IG German Mouse Clinic - Deciphering Comorbidity in Human Disease Models

In the IG German Mouse Clinic (IG GMC), we are using the mouse as model to analyze the molecular pathogenesis and comorbidity of human diseases. The IG GMC offers systemic phenotyping of mouse models, phenotyping under environmental challenge conditions, archiving and dissemination through the European Mouse Mutant Archive (EMMA) and coordination of mouse model production for NGFN IGs.
The NGFN operates an advanced mouse phenotyping facility, the German Mouse Clinic. We offer a systemic phenotypic analysis of mouse models in a primary screening of more than 320 parameters in the areas of behavior, bone and cartilage, neurology, clinical chemistry, immunology, allergy, steroid metabolism, energy metabolism, lung function, vision/ eye and pain perception, molecular phenotyping and pathology. To explore the complex relationship between environmental changes and genetic factors, we plan to break new ground by setting up standardized challenge platforms for mouse phenotyping – the GMC II. In order to identify genetically determined phenotypes dependent on environmental factors, we are focusing on major environmental risk factors for human health. We have chosen five areas – diet, air, stress, exercise and immunity – representing the major interfaces of the organism with the environment. In addition, archiving and dissemination of mouse models is provided by the IG GMC through EMMA. The coordination of the production of mouse models for NGFN IGs as well as a link to the generation of large animal models is offered by the established coordination unit of the IG GMC.