2013
91 Alexandrov LB, Nik-Zainal S, Wedge DC, Aparicio SAJR, Behjati S, Lichter P, Meyerson M, Grimmond SM, Seibert R, Campo E, Shibata T, Pfister SM, Campbell PJ, Stratton MR. Signatures of mutational processes in human cancer. Nature 2013 (accepted).
90 Beier CP, Kumar P, Meyer K, Leukel P, Bruttel V, Aschenbrenner I,Riemenschneider MJ, Fragoulis A, Rümmele P, Lamszus K, Schulz JB, Weis J, Bogdahn U, Wischhusen J, Hau P, Spang R, Beier D. The cancer stem cell subtype determines immune infiltration of glioblastoma. Stem Cells Dev. 2012 Oct 10;21(15):2753-61. doi: 10.1089/scd.2011.0660. Epub 2012 Jul 16. PubMed PMID: 22676416; PubMed Central PMCID: PMC3464079.
89 Chirasani SR, Leukel P, Gottfried E, Hochrein J, Stadler K, Neumann B, Oefner PJ, Gronwald W, Bogdahn U, Hau P, Kreutz M, Grauer OM. Diclofenac inhibitslactate formation and efficiently counteracts local immune suppression in amurine glioma model. Int J Cancer. 2013 Feb 15;132(4):843-53. doi: 10.1002/ijc.27712. Epub 2012 Jul 21. PubMed PMID: 22752934.
88 Filatova A, Acker T, Garvalov BK. The cancer stem cell niche(s): the crosstalk between glioma stem cells and their microenvironment. Biochim Biophys Acta. 2013:1830(2):2496-508.
87 Hovestadt V, Remke M, Kool M, Pietsch T, Northcott PA, Fischer R, Cavalli FM, Ramaswamy V, Zapatka M, Reifenberger G, Rutkowski S, Schick M, Bewerunge-Hudler M, Korshunov A, Lichter P, Taylor MD, Pfister SM, Jones DT. Robust molecular subgrouping and copy-number profiling of medulloblastoma from small amounts of archival tumour material using high-density DNA methylation arrays. Acta Neuropathol. 2013 Jun;125(6):913-6. doi: 10.1007/s00401-013-1126-5.
86 Jones DTW, Hutter B, Jäger N, Korshunov A, Collins VP, Jabado N, Eils R, Lichter P, Pfister SM. Recurrent FGFR1 hotspot mutations represent a novel therapeutic target in childhood astrocytoma. Nat Genetics 2013 (accepted)
85 Nakata S, Campos B, Bageritz J, Bermejo JL, Becker N, Engel F, Acker T, Momma S, Herold-Mende C, Lichter P, Radlwimmer B, Goidts V. LGR5 is a marker of poor prognosis in glioblastoma and is required for survival of brain cancer stem-like cells. Brain Pathol. 2013 Jan;23(1):60-72.
84 Ramm Sander P, Hau P, Koch S, Schütze K, Bogdahn U, Kalbitzer HR, Aigner L. Stem cell metabolic and spectroscopic profiling. Trends Biotechnol. 2013Mar;31(3):204-13. doi: 10.1016/j.tibtech.2013.01.008. Epub 2013 Feb 4. PubMed PMID: 23384506.
83 Reuss DE, Piro RM, Jones DT, Simon M, Ketter R, Kool M, Becker A, Sahm F,Pusch S, Meyer J, Hagenlocher C, Schweizer L, Capper D, Kickingereder P, Mucha J, Koelsche C, Jäger N, Santarius T, Tarpey PS, Stephens PJ, Andrew Futreal P, Wellenreuther R, Kraus J, Lenartz D, Herold-Mende C, Hartmann C, Mawrin C, Giese N, Eils R, Collins VP, König R, Wiestler OD, Pfister SM, von Deimling A. Secretory meningiomas are defined by combined KLF4 K409Q and TRAF7 mutations. Acta Neuropathol. 2013 Mar;125(3):351-8.
82 Schüle R, Dictus C, Campos B, Wan F, Felsberg J, Ahmadi R, Centner FS, Grabe N, Reifenberger G, Bermejo JL, Unterberg A, Herold-Mende C. Potential canonical wnt pathway activation in high-grade astrocytomas. Scientific World Journal. 2012;2012:697313. doi: 10.1100/2012/697313. Epub 2012 Aug 2.
