2013

209 Albayrak O, Pütter C, Volckmar AL, Cichon S, Hoffmann P, Nöthen MM, Jöckel KH, Schreiber S, Wichmann HE, Faraone SV, Neale BM, Herpertz-Dahlmann B, Lehmkuhl G, Sinzig J, Renner TJ, Romanos M, Warnke A, Lesch KP, Reif A, Schimmelmann BG, Scherag A, Hebebrand J, Hinney A; Psychiatric GWAS Consortium: ADHD Subgroup.  Common obesity risk alleles in childhood attention-deficit/hyperactivity disorder.  Am J Med Genet B Neuropsychiatr Genet. 2013 Mar 26. doi: 10.1002/ajmg.b.32144. [Epub ahead of print] PubMed PMID: 23533005. 

208 Berndt SI, Gustafsson S, Mägi R, Ganna A, Wheeler E, Feitosa MF, Justice AE, Monda KL, Croteau-Chonka DC, Day FR, Esko T, Fall T, Ferreira T, Gentilini D, Jackson AU, Luan J, Randall JC, Vedantam S, Willer CJ, Winkler TW, Wood AR, Workalemahu T, Hu YJ, Lee SH, Liang L, Lin DY, Min JL, Neale BM, Thorleifsson G, Yang J, Albrecht E, Amin N, Bragg-Gresham JL, Cadby G, den Heijer M, Eklund N, Fischer K, Goel A, Hottenga JJ, Huffman JE, Jarick I, Johansson A, Johnson T, Kanoni S, Kleber ME, König IR, Kristiansson K, Kutalik Z, Lamina C, Lecoeur C, Li G, Mangino M, McArdle WL, Medina-Gomez C, Müller-Nurasyid M, Ngwa JS, Nolte IM, Paternoster L, Pechlivanis S, Perola M, Peters MJ, Preuss M, Rose LM, Shi J, Shungin D, Smith AV, Strawbridge RJ, Surakka I, Teumer A, Trip MD, Tyrer J, Van Vliet-Ostaptchouk JV, Vandenput L, Waite LL, Zhao JH, Absher D, Asselbergs FW, Atalay M, Attwood AP, Balmforth AJ, Basart H, Beilby J, Bonnycastle LL, Brambilla P, Bruinenberg M, Campbell H, Chasman DI, Chines PS, Collins FS, Connell JM, Cookson WO, de Faire U, de Vegt F, Dei M, Dimitriou M, Edkins S, Estrada K, Evans DM, Farrall M, Ferrario MM, Ferrières J, Franke L, Frau F, Gejman PV, Grallert H, Grönberg H, Gudnason V, Hall AS, Hall P, Hartikainen AL, Hayward C, Heard-Costa NL, Heath AC, Hebebrand J, Homuth G, Hu FB, Hunt SE, Hyppönen E, Iribarren C, Jacobs KB, Jansson JO, Jula A, Kähönen M, Kathiresan S, Kee F, Khaw KT, Kivimäki M, Koenig W, Kraja AT, Kumari M, Kuulasmaa K, Kuusisto J, Laitinen JH, Lakka TA, Langenberg C, Launer LJ, Lind L, Lindström J, Liu J, Liuzzi A, Lokki ML, Lorentzon M, Madden PA, Magnusson PK, Manunta P, Marek D, März W, Leach IM, McKnight B, Medland SE, Mihailov E, Milani L, Montgomery GW, Mooser V, Mühleisen TW, Munroe PB, Musk AW, Narisu N, Navis G, Nicholson G, Nohr EA, Ong KK, Oostra BA, Palmer CN, Palotie A, Peden JF, Pedersen N, Peters A, Polasek O, Pouta A, Pramstaller PP, Prokopenko I, Pütter C, Radhakrishnan A, Raitakari O, Rendon A, Rivadeneira F, Rudan I, Saaristo TE, Sambrook JG, Sanders AR, Sanna S, Saramies J, Schipf S, Schreiber S, Schunkert H, Shin SY, Signorini S, Sinisalo J, Skrobek B, Soranzo N, Stan?áková A, Stark K, Stephens JC, Stirrups K, Stolk RP, Stumvoll M, Swift AJ, Theodoraki EV, Thorand B, Tregouet DA, Tremoli E, Van der Klauw MM, van Meurs JB, Vermeulen SH, Viikari J, Virtamo J, Vitart V, Waeber G, Wang Z, Widén E, Wild SH, Willemsen G, Winkelmann BR, Witteman JC, Wolffenbuttel BH, Wong A, Wright AF, Zillikens MC, Amouyel P, Boehm BO, Boerwinkle E, Boomsma DI, Caulfield MJ, Chanock SJ, Cupples LA, Cusi D, Dedoussis GV, Erdmann J, Eriksson JG, Franks PW, Froguel P, Gieger C, Gyllensten U, Hamsten A, Harris TB, Hengstenberg C, Hicks AA, Hingorani A, Hinney A, Hofman A, Hovingh KG, Hveem K, Illig T, Jarvelin MR, Jöckel KH, Keinanen-Kiukaanniemi SM, Kiemeney LA, Kuh D, Laakso M, Lehtimäki T, Levinson DF, Martin NG, Metspalu A, Morris AD, Nieminen MS, Njølstad I, Ohlsson C, Oldehinkel AJ, Ouwehand WH, Palmer LJ, Penninx B, Power C, Province MA, Psaty BM, Qi L, Rauramaa R, Ridker PM, Ripatti S, Salomaa V, Samani NJ, Snieder H, Sørensen TI, Spector TD, Stefansson K, Tönjes A, Tuomilehto J, Uitterlinden AG, Uusitupa M, van der Harst P, Vollenweider P, Wallaschofski H, Wareham NJ, Watkins H, Wichmann HE, Wilson JF, Abecasis GR, Assimes TL, Barroso I, Boehnke M, Borecki IB, Deloukas P, Fox CS, Frayling T, Groop LC, Haritunian T, Heid IM, Hunter D, Kaplan RC, Karpe F, Moffatt MF, Mohlke KL, O'Connell JR, Pawitan Y, Schadt EE, Schlessinger D, Steinthorsdottir V, Strachan DP, Thorsteinsdottir U, van Duijn CM, Visscher PM, Di Blasio AM, Hirschhorn JN, Lindgren CM, Morris AP, Meyre D, Scherag A, McCarthy MI, Speliotes EK, North KE, Loos RJ, Ingelsson E.  Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.  Nat Genet. 2013 Apr 7. doi: 10.1038/ng.2606. [Epub ahead of print] PubMed PMID:23563607.

207 Berulava T, Ziehe M, Klein-Hitpass L, Mladenov E, Thomale J, Ruther U, Horsthemke B (2013)  FTO levels affect RNA modifications and the transcriptome.  Eur J Hum Genet 21: 317-323

206 de Groot JC, Weidner C, Krausze J, Kawamoto K, Schroeder FC, Sauer S, Büssow K. Structural Characterization of Amorfrutins Bound to the Peroxisome Proliferator-Activated Receptor ?. Journal of Medicinal Chemistry. 2013; 56(4):1535-1543

205 Feldmann R, Fischer C, Kodelja V, Behrens S, Haas S, Vingron M, Timmermann B, Geikowski A, Sauer S.  Genome-wide analysis of LXR? activation reveals new transcriptional networks in human atherosclerotic foam cells.  Nucleic Acids Res. 2013 Apr 1;41(6):3518-31.

204 Feldmann R, Geikowski A, Weidner C, Witzke A, Kodelja V, Schwarz T, Gabriel M, Erker T, Sauer S. Foam Cell Specific LXR? Ligand. PLoS One. 2013;8(2):e57311.

203 Fernández-Rhodes L, Demerath EW, Cousminer DL, Tao R, Dreyfus JG, Esko T, Smith AV, Gudnason V, Harris TB, Launer L, McArdle PF, Yerges-Armstrong LM, Elks CE, Strachan DP, Kutalik Z, Vollenweider P, Feenstra B, Boyd HA, Metspalu A, Mihailov E, Broer L, Zillikens MC, Oostra B, van Duijn CM, Lunetta KL, Perry JR, Murray A, Koller DL, Lai D, Corre T, Toniolo D, Albrecht E, Stöckl D, Grallert H, Gieger C, Hayward C, Polasek O, Rudan I, Wilson JF, He C, Kraft P, Hu FB, Hunter DJ, Hottenga JJ, Willemsen G, Boomsma DI, Byrne EM, Martin NG, Montgomery GW, Warrington NM, Pennell CE, Stolk L, Visser JA, Hofman A, Uitterlinden AG, Rivadeneira F, Lin P, Fisher SL, Bierut LJ, Crisponi L, Porcu E, Mangino M, Zhai G, Spector TD, Buring JE, Rose LM, Ridker PM, Poole C, Hirschhorn JN, Murabito JM, Chasman DI, Widen E, North KE, Ong KK, Franceschini N.  Association of Adiposity Genetic Variants With Menarche Timing in 92,105 Women of European Descent.  Am J Epidemiol. 2013 Apr 4. [Epub ahead of print]

202 Hebebrand J, Hinney A, Knoll N, Volckmar AL, Scherag A. Molekulargenetische Aspekte der Körpergewichtsregulation. Dtsch Arztebl Int 2013; 110(19): 338-44.

201 Helwig M, Herwig A, Heldmaier G, Barrett P, Mercer JG, Klingenspor M.  Photoperiod-dependent regulation of carboxypeptidase E affects the selective processing of neuropeptides in the seasonal Siberian hamster (Phodopus sungorus).  J Neuroendocrinol. 2013 Feb;25(2):190-7. doi: 10.1111/j.1365-2826.2012.02384.

200 Holzhauser S, Freiwald A, Weise C, Multhaup G, Han CT, Sauer S.  Discovery and Characterization of Protein-Modifying Natural Products by MALDI Mass Spectrometry Reveal Potent SIRT1 and p300 Inhibitors.  Angew Chem Int Ed Engl. 2013 May 3;52(19):5171-4.

199 Knoll N, Jarick I, Volckmar AL, Klingenspor M, Illig T, Grallert H, Gieger C, Wichmann HE, Peters A, Hebebrand J, Scherag A, Hinney A.  Gene set of nuclear-encoded mitochondrial regulators is enriched for common inherited variation in obesity.  PLoS One. 2013; 8(2): e55884. doi: 10.1371/journal.pone.0055884

198 Nordström V, Willershäuser M, Herzer S, Rozman J, von Bohlen Und Halbach O, Meldner S, Rothermel U, Kaden S, Roth FC, Waldeck C, Gretz N, de Angelis MH, Draguhn A, Klingenspor M, Gröne HJ, Jennemann R.  Neuronal expression of glucosylceramide synthase in central nervous system regulates body weight and energy homeostasis.  PLoS Biol. 2013 Mar;11(3):e1001506. doi: 10.1371/journal.pbio.1001506. Epub 2013 Mar 12.                                             

197 Pechlivanis S, Mühleisen TW, Möhlenkamp S, Schadendorf D, Erbel R, Jöckel KH, Hoffmann P, Nöthen MM, Scherag A, Moebus S;Heinz Nixdorf Recall Study Investigative Group. Risk loci for coronary artery calcification replicated at 9p21 and 6q24 in the Heinz Nixdorf Recall Study.  BMC Med Genet. 2013 Feb 8;14:23.

196 Pott W, Albayrak O, Hinney A, Hebebrand J, Pauli-Pott U.  Successful treatment with atomoxetine of an adolescent boy with attention deficit/hyperactivity disorder, extreme obesity, and reduced melanocortin 4 receptor function.  Obes Facts. 2013;6(1):109-15. doi: 10.1159/000348792. Epub 2013 Mar 6. PubMed PMID:23493066.
 
195 Scherag  A.  Missing heritability of complex traits and G-E interactions. GMS Medizinische Informatik, Biometrie und Epidemiologie 2013, Vol. 9(2), ISSN 1860-9171.

194 Schimmelmann BG, Hinney A, Scherag A, Pütter C, Pechlivanis S, Cichon S, Jöckel KH, Schreiber S, Wichmann HE, Albayrak O, Dauvermann M, Konrad K, Wilhelm C, Herpertz-Dahlmann B, Lehmkuhl G, Sinzig J, Renner TJ, Romanos M, Warnke A, Lesch KP, Reif A, Hebebrand J. Bipolar disorder risk alleles in children with ADHD.  J Neural Transm. 2013 May 28. [Epub ahead of print] PubMed PMID: 23712748.

193 Tews D, Fischer-Posovszky P, Fromme T, Klingenspor M, Fischer J, Rüther U, Barth TF, Möller P, Debatin KM, Wabitsch M.  FTO deficiency induces UCP-1 expression and mitochondrial uncoupling in adipocytes'  Endocrinology. 2013 Jun 10. [Epub ahead of print]
 
192 Vimaleswaran KS, Berry DJ, Lu C, Tikkanen E, Pilz S, Hiraki LT, Cooper JD, Dastani Z, Li R, Houston DK, Wood AR, Michaëlsson K, Vandenput L, Zgaga L, Yerges-Armstrong LM, McCarthy MI, Dupuis J, Kaakinen M, Kleber ME, Jameson K, Arden N, Raitakari O, Viikari J, Lohman KK, Ferrucci L, Melhus H, Ingelsson E, Byberg L, Lind L, Lorentzon M, Salomaa V, Campbell H, Dunlop M, Mitchell BD, Herzig KH, Pouta A, Hartikainen AL; Genetic Investigation of Anthropometric Traits-GIANT Consortium, Streeten EA, Theodoratou E, Jula A, Wareham NJ, Ohlsson C, Frayling TM, Kritchevsky SB, Spector TD, Richards JB, Lehtimäki T, Ouwehand WH, Kraft P, Cooper C, März W, Power C, Loos RJ, Wang TJ, Järvelin MR, Whittaker JC, Hingorani AD, Hyppönen E.  Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts.  PLoS Med. 2013;10(2):e1001383. doi: 10.1371/journal.pmed.1001383. Epub 2013 Feb 5.

191 Vogel H, Mirhashemi F, Liehl B, Taugner F, Kluth O, Kluge R, Joost HG, Schürmann A.  Estrogen Deficiency Aggravates Insulin Resistance and Induces ?-Cell Loss and Diabetes in Female New Zealand Obese Mice.  Horm Metab Res. Jan 15 (2013).

190 VoVogel H, Montag D, Kanzleiter T, Jonas W, Matzke D, Scherneck S, Chadt A, Töle J, Kluge R, Joost HG, Schürmann A.  An interval of the obesity QTL Nob3.38 within a QTL hotspot on chromosome 1 modulates behavioral phenotypes.  PLoS One. 8:e53025 (2013).

