Cardiovascular disease refers to the class of diseases that involve the heart or blood vessels. The term includes all heart, vessels and circulation diseases that are inherited but not acquired due to an injury.
Risk factors are high blood pressure, diabetes, overweight, high amount of blood lipids, tobacco smoke and alcohol abuse but also family history and age. Furthermore, the incidence of cardiovascular diseases is higher in men than in women.
The diseases of the cardiovascular system like heart failure, stroke and heart attack are the number one cause of death and disability worldwide. An estimated 17.5 million people died from cardiovascular disease in 2005, mainly from heart attacks (7.6 million) and strokes (5.7 million), representing 30 % of all global deaths. By 2015 an estimated 20 million people will die from cardiovascular disease. (Source: WHO)
The uptake, transport, chemical reactions, and elimination of substances through an organism are called metabolism. When these body processes get out of balance metabolic diseases may be the consequence - e.g. some of the best known like diabetes mellitus, disorders of the thyroid or the parathyroid glands as well as adiposity (obesity) and overweight.
In order to develop novel, more effective methods of diagnosis and treatment, scientists of the NGFN investigate the genomic variants and test their clinical relevance, the modifiers and molecular pathway mechanisms of cardiovascular diseases, and transfer those achievements to clinical applications.