Publikationen

2013

15 Grimm C., L. Chavez, M. Vilardell, A.L. Farrall, S. Tierling, J.W. Boehm, P. Grote, M. Lienhard, J. Dietrich, B. Timmermann, J. Walter, M.R. Schweiger, H. Lehrach, R. Herwig, B.G. Herrmann and M. Morkel. DNA-Methylome Analysis of Mouse Intestinal Adenoma Identifies a Tumour-Specific Signature That Is Partly Conserved in Human Colon Cancer. PLoS Genet. 2013 9(2):e1003250. doi:10.1371/journal.pgen.1003250.                          

14 Kamburov A, Stelzl U, Lehrach H, Herwig R.  The ConsensusPathDB interaction database: 2013 update.  Nucleic Acids Research.2013; 41(Database issue):D793-800.

13 Gries J.,  D. Schumacher, J. Arand, P. Lutsik, M. Rivera-Markelova, I. Fichtner, J. Walter, C. Sers and S. Tierling. Bi-PROF: Bisulfite profiling of target regions using 454 GS FLX Titanium technology. Epigenetics. 2013 Jun 10;8(7). [Epub ahead of print]

2012

12 Börno ST, Fischer A, Kerick M, Fälth M, Laible M, Brase JC, Kuner R, Dahl A, Grimm C, Sayanjali B, Isau M, Röhr C, Wunderlich A, Timmermann B, Claus R, Plass C, Graefen M, Simon R, Demichelis F, Rubin MA, Sauter G, Schlomm T, Sültmann H, Lehrach H, Schweiger MR. Increase in genome-wide differential DNA methylation in TMPRSS2:ERG fusion negative prostate cancers with miRNA-26a hypermethylation. Cancer Discov. 2012 Nov;2(11):1024-35. doi: 10.1158/2159-8290.CD-12-0041. Epub 2012 Aug 28.

11 Dreher F, Kreitler T, Hardt C, Kamburov A, Yildirimman R, Schellander K, Lehrach H, Lange BMH, Herwig R.  DIPSBC - Data Integration Platform for Systems Biology Collaborations.  BMC Bioinformatics. 2012 May 8;13:85. doi: 10.1186/1471-2105-13-85.

10 Farrall AL, Riemer P, Leushacke M, Sreekumar A, Grimm C, Herrmann BG, Morkel M.  Wnt and BMP signals control intestinal adenoma cell fates.  Int J Cancer. 2012 Feb 18. doi: 10.1002/ijc.27500.

9 Haupt A, Joberty G, Bantscheff M, Frohlich H, Stehr H, Schweiger MR, Fischer A, Kerick M, Boerno ST, Dahl A, Lappe M, Lehrach H, Gonzalez C, Drewes G, Lange BM. Hsp90 inhibition differentially destabilises MAP kinase and TGF-beta signalling components in cancer cells revealed by kinase-targeted chemoproteomics. BMC Cancer. 2012 Jan 25;12:38. doi: 10.1186/1471-2407-12-38.

2011

8 Hallen L., Klein H., Stoschek C., Wehrmeyer S., Nonhoff U., Ralser M., Wilde J., Röhr C., Schweiger M.R., Zatloukal K., Vingron M., Lehrach H., Konthur Z. and S. Krobitsch. The KRAB-containing zinc-finger transcriptional regulator ZBRK1 activates SCA2 gene transcription through direct interaction with its gene product, ataxin-2. Hum Mol Genet. 2011 Jan 1;20(1):104-14.

7 Kerick M, Isau M, Timmermann B, Sültmann H, Herwig R, Krobitsch S, Schaefer G, Verdorfer I, Bartsch G, Klocker H, Lehrach H, Schweiger MR. Targeted high throughput sequencing in clinical cancer settings: formaldehyde fixed-paraffin embedded (FFPE) tumor tissues, input amount and tumor heterogeneity. BMC Med Genomics. 2011 Sep 29;4:68.

6 Lutsik P, Feuerbach L, Arand J, Lengauer T, Walter J, Bock C. BiQ Analyzer HT: locus-specific analysis of DNA methylation by high-throughput bisulfite sequencing. Nucleic Acids Res. 2011, Epub May 11.

5 Schweiger M.R., Kerick M., Timmermann B. and M.Isau T. The power of NGS technologies to delineate the genome organization in cancer: From mutations to structural variations and epigenetic alterations. Cancer Metastasis Rev. 2011 Jan 27.

2010

4 Boerno S.T., Grimm C., Lehrach H. and Michal-Ruth Schweiger. Next Generation Sequencing Technologies for DNA Methylation Analyses in Cancer Genomics. Epigenomics 2010 April; 2(2): 199-209,

3 Chavez L, Jozefczuk J, Grimm C, Dietrich J, Timmerman T, Lehrach H, Herwig R and James Adjaye. Computational analysis of genome-wide DNA-methylation during the differentiation of human embryonic stem cells along the endodermal lineage. Genome Res., 2010 Oct; 20(10): 1441-50.

2 Timmermann B., Kerick M., Röhr C., Fischer A., Isau M., Boerno S., Wunderlich A., Barmeyer C., Seemann P., Koenig J., Lappe M., Kuss A.W., Garshasbi M., Bertram L., Trappe K., Werber M., Herrmann B.G., Zatloukal K., Lehrach H. and Michal R. Schweiger. Somatic mutation profiles of MSI and MSS colorectal cancer identified by whole exome next generation sequencing and bioinformatics analysis PLoS One 2010 Dec 22;5(12):e15661.

2009

1 Chavez L, Bais AS, Vingron M, Lehrach H, Adjaye J, Herwig R. In silicoidentification of a core regulatory network of OCT4 in human embryonic stem cells using an integrated approach. BMC Genomics. 2009 Jul 15; 10: 314.