189 Volckmar AL, Pütter C, Song JY, Graniger J, Knoll N, Wolters B, Hebebrand J, Scherag A, Reinehr T, Hinney A. Analyses of Non-Synonymous Obesity Risk Alleles in SH2B1 (rs7498665) and APOB48R (rs180743) in Obese Children and Adolescents Undergoing a 1-year Lifestyle Intervention.  Exp Clin Endocrinol Diabetes. 2013 (in press)

188 Weidner C, Wowro SJ, Freiwald A, Kawamoto K, Witzke A, Kliem M, Siems K, Müller-Kuhrt L, Schroeder FC, Sauer S.  Amorfrutin B is an efficient natural peroxisome proliferator-activated receptor gamma (PPAR?) agonist with potent glucose-lowering properties.  Diabetologia. 2013 May 18. Epub ahead of print]

2012

187 Bradfield PJ, Taal HR, Timpson NJ, Scherag A, Lecoeur C, Warrington NM, Hypponen E, Holst C, Valcarcel B, Thiering E, Salem RM, Schumacher FR, Cousminer DL, Sleiman PMA, Zhao J, Berkowitz RI, Vimaleswaran KS, Jarick I, Pennell CE, Evans DM, Pourcain BS, Berry DJ, Mook-Kanamori DO, Hofman A, Rivadeinera F, Uitterlinden AG, van Duijn CM, van der Valk RJP, de Jongste DC, Postma DS, Boomsma DI, Gauderman WJ, Hassanein WT, Lindgren CM, Mägi R, Boreham CAG, Neville CE, Moreno LA, Elliott P, Pouta A, Hartikainen AL, Li M, Raitakari O, Lehtimäki T, Eriksson JG, Palotie A, Dallongeville J, Das S, Deloukas P, McMahon G, Ring SM, Kemp JP, Buxton JL, Blakemore AIF, Bustamante M, Guxens M, Hirschhorn JN, Gillman MW, Kreiner-Møller E, Bisgaard H, Gilliland FD, Heinrich J, Wheeler E, Barroso I, O'Rahilly S, Meirhaeghe A, Sørensen TIA, Power C, Palmer LJ, Hinney A, Widen E, Farooqi IS, McCarthy MI, Froguel P, Meyre D, Hebebrand J, Jarvelin MR, Jaddoe VWV, Smith GD, Hakonarson H, Grant SFA for the Early Growth Genetics (EGG) Consortium.  A genome-wide association meta-analysis identifies new childhood obesity loci.  Nat Genet 2012; 44(5): 526-531

186 Fischer-Posovszky P, Tews D, Horenburg S, Debatin KM, Wabitsch M. Differential function of Akt1 and Akt2 in human adipocytes. Mol Cell Endocrinol. 2012 Jul 6;358(1):135-43

185 Föcker M, Timmesfeld N, Scherag S, Knoll N, Singmann P, Wang-Sattler R, Bühren K, Schwarte R, Egberts K, Fleischhaker C, Adamski J, Illig T, Suhre K, Albayrak O, Hinney A, Herpertz-Dahlmann B, Hebebrand J.  Comparison of metabolic profiles of acutely ill and short-term weight recovered patients with anorexia nervosa reveals alterations of 33 out of 163 metabolites.  J Psychiatr Res. 2012 Dec;46(12):1600-9. doi: 10.1016/j.jpsychires.2012.08.015. Epub 2012 Sep 12. PubMed PMID: 22981704.

184 Freitag CM, Asherson P, Hebebrand J.  Behavioural genetics of childhood disorders.  Curr Top Behav Neurosci. 2012;12:395-428. doi: 10.1007/7854_2011_178. PubMed PMID: 22382729.

183 Hebebrand J, Albayrak Ö. Leptin treatment of patients with anorexia nervosa?The urgent need for initiation of clinical studies.  Eur Child Adolesc Psychiatry.2012 Feb;21(2):63-6. PubMed PMID: 22290117.

182 Hebebrand J.  OBESITY FACTS - a Success Story.  Obes Facts. 2012;5(1):151-153. Epub 2012 Mar 2. PubMed PMID: 22433626. 

181 Ichimura A, Hirasawa A, Poulain-Godefroy O, Bonnefond A, Hara T, Yengo L, Kimura I, Leloire A, Liu N, Iida K, Choquet H, Besnard P, Lecoeur C, Vivequin S, Ayukawa K, Takeuchi M, Ozawa K, Tauber M, Maffeis C, Morandi A, Buzzetti R, Elliott P, Pouta A, Jarvelin MR, Körner A, Kiess W, Pigeyre M, Caiazzo R, Van Hul W, Van Gaal L, Horber F, Balkau B, Lévy-Marchal C, Rouskas K, Kouvatsi A, Hebebrand J, Hinney A, Scherag A, Pattou F, Meyre D, Koshimizu TA, Wolowczuk I, Tsujimoto G, Froguel P.  Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human.  Nature. 2012 Feb 19;483(7389):350-4. doi: 10.1038/nature10798. PMID: 22343897 [PubMed - in process] 

180 Knoll N, Volckmar AL, Pütter C, Scherag A, Kleber M, Hebebrand J, Hinney A, Reinehr T.  The fatty acid amide hydrolase (FAAH) gene variant rs324420 AA/AC is not associated with weight loss in a 1-year lifestyle intervention for obese children and adolescents. 8. Horm Metab Res. 2012 Jan;44(1):75-7. doi: 10.1055/s-0031-1291306. Epub 2011 Nov

179 "Kuehnen P, Mischke M, Wiegand S, Sers C, Horsthemke B, Grueters A, Krude H (2012)  An Alu element-associated hypermethylation variant of the POMC gene is associated with childhood obesity. PLoS Genetics, 8: e1002543                                                                               

178 Lee AWS, Hengstler H, Schwald K, Berriel-Diaz M, Loreth D, Kirsch M, Kretz O, Haas CA, Hrabe de Angelis M, Herzig S, Brümmendorf T, Klingenspor M, Rathjen FG, Rozman J, Nicholson G, Cox RD, Schäfer MKE.  Functional Inactivation of the Genome-Wide Association Study Obesity Gene Neuronal Growth Regulator 1 in Mice Causes a Body Mass Phenotype.  PLoS One. 2012;7(7):e41537.

177 Lubura M, Hesse D, Neumann N, Scherneck S, Wiedmer P, Schürmann A.  Non-invasive quantification of white and brown adipose tissues and liver fat content by computed tomography in mice.  PLoS One. 7:e37026 (2012).

176 Morris AP, Voight BF, Teslovich TM, Ferreira T, Segrè AV, Steinthorsdottir V, Strawbridge RJ, Khan H, Grallert H, Mahajan A, Prokopenko I, Kang HM, Dina C, Esko T, Fraser RM, Kanoni S, Kumar A, Lagou V, Langenberg C, Luan J, Lindgren CM, Müller-Nurasyid M, Pechlivanis S, Rayner NW, Scott LJ, Wiltshire S, Yengo L, Kinnunen L, Rossin EJ, Raychaudhuri S, Johnson AD, Dimas AS, Loos RJ, Vedantam S, Chen H, Florez JC, Fox C, Liu CT, Rybin D, Couper DJ, Kao WH, Li M, Cornelis MC, Kraft P, Sun Q, van Dam RM, Stringham HM, Chines PS, Fischer K, Fontanillas P, Holmen OL, Hunt SE, Jackson AU, Kong A, Lawrence R, Meyer J, Perry JR, Platou CG, Potter S, Rehnberg E, Robertson N, Sivapalaratnam S, Stan?áková A, Stirrups K, Thorleifsson G, Tikkanen E, Wood AR, Almgren P, Atalay M, Benediktsson R, Bonnycastle LL, Burtt N, Carey J, Charpentier G, Crenshaw AT, Doney AS, Dorkhan M, Edkins S, Emilsson V, Eury E, Forsen T, Gertow K, Gigante B, Grant GB, Groves CJ, Guiducci C, Herder C, Hreidarsson AB, Hui J, James A, Jonsson A, Rathmann W, Klopp N, Kravic J, Krjut?kov K, Langford C, Leander K, Lindholm E, Lobbens S, Männistö S, Mirza G, Mühleisen TW, Musk B, Parkin M, Rallidis L, Saramies J, Sennblad B, Shah S, Sigurðsson G, Silveira A, Steinbach G, Thorand B, Trakalo J, Veglia F, Wennauer R, Winckler W, Zabaneh D, Campbell H, van Duijn C, Uitterlinden AG, Hofman A, Sijbrands E, Abecasis GR, Owen KR, Zeggini E, Trip MD, Forouhi NG, Syvänen AC, Eriksson JG, Peltonen L, Nöthen MM, Balkau B, Palmer CN, Lyssenko V, Tuomi T, Isomaa B, Hunter DJ, Qi L; Wellcome Trust Case Control Consortium; Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC) Investigators; Genetic Investigation of ANthropometric Traits (GIANT) Consortium; Asian Genetic Epidemiology Network?Type 2 Diabetes (AGEN-T2D) Consortium; South Asian Type 2 Diabetes (SAT2D) Consortium, Shuldiner AR, Roden M, Barroso I, Wilsgaard T, Beilby J, Hovingh K, Price JF, Wilson JF, Rauramaa R, Lakka TA, Lind L, Dedoussis G, Njølstad I, Pedersen NL, Khaw KT, Wareham NJ, Keinanen-Kiukaanniemi SM, Saaristo TE, Korpi-Hyövälti E, Saltevo J, Laakso M, Kuusisto J, Metspalu A, Collins FS, Mohlke KL, Bergman RN, Tuomilehto J, Boehm BO, Gieger C, Hveem K, Cauchi S, Froguel P, Baldassarre D, Tremoli E, Humphries SE, Saleheen D, Danesh J, Ingelsson E, Ripatti S, Salomaa V, Erbel R, Jöckel KH, Moebus S, Peters A, Illig T, de Faire U, Hamsten A, Morris AD, Donnelly PJ, Frayling TM, Hattersley AT, Boerwinkle E, Melander O, Kathiresan S, Nilsson PM, Deloukas P, Thorsteinsdottir U, Groop LC, Stefansson K, Hu F, Pankow JS, Dupuis J, Meigs JB, Altshuler D, Boehnke M, McCarthy MI; DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium.  Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.  Nat Genet. 2012 Sep;44(9):981-90. doi: 10.1038/ng.2383. Epub 2012 Aug 12.

175 Mühlhaus J, Pütter C, Brumm H, Grallert H, Illig T, Scherag S, Reinehr T, Pott W, Albayrak Ö, Wang HJ, Bau AM, Wiegand S, Grüters A, Krude H, Hebebrand J, Hinney A, Biebermann H, Scherag A.  Do common variants separate between obese melanocortin-4 receptor gene mutation carriers and non-carriers? The impact of cryptic relatedness.  Horm Res Paediatr. 2012;77(6):358-68. doi: 10.1159/000338999. Epub 2012 Jun 9. PubMed PMID: 22688572.                                                                               

174 Müller TD, Greene BH, Bellodi L, Cavallini MC, Cellini E, Bella DD, Ehrlich S, Erzegovesi S, Estivill X, Fernández-Aranda F, Fichter M, Fleischhaker C, Scherag S, Gratacòs M, Grallert H, Herpertz-Dahlmann B, Herzog W, Illig T, Lehmkuhl U, Nacmias B, Ribasés M, Ricca V, Schäfer H, Scherag A, Sorbi S, Wichmann HE, Hebebrand J, Hinney A.  Fat Mass and Obesity Associated Gene (FTO) in Eating Disorders: Evidence for Association of the rs9939609 Obesity Risk Allele with Bulimia nervosa and Anorexia nervosa.  Obes Facts 2012; 5(3): 408-419                                                                                                    

173 Olszewski PK, Rozman J, Jacobsson JA, Rathkolb B, Strömberg S, Hans W, Klockars A, Alsiö J, Risrus U, Becker L, Hölter SM, Elvert R, Ehrhardt N, Gailus-Durner V, Fuchs H, Fredriksson R , Wolf E, Klopstock T, Wurst W, Levine AS, Marcus C, Hrabe de Angelis M, Klingenspor M, Schiöth HB, Kilimann MW.  Neurobeachin, a Regulator of Synaptic Protein Targeting, Is Associated with Body Fat Mass and Feeding Behavior in Mice and Body-Mass Index in Humans.  PLoS Genet. 2012;8(3):e1002568                                                                                                    

172 Perry JR, Voight BF, Yengo L, Amin N, Dupuis J, Ganser M, Grallert H, Navarro P, Li M, Qi L, Steinthorsdottir V, Scott RA, Almgren P, Arking DE, Aulchenko Y, Balkau B, Benediktsson R, Bergman RN, Boerwinkle E, Bonnycastle L, Burtt NP, Campbell H, Charpentier G, Collins FS, Gieger C, Green T, Hadjadj S, Hattersley AT, Herder C, Hofman A, Johnson AD, Kottgen A, Kraft P, Labrune Y, Langenberg C, Manning AK, Mohlke KL, Morris AP, Oostra B, Pankow J, Petersen AK, Pramstaller PP, Prokopenko I, Rathmann W, Rayner W, Roden M, Rudan I, Rybin D, Scott LJ, Sigurdsson G, Sladek R, Thorleifsson G, Thorsteinsdottir U, Tuomilehto J, Uitterlinden AG, Vivequin S, Weedon MN, Wright AF; MAGIC; DIAGRAM Consortium; GIANT Consortium, Hu FB, Illig T, Kao L, Meigs JB, Wilson JF, Stefansson K, van Duijn C, Altschuler D, Morris AD, Boehnke M, McCarthy MI, Froguel P, Palmer CN, Wareham NJ, Groop L, Frayling TM, Cauchi S.  Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.  PLoS Genet. 2012 May;8(5):e1002741. doi: 10.1371/journal.pgen.1002741. Epub 2012 May 31.                                                                                                    

