• NGFN: A PORTRAIT
• NGFN-PLUS
• NGFN-TRANSFER
• INTERNATIONAL PROJECTS
• • 1000 Genomes Project
  • Genomics and Physiopathology of Cardiovascular and Metabolic Diseases
  • International Cancer Genome Consortium
• GENOME RESEARCH

AREAS OF DISEASE

• Cardiovascular disease
• Cancer
• Neuronal diseases
• Infections and Inflammations
• Environmental factors

These pages will not be updated anymore since 2014.

Cardiovascular diseases as well as the metabolic diseases diabetes and obesity are complex multifactorial diseases of high socioeconomic importance. Scientific progress in recent years has made it clear that genomics and related sciences have substantial impact on advances in their diagnostic and therapy.

In light of existing skills and resources in the area of genomics and physiopathology of cardiovascular and metabolic diseases, the joining of French and German capacities in these fields is of high interest and benefit to scientists from both countries. For this reason, the German BMBF und the French Agence Nationale de la Recherche (ANR) lauched the funding initiative of Genomics and Physiopathology of Cardiovascular and Metabolic Diseases.
Bilateral scientific collaboration through jointly funded research projects will promote the identification and characterization of susceptibility genes and gene products as well as their interactions in cardiovascular and metabolic diseases. By creating synergies these collaborations will form the basis for paving the way towards translation of results into benefits for medicine and industry to understand genomics and physiopathology of cardiovascular and metabolic diseases and provide new therapies.

Research proposals shall focus on a central research question on genomics and physiopathology analyses of cardiovascular and metabolic diseases. They aim either the genomic and phenotypic analyses of cardiovascular and metabolic diseases (e.g. follow-ups of genome-wide association studies, replication studies, additional genotyping, subphenotyping) or the functional or mechanistic characterization of identified disease-genes employing animal or cellular models. The research should especially focus on the translation of results into clinically relevant applications.

The NGFN is involved in this important bi-national research initiative with the German partner Prof. Dr. Hugo Katus, University Clinics Heidelberg, with the project “INSIGHT-DCM – New Insights into Genomics of hereditary Dilated Cardiomyopathy (DCM)”.