Mutanom

Koordinator: Prof. Dr. Hans Lehrach

Institut: Max-Planck Institut für molekulare Genetik

Homepage: www.molgen.mpg.de

Funded through the NGFN Plus Research initiative. The IG Mutanom aims to characterise the functional consequences of somatic mutations and to develop models that predict the outcome of such genetic alterations on a molecular pathway level, cellular and organism level. From very early on in this project our results will be translated into the clinical and Public Health sector with the goal to define new diagnostic and therapeutic strategies. At the beginning of the project our effort will concentrate on characterising „driver“ mutations (i.e. mutations that occur in cancer due to selective   pressure) that already have been selected from databases and from the scientific literature, which will be characterised in close collaboration among the different subprojects. The consortium has complementary expertises in the fields of proteomics (MPIMG, DKFZ, MDC) functional genomics (MPI-MG, DKFZ) and modelling (MPIMG). Clinical partners and companies (e.g. Cellzome) are part of the project and will carry out mass spectrometry analysis, expression profiling, provide tissue samples or clones. Academic experts (SOCMED) will ensure from the early beginning of the project that the translational aspects of the project will be fully exploited.