171 Scott RA, Lagou V, Welch RP, Wheeler E, Montasser ME, Luan J, Mägi R, Strawbridge RJ, Rehnberg E, Gustafsson S, Kanoni S, Rasmussen-Torvik LJ, Yengo L, Lecoeur C, Shungin D, Sanna S, Sidore C, Johnson PC, Jukema JW, Johnson T, Mahajan A, Verweij N, Thorleifsson G, Hottenga JJ, Shah S, Smith AV, Sennblad B, Gieger C, Salo P, Perola M, Timpson NJ, Evans DM, Pourcain BS, Wu Y, Andrews JS, Hui J, Bielak LF, Zhao W, Horikoshi M, Navarro P, Isaacs A, O'Connell JR, Stirrups K, Vitart V, Hayward C, Esko T, Mihailov E, Fraser RM, Fall T, Voight BF, Raychaudhuri S, Chen H, Lindgren CM, Morris AP, Rayner NW, Robertson N, Rybin D, Liu CT, Beckmann JS, Willems SM, Chines PS, Jackson AU, Kang HM, Stringham HM, Song K, Tanaka T, Peden JF, Goel A, Hicks AA, An P, Müller-Nurasyid M, Franco-Cereceda A, Folkersen L, Marullo L, Jansen H, Oldehinkel AJ, Bruinenberg M, Pankow JS, North KE, Forouhi NG, Loos RJ, Edkins S, Varga TV, Hallmans G, Oksa H, Antonella M, Nagaraja R, Trompet S, Ford I, Bakker SJ, Kong A, Kumari M, Gigante B, Herder C, Munroe PB, Caulfield M, Antti J, Mangino M, Small K, Miljkovic I, Liu Y, Atalay M, Kiess W, James AL, Rivadeneira F, Uitterlinden AG, Palmer CN, Doney AS, Willemsen G, Smit JH, Campbell S, Polasek O, Bonnycastle LL, Hercberg S, Dimitriou M, Bolton JL, Fowkes GR, Kovacs P, Lindström J, Zemunik T, Bandinelli S, Wild SH, Basart HV, Rathmann W, Grallert H; DIAbetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium, Maerz W, Kleber ME, Boehm BO, Peters A, Pramstaller PP, Province MA, Borecki IB, Hastie ND, Rudan I, Campbell H, Watkins H, Farrall M, Stumvoll M, Ferrucci L, Waterworth DM, Bergman RN, Collins FS, Tuomilehto J, Watanabe RM, de Geus EJ, Penninx BW, Hofman A, Oostra BA, Psaty BM, Vollenweider P, Wilson JF, Wright AF, Hovingh GK, Metspalu A, Uusitupa M, Magnusson PK, Kyvik KO, Kaprio J, Price JF, Dedoussis GV, Deloukas P, Meneton P, Lind L, Boehnke M, Shuldiner AR, van Duijn CM, Morris AD, Toenjes A, Peyser PA, Beilby JP, Körner A, Kuusisto J, Laakso M, Bornstein SR, Schwarz PE, Lakka TA, Rauramaa R, Adair LS, Smith GD, Spector TD, Illig T, de Faire U, Hamsten A, Gudnason V, Kivimaki M, Hingorani A, Keinanen-Kiukaanniemi SM, Saaristo TE, Boomsma DI, Stefansson K, van der Harst P, Dupuis J, Pedersen NL, Sattar N, Harris TB, Cucca F, Ripatti S, Salomaa V, Mohlke KL, Balkau B, Froguel P, Pouta A, Jarvelin MR, Wareham NJ, Bouatia-Naji N, McCarthy MI, Franks PW, Meigs JB, Teslovich TM, Florez JC, Langenberg C, Ingelsson E, Prokopenko I, Barroso I Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.  Nat Genet. 2012 Sep;44(9):991-1005. doi: 10.1038/ng.2385. Epub 2012 Aug 12.                                                                                                    

170 Strawbridge RJ, Dupuis J, Prokopenko I, Barker A, Ahlqvist E, Rybin D, Petrie JR, Travers ME, Bouatia-Naji N, Dimas AS, Nica A, Wheeler E, Chen H, Voight BF, Taneera J, Kanoni S, Peden JF, Turrini F, Gustafsson S, Zabena C, Almgren P, Barker DJ, Barnes D, Dennison EM, Eriksson JG, Eriksson P, Eury E, Folkersen L, Fox CS, Frayling TM, Goel A, Gu HF, Horikoshi M, Isomaa B, Jackson AU, Jameson KA, Kajantie E, Kerr-Conte J, Kuulasmaa T, Kuusisto J, Loos RJ, Luan J, Makrilakis K, Manning AK, Martínez-Larrad MT, Narisu N, Nastase Mannila M, Ohrvik J, Osmond C, Pascoe L, Payne F, Sayer AA, Sennblad B, Silveira A, Stancáková A, Stirrups K, Swift AJ, Syvänen AC, Tuomi T, van 't Hooft FM, Walker M, Weedon MN, Xie W, Zethelius B; DIAGRAM Consortium; GIANT Consortium; MuTHER Consortium; CARDIoGRAM Consortium; C4D Consortium, Ongen H, Mälarstig A, Hopewell JC, Saleheen D, Chambers J, Parish S, Danesh J, Kooner J, Ostenson CG, Lind L, Cooper CC, Serrano-Ríos M, Ferrannini E, Forsen TJ, Clarke R, Franzosi MG, Seedorf U, Watkins H, Froguel P, Johnson P, Deloukas P, Collins FS, Laakso M, Dermitzakis ET, Boehnke M, McCarthy MI, Wareham NJ, Groop L, Pattou F, Gloyn AL, Dedoussis GV, Lyssenko V, Meigs JB, Barroso I, Watanabe RM, Ingelsson E, Langenberg C, Hamsten A, Florez JC. Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. Diabetes. 2011 Oct;60(10):2624-34. doi: 10.2337/db11-0415. Epub 2011 Aug 26.                                                                                                    

169 Tups A, Stöhr S, Helwig M, Barrett P, Krol E, Schachtner J, Mercer JG, Klingenspor M.  Seasonal leptin resistance is associated with impaired signalling via JAK2-STAT3 but not ERK, possibly mediated by reduced hypothalamic GRB2 protein.  J Comp Physiol B (2012) 182:553?567                                                                                                    

168 Vogel H, Scherneck S, Kanzleiter T, Benz V, Kluge R, Stadion M, Kryvych S, Blüher M, Klöting N, Joost HG, Schürmann A.  Loss of function of Ifi202b by a microdeletion on chromosome 1 of C57BL/6J mice suppresses 11?-hydroxysteroid dehydrogenase type 1 expression and  development of obesity.  Hum Mol Genet. 21, 3845-3857 (2012)                                                                                                    

167 Volckmar AL, Bolze F, Jarick I, Knoll N, Scherag A, Reinehr T, Illig T, Grallert H, Wichmann HE, Wiegand S, Biebermann H, Krude H, Fischer-Posovszky P, Rief W, Wabitsch M, Klingenspor M, Hebebrand J, Hinney A.   Mutation screen in the GWAS derived obesity gene SH2B1 including functional analyses of detected variants. BMC Med Genomics 2012; 5:65. doi: 10.1186/1755-8794-5-65.10.1186/1755-8794-5-65.                                                                                                    

166 von Schnurbein, J., A. Moss, S.A. Nagel, H. Muehleder, K.M. Debatin, I.S. Farooqi, and M. Wabitsch.   Leptin Substitution Results in the Induction of Menstrual Cycles in an Adolescent with Leptin Deficiency and Hypogonadotropic Hypogonadism. Horm Res Paediatr. (2012).                                                                                                    

165 Wahl S, Yu Z, Kleber M, Singmann P, Holzapfel C, He Y, Mittelstrass K, Polonikov A, Prehn C, Römisch-Margl W, Adamski J, Suhre K, Grallert H, Illig T, Wang-Sattler R, Reinehr T.  Childhood obesity is associated with changes in the serum metabolite profile.  Obes Facts. 2012;5(5):660-70. doi: 10.1159/000343204. Epub 2012 Oct 4.                                                                                                    

164 Weidner C, de Groot JC, Prasad A, Freiwald A, Quedenau C, Kliem M, Witzke A, Kodelja V, Han CT, Giegold S, Baumann M, Klebl B, Siems K, Müller-Kuhrt L, Schürmann A, Schüler R, Pfeiffer AF, Schroeder FC, Büssow K, Sauer S.  Amorfrutins are potent antidiabetic dietary natural products.  Proc Natl Acad Sci U S A. 109:7257-7262.                                                                                              

163 Wojciechowski P, Lipowska A, Rys P, Ewens KG, Franks S, Tan S, Lerchbaum E, Vcelak J, Attaoua R, Straczkowski M, Azziz R, Barber TM, Hinney A, Obermayer-Pietsch B, Lukasova P, Bendlova B, Grigorescu F, Kowalska I, Goodarzi MO; GIANT Consortium, Strauss JF 3rd, McCarthy MI, Malecki MT.  Impact of FTO genotypes on BMI and weight in polycystic ovary syndrome: a systematic review and meta-analysis.  Diabetologia. 2012 Oct;55(10):2636-45. doi: 10.1007/s00125-012-2638-6. Epub 2012 Jul 18. Review. Erratum in: Diabetologia. 2012 Oct;55(10):2858-9. PubMed PMID: 22801903; PubMed Central PMCID: PMC3433670.                                                                                                    

2011

162 Albayrak O, Albrecht B, Scherag S, Barth N, Hinney A, Hebebrand J. Successful methylphenidate treatment of early onset extreme obesity in a child with a melanocortin-4 receptor gene mutation and attention deficit/hyperactivity disorder. Eur J Pharmacol. 2011 Jan 3. [Epub ahead of print] PubMed PMID: 21211528.

161 Bolze F, Rink N, Brumm H, Kühn R, Mocek S, Schwarz AE, Kless C, Biebermann H, Wurst W, Rozman J, Klingenspor M. Characterization of the melanocortin-4-receptor nonsense mutation W16X in vitro and in vivo. Pharmacogenomics J. 2011 Oct 4. doi:
10.1038/tpj.2011.43

160 Brumm H, Mühlhaus J, Bolze F, Scherag S, Hinney A, Hebebrand J, Wiegand S, Klingenspor M, Grüters A, Krude H, Biebermann H. Rescue of Melanocortin 4 Receptor (MC4R) Nonsense Mutations by Aminoglycoside-Mediated Read-Through. Obesity (Silver Spring). 2011 Jul 7. doi: 10.1038/oby.2011.202. [Epub ahead of print] PubMed PMID: 21738238.

159 Fischer-Posovszky P, Keuper M, Nagel S, Hesse D, Schürmann A, Debatin KM, Strauss G, Wabitsch M. Downregulation of FLIP by cycloheximide sensitizes human fat cells to CD95-induced apoptosis. Exp Cell Res. 317:2200-2209 (2011).

158 Föcker M, Timmesfeld N, Scherag S, Bühren K, Langkamp M, Dempfle A, Sheridan EM, de Zwaan M, Fleischhaker C, Herzog W, Egberts K, Zipfel S, Herpertz-Dahlmann B, Hebebrand J. Screening for anorexia nervosa via measurement of serum leptin levels. J Neural Transm. 2011 Apr;118(4):571-8. Epub 2011 Jan 22. PubMed PMID: 21258826.

157 Frank S, M. Heni, A. Moss, J. von Schnurbein, A. Fritsche, H.U. Haring, S. Farooqi, H. Preissl, and M. Wabitsch. Leptin Therapy in a Congenital Leptin-Deficient Patient Leads to Acute and Long-Term Changes in Homeostatic, Reward, and Food-Related Brain Areas. J Clin Endocrinol Metab. 96(8):1283-1287 (2011).

156 Fröhlich G, Pott W, Albayrak Ö, Hebebrand J, Pauli-Pott U. Conditions of long-term success in a lifestyle intervention for overweight and obese youths. Pediatrics. 2011 Oct;128(4):e779-85. Epub 2011 Sep 12. PubMed PMID: 21911346.

155 Fromme T and Klingenspor M. Uncoupling protein 1 expression and high fat diets. Am J Physiol Regul Integr Comp Physiol. 2011 Jan; 300(1):R1-8

154 Günther T, Schmitt AO, Bortfeldt RH, Hinney A, Hebebrand J, Brockmann GA. Where in the genome are significant single nucleotide polymorphisms from genome-wide association studies located? OMICS. 2011 Jul-Aug;15(7-8):507-12. doi: 10.1089/omi.2010.0154. Epub 2011 Jun 23. PubMed PMID: 21699402.

153 Hantschel C, Wagener A, Neuschl C, Teupser D, Brockmann GA. Features of the metabolic syndrome in the Berlin Fat Mouse as a model for human obesity. Obes Facts 2011; 4(4):270-277

152 Hebebrand J, Buitelaar JK. On the way to DSM-V. Eur Child Adolesc Psychiatry.2011 Feb;20(2):57-60. PubMed PMID: 21267613; PubMed Central PMCID: PMC3038228.

151 Hebebrand J, Bulik CM. Critical appraisal of the provisional DSM-5 criteria for anorexia nervosa and an alternative proposal. Int J Eat Disord. 2011 Dec;44(8):665-78. doi: 10.1002/eat.20875. Epub 2010 Nov 15. PubMed PMID:22072403.

150 Hebebrand J. Pharmacotherapy of anorexia nervosa: more questions than answers. J Am Acad Child Adolesc Psychiatry. 2011 Sep;50(9):854-6. PubMed PMID: 21871366.

149 Hebebrand J. Obesity Facts. Contents of this issue. Obes Facts. 2011;4(1):6-8. Epub 2011 Feb 18. PubMed PMID: 21372605.

148 Hinney A, Scherag A, Jarick I, Albayrak Ö, Pütter C, Pechlivanis S, Dauvermann MR, Beck S, Weber H, Scherag S, Nguyen TT, Volckmar AL, Knoll N, Faraone SV, Neale BM, Franke B, Cichon S, Hoffmann P, Nöthen MM, Schreiber S, Jöckel KH, Wichmann HE, Freitag C, Lempp T, Meyer J, Gilsbach S, Herpertz-Dahlmann B, Sinzig J, Lehmkuhl G, Renner TJ, Warnke A, Romanos M, Lesch KP, Reif A, Schimmelmann BG, Hebebrand J; Psychiatric GWAS Consortium: Genome-wide association study in German patients with attention deficit/hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet. 2011 Dec;156B(8):888-97. doi: 10.1002/ajmg.b.31246. Epub 2011 Oct 19. PubMed PMID: 22012869.

147 Hinney A, Scherag S, Hebebrand J. Genetic findings in anorexia and bulimia nervosa. Prog Mol Biol Transl Sci. 2010;94:241-70. doi: 10.1016/S1877-1173(10)94009-X. Review. PubMed PMID: 21036328.

146 Jarick I, Vogel CI, Scherag S, Schäfer H, Hebebrand J, Hinney A / Scherag A. Novel common copy number variation for early onset extreme obesity on chromosome  11q11 identified by a genome-wide analysis. Hum Mol Genet. 2011 Feb 15;20(4):840-52.

145 Jiao H, Arner P, Dickson SL, Vidal H, Mejhert N, Henegar C, Taube M, Hansson C, Hinney A, Galan P, Simon C, Silveira A, Benrick A, Jansson JO, Bouloumié A, Langin D, Laville M, Debard C, Axelsson T, Rydén M, Kere J, Dahlman-Wright K, Hamsten A, Clement K, Dahlman I. Genetic association and gene expression analysis identify FGFR1 as a new susceptibility gene for human obesity. J Clin Endocrinol Metab. 2011 Jun;96(6):E962-6. Epub 2011 Mar 23. PubMed PMID: 21430024.

144 Jiao H, Arner P, Hoffstedt J, Brodin D, Dubern B, Czernichow S, van't Hooft F, Axelsson T, Pedersen O, Hansen T, Sørensen TI, Hebebrand J, Kere J, Dahlman-Wright K, Hamsten A, Clement K, Dahlman I. Genome wide association study identifies KCNMA1 contributing to human obesity. BMC Med Genomics. 2011 Jun 28;4:51. PubMed PMID: 21708048; PubMed Central PMCID: PMC3148553.

143 Kiess W, Sergejev E, Körner A, Hebebrand J. Is it possible to treat obesity in children and adolescents?]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2011 May;54(5):527-32. German. PubMed PMID: 21547642.

