Publikationen


2013


55 Bassik MC, Martin Kampmann, Robert Jan Lebbink, Shuyi Wang, Marco Y. Hein, Ina Poser, Jimena Weibezahn, Max A. Horlbeck, Siyuan Chen, Matthias Mann, Anthony A. Hyman, Emily M. LeProust, Michael T. McManus, Jonathan S. Weissman.  A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility.  Cell. 2013;152(4):909-22. doi:10.1016/j.cell.2013.01.030.

54 Eberl HC, Cornelia G. Spruijt, Christian D. Kelstrup, Michiel Vermeulen and Matthias Mann.  A map of general and specialized chromatin readers in mouse tissues generated by highly sensitive, label-free interaction proteomics.  Mol Cell. 2013; 49(2):368-78. doi:10.1016/j.molcel.2012.10.026.

53 GiesGiesert F, Hofmann A, Bürger A, Zerle J, Kloos K, Hafen U, Ernst L, Zhang J, Vogt-Weisenhorn DM, Wurst W. Expression analysis of lrrk1, lrrk2 and lrrk2 splice variants in mice.  PLoS One. 2013 May 10;8(5):e63778. doi: 10.1371/journal.pone.0063778. Print 2013.

52 Kallenborn-Gerhardt W, Lu R, Syhr KM, Heidler J, von Melchner H, Geisslinger G, Bangsow T, Schmidtko A.  Antioxidant activity of Sestrin 2 controls neuropathic pain after peripheral nerve injury.  Antioxid Redox Signal. 2013 Epub ahead of print.

51 Kappei D, Butter F, Benda C, Scheibe M, Dra?kovi? I, Stevense M, Novo CL, Basquin C, Araki M, Araki K, Krastev DB, Kittler R, Jessberger R, Londoño-Vallejo JA, Mann M, Buchholz F. HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment.  EMBO J. 2013 May 17. doi: 10.1038/emboj.2013.105.

50 Ladewig, J.*, Koch, P.*, Brüstle, O. (2013) Leveling Waddington: the emergence of direct programming and the loss of cell fate hierarchies. Nat Rev Mol Cell Biol doi:10.1038/nrm3543.

49 Merkl C, Saalfrank A, Riesen N, Kühn R, Pertek A, Eser S, Hardt MS, Kind A, Saur D, Wurst W, Iglesias A, Schnieke A.  Efficient generation of rat induced pluripotent stem cells using a non-viral inducible vector. PLoS One. 2013;8(1):e55170. doi: 10.1371/journal.pone.0055170. Epub 2013 Jan 31.

48 Peitz, M., Jungverdorben, J., Brüstle, O. (2013) Disease-specific iPS cell models in neuroscience. Curr Mol Med (in press).

47 Starokadomskyy P, Nathan Gluck, Haiying Li, Baozhi Chen, Mathew Wallis, Gabriel N Maine, Xicheng Mao, Iram Zaidi, Marco Y Hein, Fiona McDonald, Steffen Lenzner, Agnes Zecha, Hans-Hilger Ropers, Andreas W Kuss, Julie McGaughran, Jozef Gécz, Ezra Burstein.  CCDC22 deficiency in humans blunts activation of pro-inflammatory NF-kB signaling. Accepted at the Journal of Clinical Investigation. J Clin Invest. 2013 May 1;123(5):2244-56. doi: 10.1172/JCI66466. Epub 2013 Apr 8.

46 Wefers B, Meyer M, Ortiz O, Hrabé de Angelis M, Hansen J, Wurst W, Kühn R.   Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides. Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3782-7.

