Genome snippets against breast cancer – New approach revealing complex interplay

Via a newly developed strategy, scientists of the National Genome Research Network (NGFN-Plus) have revealed the role of regulatory microRNAs (miRNAs) for a signaling pathway with a pivotal role in breast cancer proliferation and pathogenesis. PD Dr Stefan Wiemann and Dr Özgür Sahin and their team at the German Cancer Research Center discovered three miRNAs inhibiting this signaling pathway and thus slowing down the growth of tumor cells. The especially developed approach combines high throughput proteomic readout with computer based data analyses and allows examination on network level instead of just looking at single components separately.

Publikation:
Uhlmann et al.: Global microRNA level regulation of EGFR-driven cell cycle protein network in breast cancer. 
Molecular Systems Biology, February 14th 2012