142 Kilpeläinen TO, Qi L, Brage S, Sharp SJ, Sonestedt E, Demerath E, Ahmad T, Mora S, Kaakinen M, Sandholt CH, Holzapfel C, Autenrieth CS, Hyppönen E, Cauchi S, He M, Kutalik Z, Kumari M, Stan?áková A, Meidtner K, Balkau B, Tan JT, Mangino M, Timpson NJ, Song Y, Zillikens MC, Jablonski KA, Garcia ME, Johansson S, Bragg-Gresham JL, Wu Y, van Vliet-Ostaptchouk JV, Onland-Moret NC, Zimmermann E, Rivera NV, Tanaka T, Stringham HM, Silbernagel G, Kanoni S, Feitosa MF, Snitker S, Ruiz JR, Metter J, Larrad MT, Atalay M, Hakanen M, Amin N, Cavalcanti-Proença C, Grøntved A, Hallmans G, Jansson JO, Kuusisto J, Kähönen M, Lutsey PL, Nolan JJ, Palla L, Pedersen O, Pérusse L, Renström F, Scott RA, Shungin D, Sovio U, Tammelin TH, Rönnemaa T, Lakka TA, Uusitupa M, Rios MS, Ferrucci L, Bouchard C, Meirhaeghe A, Fu M, Walker M, Borecki IB, Dedoussis GV, Fritsche A, Ohlsson C, Boehnke M, Bandinelli S, van Duijn CM, Ebrahim S, Lawlor DA, Gudnason V, Harris TB, Sørensen TI, Mohlke KL, Hofman A, Uitterlinden AG, Tuomilehto J, Lehtimäki T, Raitakari O, Isomaa B, Njølstad PR, Florez JC, Liu S, Ness A, Spector TD, Tai ES, Froguel P, Boeing H, Laakso M, Marmot M, Bergmann S, Power C, Khaw KT, Chasman D, Ridker P, Hansen T, Monda KL, Illig T, Järvelin MR, Wareham NJ, Hu FB, Groop LC, Orho-Melander M, Ekelund U, Franks PW, Loos RJ. Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. PLoS Med. 2011 Nov;8(11):e1001116. Epub 2011 Nov 1.

141 Knoll S, Bulik CM, Hebebrand J. Do the currently proposed DSM-5 criteria for anorexia nervosa adequately consider developmental aspects in children and adolescents? Eur Child Adolesc Psychiatry. 2011 Feb;20(2):95-101. Epub 2010 Nov 25. PubMed PMID: 21107872.

140 Lanktree MB, Guo Y, Murtaza M, Glessner JT, Bailey SD, Onland-Moret NC, Lettre G, Ongen H, Rajagopalan R, Johnson T, Shen H, Nelson CP, Klopp N, Baumert J, Padmanabhan S, Pankratz N, Pankow JS, Shah S, Taylor K, Barnard J, Peters BJ, Maloney CM, Lobmeyer MT, Stanton A, Zafarmand MH, Romaine SP, Mehta A, van Iperen EP, Gong Y, Price TS, Smith EN, Kim CE, Li YR, Asselbergs FW, Atwood LD, Bailey KM, Bhatt D, Bauer F, Behr ER, Bhangale T, Boer JM, Boehm BO, Bradfield JP, Brown M, Braund PS, Burton PR, Carty C, Chandrupatla HR, Chen W, Connell J, Dalgeorgou C, Boer A, Drenos F, Elbers CC, Fang JC, Fox CS, Frackelton EC, Fuchs B, Furlong CE, Gibson Q, Gieger C, Goel A, Grobbee DE, Hastie C, Howard PJ, Huang GH, Johnson WC, Li Q, Kleber ME, Klein BE, Klein R, Kooperberg C, Ky B, Lacroix A, Lanken P, Lathrop M, Li M, Marshall V, Melander O, Mentch FD, Meyer NJ, Monda KL, Montpetit A, Murugesan G, Nakayama K, Nondahl D, Onipinla A, Rafelt S, Newhouse SJ, Otieno FG, Patel SR, Putt ME, Rodriguez S, Safa RN, Sawyer DB, Schreiner PJ, Simpson C, Sivapalaratnam S, Srinivasan SR, Suver C, Swergold G, Sweitzer NK, Thomas KA, Thorand B, Timpson NJ, Tischfield S, Tobin M, Tomaszweski M, Verschuren WM, Wallace C, Winkelmann B, Zhang H, Zheng D, Zhang L, Zmuda JM, Clarke R, Balmforth AJ, Danesh J, Day IN, Schork NJ, de Bakker PI, Delles C, Duggan D, Hingorani AD, Hirschhorn JN, Hofker MH, Humphries SE, Kivimaki M, Lawlor DA, Kottke-Marchant K, Mega JL, Mitchell BD, Morrow DA, Palmen J, Redline S, Shields DC, Shuldiner AR, Sleiman PM, Smith GD, Farrall M, Jamshidi Y, Christiani DC, Casas JP, Hall AS, Doevendans PA, Christie JD, Berenson GS, Murray SS, Illig T, Dorn GW 2nd, Cappola TP, Boerwinkle E, Sever P, Rader DJ, Reilly MP, Caulfield M, Talmud PJ, Topol E, Engert JC, Wang K, Dominiczak A, Hamsten A, Curtis SP, Silverstein RL, Lange LA, Sabatine MS, Trip M, Saleheen D, Peden JF, Cruickshanks KJ, März W, O'Connell JR, Klungel OH, Wijmenga C, Maitland-van der Zee AH, Schadt EE, Johnson JA, Jarvik GP, Papanicolaou GJ; Hugh Watkins on behalf of PROCARDIS, Grant SF, Munroe PB, North KE, Samani NJ, Koenig W, Gaunt TR, Anand SS, van der Schouw YT;  Meena Kumari on behalf of the Whitehall II Study and the WHII 50K Group, Soranzo N, Fitzgerald GA, Reiner A, Hegele RA, Hakonarson H, Keating BJ. Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. Am J Hum Genet. 2011 Jan 7;88(1):6-18. Epub 2010 Dec 30.

139 Mirhashemi F, Scherneck S, Kluth O, Kaiser D, Vogel H, Kluge R, Schürmann A, Neschen S, Joost HG. Diet Dependence of Diabetes in the New Zealand Obese (NZO) Mouse: Total Fat, But not Fat Quality or Sucrose Accelerates and Aggravates Diabetes. Exp Clin Endocrinol Diabetes. 119:167-171 (2011).

138 Mittelstrass K, Ried JS, Yu Z, Krumsiek J, Gieger C, Prehn C, Roemisch-Margl W, Polonikov A, Peters A, Theis FJ, Meitinger T, Kronenberg F, Weidinger S, Wichmann HE, Suhre K, Wang-Sattler R, Adamski J, Illig T. Discovery of sexual dimorphisms in metabolic and genetic biomarkers. PLoS Genet. 2011 Aug;7(8):e1002215. Epub 2011 Aug 11.

137 Müller TD, Tschöp MH, Jarick I, Ehrlich S, Scherag S, Herpertz-Dahlmann B, Zipfel S, Herzog W, de Zwaan M, Burghardt R, Fleischhaker C, Klampfl K, Wewetzer C, Herpertz S, Zeeck A, Tagay S, Burgmer M, Pfluger PT, Scherag A, Hebebrand J, Hinney A. Genetic variation of the ghrelin activator gene ghrelin O-acyltransferase (GOAT) is associated with anorexia nervosa. Journal of Psychiatric Research 2011; 45:706-11

136 Oppert JM, Sørensen TI, Hebebrand J, Woodward E, Blundell JE. Opportunities for European obesity research in the coming decade - a perspective from the European association for the study of obesity (EASO). Obes Facts. 2011;4(6):425-6. Epub 2011 Dec 30. PubMed PMID: 22248991.

135 Pütter C, Pechlivanis S, Nöthen MM, Jöckel KH, Wichmann HE, Scherag A. Missing heritability in the tails of quantitative traits? A simulation study on the impact of slightly altered true genetic models. Hum Hered. 2011;72(3):173-81.

134 Raum E, Küpper-Nybelen J, Lamerz A, Hebebrand J, Herpertz-Dahlmann B, Brenner H. Tobacco smoke exposure before, during, and after pregnancy and risk of overweight at age 6. Obesity (Silver Spring). 2011 Dec;19(12):2411-7. doi: 10.1038/oby.2011.129. Epub 2011 May 26. PubMed PMID: 21617637.

133 Rediger A, Piechowski CL, Yi CX, Tarnow P, Strotmann R, Grüters A, Krude H, Schöneberg T, Tschöp MH, Kleinau G, Biebermann H. Mutually opposite signal modulation by hypothalamic heterodimerization of ghrelin and melanocortin-3 receptors. J Biol Chem. 2011 Nov 11;286(45):39623-31. Epub 2011 Sep 22.

132 Reinehr T / Scherag A, Wang HJ, Roth CL, Kleber M, Scherag S, Boes T, Vogel C, Hebebrand J, Hinney A. Relationship between MTNR1B (melatonin receptor 1B gene) polymorphism rs10830963 and glucose levels in overweight children and adolescents. Pediatr Diabetes. 2011 Mar 3. doi: 10.1111/j.1399-5448.2010.00738.x. [Epub ahead of print] PubMed PMID: 21366812.

131 Rosskopf D, Schwahn C, Neumann F, Bornhorst A, Rimmbach C, Mischke M, Wolf S, Geissler I, Kocher T, Grabe HJ, Nauck M, Hebebrand J, Kroemer HK, Friedrich N, Völzke H, Wallaschofski H. The growth hormone-IGF-I axis as a mediator for the association between FTO variants and body mass index: results of the Study of Health in Pomerania. Int J Obes (Lond). 2011 Mar;35(3):364-72. Epub 2010 Aug 24.PMID: 20733585

130 Schäfer N, Wagener A, Hantschel C, Mauel S, Gruber AD, Brockmann GA. High insulin and IGF-I levels maintain glucose homeostasis in the Berlin Fat Mouse Inbred line. Growth Factors 2011; 29(6):298-309

129 Scherag A, Kleber M, Boes T, Kolbe AL, Ruth A, Grallert H, Illig T, Heid IM, Toschke AM, Grau K; NUGENOB Consortium, Sørensen TI, Hebebrand J, Hinney A, Reinehr T. SDCCAG8 obesity alleles and reduced weight loss after a lifestyle intervention in overweight children and adolescents. Obesity (Silver Spring). 2012 Feb;20(2):466-70. doi: 10.1038/oby.2011.339. Epub 2011 Nov 17.

128 Schulz N, Himmelbauer H, Rath M, van Weeghel M, Houten S, Kulik W, Suhre K, Scherneck S, Vogel H, Kluge R, Wiedmer P, Joost HG, Schürmann A. Role of Medium- and Short-Chain L-3-Hydroxyacyl-CoA Dehydrogenase in the Regulation of Body Weight and Thermogenesis. Endocrinology. 152:4641-4651. (2011)

127 Slof-Op 't Landt MC, Meulenbelt I, Bartels M, Suchiman E, Middeldorp CM, Houwing-Duistermaat JJ, van Trier J, Onkenhout EJ, Vink JM, van Beijsterveldt CE, Brandys MK, Sanders N, Zipfel S, Herzog W, Herpertz-Dahlmann B, Klampfl K, Fleischhaker C, Zeeck A, de Zwaan M, Herpertz S, Ehrlich S, van Elburg AA, Adan RA, Scherag S, Hinney A, Hebebrand J, Boomsma DI, van Furth EF, Slagboom PE. Association study in eating disorders: TPH2 associates with anorexia nervosa and self-induced vomiting. Genes Brain Behav. 2011 Mar;10(2):236-43. doi: 10.1111/j.1601-183X.2010.00660.x. Epub 2010 Nov 22. PubMed PMID: 20946355.

126 Song JY, Wang HJ, Ma J, Xu ZY, Hinney A, Hebebrand J, Wang Y. Association of the rs10830963 polymorphism in MTNR1B with fasting glucose levels in Chinese children and adolescents. Obes Facts. 2011;4(3):197-203. Epub 2011 Jun 6. PubMed PMID: 21701235.

125 Speakman JR, Levitsky DA, Allison DB, Bray MS, de Castro JM, Clegg DJ, Clapham JC, Dulloo AG, Gruer L, Haw S, Hebebrand J, Hetherington MM, Higgs S, Jebb SA, Loos RJ, Luckman S, Luke A, Mohammed-Ali V, O'Rahilly S, Pereira M, Perusse L, Robinson TN, Rolls B, Symonds ME, Westerterp-Plantenga MS. Set points, settling points and some alternative models: theoretical options to understand how genes and environments combine to regulate body adiposity. Dis Model Mech. 2011 Nov;4(6):733-45. Review. PubMed PMID: 22065844; PubMed Central PMCID: PMC3209643.

124 Speliotes EK, Yerges-Armstrong LM, Wu J, Hernaez R, Kim LJ, Palmer CD, Gudnason V, Eiriksdottir G, Garcia ME, Launer LJ, Nalls MA, Clark JM, Mitchell BD, Shuldiner AR, Butler JL, Tomas M, Hoffmann U, Hwang SJ, Massaro JM, O'Donnell CJ, Sahani DV, Salomaa V, Schadt EE, Schwartz SM, Siscovick DS; NASH CRN; GIANT Consortium; MAGIC Investigators, Voight BF, Carr JJ, Feitosa MF, Harris TB, Fox CS, Smith AV, Kao WH, Hirschhorn JN, Borecki IB; GOLD Consortium. Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits. PLoS Genet. 2011 Mar;7(3):e1001324. Epub 2011 Mar 10.

123 Stepanow S, Reichwald, K., Huse, K., Gausmann, U., Nebel, A., Rosenstiel, P., Fischer-Posovszky. P., Wabitsch, M., Platzer, M. Allele-Specific, Age-dependent and BMI-associated DNA Methylation of Human MCHR1. PLoS One. 6(5):e17711 (2011).

122 Strawbridge RJ., Wabitsch, M., et al. Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. Diabetes. 60(10):2624-2634 (2011).

121 Suhre K, Shin SY, Petersen AK, Mohney RP, Meredith D, Wägele B, Altmaier E; CARDIoGRAM, Deloukas P, Erdmann J, Grundberg E, Hammond CJ, de Angelis MH, Kastenmüller G, Köttgen A, Kronenberg F, Mangino M, Meisinger C, Meitinger T, Mewes HW, Milburn MV, Prehn C, Raffler J, Ried JS, Römisch-Margl W, Samani NJ, Small KS, Wichmann HE, Zhai G, Illig T, Spector TD, Adamski J, Soranzo N, Gieger C. Human metabolic individuality in biomedical and pharmaceutical research. Nature. 2011 Aug 31;477(7362):54-60. doi: 10.1038/nature10354.

120 Tews D, Fischer-Posovszky P, Wabitsch M. Regulation of FTO and FTM expression during human preadipocyte differentiation. Horm Metab Res 2011 Jan;43(1):17-21

119 Vogel CI, Boes T, Reinehr T, Roth CL, Scherag S, Scherag A, Hebebrand J, Hinney A. Common variants near MC4R: exploring gender effects in overweight and obese children and adolescents participating in a lifestyle intervention. Obes Facts. 2011;4(1):67-75. Epub 2011 Feb 22.