2012

45 Bradley A, Anastassiadis K, Ayadi A, Battey JF, Bell C, Birling MC, Bottomley J, Brown SD, Bürger A, Bult CJ, Bushell W, Collins FS, Desaintes C, Doe B, Economides A, Eppig JT, Finnell RH, Fletcher C, Fray M, Frendewey D, Friedel RH, Grosveld FG, Hansen J, Hérault Y, Hicks G, Hörlein A, Houghton R, Hrabé de Angelis M, Huylebroeck D, Iyer V, de Jong PJ, Kadin JA, Kaloff C, Kennedy K, Koutsourakis M, Lloyd KC, Marschall S, Mason J, McKerlie C, McLeod MP, von Melchner H, Moore M, Mujica AO, Nagy A, Nefedov M, Nutter LM, Pavlovic G, Peterson JL, Pollock J, Ramirez-Solis R, Rancourt DE, Raspa M, Remacle JE, Ringwald M, Rosen B, Rosenthal N, Rossant J, Ruiz Noppinger P, Ryder E, Schick JZ, Schnütgen F, Schofield P, Seisenberger C, Selloum M, Simpson EM, Skarnes WC, Smedley D, Stanford WL, Stewart AF, Stone K, Swan K, Tadepally H, Teboul L, Tocchini-Valentini GP, Valenzuela D, West AP, Yamamura K, Yoshinaga Y, Wurst W. 3. The mammalian gene function resource: the International Knockout Mouse Consortium.  Mamm Genome. 2012 Oct;23(9-10):580-6. doi: 10.1007/s00335-012-9422-2. Epub 2012 Sep 12.

44 Ding L, Poser I, Paszkowski-Rogacz M, Buchholz F.  From RNAi Screens to Molecular Function in Embryonic Stem Cells. Stem Cell Rev Rep. 2012 Mar;8(1):32-42.

43 Frost A, Marc G. Elgort, Onn Brandman, Clinton Ives, Sean R. Collins, Lakshmi Miller-Vedam, Jimena Weibezahn, Marco Y. Hein, Ina Poser, Matthias Mann, Anthony A. Hyman and Jonathan S. Weissman.  Comparing Genetic Interactions between S. pombe and S. cerevisiaeReveals Functional Repurposing and Identifies New Determinants ofOrganelle Homeostasis and Mitotic Transitions.  Cell. 2012;149(6):1339-52. doi:10.1016/j.cell.2012.04.028.

42 Hilger M and Matthias Mann:  Triple SILAC to determine stimulus specific interactions in the Wnt pathway.  J Proteome Res. 2012; 11(2):982-94. Epub 2011 Nov 18. doi:10.1021/pr200740a.

41 Mellett M, Atzei P, Horgan A, Hams E, Floss T, Wurst W, Fallon PG, Moynagh PN.  Orphan receptor IL-17RD tunes IL-17A signalling and is required for neutrophilia. 1.  Nat Commun. 2012;3:1119. doi: 10.1038/ncomms2127.

40 Meyer M, Ortiz O, Hrabé de Angelis M, Wurst W, Kühn R.  Modeling disease mutations by gene targeting in one-cell mouse embryos.  Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9354-9.

39 Peng C, Li N, Ng YK, Zhang J, Meier F, Theis FJ, Merkenschlager M, Chen W, Wurst W, Prakash N. 2.  A unilateral negative feedback loop between miR-200 microRNAs and Sox2/E2F3 controls neural progenitor cell-cycle exit and differentiation.  J Neurosci. 2012 Sep 19;32(38):13292-308.

38 Rostovskaya M, Fu J, Obst M, Baer I, Weidlich S, Wang H, Smith AJH, Anastassiadis K and Stewart AF.  Transposon mediated BAC transgenesis in human ES cells (2012)  Nucleic Acids Res. 40, e150.

37 Royer L, Stewart AF and Schroeder M.  Evaluating coverage and accuracy of protein interaction datasets with network compression (2012)  PLoS One, 7:e35729.

36 Wefers B, Hitz C, Hölter SM, Trümbach D, Hansen J, Weber P, Pütz B, Deussing JM, de Angelis MH, Roenneberg T, Zheng F, Alzheimer C, Silva A, Wurst W, Kühn R.  MAPK signaling determines anxiety in the juvenile mouse brain but depression-like behavior in adults.  PLoS One. 2012;7(4):e35035. Epub 2012 Apr 18.

