Publikationen


2012

21 Berg D, Wolff C, Malinowsky K, Tran K, Walch A, Bronger H, Schuster T, Höfler H, Becker KF. Profiling signalling pathways in formalin-fixed and paraffin-embedded breast cancer tissues reveals cross-talk between EGFR, HER2, HER3 and uPAR. J Cell Physiol. 2012 Jan;227(1):204-12. doi: 10.1002/jcp.22718.

20 Malinowsky K, Raychaudhuri M, Buchner T, Thulke S, Wolff C, Höfler H, Becker KF, Avril S. Common protein biomarkers assessed by reverse phase protein arrays show considerable intratumoral heterogeneity in breast cancer tissues. PLoS One.  2012;7(7):e40285. doi: 10.1371/journal.pone.0040285.

19 Malinowsky K, Wolff C, Berg D, Schuster T, Walch A, Bronger H, Mannsperger H,  Schmidt C, Korf U, Höfler H, Becker KF. uPA and PAI-1-Related Signaling Pathways  Differ between Primary Breast Cancers and Lymph Node Metastases. Transl Oncol. 2012 Apr;5(2):98-104.

18 Schuster C, Malinowsky K, Liebmann S, Berg D, Wolff C, Tran K, Schott C, ReuS, Neumann J, Faber C, Höfler H, Kirchner T, Becker KF, Hlubek F.   Antibodyvalidation by combining immunohistochemistry and protein extraction fromformalin-fixed paraffin-embedded tissues. Histopathology. 2012May;60(6B):E37-E50. doi: 10.1111/j.1365-2559.2012.04184.

17 Slotta-Huspenina J, Berg D, Bauer K, Wolff C, Malinowsky K, Bauer L, Drecoll E, Bettstetter M, Feith M, Walch A, Höfler H, Becker KF, Langer R. Evidence of prognostic relevant expression profiles of heat-shock proteins and glucose-regulated proteins in oesophageal adenocarcinomas. PLoS One. 2012;7(7):e41420. doi: 10.1371/journal.pone.0041420.

16 Wulfkuhle JD, Berg D, Wolff C, Langer R, Tran K, Illi J, Espina V, Pierobon M, Deng J, DeMichele A, Walch A, Bronger H, Becker I, Waldhör C, Höfler H, Esserman  L; I-SPY 1 TRIAL Investigators, Liotta LA, Becker KF, Petricoin EF 3rd. Molecular analysis of HER2 signaling in human breast cancer by functional protein pathway activation mapping. Clin Cancer Res. 2012 Dec 1;18(23):6426-35. doi: 10.1158/1078-0432.CCR-12-0452.


2011


15  Berg D, Langer R, Tran K, Walch A, Schuster T, Bronger H, Becker KF. Protein Microarray-based Comparison of HER2, Estrogen Receptor, and Progesterone Receptor Status in Core Biopsies and Surgical Specimens From FFPE Breast Cancer Tissues. Appl Immunohistochem Mol Morphol. 2011 Feb 2. [Epub ahead of print]

14  Berg D, Malinowsky K, Reischauer B, Wolff C, Becker KF. Use of formalin-fixed and paraffin-embedded tissues for diagnosis and therapy in routine clinical settings. Methods Mol Biol. 2011;785:109-22.

13  Berg D, Wolff C, Langer R, Schuster T, Feith M, Slotta-Huspenina J, Malinowsky K, Becker KF. Discovery of new molecular subtypes in oesophageal adenocarcinoma. PLoS One. 2011;6(9):e23985. Epub 2011 Sep 23.

12  Wolff C, Malinowsky K, Berg D, Schragner K, Schuster T, Walch A, Bronger H,Höfler H, Becker KF. Signalling networks associated with urokinase-typeplasminogen activator (uPA) and its inhibitor PAI-1 in breast cancer tissues: new insights from protein microarray analysis. J Pathol. 2011 Jan;223(1):54-63.

11  Wolff C, Schott C, Porschewski P, Reischauer B, Becker KF. Successful protein extraction from over-fixed and long-term stored formalin-fixed tissues. PLoS One. 2011 Jan 31;6(1):e16353
2010


2010

  
10  Becker KF, Berg D, Malinowsky K, Wolff C, Ergin B, Meding S, Walch A, Höfler  H. Update on protein analysis of fixed tissues]. Pathologe. 2010 Oct;31 Suppl2:263-7.

9  Becker KF, Taylor CR. Liquid Morphology': Immunochemical Analysis of Proteins Extracted From Formalin-fixed Paraffin-embedded Tissues: Combining Proteomics With Immunohistochemistry. Appl Immunohistochem Mol Morphol. 2010 Sep 7. [Epub ahead of print]

8  Berg D, Bronger H, Walch A, Höfler H, Becker KF. Analysis of signalling pathways in formalin-fixed breast cancer tissues]. Pathologe. 2010 Oct;31 Suppl 2:296-9.

7  Berg D, Hipp S, Malinowsky K, et al. Molecular profiling of signalling pathways in formalin fixed and paraffin embedded cancer tissues. European Journal of Cancer 2010;46:47-55

6  Corbo V, Dalai I, Scardoni M, Barbi S, Beghelli S, Bersani S, Albarello L, Doglioni C, Schott C, Capelli P, Chilosi M, Boninsegna L, Becker KF, Falconi M, Scarpa A. MEN1 in pancreatic endocrine tumors: analysis of gene and protein status in 169 sporadic neoplasms reveals alterations in the vast majority of cases. Endocr Relat Cancer. 2010 Aug 16;17(3):771-83.

5  Ergin B, Meding S, Langer R, Kap M, Viertler C, Schott C, Ferch U, Riegman P, Zatloukal K, Walch A, Becker KF. Proteomic analysis of PAXgene-fixed tissues. J Proteome Res. 2010 Oct 1;9(10):5188-96.

4  Hipp S, Berg D, Ergin B, Schuster T, Hapfelmeier A, Walch A, Avril S, Schmalfeldt B, Höfler H, Becker KF. Interaction of Snail and p38 mitogen activated protein kinase results in shorter overall survival of ovarian cancer patients. Virchows Arch. 2010 Dec;457(6):705-13.

3  Malinowsky K, Böllner C, Hipp S, Berg D, Schmitt M, Becker KF. UPA and PAI-1 Analysis from Fixed Tissues - New Perspectives for a Known Set of Predictive Markers. Curr Med Chem. 2010 Oct 13. [Epub ahead of print]

2  Malinowsky K, Wolff C, Ergin B, Berg D, Becker KF. Deciphering signaling pathways in clinical tissues for personalized medicine using protein microarrays. J Cell Physiol. 2010 Nov;225(2):364-70

1  Wolff C, Malinowsky K, Berg D, Schragner K, Schuster T, Walch A, Bronger H, Höfler H, Becker KF. Signalling networks associated with urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 in breast cancer tissues: new insights from protein microarray analysis. J Pathol. 2010 Sep 27. [Epub ahead of print]