118 Winter Y, Back T, Scherag A, Linseisen J, Rohrmann S, Lanczik O, Hinney A,Scherag S, Neumaier M, Ringleb PA, Dodel R, Hebebrand J. Evaluation of the obesity genes FTO and MC4R and the type 2 diabetes mellitus gene TCF7L2 for contribution to stroke risk: The Mannheim-Heidelberg Stroke Study. Obes Facts. 2011;4(4):290-6. Epub 2011 Aug 1. PubMed PMID: 21921652.

2010

117 Berulava T, Horsthemke B (2010) Comment on: Jowett et al. Genetic variation at the FTO locus influences RBL2 gene expression. Diabetes, 59:e9

116 Berulava T, Horsthemke B. The obesity-associated SNPs in intron 1 of the FTO gene affect primary transcript levels. Eur J Hum Genet, 9:1054-1056

115 Choquet H, Labrune Y, De Graeve F, Hinney A, Hebebrand J, Scherag A, Lecoeur C, Tauber M, Balkau B, Elliot P, Jarvelin MR, Walley AJ, Besnard P, Froguel P, Meyre D. Lack of Association of CD36 SNPs With Early Onset Obesity: A Meta-Analysis in 9,973 European Subjects. Obesity (Silver Spring). 2010 Oct 21. [Epub ahead of print]

114 Deussing JM, Johannes Breu,Claudia Kühne, Magdalena Kallnik, Mirjam Bunck, Lisa Glasl, Yi-Chun Yen, Mathias V. Schmidt, Regine Zurmühlen, Annette M. Vogl, Valérie Gailus-Durner, Helmut Fuchs, Sabine M. Hölter, Rainer Landgraf, Martin Hrabé de Angelis, Florian Holsboer, Wolfgang Wurst. Urocortin 3 modulates social discrimination abilities via corticotropin-releasing hormone receptor type 2. Journal of Neuroscience 30 (27): 9103-9116.

113 Dupuis, J., Langenberg, C., Prokopenko, I., Saxena, R., Soranzo, N., Jackson, A.U., Wheeler, E., Glazer, N.L., Bouatia-Naji, N., Grallert, H., Gieger, C., Meisinger, C., Wichmann, H.E., Illig, T., Barroso, I. for the MAGIC investigators et al. "New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. " Nature Genetics 42(2), 105-116 (2010)

112 Fischer-Posovszky P,  von Schnurbein J, Moepps B,  Lahr G, Strauss G, Barth TF, Kassubek J, Mühleder H, Möller P, Debatin KM, Gierschik P, Wabitsch MA. New missense mutation in the leptin gene causes mild obesity and hypogonadism without affecting T cell responsiveness. J Clin Endo Metab. 2010

111 Fischer-Posovszky P, von Schnurbein J, Moepps B, Lahr G, Strauss G, Barth TF,  Kassubek J, Mühleder H, Möller P, Debatin KM, Gierschik P, Wabitsch M. A new missense mutation in the leptin gene causes mild obesity and hypogonadism without affecting T cell responsiveness: J Clin Endocrinol Metab. In press.

110 Freiwald A, Mao L, Kodelja V, Kliem M, Schuldt D, Schreiber S, Franke A and Sauer S. Differential analysis of crohn disease and ulcerative colitis by mass spectrometry. Inflammatory Bowel Diseases, in press

109 Grallert H, Herder C, Marzi C, Meisinger C, Wichmann HE, Rathmann W, Illig T. "Association of genetic variation in KCNQ1 with type 2 diabetes in the KORA surveys." Horm Metab Res. 2010 Feb;42(2):149-51. Epub 2009 Oct 1.

108 Gratacòs M, Escaramís G, Bustamante M, Saus E, Agüera Z, Bayés M, Cellini E, de Cid R, Fernández-Aranda F, Forcano L, González JR, Gorwood P, Hebebrand J, Hinney A, Mercader JM, Nacmias B, Ramoz N, Ribasés M, Ricca V, Romo L, Sorbi S, Versini A, Estivill X. Role of the neurotrophin network in eating disorders' subphenotypes: body mass index and age at onset of the disease. J Psychiatr Res. 2010 Oct;44(13):834-40. Epub 2010 Mar 9. PubMed PMID: 20219210.

107 Günther T, Schmitt AO, Bortfeldt RH, Hinney A, Hebebrand J, Brockmann GA. Where in the genome are significant single nucleotide polymorphismsfrom genome-wide association studies located?  OMICS: A Journal of Integrative Biology. 2010; accepted

106 Hageman RS, Wagener A, Hantschel C, Svenson KL, Churchill GA, Brockmann GA. High fat diet leads to increased storage of mono-unsaturated fatty acids and tissue specific risk factors for diseases in DBA/2 mice. Physiol. Genomics. 2010; 42:55-66.

105 Hebebrand J, Scherag A, Schimmelmann BG, Hinney A. Child and adolescentpsychiatric genetics. Eur Child Adolesc Psychiatry. 2010 Mar;19(3):259-79. Epub 2010 Feb 6. PubMed PMID: 20140632.

104 Hebebrand J, Volckmar AL, Knoll N, Hinney A. Chipping away the 'missingheritability': GIANT steps forward in the molecular elucidation of obesity - but still lots to go. Obes Facts. 2010 Oct;3(5):294-303. Epub 2010 Oct 15. Review.PubMed PMID: 20975295.

103 Hebebrand J. The ongoing identification of novel obesity genes. Obes Facts.2010 Jun;3(3):157-8. Epub 2010 Jun 18. PubMed PMID: 20616604.

102 Hebebrand J, Bammann K, Hinney A. Genetic determinants of obesity. Current issues]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2010 Jul;53(7):674-80. Review. German. PubMed PMID: 20631977.

101 Heid IM, Jackson AU, Randall JC, Winkler TW, Qi L, Steinthorsdottir V, Thorleifsson G, Zillikens MC, Speliotes EK, Mägi R, Workalemahu T, White CC, Bouatia-Naji N, Harris TB, Berndt SI, Ingelsson E, Willer CJ, Weedon MN, Luan J, Vedantam S, Esko T, Kilpeläinen TO, Kutalik Z, Li S, Monda KL, Dixon AL, Holmes CC, Kaplan LM, Liang L, Min JL, Moffatt MF, Molony C, Nicholson G, Schadt EE, Zondervan KT, Feitosa MF, Ferreira T, Allen HL, Weyant RJ, Wheeler E, Wood AR; MAGIC, Estrada K, Goddard ME, Lettre G, Mangino M, Nyholt DR, Purcell S, Smith AV, Visscher PM, Yang J, McCarroll SA, Nemesh J, Voight BF, Absher D, Amin N, Aspelund T, Coin L, Glazer NL, Hayward C, Heard-Costa NL, Hottenga JJ, Johansson A, Johnson T, Kaakinen M, Kapur K, Ketkar S, Knowles JW, Kraft P, Kraja AT, Lamina C, Leitzmann MF, McKnight B, Morris AP, Ong KK, Perry JR, Peters MJ, Polasek O, Prokopenko I, Rayner NW, Ripatti S, Rivadeneira F, Robertson NR, Sanna S, Sovio U, Surakka I, Teumer A, van Wingerden S, Vitart V, Zhao JH, Cavalcanti-Proença C, Chines PS, Fisher E, Kulzer JR, Lecoeur C, Narisu N, Sandholt C, Scott LJ, Silander K, Stark K, Tammesoo ML, Teslovich TM, Timpson NJ, Watanabe RM, Welch R, Chasman DI, Cooper MN, Jansson JO, Kettunen J, Lawrence RW, Pellikka N, Perola M, Vandenput L, Alavere H, Almgren P, Atwood LD, Bennett AJ, Biffar R, Bonnycastle LL, Bornstein SR, Buchanan TA, Campbell H, Day IN, Dei M, Dörr M, Elliott P, Erdos MR, Eriksson JG, Freimer NB, Fu M, Gaget S, Geus EJ, Gjesing AP, Grallert H, Grässler J, Groves CJ, Guiducci C, Hartikainen AL, Hassanali N, Havulinna AS, Herzig KH, Hicks AA, Hui J, Igl W, Jousilahti P, Jula A, Kajantie E, Kinnunen L, Kolcic I, Koskinen S, Kovacs P, Kroemer HK, Krzelj V, Kuusisto J, Kvaloy K, Laitinen J, Lantieri O, Lathrop GM, Lokki ML, Luben RN, Ludwig B, McArdle WL, McCarthy A, Morken MA, Nelis M, Neville MJ, Paré G, Parker AN, Peden JF, Pichler I, Pietiläinen KH, Platou CG, Pouta A, Ridderstråle M, Samani NJ, Saramies J, Sinisalo J, Smit JH, Strawbridge RJ, Stringham HM, Swift AJ, Teder-Laving M, Thomson B, Usala G, van Meurs JB, van Ommen GJ, Vatin V, Volpato CB, Wallaschofski H, Walters GB, Widen E, Wild SH, Willemsen G, Witte DR, Zgaga L, Zitting P, Beilby JP, James AL, Kähönen M, Lehtimäki T, Nieminen MS, Ohlsson C, Palmer LJ, Raitakari O, Ridker PM, Stumvoll M, Tönjes A, Viikari J, Balkau B, Ben-Shlomo Y, Bergman RN, Boeing H, Smith GD, Ebrahim S, Froguel P, Hansen T, Hengstenberg C, Hveem K, Isomaa B, Jørgensen T, Karpe F, Khaw KT, Laakso M, Lawlor DA, Marre M, Meitinger T, Metspalu A, Midthjell K, Pedersen O, Salomaa V, Schwarz PE, Tuomi T, Tuomilehto J, Valle TT, Wareham NJ, Arnold AM, Beckmann JS, Bergmann S, Boerwinkle E, Boomsma DI, Caulfield MJ, Collins FS, Eiriksdottir G, Gudnason V, Gyllensten U, Hamsten A, Hattersley AT, Hofman A, Hu FB, Illig T, Iribarren C, Jarvelin MR, Kao WH, Kaprio J, Launer LJ, Munroe PB, Oostra B, Penninx BW, Pramstaller PP, Psaty BM, Quertermous T, Rissanen A, Rudan I, Shuldiner AR, Soranzo N, Spector TD, Syvanen AC, Uda M, Uitterlinden A, Völzke H, Vollenweider P, Wilson JF, Witteman JC, Wright AF, Abecasis GR, Boehnke M, Borecki IB, Deloukas P, Frayling TM, Groop LC, Haritunians T, Hunter DJ, Kaplan RC, North KE, O'Connell JR, Peltonen L, Schlessinger D, Strachan DP, Hirschhorn JN, Assimes TL, Wichmann HE, Thorsteinsdottir U, van Duijn CM, Stefansson K, Cupples LA, Loos RJ, Barroso I, McCarthy MI, Fox CS, Mohlke KL, Lindgren CM. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nature Genetics. 2010 Nov;42(11):949-60. doi:10.1038/ng.685

100 Heid IM, Henneman P, Hicks A, Coassin S, Winkler T, Aulchenko YS, Fuchsberger C, Song K, Hivert MF, Waterworth DM, Timpson NJ, Richards JB, Perry JR, Tanaka T, Amin N, Kollerits B, Pichler I, Oostra BA, Thorand B, Frants RR, Illig T, Dupuis J, Glaser B, Spector T, Guralnik J, Egan JM, Florez JC, Evans DM, Soranzo N, Bandinelli S, Carlson OD, Frayling TM, Burling K, Smith GD, Mooser V, Ferrucci L, Meigs JB, Vollenweider P, Dijk KW, Pramstaller P, Kronenberg F, van Duijn CM. "Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: results of genome-wide association analyses including 4659 European individuals." Atherosclerosis. 2010 Feb;208(2):412-20. Epub 2009 Dec 2.

99 Hinney A, Vogel CI, Hebebrand J. From monogenic to polygenic obesity: recentadvances. Eur Child Adolesc Psychiatry. 2010 Mar;19(3):297-310. Epub 2010 Feb 3. PubMed PMID: 20127379; PubMed Central PMCID: PMC2839509.

98 Holzapfel C, Grallert H, Huth C, Wahl S, Fischer B, Döring A, Rückert IM, Hinney A, Hebebrand J, Wichmann HE, Hauner H, Illig T, Heid IM. "Genes and lifestyle factors in obesity: results from 12 462 subjects from MONICA/KORA." Int J Obes (Lond) 34(10), 1538-1545 (2010)

97 Holzapfel C, Siegrist M, Rank M, Langhof H, Grallert H, Baumert J, Irimie C, Klopp N, Wolfarth B, Illig T, Hauner H, Halle M. "Association of a melatonin receptor 1B (MTNR1B) gene variant with fasting glucose and HOMA-B in children and adolescents of high BMI-SDS groups." Eur J Endocrinol. 2011 Feb;164(2):205-212. Epub 2010 Nov 8.

96 Holzapfel C, Grallert H, Baumert J, Thorand B, Döring A, Wichmann HE, Hauner H, Illig T, Mielck A. "First investigation of two obesity-related loci (TMEM18, FTO) concerning their association with educational level as well as income: the MONICA/KORA study." J Epidemiol Community Health. 2011 Feb;65(2):174-6. Epub 2010 Jul 13.

95 Kempf K, Rose B, Illig T, Rathmann W, Strassburger K, Thorand B, Meisinger C, Wichmann HE, Herder C, Vollmert C. Vaspin (SERPINA12) genotypes and risk of type 2 diabetes: Results from the MONICA/KORA studies. Exp Clin Endocrinol Diabetes. 2010 Mar;118(3):184-9. Epub 2008 Aug 25.

94 Konrad K, Dempfle A, Friedel S, Heiser P, Holtkamp K, Walitza S, Sauer S,Warnke A, Remschmidt H, Gilsbach S, Schäfer H, Hinney A, Hebebrand J,Herpertz-Dahlmann B. Familiality and molecular genetics of attention networks in ADHD. Am J Med Genet B Neuropsychiatr Genet. 2010 Jan 5;153B(1):148-58.

93 Linsel-Nitschke P, Heeren J, Aherrahrou Z, Bruse P, Gieger C, Illig T,Prokisch H, Heim K, Doering A, Peters A, Meitinger T, Wichmann HE, Hinney A,Reinehr T, Roth C, Ortlepp JR, Soufi M, Sattler AM, Schaefer J, Stark K,Hengstenberg C, Schaefer A, Schreiber S, Kronenberg F, Samani NJ, Schunkert H, Erdmann J. Genetic variation at chromosome 1p13.3 affects sortilin mRNA expression, cellular LDL-uptake and serum LDL levels which translates to the risk of coronary artery disease. Atherosclerosis. 2010 Jan;208(1):183-9. Epub 2009 Jul 8. PubMed PMID: 19660754.

92 Liviu Aron, Pontus Klein, Trang T. Pham, Edgar R. Kramer,Wolfgang Wurst, Rüdiger Klein. Pro-survival role for Parkinson?s associated gene DJ-1 revealed in trophically impaired dopaminergic neurons. PLOS Biol. 2010 Apr 6;8(4):e1000349.

