Translationsforschung in Gesundheitswesen und Public Health

Leitung:    Prof. Dr. Angela Brand                                                                           PD Dr. Bodo Lange
Institut: Maastricht University,                                                                     Max-Planck-Institut für Molekulare Genetik

Brain Tumor Network Prof. Peter Lichter Deutsches Krebsforschungszentrum Heidelberg
Cellular Systems Genomics in Health and Disease PD Dr. Stefan Wiemann Deutsches Krebsforschungszentrum Heidelberg
Deciphering Oncogene Dependencies Dr. Roman Thomas MPI für neurologische Forschung Köln
Epilepsy and Migraine Integrated Network (EMINet) Prof. Christian Kubisch Universität Köln
From Disease Genes to Protein Pathways (DiGTOP) Prof. Wolfgang Wurst Helmholtz Zentrum München
Functional and Translational Genomics of Acute Leukemias Prof. Christian Hagemeier Charité Berlin
Functional Genomics of Parkinson Prof. Thomas Gasser Universität Tübingen
Gene Identification and Functional Analyses in Alzheimer´s Disease PD Dr. Matthias Riemenschneider Technische Universität München
Genetics of Alcohol Addiction Prof. Rainer Spanagel Zentralinstitut für Seelische Erkrankungen
Genetics of Heart Failure Prof. Hugo Katus Universität Heidelberg
Genome Research Network in Pancreatic Cancer Prof. Thomas M. Gress Universität Marburg
Genomics of Atherosclerosis Prof. Heribert Schunkert Universität Lübeck
German Mental Retardation Network (MRNET) Prof. André Reis Universität Erlangen
German Mouse Clinic - Deciphering Prof. Martin Hrabé de Angelis Helmholtz Zentrum München
Integrated Genome Network of Prostate Cancer PD Dr. Holger Sültmann Deutsches Krebsforschungszentrum Heidelberg
Integrated Genomic Investigation of Colorectal Carcinoma Prof. Kari Hemminki Deutsches Krebsforschungszentrum Heidelberg
MHC Haplotype Sequencing: An Intergrated Approach to Common Disease Dr. Margret Hoehe MPI für molekulare Genetik Berlin

List of Innovation Alliances in NGFN-Transfer

Integrated Genome Research Network



Anti-malarial Agents Dr. Birte Sönnichsen Cenix Bioscience Dresden
Breast Cancer Kit Prof. Jan G. Hengstler Leibniz Institut für Arbeitsphysiologie an der Universität Dortmund
Heart Failure Therapy Prof. Markus Hecker Universität Heidelberg
Metabolomic signatures of heart failure Prof. Hugo Katus Universität Heidelberg
New Tools for the Prevention of Cardiovascular Diseases and Disorders in Chronic Kidney Disease PD Dr. Joachim Jankowski Charité Berlin
Protein analysis of formalin-fixed tumor (FFPE) samples PD Dr. Karl-Friedrich Becker Technische Universität München
Subgenome Fractionation for High Throughput Sequencing Dr. Bernhard Korn Deutsches Krebsforschungszentrum Heidelberg
Whole genome and transcriptome amplification in large biobanks Prof. H.-Erich Wichmann;
Dr. Christian Korfhage
Helmholtz Zentrum München;
Qiagen GmbH Hilden

The output of the NGFN from 2001 until 2008

includes over 80 patent applications, 2,400 scientific publications, and cooperation in 60 EU projects. The gain in insight into cause and process of disease development through the identification of molecular target structures has lead to a direct transfer of the results into development and optimization of diagnostics and therapeutics. A portfolio of results is ready for in-licensing or collaboration partnerships for further development. The scientists succeeded in discovering genetic variations with implications for Alzheimer's disease, epilepsy, Depression, Parkinson´s disease, cancer, susceptibility to allergies, adipositas, coronary heart disease, heart failure and enteritis. They developed DNA chips and identified gene signatures for neuroblastoma, Parkinson's disease, prostate cancer and heart failure that constitute a substantial advance in prognosis and diagnosis. They developed tools against autoimmune diseases, established systematic proof-of-principle approaches such as animal models and cell-based assays, used active semiconductor chips to develop highly complex peptide arrays and optimized micro-endoscopes for brain analysis. In one of the world's largest projects for the analysis of disease-causing genetic variations, the genetic information of up to 25,000 patients and controls is being examined with the help of DNA chips.

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