81 Tönjes M, Barbus S, Park YJ, Wang W, Schlotter M, Lindroth AM, Pleier SV, Bai AHC, Karra D, Piro RM, Felsberg J, Addington A, Lemke D, Weibrecht I, Hovestadt V, Rolli CG, Campos B, Turcan S, Sturm D, Witt H, Chan TA, Herold-Mende C, Kemkemer R, König R, Schmidt K, Hull WE, Pfister SM, Jugold M, Hutson SM, Plass C, Okun JG, Reifenberger G, Lichter P, Radlwimmer B. BCAT1 promotes cell proliferation via amino acid catabolism in IDH1 wildtype gliomas. Nat Med. 2013 Jun 23. doi: 10.1038/nm.3217. [Epub ahead of print]
2012
80 Ali R, Campos B, Dyckhoff G, Haefeli WE, Herold-Mende C, Burhenne J. Quantification of retinoid concentrations in human serum and brain tumor tissues. Anal Chim Acta. 2012 May 6;725:57-66. doi: 10.1016/j.aca.2012.03.003. Epub 2012 Mar 17.
79 Balss J, Pusch S, Beck AC, Herold-Mende C, Krämer A, Thiede C, Buckel W, Langhans CD, Okun JG, von Deimling A. Enzymatic assay for quantitative analysis of (D)-2-hydroxyglutarate. Acta Neuropathol. 2012 Dec;124(6):883-91.
78 Beier CP, Kumar P, Meyer K, Leukel P, Bruttel V, Aschenbrenner I, Riemenschneider M, Fragoulis A, Rümmele P, Lamszus K, Schulz JB, Weis J, Bogdahn U, Wischhusen J, Hau P, Spang R, Beier D.S The Cancer Stem Cell Subtype Determines Immune Infiltration of Glioblastoma. Stem Cells Dev. 2012 Oct 10;21(15):2753-61.
77 Beier D, Schriefer B, Brawanski K, Hau P, Weis J, Schulz JB, Beier CP. Efficacy of clinically relevant temozolomide dosing schemes in glioblastoma cancer stem cell lines. J Neurooncol. 2012 Aug;109(1):45-52. Epub 2012 Apr 29.
76 Brockschmidt A, Trost D, Peterziel H, Zimmermann K, Ehrler M, Grassmann H, Waha A, Stabenow D, Brockschmidt FF, Hoischen A, Kalla C, Waha A, Seifert G, Knolle PA, Latz E, Wolfgang Wick, Volkmar H. Hans, Alexander Pfeifer, Angel P, Hess J, Weber RG. KIAA1797 encodes a novel focal adhesion protein with tumor suppressor function in human gliomas Brain. 2012 Apr;135(Pt 4):1027-41. doi: 10.1093/brain/aws045. Epub 2012 Mar 16.
75 Campos B., Warta R., Chaisaingmongkol J., Popanda O., Hartmann C., von Deimling A., Unterberg A., Plass C., Schmezer P., Herold-Mende C. Epigenetically Mediated Down-regulation of the Differentiation-Promoting Chaperon Protein CRABP2 in Astrocytic Gliomas Int J Cancer. 2012 Oct 15;131(8):1963-8. doi: 10.1002/ijc.27446. Epub 2012 Mar 8.
74 Fassl A., Tagscherer K., Richter J., Berriel Diaz M., Alcantara Llaguno S.R., Campos B., Herold-Mende C., Herzig S., Schmidt M.H.H., Parada L.F., Wiestler O.D., Roth W. Notch1 signaling promotes survival of glioblastoma cells via EGFR-mediated induction of anti-apoptotic Mcl-1. Oncogene 2012 Jan 16. doi: 10.1038/onc.2011.615. [Epub ahead of print]
73 Haag D, Zipper P, Westrich V, Karra D, Pfleger K, Toedt G, Blond F, Delhomme N, Hahn M, Reifenberger J, Reifenberger G, Lichter P. Nos2 inactivation promotes the development of medulloblastoma in Ptch1(+/-) mice by deregulation of Gap43-dependent granule cell precursor migration. PLoS Genet. 2012;8(3):e1002572.
72 Hau P, Jachimczak P, Schlaier J, Bogdahn U. TGF-ß2 signaling in high-gradegliomas. Curr Pharm Biotechnol. 2011 Dec;12(12):2150-7. Review. PubMed PMID: 21619538.
71 Kees T, Lohr J, Noack J, Mora R, Gdynia G, Tödt G, Ernst A, Radlwimmer B, Falk CS, Herold-Mende C, Régnier-Vigouroux A. Microglia isolated from patients with glioma gain antitumor activities on poly (I:C) stimulation. Neuro Oncol. 2012 Jan;14(1):64-78. Epub 2011 Oct 20.
70 Khuong-Quang DA, Buczkowicz P, Rakopoulos P, Liu XY, Fontebasso AM, Bouffet E, Bartels U, Albrecht S, Schwartzentruber J, Letourneau L, Bourgey M, Bourque G, Montpetit A, Bourret G, Lepage P, Fleming A, Lichter P, Kool M, von Deimling A, Sturm D, Korshunov A, Faury D, Jones DT, Majewski J, Pfister SM, Jabado N, Hawkins C. K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas. Acta Neuropathol. 2012 Sep;124(3):439-47.