91 Marzi, C., Albrecht, E., Hysi, P., Lagou, V., Waldenberger, M., Tönjes, A., Prokopenko, I., Heim, K., Blackburn, H., Ried, J.S., Kleber, M.E., Mangino, M., Thorand, B., Peters, A., Grallert, H., Geistlinger, L., Wichmann, H.E., Illig, T., Gieger, C. et al. Genome-Wide Association Study Identifies Two Novel Regions at 11p15.5-p13 and 1p31 with Major Impact on Acute-Phase Serum Amyloid A. PLoS Genetics 6(11):e1001213, 1-8 (2010)

90 Meyer CW, Willershäuser M, Jastroch M, Rourke B, Fromme T, Oelkrug R, Heldmaier G, Klingenspor M. Adaptive thermogenesis and thermal conductance in wildtype and UCP1-KO mice. Am J Physiol Regul Integr Comp Physiol. 2010 Nov; 299(5):R1396-406.

89 Müller TD, Tschöp MH, Jarick I, Ehrlich S, Scherag S, Herpertz-Dahlmann B, Zipfel S, Herzog W, de Zwaan M, Burghardt R, Fleischhaker C, Klampfl K, Wewetzer C, Herpertz S, Zeeck A, Tagay S, Burgmer M, Pfluger PT, Scherag A, Hebebrand J, Hinney A. Genetic variation of the ghrelin activator gene ghrelin O-acyltransferase (GOAT) is associated with anorexia nervosa. Journal of Psychiatric Research 2010; [Epub ahead of print]

88 Müller, TD., Brönner, G., Wandolski, M., Carrie, J., Nguyen, T.T., Greene, B.H., Scherag, A., Grallert, H., Vogel, C.I.G., Scherag, S., Rief, W., Wichmann, H.E., Illig, T., Schaefer, H., Hebebrand, J., Hinney, A. Mutation screen and association studies for the fatty acid amide hydrolase (FAAH) gene and early onset and adult obesity. BMC Med Genet 11:2, 1-9 (2010)

87 Neuschl C, Hantschel C, Wagener A, Schmitt AO, Illig T, Brockmann GA. A unique genetic defect on chromosome 3 is responsible for juvenile obesity in the Berlin Fat Mouse. Int. J. Obesity. 2010; 34(12):1706-1714

86 Pechlivanis S, Scherag A, Mühleisen TW, Möhlenkamp S, Horsthemke B, Boes T, Bröcker-Preuss M, Mann K, Erbel R, Jöckel KH, Nöthen MM, Moebus S; for the Heinz Nixdorf Recall Study Group. Coronary Artery Calcification and Its Relationship to Validated Genetic Variants for Diabetes Mellitus Assessed in the Heinz Nixdorf Recall Cohort. Arterioscler Thromb Vasc Biol. 2010 Jul 8.

85 Perry JR, Weedon MN, Langenberg C, Jackson AU, Lyssenko V, Sparsø T, Thorleifsson G, Grallert H, Ferrucci L, Maggio M, Paolisso G, Walker M, Palmer CN, Payne F, Young E, Herder C, Narisu N, Morken MA, Bonnycastle LL, Owen KR, Shields B, Knight B, Bennett A, Groves CJ, Ruokonen A, Jarvelin MR, Pearson E, Pascoe L, Ferrannini E, Bornstein SR, Stringham HM, Scott LJ, Kuusisto J, Nilsson P, Neptin M, Gjesing AP, Pisinger C, Lauritzen T, Sandbaek A, Sampson M, Zeggini ME, Lindgren CM, Steinthorsdottir V, Thorsteinsdottir U, Hansen T, Schwarz P, Illig T, Laakso M, Stefansson K, Morris AD, Groop L, Pedersen O, Boehnke M, Barroso I, Wareham NJ, Hattersley AT, McCarthy MI, Frayling TM. Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes. Hum Mol Genet. 2010 Feb 1;19(3):535-44. Epub 2009 Nov 18.

84 Roth CL, Enriori PJ, Gebhardt U, Hinney A, Müller HL, Hebebrand J, Reinehr T, Cowley MA. Changes of peripheral alpha-melanocyte-stimulating hormone inchildhood obesity. Metabolism. 2010 Feb;59(2):186-94. Epub 2009 Sep 18. PubMed PMID: 19766264.

83 Rzehak P, Scherag A, Grallert H, Sausenthaler S, Koletzko S, Bauer CP, SchaafB, von Berg A, Berdel D, Borte M, Herbarth O, Krämer U, Illig T, Wichmann HE, Hebebrand J, Heinrich J; GINI and LISA Study Group. Associations between BMI and the FTO gene are age dependent: results from the GINI and LISA birth cohort studies up to age 6 years. Obes Facts. 2010 Jun;3(3):173-80. Epub 2010 May 28. PubMed PMID: 20616607.

82 Sauber J, Grothe J, Behm M, Scherag A, Grallert H, Illig T, Hinney A, Hebebrand J, Wiegand S, Grüters A, Krude H, Biebermann H. Association of variants in gastric inhibitory polypeptide receptor gene with impaired glucose homeostasis in obese children and adolescents from Berlin. Eur J Endocrinol. 2010 Aug;163(2):259-64. Epub 2010 Jun 1.

81 Sauer S, Kliem M. Mass spectrometry tools for the classification and identification of bacteria. Nature Rev Microbiol. 2010 Jan;8(1):74-82.

80 Saxena, R., Hivert, M.F., Langenberg, C., Tanaka, T., Pankow, J.S., Vollenweider, P., Lyssenko, V., Bouatia-Naji, N., Dupuis, J., Jackson, A.U., Kao, W.H.L., Li, M., Glazer, N.L., Manning, A.K., Luan, J., Stringham, H.M., Prokopenko, I., Johnson, T., Grarup, N., Boesgaard, T.W., Lecoeur, C., Grallert, H., Illig, T., Wichmann, H.E., Watanabe, R.M. for the MAGIC investigators et al. Genetic variation in GIPR influneces the glucose and insulin responses to an oral glucose challenge. Nature Genetics 42(2), 142-148 (2010)

79 Sayk F, Heutling D, Dodt C, Iwen KA, Wellhoner JP, Scherag S, Hinney A,Hebebrand J, Lehnert H. Sympathetic Function in Human Carriers of Melanocortin-4 Receptor Gene Mutations. J Clin Endocrinol Metab. 2010 Feb 10. [Epub ahead of print] PubMed PMID: 20147580.

78 Scherag A, Dina C , Hinney A, Vatin V, Scherag S, Vogel CIG, Müller TD, Grallert H, Wichmann HE, Balkau B, Heude B, Jarvelin MR, Hartikainen AL, Levy-Marchal C, Weill J, Delplanque J, Körner A, Kiess W, Kovacs P, Rayner NW, Prokopenko I, McCarthy MI, Schäfer H, Jarick I, Boeing H, Fisher E, Reinehr T, Heinrich J, Rzehak P, Berdel D, Borte M, Biebermann H, Krude H, Rosskopf D, Rimmbach C, Rief W, Fromme T, Klingenspor M, Schürmann A, Schulz N, Nöthen MM, Mühleisen TW, Erbel R, Jöckel KH, Moebus S, Boes T, Illig T, Froguel P, Hebebrand J, Meyre D.

77 Scherag S, Hebebrand J, Hinney A. Eating disorders: the current status ofmolecular genetic research. Eur Child Adolesc Psychiatry. 2010 Mar;19(3):211-26. Epub 2009 Dec 24. PubMed PMID: 20033240; PubMed Central PMCID: PMC2839487.

76 Scherag A, Hebebrand J, Wichmann HE, Jöckel KH. Evaluating Strategies for Marker Ranking in Genome-wide Association Studies of Complex Traits. Methods Inf Med. 2010 Dec 8;49(6):632-40.

75 Scherag A, Jarick I, Grothe J, Biebermann H, Scherag S, Volckmar AL, Vogel CIG, Greene B, Hebebrand J, Hinney A. Investigation of a Genome Wide Association Signal for Obesity: Synthetic Association and Haplotype Analyses at the Melanocortin 4 Receptor gene Locus. PLoS ONE 2010; 5(11):e13967

74 Schmitt AO, Aßmus J, Bortfeldt RH, Brockmann GA. CandiSNPer: a web-tool for the identification of candidate SNPs for causal variants. Bioinformatics. 2010;26(7):969-970

73 Speliotes, E.K., Willer, C.J., Berndt, S.I., Monda, K.L., Thorleifsson, G., Jackson, A.U., Lango Allen, H., Lindgren, C., Luan, J., Mägi, R., Randall, J.C., Vedantam, S., Winkler, T.W., Qi, L., Heid, I.M., Rzehak, P., Heinrich, J., Illig, T., Peters, A., Wichmann, H.E., Loos, R.J.F. et al. Association analyses of 249, 796 individuals reveal 18 new loci associated with body mass index. Nat Genet 42(11), 937-948 (2010)

72 Tan, S., Scherag, A., Janssen, O.E., Hahn, S., Lahner, H., Dietz, T., Scherag, S., Grallert, H., Ganz Vogel, C.I., Kimmig, R., Illig, T., Mann, K., Hebebrand, J., Hinney, A.Large effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variants in patients with polycystic ovary syndrome (PCOS). BMC Med Genet 11:12, 1-9 (2010)

71 Tews D, Fischer-Posovszky P, Wabitsch M. FTO - Friend or foe? Horm Metab Res. 2010 Feb;42(2):75-80.

70 Vegiopoulos A, Müller-Decker K, Strzoda D, Schmitt I, Chichelnitskiy E, Ostertag A, Berriel Diaz M, Rozman J, Hrabe de Angelis M, Nüsing RM, Meyer CW, Wahli W, Klingenspor M, Herzig S. Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes. Science. 2010 May 28;328(5982):1158-61.

69 Versini A, Ramoz N, Le Strat Y, Scherag S, Ehrlich S, Boni C, Hinney A,Hebebrand J, Romo L, Guelfi JD, Gorwood P. Estrogen receptor 1 gene (ESR1) is associated with restrictive anorexia nervosa. Neuropsychopharmacology. 2010 Jul;35(8):1818-25. Epub 2010 Apr 7. PubMed PMID: 20375995.

68 Voight BF, Scott LJ, Steinthorsdottir V, Morris AP, Dina C, Welch RP, Zeggini E, Huth C, Aulchenko YS, Thorleifsson G, McCulloch LJ, Ferreira T, Grallert H, Amin N, Wu G, Willer CJ, Raychaudhuri S, McCarroll SA, Langenberg C, Hofmann OM, Dupuis J, Qi L, Segrè AV, van Hoek M, Navarro P, Ardlie K, Balkau B, Benediktsson R, Bennett AJ, Blagieva R, Boerwinkle E, Bonnycastle LL, Bengtsson Boström K, Bravenboer B, Bumpstead S, Burtt NP, Charpentier G, Chines PS, Cornelis M, Couper DJ, Crawford G, Doney AS, Elliott KS, Elliott AL, Erdos MR, Fox CS, Franklin CS, Ganser M, Gieger C, Grarup N, Green T, Griffin S, Groves CJ, Guiducci C, Hadjadj S, Hassanali N, Herder C, Isomaa B, Jackson AU, Johnson PR, Jørgensen T, Kao WH, Klopp N, Kong A, Kraft P, Kuusisto J, Lauritzen T, Li M, Lieverse A, Lindgren CM, Lyssenko V, Marre M, Meitinger T, Midthjell K, Morken MA, Narisu N, Nilsson P, Owen KR, Payne F, Perry JR, Petersen AK, Platou C, Proença C, Prokopenko I, Rathmann W, Rayner NW, Robertson NR, Rocheleau G, Roden M, Sampson MJ, Saxena R, Shields BM, Shrader P, Sigurdsson G, Sparsø T, Strassburger K, Stringham HM, Sun Q, Swift AJ, Thorand B, Tichet J, Tuomi T, van Dam RM, van Haeften TW, van Herpt T, van Vliet-Ostaptchouk JV, Walters GB, Weedon MN, Wijmenga C, Witteman J, Bergman RN, Cauchi S, Collins FS, Gloyn AL, Gyllensten U, Hansen T, Hide WA, Hitman GA, Hofman A, Hunter DJ, Hveem K, Laakso M, Mohlke KL, Morris AD, Palmer CN, Pramstaller PP, Rudan I, Sijbrands E, Stein LD, Tuomilehto J, Uitterlinden A, Walker M, Wareham NJ, Watanabe RM, Abecasis GR, Boehm BO, Campbell H, Daly MJ, Hattersley AT, Hu FB, Meigs JB, Pankow JS, Pedersen O, Wichmann HE, Barroso I, Florez JC, Frayling TM, Groop L, Sladek R, Thorsteinsdottir U, Wilson JF, Illig T, Froguel P, van Duijn CM, Stefansson K, Altshuler D, Boehnke M, McCarthy MI; MAGIC investigators; GIANT Consortium. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet. 2010 Jul;42(7):579-89.

67 Wagener A, Goessling HF, Schmitt AO, Mauel S, Gruber AD, Reinhardt R, Brockmann GA. Genetic and diet effects on Ppar-alpha and Ppar-gamma signaling pathways in the Berlin Fat Mouse Inbred line with genetic predisposition for obesity. Lipids. Health. Dis. 2010; 9(1):99

66 Widiker S, Kärst S, Wagener A, Brockmann GA. High-fat diet feeding leads to a decreased methylation of Mc4r gene in the obese BFMI and the lean B6 mouse lines. J. Appl. Genet. 2010; 51(2): 193-197

2009

65 Baek YS, Haas S, Hackstein H, Bein G, Hernandez-Santana M, Lehrach H, Sauer S, Seitz H. BMC Immunol. 2009 Apr 2;10:18.

64 Blüher M, Bashan N, Shai I, Harman-Boehm I, Tarnovscki T, Avinaoch E, Stumvoll M, Dietrich A, Klöting N, Rudich A. Activated Ask1-MKK4-p38MAPK/JNK stress signaling pathway in human omental fat tissue may link macrophage infiltration to whole-body Insulin sensitivity. J Clin Endocrinol Metab. 2009 Jul;94(7):2507-15.
63 Blüher M. Fat Tissue and Long Life. Obes Facts. 2008;1(4):176-182.Blüher M. Adipose tissue dysfunction in obesity. Exp Clin Endocrinol Diabetes. 2009 Jun;117(6):241-50.

62 Böhme M, Grallert H, Klapper M, Gieger C, Fischer A, Heid I, Wichmann HE, Döring F, Illig T. Association between functional FABP2 promoter haplotypes and body mass index: Analyses of 8072 participants of the KORA cohort study.  Mol Nutr Food Res. 2009 Jan 20.

61 Bolze F, Klingenspor M. Mouse models for the central melanocortin system. Genes Nutr, 2009,  March 6, 2009.

60 Böttcher Y, Unbehauen H, Klöting N, Ruschke K, Körner A, Schleinitz D, Tönjes A, Enigk B, Wolf S, Dietrich K, Koriath M, Scholz GH, Tseng YH, Dietrich A, Schön MR, Kiess W, Stumvoll M, Blüher M, Kovacs P. Adipose tissue expression and genetic variants of the bone morphogenetic protein receptor 1A gene (BMPR1A) are associated with human obesity. Diabetes. 2009 Sep;58(9):2119-28.

