NGFN-PLUS

Mutanom

upload/mediapool//110/VERBUND_Portr_C3_A4t_Dr_Lange_Mutanom.JPG
Coordinator:    PD Dr. Bodo M.H. Lange
Institution: Max-Planck Institut für molekulare Genetik
Homepage: www.molgen.mpg.de
Koordinator: Prof. Dr. Hans Lehrach

Institut: Max-Planck Institut für molekulare Genetik

Homepage: www.molgen.mpg.de

Funded through the NGFN Plus Research initiative, the IG Mutanom characterises the functional consequences of somatic mutations and develops models that predict the outcome of such genetic alterations on a molecular pathway level, cellular and organism level. From very early on in this project our results are translated into the clinical and Public Health sector with the goal to define new diagnostic and therapeutic strategies. First, the effort concentrates on characterising „driver“ mutations (i.e. mutations that occur in cancer due to selective pressure) that already have been selected from databases and from the scientific literature, which will be characterised in close collaboration among the different subprojects. The consortium has complementary expertises in the fields of proteomics (MPIMG, DKFZ, MDC) functional genomics (MPI-MG, DKFZ) and modelling (MPIMG). Clinical partners and companies (e.g. Cellzome) are part of the project and carry out mass spectrometry analysis, expression profiling, provide tissue samples or clones. Academic experts (SOCMED)  ensure from the early beginning of the project that the translational aspects of the project is fully exploited.

Latest results can be found in detail in the descriptions of the subprojects
Subprojects:
SEARCH
INTRANET (Members login)
login:
password:
KTT
MEDIA
NGFN-MEETING-2012
NGFN- MEETING
LINKS