, Michalski AM, Wölfl S, Hasan MT, Lüthi A, Sprengel R. Faithful expression of multiple proteins via 2A-peptide self-processing: a versatile and reliable method for manipulating brain circuits. J Neurosci. 2009 Jul 8;29(27):8621-9. No abstract available

6 Treutlein J, Cichon S, Ridinger M, Wodarz N, Soyka M, Maier W, Dahmen N, Scherbaum N, Nöthen MM, Steffens M, Wienker TF, Frank J, Wichmann HE, Schreiber S, Jöckel KH,  Sommer W, Gebicke-Haerter P, Kiefer F, Spanagel R, Mann K, Rietschel M (2009) Genome-wide association study of alcohol dependence. Arch Gen Psychiatry. 2009 Jul;66(7):773-84.

5 Vengeliene V, Celerier E, Chaskiel L, Penzo F, Spanagel R  Compulsive drug and food taking behaviour in rodents. Addict Biol (2009) 14:384-96

4 von der Goltz C, Vengeliene V, Bilbao A, Perreau-Lenz S, Pawlak C, Mann K, Kiefer F, Spanagel R (2009) Cue-induced alcohol-seeking behaviour is reduced by disrupting the reconsolidation of alcohol-related memories. Psychopharmacology 205, 389-97

2008    

3 Engblom D, Bilbao-Leis A, Sanchis-Segura C, Dahan L, Perreau-Lenz S, Balland M, Rodriguez Parkitna J, Lujan R, Halbout B, Mameli M, Parlato R, Sprengel R, Lüscher C, Schütz G, Spanagel R. Glutamate receptors on dopamine neurons control the persistence of cocaine-seeking. Neuron. 2008; 59:497-508

2 Racz I, Schurmann B, Karpushova A, Reuter M, Cichon S, Montag C, Furst R, Schutz C, Franke PE, Strohmaier J, Wienker TF, Terenius L, Osby U, Gunnar A, Maier W, Bilkei-Gorzo A, Nothen M, Zimmer A (2008) The opioid peptides enkephalin and beta-endorphin in alcohol dependence. Biol Psychiatry 2008; 64: 989-997.

1 Schumann G, Johann M, Frank J, Preuss U, Dahmen N, Laucht M, Rietschel M,Rujescu D, Lourdusamy A, Clarke TK, Krause K, Dyer A, Depner M, Wellek S,Treutlein J, Szegedi A, Giegling I, Cichon S, Blomeyer D, Heinz A, Heath S,Lathrop M, Wodarz N, Soyka M, Spanagel R, Mann K. Systematic analysis ofglutamatergic neurotransmission genes in alcohol dependence and adolescent risky drinking behavior. Arch Gen Psychiatry. 2008 Jul;65(7):826-38. PubMed PMID:18606955.