59 Brockmann GA, Tsaih S, Neuschl C, Churchill GA, Li R. Genetic factors contributing to obesity and body weight can act through mechanisms affecting muscle weight, fat weight or both. Physiol. Genomics. 2009; 36:114-126

58 Cox A, Dumont BL, Ding Y, Bell JT, Brockmann GA, Bult C, Paigen B, Flint J, Churchill GA, Broman KW. A new standard genetic map for the laboratory mouse. Genetics. 2009; 182:1335-1344

57 Fischer J, Koch L, Emmerling C, Vierkotten J, Peters T, Brüning JC, Rüther U. Inactivation of the Fto gene protects from obesity. Nature. 2009 Apr 16;458(7240):894-8.

56 Freiwald A, Sauer S. Nature Protoc. 2009;4(5):732-42.
55 Fromme T, Hoffmann C, Nau K, Rozman J, Reichwald K, Utting M, Platzer M, Klingenspor M. An intronic single base exchange leads to a brown adipose tissue specific loss of Ucp3 expression and an altered body mass trajectory. Physiol Genomics. 2009 Jun 10;38(1):54-62. doi:10.1152/physiolgenomics.00249.2007

54 Gueorguiev M, Lecoeur C, Meyre D, Benzinou M, Mein CA, Hinney A, Vatin V,Weill J, Heude B, Hebebrand J, Grossman AB, Korbonits M, Froguel P. Associationstudies on ghrelin and ghrelin receptor gene polymorphisms with obesity. Obesity (Silver Spring). 2009 Apr;17(4):745-54. Epub 2009 Jan 22. PubMed PMID: 19165163.

53 Heid IM, Huth C, Loos RJ, Kronenberg F, Adamkova V, Anand SS, Ardlie K, Biebermann H, Bjerregaard P, Boeing H, Bouchard C, Ciullo M, Cooper JA, Corella D, Dina C, Engert JC, Fisher E, Francès F, Froguel P, Hebebrand J, Hegele RA, Hinney A, Hoehe MR, Hu FB, Hubacek JA, Humphries SE, Hunt SC, Illig T, Järvelin MR, Kaakinen M, Kollerits B, Krude H, Kumar J, Lange LA, Langer B, Li S, Luchner A, Lyon HN, Meyre D, Mohlke KL, Mooser V, Nebel A, Nguyen TT, Paulweber B, Perusse L, Qi L, Rankinen T, Rosskopf D, Schreiber S, Sengupta S, Sorice R, Suk A, Thorleifsson G, Thorsteinsdottir U, Völzke H, Vimaleswaran KS, Wareham NJ, Waterworth D, Yusuf S, Lindgren C, McCarthy MI, Lange C, Hirschhorn JN, Laird N, Wichmann HE. Meta-analysis of the INSIG2 association with obesity including 74,345 individuals: does heterogeneity of estimates relate to study design? PLoS Genet. 2009 Oct;5(10):e1000694. Epub 2009 Oct 23.

52 Helwig M, Archer ZA, Heldmaier G, Tups A, Mercer JG, Klingenspor M. Photoperiodic regulation of satiety mediating neuropeptides in the brainstem of the seasonal Siberian hamster (Phodopus sungorus). J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2009 Jul;195(7):631-42. doi 10.1007/s00359-009-0438-3

51 Helwig M, Archer ZA, Heldmaier G, Tups A, Mercer JG, Klingenspor M. Photoperiodic regulation of satiety mediating neuropeptides in the brainstem of the seasonal Siberian hamster (Phodopus sungorus). J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2009 Jul;195(7):631-42. doi 10.1007/s00359-009-0438-3

50 Herder C, Lankisch M, Ziegler D, Rathmann W, Koenig W, Illig T, Döring A, Thorand B, Holle R, Giani G, Martin S, Meisinger C. Subclinical inflammation and diabetic polyneuropathy: MONICA/KORA Survey F3 (Augsburg, Germany). Diabetes Care. 2009 Apr;32(4):680-2. Epub 2009 Jan 8.

49 Hesse D, Dunn M, Heldmaier G, Klingenspor M, Rozman J. Behavioural mechanisms affecting energy regulation in mice prone or resistant to diet- induced obesity. Physiol Behav. 2010 Mar 3;99(3):370-80. doi:10.1016/j.physbeh.2009.12.001

48 Hughes DA, Hinney A, Brumm H, Wermter AK, Biebermann H, Hebebrand J, Stoneking M. Increased constraints on MC4R during primate and human evolution. Hum Genet 124(6): 633-47, 2009

47 Khasawneh J, Schulz MD, Walch A, Rozman J, Hrabe de Angelis M, Klingenspor M, Buck A, Schwaiger M, Saur D, Schmid RM, Klöppel G, Sipos B, Greten FR, Arkan MC. Inflammation and mitochondrial fatty acid ?-oxidation link obesity to early tumor promotion. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3354-9. doi: 10.1073/pnas.0802864106

46 Klöting N, Berthold S, Kovacs P, Schön MR, Fasshauer M, Ruschke K, Stumvoll M, Blüher M. MicroRNA expression in human omental and subcutaneous adipose tissue. PLoS One. 2009;4(3):e4699.

45 Kolz M, Johnson T, Sanna S, Teumer A, Vitart V, Perola M, Mangino M, Albrecht E, Wallace C, Farrall M, Johansson A, Nyholt DR, Aulchenko Y, Beckmann JS, Bergmann S, Bochud M, Brown M, Campbell H; EUROSPAN Consortium, Connell J, Dominiczak A, Homuth G, Lamina C, McCarthy MI; ENGAGE Consortium, Meitinger T, Mooser V, Munroe P, Nauck M, Peden J, Prokisch H, Salo P, Salomaa V, Samani NJ, Schlessinger D, Uda M, Völker U, Waeber G, Waterworth D, Wang-Sattler R, Wright AF, Adamski J, Whitfield JB, Gyllensten U, Wilson JF, Rudan I, Pramstaller P, Watkins H; PROCARDIS Consortium, Doering A, Wichmann HE; KORA Study, Spector TD, Peltonen L, Völzke H, Nagaraja R, Vollenweider P, Caulfield M; WTCCC, Illig T, Gieger C. Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. PLoS Genet. 2009 Jun;5(6):e1000504. Epub 2009 Jun 5.

44 Kong A, Steinthorsdottir V, Masson G, Thorleifsson G, Sulem P, Besenbacher S, Jonasdottir A, Sigurdsson A, Kristinsson KT, Jonasdottir A, Frigge ML, Gylfason A, Olason PI, Gudjonsson SA, Sverrisson S, Stacey SN, Sigurgeirsson B, Benediktsdottir KR, Sigurdsson H, Jonsson T, Benediktsson R, Olafsson JH, Johannsson OT, Hreidarsson AB, Sigurdsson G; DIAGRAM Consortium, Ferguson-Smith AC, Gudbjartsson DF, Thorsteinsdottir U, Stefansson K. Parental origin of sequence variants associated with complex diseases. Nature. 2009 Dec 17;462(7275):868-74.

43 Laumen H, Saningong AD, Heid IM, Hess J, Herder C, Claussnitzer M, Baumert J, Lamina C, Rathmann W, Sedlmeier EM, Klopp N, Thorand B, Wichmann HE, Illig T, Hauner H. Functional characterization of promoter variants of the adiponectin gene complemented by epidemiological data. Diabetes. 2009 Apr;58(4):984-91. Epub 2008 Dec 15.

42 Lindgren CM, Heid IM, Randall JC, Lamina C, Steinthorsdottir V, Qi L, Speliotes EK, Thorleifsson G, Willer CJ, Herrera BM, Jackson AU, Lim N, Scheet P, Soranzo N, Amin N, Aulchenko YS, Chambers JC, Drong A, Luan J, Lyon HN, Rivadeneira F, Sanna S, Timpson NJ, Zillikens MC, Zhao JH, Almgren P, Bandinelli S, Bennett AJ, Bergman RN, Bonnycastle LL, Bumpstead SJ, Chanock SJ, Cherkas L, Chines P, Coin L, Cooper C, Crawford G, Doering A, Dominiczak A, Doney AS, Ebrahim S, Elliott P, Erdos MR, Estrada K, Ferrucci L, Fischer G, Forouhi NG, Gieger C, Grallert H, Groves CJ, Grundy S, Guiducci C, Hadley D, Hamsten A, Havulinna AS, Hofman A, Holle R, Holloway JW, Illig T, Isomaa B, Jacobs LC, Jameson K, Jousilahti P, Karpe F, Kuusisto J, Laitinen J, Lathrop GM, Lawlor DA, Mangino M, McArdle WL, Meitinger T, Morken MA, Morris AP, Munroe P, Narisu N, Nordström A, Nordström P, Oostra BA, Palmer CN, Payne F, Peden JF, Prokopenko I, Renström F, Ruokonen A, Salomaa V, Sandhu MS, Scott LJ, Scuteri A, Silander K, Song K, Yuan X, Stringham HM, Swift AJ, Tuomi T, Uda M, Vollenweider P, Waeber G, Wallace C, Walters GB, Weedon MN; Wellcome Trust Case Control Consortium, Witteman JC, Zhang C, Zhang W, Caulfield MJ, Collins FS, Davey Smith G, Day IN, Franks PW, Hattersley AT, Hu FB, Jarvelin MR, Kong A, Kooner JS, Laakso M, Lakatta E, Mooser V, Morris AD, Peltonen L, Samani NJ, Spector TD, Strachan DP, Tanaka T, Tuomilehto J, Uitterlinden AG, van Duijn CM, Wareham NJ, Hugh Watkins; Procardis Consortia, Waterworth DM, Boehnke M, Deloukas P, Groop L, Hunter DJ, Thorsteinsdottir U, Schlessinger D, Wichmann HE, Frayling TM, Abecasis GR, Hirschhorn JN, Loos RJ, Stefansson K, Mohlke KL, Barroso I, McCarthy MI; Giant Consortium. Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet. 2009 Jun;5(6):e1000508. Epub 2009 Jun 26. Erratum in: PLoS Genet. 2009 Jul;5(7). doi: 10.1371/annotation/b6e8f9f6-2496-4a40-b0e3-e1d1390c1928.

41 Meyer CW, Wagener A, Rink N, Hantschel C, Heldmaier G, Klingenspor M, Brockmann BA. High energy digestion efficiency and altered lipid metabolism contribute to obesity in BFMI mice. Obesity (2009) 17 11, 1988–1993. doi:10.1038/oby.2009.124

40 Perry JR, Weedon MN, Langenberg C, Jackson AU, Lyssenko V, Sparsø T, Thorleifsson G, Grallert H, Ferrucci L, Maggio M, Paolisso G, Walker M, Palmer CN, Payne F, Young E, Herder C, Narisu N, Morken MA, Bonnycastle LL, Owen KR, Shields B, Knight B, Bennett A, Groves CJ, Ruokonen A, Jarvelin MR, Pearson E, Pascoe L, Ferrannini E, Bornstein SR, Stringham HM, Scott LJ, Kuusisto J, Nilsson P, Neptin M, Gjesing AP, Pisinger C, Lauritzen T, Sandbaek A, Sampson M, Zeggini ME, Lindgren CM, Steinthorsdottir V, Thorsteinsdottir U, Hansen T, Schwarz P, Illig T, Laakso M, Stefansson K, Morris AD, Groop L, Pedersen O, Boehnke M, Barroso I, Wareham NJ, Hattersley AT, McCarthy MI, Frayling TM. Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes. Hum Mol Genet. 2010 Feb 1;19(3):535-44. Epub 2009 Nov 18.

39 Prokopenko I, Langenberg C, Florez JC, Saxena R, Soranzo N, Thorleifsson G, Loos RJ, Manning AK, Jackson AU, Aulchenko Y, Potter SC, Erdos MR, Sanna S, Hottenga JJ, Wheeler E, Kaakinen M, Lyssenko V, Chen WM, Ahmadi K, Beckmann JS, Bergman RN, Bochud M, Bonnycastle LL, Buchanan TA, Cao A, Cervino A, Coin L, Collins FS, Crisponi L, de Geus EJ, Dehghan A, Deloukas P, Doney AS, Elliott P, Freimer N, Gateva V, Herder C, Hofman A, Hughes TE, Hunt S, Illig T, Inouye M, Isomaa B, Johnson T, Kong A, Krestyaninova M, Kuusisto J, Laakso M, Lim N, Lindblad U, Lindgren CM, McCann OT, Mohlke KL, Morris AD, Naitza S, Orrù M, Palmer CN, Pouta A, Randall J, Rathmann W, Saramies J, Scheet P, Scott LJ, Scuteri A, Sharp S, Sijbrands E, Smit JH, Song K, Steinthorsdottir V, Stringham HM, Tuomi T, Tuomilehto J, Uitterlinden AG, Voight BF, Waterworth D, Wichmann HE, Willemsen G, Witteman JC, Yuan X, Zhao JH, Zeggini E, Schlessinger D, Sandhu M, Boomsma DI, Uda M, Spector TD, Penninx BW, Altshuler D, Vollenweider P, Jarvelin MR, Lakatta E, Waeber G, Fox CS, Peltonen L, Groop LC, Mooser V, Cupples LA, Thorsteinsdottir U, Boehnke M, Barroso I, Van Duijn C, Dupuis J, Watanabe RM, Stefansson K, McCarthy MI, Wareham NJ, Meigs JB, Abecasis GR. Variants in MTNR1B influence fasting glucose levels. Nat Genet. 2009 Jan;41(1):77-81. Epub 2008 Dec 7.

38 Rediger A, Tarnow P, Bickenbach A, Schaefer M, Krude H, Gruters A, Biebermann H. Heterodimerization of Hypothalamic G-Protein-Coupled Receptors Involved in Weight Regulation. Obes Facts 2(2): 80-86, 2009.

37 Reinehr T, Hebebrand J, Friedel S, Toschke AM, Brumm H, Biebermann H, Hinney A. Lifestyle intervention in obese children with variations in the melanocortin 4 receptor gene. Obesity (Silver Spring). 17(2): 382-9, 2009

36 Reinehr T, Hinney A, Toschke AM, Hebebrand J. Aggravating effect of INSIG2 andFTO on overweight reduction in a one-year lifestyle intervention. Arch Dis Child.2009 Dec;94(12):965-7. Epub 2009 Feb 17. PubMed PMID: 19224890.

35 Ruschke K, Ebelt H, Klöting N, Boettger T, Raum K, Blüher M, Braun T.Defective peripheral nerve development is linked to abnormal architecture and metabolic activity of adipose tissue in Nscl-2 mutant mice. PLoS One. 2009;4(5):e5516.