2011

35 Bolze F, Rink N, Brumm H, Kühn R, Mocek S, Schwarz AE, Kless C, Biebermann H, Wurst W, Rozman J, Klingenspor M. Characterization of the melanocortin-4-receptor nonsense mutation W16X in vitro and in vivo. Pharmacogenomics J. 2011 Oct 4. doi: 10.1038/tpj.2011.43. [Epub ahead of print]

34 Ding L, Poser I, Paszkowski-Rogacz M, Buchholz F. From RNAi Screens to Molecular Function in Embryonic Stem Cells. Stem Cell Rev. 2011 Apr 28.

33 Elefsinioti, A, Ömer Sinan Saraç, Anna Hegele, Conrad Plake, Nina C. Hubner, Ina Poser, Mihail Sarov, Anthony Hyman, Matthias Mann, Michael Schroeder, Ulrich Stelzl and Andreas Beyer. Large-scale De Novo Prediction of Physical Protein-Protein Association. Mol Cell Proteomics. 2011 Nov;10(11). doi:10.1074/mcp.M111.010629

32 Elling, U., Taubenschmid, J., Wirnsberger, G., O'Malley, R., Demers, S.-P., Vanhaelen, Q., Shukalyuk, A.I., Schmauss, G., Schramek, D., Schnütgen, F., von Melchner, H., Ecker, J.R., Stanford, W.L., Zuber, J., Stark, A., and Penninger, J.M. Forward and Reverse Genetics through Derivation of Haploid Mouse Embryonic Stem Cells. Cell Stem Cell 9, 563-547

31 Fischer T, Faus-Kessler T, Welzl G, Simeone A, Wurst W, Prakash N. Fgf15-mediated control of neurogenic and proneural gene expression regulates dorsal midbrain neurogenesis. Dev Biol. 2011 Feb 15;350(2):496-510. Epub 2010 Dec 21.

30 Hofemeister, H, Ciotta, G, Fu J, Seibert P, Schulz A, Maresca M, Sarov M, Anastassiadis K and Stewart AF. Recombineering, transfection, Western, IP and ChIP methods for protein tagging via gene targeting or BAC transgenesis. Methods 53, 437-52.

29 Kleinhammer A, Wurst W, Kühn R. Constitutive and conditional RNAi transgenesis in mice. Methods. 2011 Apr;53(4):430-6. Epub 2010 Dec 22.

28 Krastev DB, Buchholz F. Ribosome biogenesis and p53: Who is regulating whom? Cell Cycle. Oct 15;10(20):3417-8

27 Krastev, Dragomir B.  Mikolaj Slabicki, Maciej Paszkowski-Rogacz, Nina C. Hubner, Magno Junqueira, Andrej Shevchenko, Matthias Mann, Karla M. Neugebauer and Frank Buchholz. A systematic RNAi synthetic interaction screen reveals a link between p53 and snoRNP assembly. Nature Cell Biology 13, 809?818 (2011). doi:10.1038/ncb2264

26 Medenbach Jan,  Markus Seiler and Matthias W. Hentze. Translational control via protein-regulated upstream open reading frames. Cell. 2011 Jun 10;145(6):902-13

25 Nitzsche A, Paszkowski-Rogacz M, Matarese F, Janssen-Megens E.M, Hubner NC, Schulz H,, de Vries I, Ding L, Huebner N, Mann M, Stunnenberg HG, Buchholz F. RAD21 cooperates with pluripotency transcription factors in the maintenance of embryonic stem cell identity. PLoS One. May 12;6(5):e19470.

24 Peng C, Aron L, Klein R, Li M, Wurst W, Prakash N, Le W. Pitx3 is a critical mediator of GDNF-induced BDNF expression in nigrostriatal dopaminergic neurons. J Neurosci. 2011 Sep 7;31(36):12802-15.

23 Pihlajamäki J, Lerin C, Itkonen P, Boes T, Floss T, Schroeder J, Dearie F, Crunkhorn S, Burak F, Jimenez-Chillaron JC, Kuulasmaa T, Miettinen P, Park PJ, Nasser I, Zhao Z, Zhang Z, Xu Y, Wurst W, Ren H, Morris AJ, Stamm S, Goldfine AB, Laakso M, Patti ME. Expression of the splicing factor gene SFRS10 is reduced in human obesity and contributes to enhanced lipogenesis. Cell Metabolism 2011 Aug 3;14(2):208-18.