34 Salanti G, Southam L, Altshuler D, Ardlie K, Barroso I, Boehnke M, Cornelis MC, Frayling TM, Grallert H, Grarup N, Groop L, Hansen T, Hattersley AT, Hu FB, Hveem K, Illig T, Kuusisto J, Laakso M, Langenberg C, Lyssenko V, McCarthy MI, Morris A, Morris AD, Palmer CN, Payne F, Platou CG, Scott LJ, Voight BF, Wareham NJ, Zeggini E, Ioannidis JP. Underlying genetic models of inheritance in established type 2 diabetes associations. Am J Epidemiol. 2009 Sep 1;170(5):537-45. Epub 2009 Jul 14.

33 Scherag A, Hebebrand J, Schäfer H, Müller HH. Flexible designs for genomewide association studies. Biometrics. 2009; 65:815-21.

32 Scherneck S, Nestler M, Vogel H, Blüher M, Block MD, Mauricio MB, Herzig S, Schulz N, Teichert M, Tischer M, Al-Hasani H, Kluge R, Schürmann A, and Joost HG. Positional cloning of zinc finger domain transcription factor Zfp69, a candidate gene for obesity-associated diabetes contributed by mouse locus Nidd/SJL. PLoS Genetics  5:e1000541 (2009).

31 Schimmelmann BG, Friedel S, Nguyen TT, Sauer S, Ganz Vogel CI, Konrad K, Wilhelm C, Sinzig J, Renner TJ, Romanos M, Palmason H, Dempfle A, Walitza S, Freitag C, Meyer J, Linder M, Schäfer H, Warnke A, Lesch KP, Herpertz-Dahlman B, Hinney A, Hebebrand J. J Psychiatr Res. 2009 Jul;43(10):941-5. Epub 2009 Feb 14.

30 Schleinitz D, Klöting N, Körner A, Berndt J, Reichenbächer M, Tönjes A, Ruschke K, Böttcher Y, Dietrich K, Enigk B, Filz M, Schön MR, Jenkner J, Kiess W, Stumvoll M, Blüher M, Kovacs P. Effect of Genetic Variation in the Human Fatty Acid Synthase Gene (FASN) on Obesity and Fat Depot-Specific mRNA Expression. Obesity (Silver Spring). 2009 Oct 29.

29 Schmitt AO, Bortfeld R, Neuschl C, Brockmann GA. RandoMate - a program for the generation of random mating schemes for small laboratory animals.  Mamm. Genome 2009; 20(5):321-325

28 Schmitt AO, Schuchhardt J, Brockmann GA. The action of key factors in protein evolution at high temporal resolution. PLoS ONE. 2009; 4(3):e4821. doi:10.1371/journal.pone.0004821

27 Stritzke J, Linsel-Nitschke P, Markus MR, Mayer B, Lieb W, Luchner A, Döring A, Koenig W, Keil U, Hense HW, Schunkert H; MONICA/KORA Investigators. Association between degenerative aortic valve disease and long-term exposure to cardiovascular risk factors: results of the longitudinal population-based KORA/MONICA survey. Eur Heart J. 2009 Aug;30(16):2044-53. Epub 2009 Jul 16.

26 Vogel CI, Greene B, Scherag A, Muller TD, Friedel S, Grallert H, Heid IM, Illig T, Wichmann HE, Schafer H, Hebebrand J, Hinney A. Non-replication of an association of CTNNBL1 polymorphisms and obesity in a population of Central European ancestry. BMC Med Genet. 2009 Feb 19;10(1):14.

25 Vogel CI, Scherag A, Brönner G, Nguyen TT, Wang HJ, Grallert H, Bornhorst A,Rosskopf D, Völzke H, Reinehr T, Rief W, Illig T, Wichmann HE, Schäfer H,Hebebrand J, Hinney A. Gastric inhibitory polypeptide receptor: associationanalyses for obesity of several polymorphisms in large study groups. BMC MedGenet. 2009 Mar 2;10:19. PubMed PMID: 19254363; PubMed Central PMCID: PMC2654891.

24 Vogel H, Nestler M, Rüschendorf F, Block MD, Tischer S, Kluge R, Schurmann A, Joost HG, Scherneck S. Characterisation of Nob3, a major quantitative trait locus for obesity and hyperglycaemia on mouse Chromosome 1. Physiol Genomics. 38:226-232 (2009)

23 Wermter AK, Scherag A, Hölter K, Reichwald K, Lichtner P, Siegfried W, Blundell J, Lawton C, Whybrow S, Stubbs J, Arch JR, Meitinger T, Platzer M, Hinney A, Hebebrand J. Procolipase gene: no association with early-onset obesity or fat intake. Obes Facts. 2009 ;2:40-4.

22 Willer CJ, ..., Heid IM,... Wichman HE,... Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet. 2009 Jan;41(1):25-34. Epub 2008 Dec 14.

21 Winkler C, Illig T, Koczwara K, Bonifacio E, Ziegler AG. HHEX-IDE polymorphism is associated with low birth weight in offspring with a family history of type 1 diabetes. J Clin Endocrinol Metab. 2009 Oct;94(10):4113-5. Epub 2009 Jul 21.

20 Youn BS, Bang SI, Klöting N, Park JW, Lee N, Oh JE, Pi KB, Lee TH, Ruschke K, Fasshauer M, Stumvoll M, Blüher M.Serum progranulin concentrations may be associated with macrophage infiltration into omental adipose tissue. Diabetes. 2009 Mar;58(3):627-36

2008

19 Böhme M, Grallert H, Fischer A, Gieger C, Nitz I, Heid I, Kohl C, Wichmann HE, Illig T, Döring F; KORA Study Cohort, MTTP variants and body mass index, waist circumference and serum cholesterol level: Association analyses in 7582 participants of the KORA study cohort. Mol Genet Metab. 2008 Dec;95(4):229-32.

18 Bouatia-Naji N, De Graeve F, Brönner G, Lecoeur C, Vatin V, Durand E, LichtnerP, Nguyen TT, Heude B, Weill J, Lévy-Marchal C, Hebebrand J, Froguel P, Meyre D. INS VNTR is not associated with childhood obesity in 1,023 families: afamily-based study. Obesity (Silver Spring). 2008 Jun;16(6):1471-5. Epub 2008 Apr3. PubMed PMID: 18388898.

17 Fischer A, Grallert H, Böhme M, Gieger C, Boomgaarden I, Heid IM, Wichmann HE, Döring F, Illig I. Association analysis between the PTGES2 R298H polymorphism and body mass index in 8079 participants of the KORA study cohort. Genetic Testing 2008

16 Fischer J, Emmerling C, Ruther U. On the history of Fto. Obes Facts. 2008;1(1):43-4.

15 Herder C, Rathmann W, Strassburger K, Finner H, Grallert H, Huth C, Meisinger C, Gieger C, Martin S, Giani G, Scherbaum WA, Wichmann HE, Illig T. Variants of the PPARG, IGF2BP2, CDKAL1, HHEX, and TCF7L2 genes confer risk of type 2 diabetes independently of BMI in the German KORA studies. Horm Metab Res. 2008 Oct;40(10):722-6. Epub 2008 Jul 2.

14 Holtkamp K, Bühren K, Ponath G, von Eiff C, Herpertz-Dahlmann B, Hebebrand J, Rothermundt M. Serum levels of S100B are decreased in chronic starvation andnormalize with weight gain. J Neural Transm. 2008 Jun;115(6):937-40. Epub 2008Apr 2. PubMed PMID: 18385926.

13 Klein KM, Theisen F, Knake S, Oertel WH, Hebebrand J, Rosenow F, Hamer HM.Topiramate, nutrition and weight change: a prospective study. J Neurol Neurosurg Psychiatry. 2008 May;79(5):590-3. Epub 2007 Dec 12. PubMed PMID: 18077476.

12 Klöting N, Schleinitz D, Ruschke K, Berndt J, Fasshauer M, Tönjes A, Schön MR, Kovacs P, Stumvoll M, Blüher M. Inverse relationship between obesity and FTO gene expression in visceral adipose tissue in humans. Diabetologia. 2008 Apr;51(4):641-7.

11 Kovacs P, Berndt J, Ruschke K, Klöting N, Schön MR, Körner A, Stumvoll M, Blüher M.TCF7L2 gene expression in human visceral and subcutaneous adipose tissue is differentially regulated but not associated with type 2 diabetes mellitus. Metabolism. 2008 Sep;57(9):1227-31.

10 Linsel-Nitschke P, Götz A, Erdmann J, Braenne I, Braund P, Hengstenberg C,Stark K, Fischer M, Schreiber S, El Mokhtari NE, Schaefer A, Schrezenmeir J,Rubin D, Hinney A, Reinehr T, Roth C, Ortlepp J, Hanrath P, Hall AS, Mangino M,Lieb W, Lamina C, Heid IM, Doering A, Gieger C, Peters A, Meitinger T, WichmannHE, König IR, Ziegler A, Kronenberg F, Samani NJ, Schunkert H; Wellcome TrustCase Control Consortium (WTCCC); Cardiogenics Consortium. Lifelong reduction ofLDL-cholesterol related to a common variant in the LDL-receptor gene decreasesthe risk of coronary artery disease--a Mendelian Randomisation study. PLoS One.2008 Aug 0;3(8):e2986. Erratum in: PLoS ONE. 2008;3(9). doi:10.1371/annotation/9f64c41a-8cf6-40f2-8988-0d48b04dd8cb. Schrezenmeier, Jürgen[corrected to Schrezenmeir, Jürgen]. PubMed PMID: 18714375; PubMed Central PMCID:PMC2500189.

9 Loos RJ, Lindgren CM, Li S, Wheeler E, Zhao JH, Prokopenko I, Inouye M, Freathy RM, Attwood AP, Beckmann JS, Berndt SI; Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, Jacobs KB, Chanock SJ, Hayes RB, Bergmann S, Bennett AJ, Bingham SA, Bochud M, Brown M, Cauchi S, Connell JM, Cooper C, Smith GD, Day I, Dina C, De S, Dermitzakis ET, Doney AS, Elliott KS, Elliott P, Evans DM, Sadaf Farooqi I, Froguel P, Ghori J, Groves CJ, Gwilliam R, Hadley D, Hall AS, Hattersley AT, Hebebrand J, Heid IM; KORA, Lamina C, Gieger C, Illig T, Meitinger T, Wichmann HE, Herrera B, Hinney A, Hunt SE, Jarvelin MR, Johnson T, Jolley JD, Karpe F, Keniry A, Khaw KT, Luben RN, Mangino M, Marchini J, McArdle WL, McGinnis R, Meyre D, Munroe PB, Morris AD, Ness AR, Neville MJ, Nica AC, Ong KK, O'Rahilly S, Owen KR, Palmer CN, Papadakis K, Potter S, Pouta A, Qi L; Nurses' Health Study, Randall JC, Rayner NW, Ring SM, Sandhu MS, Scherag A, Sims MA, Song K, Soranzo N, Speliotes EK; Diabetes Genetics Initiative, Syddall HE, Teichmann SA, Timpson NJ, Tobias JH, Uda M; SardiNIA Study, Vogel CI, Wallace C, Waterworth DM, Weedon MN; Wellcome Trust Case Control Consortium, Willer CJ; FUSION, Wraight, Yuan X, Zeggini E, Hirschhorn JN, Strachan DP, Ouwehand WH, Caulfield MJ, Samani NJ, Frayling TM, Vollenweider P, Waeber G, Mooser V, Deloukas P, McCarthy MI, Wareham NJ, Barroso I, Jacobs KB, Chanock SJ, Hayes RB, Lamina C, Gieger C, Illig T, Meitinger T, Wichmann HE, Kraft P, Hankinson SE, Hunter DJ, Hu FB, Lyon HN, Voight BF, Ridderstrale M, Groop L, Scheet P, Sanna S, Abecasis GR, Albai G, Nagaraja R, Schlessinger D, Jackson AU, Tuomilehto J, Collins FS, Boehnke M, Mohlke KL. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet. 2008; 40:768-75.

8 Mercader JM, Saus E, Agüera Z, Bayés M, Boni C, Carreras A, Cellini E, de Cid R, Dierssen M, Escaramís G, Fernández-Aranda F, Forcano L, Gallego X, GonzálezJR, Gorwood P, Hebebrand J, Hinney A, Nacmias B, Puig A, Ribasés M, Ricca V, RomoL, Sorbi S, Versini A, Gratacòs M, Estivill X. Association of NTRK3 and itsinteraction with NGF suggest an altered cross-regulation of the neurotrophinsignaling pathway in eating disorders. Hum Mol Genet. 2008 May 1;17(9):1234-44.Epub 2008 Jan 18. PubMed PMID: 18203754.

7 Müller T., A. Hinney, C. Roth, J. Hebebrand,  F. Schreiner, A. Scherag, T. Nugyen, T. Reinehr: Fat mass and obesity associated' gene (FTO): no significant association of variant rs9939609 with weight loss in a lifestyle intervention and lipid metabolism markers in German obese children and adolescents. BMC Medical Genetics 2008, 9:85

6 Müller TD, Reichwald K, Brönner G, Kirschner J, Nguyen TT, Scherag A, Herzog W, Herpertz-Dahlmann B, Lichtner P, Meitinger T, Platzer M, Schäfer H, Hebebrand J, Hinney A. Lack of association of genetic variants in genes of the endocannabinoid system with anorexia nervosa. Child Adolesc Psychiatry Ment Health. 2008; 2:33.

5 Reinehr T, Friedel S, Mueller TD, Toschke AM, Hebebrand J, Hinney A. Evidence for an influence of TCF7L2 polymorphism rs7903146 on insulin resistance andsensitivity indices in overweight children and adolescents during a lifestyleintervention. Int J Obes (Lond). 2008 Oct;32(10):1521-4. Epub 2008 Sep 2. PubMed PMID: 18762805.

4 Reinehr T, Hinney A., TT. Nguyen, J. Hebebrand: Evidence for an influence of a polymorphism near the INSIG2 on weight loss during a lifestyle intervention in obese children and adolescents. Diabetes 2008;57 623-626

3 Roth CL, Hinney A, Reinehr T, Schreiner F, Nguyen TT, Müller T, Scholl C, Woelfle J, Karpushova A, Schäfer H, Nöthen MM, Hebebrand J. TCF7L2 polymorphism rs7903146 and predisposition for type 2 diabetes mellitus in obese children. Horm Metab Res. 2008 Oct;40(10):713-7. Epub 2008 Jun 10.

2 Walitza S, Scherag A, Renner TJ, Hinney A, Remschmidt H, Herpertz-Dahlmann B, Schulz E, Schäfer H, Lange KW, Wewetzer C, Gerlach M. Transmission disequilibrium studies in early onset of obsessive-compulsive disorder for polymorphisms in genes of the dopaminergic system. J Neural Transm. 2008; 115:1071-8.

1 Wermter AK, Scherag A, Meyre D, Reichwald K, Durand E, Nguyen TT, Koberwitz K, Lichtner P, Meitinger T, Schäfer H, Hinney A, Froguel P, Hebebrand J, Brönner G. Preferential reciprocal transfer of paternal/maternal DLK1 alleles to obese children: first evidence of polar overdominance in humans. Eur J Hum Genet. 2008; 16:1126-34.