22 Schmidt MV, Schülke JP, Liebl C, Stiess M, Avrabos C, Bock J, Wochnik GM, Davies HA, Zimmermann N, Scharf SH, Trümbach D, Wurst W, Zieglgänsberger W, Turck C, Holsboer F, Stewart MG, Bradke F, Eder M, Müller MB, Rein T. Tumor suppressor down-regulated in renal cell carcinoma 1 (DRR1) is a stress-induced actin bundling factor that modulates synaptic efficacy and cognition. Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):17213-8. Epub 2011 Oct 3.

21 Schnütgen F , Franziska Ehrmann, Ina Poser, Nina C Hubner, Jens Hansen, Thomas Floss, Ingrid deVries, Wolfgang Wurst, Anthony Hyman, Matthias Mann & Harald von Melchner. Resources for proteomics in mouse embryonic stem cells. Nature Methods 2011; 8:103?104. doi:10.1038/nmeth0211-103

20 Schnütgen F, Ehrmann F, Ruiz-Noppinger P, and von Melchner H. High throughput gene trapping and postinsertional modifications of gene trap alleles. Methods 53, 347-355 (2011)

19 Theis M, Buchholz F. High-throughput RNAi screening in mammalian cells with esiRNAs. Methods. Apr;53(4):424-9.

2010

18 Gould CM, Diella F, Via A, Puntervoll P, Gemünd C, Chabanis-Davidson S, Michael S, Sayadi A, Bryne JC, Chica C, Seiler M, Davey NE, Haslam N, Weatheritt RJ, Budd A, Hughes T, Pas J, Rychlewski L, Travé G, Aasland R, Helmer-Citterich M, Linding R, Gibson TJ. ELM: the status of the 2010 eukaryotic linear motif resource. Nucleic Acids Res. 2010 Jan;38:D167-80. Epub 2009 Nov 17.

17 Hubner N*, Alexander W. Bird*, Jürgen Cox, Bianca Splettstoesser, Peter Bandilla, Ina Poser, Anthony A. Hyman and Matthias Mann. Quantitative proteomics combined with BAC TransgeneOmics reveals in-vivo protein interactions. J Cell Biol. 2010 May 17;189(4):739-54. doi 10.1083/jcb.200911091

16 Hutchins JR, Toyoda Y, Hegemann B, Poser I, Hériché JK, Sykora MM, Augsburg M, Hudecz O, Buschhorn BA, Bulkescher J, Conrad C, Comartin D, Schleiffer A, Sarov M, Pozniakovsky A, Slabicki MM, Schloissnig S, Steinmacher I, Leuschner M, Ssykor A, Lawo S, Pelletier L, Stark H, Nasmyth K, Ellenberg J, Durbin R, Buchholz F, Mechtler K, Hyman AA, Peters JM. Systematic analysis of human protein complexes identifies chromosome segregation proteins. Science. 2010 Apr 30;328(5978):593-9.

15 Kleinhammer A., Wurst W, Kühn R. Gene Silencing in Mice with shRNA Vectors. submitted to METHODS IN ENZYMOLOGY, 'Guide to Techniques in Mouse Development'.

14 Meyer L, Hrabé de Angelis M, Wurst W, Kühn R. Gene Targeting by Homologous Recombination in Mouse Oocytes mediated by Zinc-Finger Nucleases. Proc. Natl. Acad. Sci. USA 2010 Aug 24; 107 (34): 15022-6

13 Morais VA, Verstreken P, Roethig A, Smet J, Snellinx A, Vanbrabant M, Haddad D, Frezza C, Mandemakers W, Vogt Weisenhorn V, Van Coster R, Wurst W, Scorrano L, De Strooper B. Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function. EMBO Journal of Molecular Medicine. 2009 1(2): 99-111.

12 Paszkowski-Rogacz M, Slabicki M, Pisabarro MT, Buchholz F. PhenoFam-gene set enrichment analysis through protein structural information. BMC Bioinformatics. 2010 May 17;11:254.

11 Schebelle L, Wolf C, Stribl C, Javaheri T, Schnütgen F, Ettinger A, Ivics Z, Hansen J, Ruiz P, von Melchner H, Wurst W, Floss T. Efficient conditional and promoter-specific in vivo expression of cDNAs of choice by taking advantage of recombinase-mediated cassette exchange using FlEx gene traps. Nucleic Acids Res. 2010, 38 (9): e106.

10 Slabicki M, Theis M, Krastev DB, Samsonov S, Mundwiller E, Junqueira M, Paszkowski-Rogacz M, Teyra J, Heninger AK, Poser I, Prieur F, Truchetto J, Confavreux C, Marelli C, Durr A, Camdessanche JP, Brice A, Shevchenko A, Pisabarro MT, Stevanin G, Buchholz F. A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia. PLoS Biol. 2010 Jun 29;8(6)

9 Vermeulen M*, H. Christian Eberl*, Filomena Materese*, Hendrik Marks, Sergei Denissov, Falk Butter, Kenneth K Lee, Jesper V Olsen, Anthony A Hyman, Henk G Stunnenberg and Matthias Mann. Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers. Cell. 2010 Sep 17;142(6):967-80. doi:10.1016/j.cell.2010.08.020

2009

8 Di Benedetto B, Wefers B, Wurst W, Kühn R. Local knockdown of ERK2 in the adult mouse brain via adeno-associated virus-mediated RNA interference. Mol Biotechnol. 2009 Mar;41(3):263-9. Epub 2008 Dec 4. Erratum in: Mol Biotechnol. 2009 Mar;41(3):308. Benedetto, Barbara Di [corrected to Di Benedetto, Barbara]. PMID: 19052925 [PubMed - in process]

7 Elefsinioti A, Ackermann M, Beyer A. Accounting for redundancy when integrating gene interaction databases. PLoS One. 2009 Oct 22;4(10):e7492.

6 Gibson TJ. Cell regulation: determined to signal discrete cooperation. Trends Biochem Sci. 2009 Oct;34(10):471-82. Epub 2009 Sep 8.

5 Morais VA, Verstreken P, Roethig A, Smet J, Snellinx A, Vanbrabant M, Haddad D, Frezza C, Mandemakers W, Vogt-Weisenhorn D, Van Coster R, Wurst W, Scorrano L, and De Strooper B.Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function. EMBO Mol Med. 2009 May;1(2):99-111.

4 Theis M, Slabicki M, Junqueira M, Paszkowski-Rogacz M, Sontheimer J, Kittler R, Heninger AK, Glatter T, Kruusmaa K, Poser I, Hyman AA, Pisabarro MT, Gstaiger M, Aebersold R, Shevchenko A, Buchholz F.Comparative profiling identifies C13orf3 as a component of the Ska complex required for mammalian cell division. EMBO J. 2009 May 20;28(10):1453-65. Epub 2009 Apr 23.

3 Theis, M; Paszkowski-Rogacz, M; Buchholz, FSKAnking with Ska3 Essential role of Ska3 in cell division revealed by combined phenotypic profiling. Cell Cycle. 2009 Nov 1;8(21):3435-7. Epub 2009 Nov 16.

2008

2 Poser I, Sarov M, Hutchins JR, Hériché JK, Toyoda Y, Pozniakovsky A, Weigl D, Nitzsche A, Hegemann B, Bird AW, Pelletier L, Kittler R, Hua S, Naumann R, Augsburg M, Sykora MM, Hofemeister H, Zhang Y, Nasmyth K, White KP, Dietzel S, Mechtler K, Durbin R, Stewart AF, Peters JM, Buchholz F, Hyman AA.BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals.Nat Methods. 2008 May;5(5):409-15. Epub 2008 Apr 6.

1 Schnütgen F, Hansen J, De-Zolt S, Horn C, Lutz M, Floss T, Wurst W, Noppinger PR, von Melchner H. Enhanced gene trapping in mouse embryonic stem cells. Nucleic Acids Res. 2008 Nov;36(20):e133. Epub 2008 Sep 23.PMID: 18812397 [PubMed - indexed for MEDLINE]