69 Müller T, Gessi M, Waha A, Isselstein L J, Luxen D, Freihoff D, Freihoff J, Becker A, Simon M, Hammes J, Denkhaus D, zur Mühlen A, Pietsch T and Waha A. Nuclear exclusion of TET is associated with loss of 5-hydroxymethylcytosine in IDH wild-type gliomas. Am J Pathol. 2012 Aug;181(2):675-83.
68 Opitz CA, Litzenburger UM, Sahm F, Ott M, Tritschler I, Trump S, Schumacher T, Jestaedt L, Schrenk D, Weller M, Jugold M, Guillemin GJ, Miller CL, Lutz C, Radlwimmer B, Lehmann I, von Deimling A, Wick W, Platten M. An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor. Nature. 2011 Oct 5;478(7368):197-203. doi: 10.1038/nature10491.
67 Peterziel H, Müller J, Danner A, Barbus S, Liu HK, Radlwimmer B, Pietsch T,Lichter P, Schütz G, Hess J, Angel P. Expression of podoplanin in human astrocytic brain tumors is controlled by the PI3K-AKT-AP-1 signaling pathway and promoter methylation. Neuro Oncol. 2012 Apr;14(4):426-39. Epub 2012 Mar 6. PubMed PMID: 22394497; PubMed Central PMCID: PMC3309862.
66 Schwartzentruber J, Korshunov A, Liu XY, Jones DT, Pfaff E, Jacob K, Sturm D, Fontebasso AM, Quang DA, Tönjes M, Hovestadt V, Albrecht S, Kool M, Nantel A, Konermann C, Lindroth A, Jäger N, Rausch T, Ryzhova M, Korbel JO, Hielscher T, Hauser P, Garami M, Klekner A, Bognar L, Ebinger M, Schuhmann MU, Scheurlen W, Pekrun A, Frühwald MC, Roggendorf W, Kramm C, Dürken M, Atkinson J, Lepage P, Montpetit A, Zakrzewska M, Zakrzewski K, Liberski PP, Dong Z, Siegel P, Kulozik AE, Zapatka M, Guha A, Malkin D, Felsberg J, Reifenberger G, von Deimling A, Ichimura K, Collins VP, Witt H, Milde T, Witt O, Zhang C, Castelo-Branco P, Lichter P, Faury D, Tabori U, Plass C, Majewski J, Pfister SM, Jabado N. Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma. Nature. 2012 Jan 29;482(7384):226-31.
65 Sturm D, Witt H, Hovestadt V, Khuong-Quang DA, Jones DT, Konermann C, Pfaff E, Tönjes M, Sill M, Bender S, Kool M, Zapatka M, Becker N, Zucknick M, Hielscher T, Liu XY, Fontebasso AM, Ryzhova M, Albrecht S, Jacob K, Wolter M, Ebinger M, Schuhmann MU, van Meter T, Frühwald MC, Hauch H, Pekrun A, Radlwimmer B, Niehues T, von Komorowski G, Dürken M, Kulozik AE, Madden J, Donson A, Foreman NK, Drissi R, Fouladi M, Scheurlen W, von Deimling A, Monoranu C, Roggendorf W, Herold-Mende C, Unterberg A, Kramm CM, Felsberg J, Hartmann C, Wiestler B, Wick W, Milde T, Witt O, Lindroth AM, Schwartzentruber J, Faury D, Fleming A, Zakrzewska M, Liberski PP, Zakrzewski K, Hauser P, Garami M, Klekner A, Bognar L, Morrissy S, Cavalli F, Taylor MD, van Sluis P, Koster J, Versteeg R, Volckmann R, Mikkelsen T, Aldape K, Reifenberger G, Collins VP, Majewski J, Korshunov A, Lichter P, Plass C, Jabado N, Pfister SM. Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma. Cancer Cell. 2012 Oct 16;22(4):425-37. doi: 10.1016/j.ccr.2012.08.024.
64 Tagscherer KE, Fassl A, Sinkovic T, Combs SE, Roth W. p53-dependent regulation of Mcl-1 contributes to synergistic cell death by ionizing radiation and the Bcl-2/Bcl-XL inhibitor ABT-737. Apoptosis. 2012 Feb; 17(2):187-199. doi 10.1007/s10495-011-0664-3.
63 von dem Knesebeck A, Felsberg J, Waha A, Hartmann W, Scheffler B, Glas M, Hammes J, Mikeska T, Yan P S, Endl E, Simon M, Reifenberger G, Pietsch T and Waha A. RANK (TNFRSF11A) is epigenetically inactivated and induces apoptosis in gliomas. Neoplasia 2012 June;14(6): 526?534.
2011
62 Augustin I, Goidts V, Bongers A, Kerr G, Vollert G, Radlwimmer B, Hartmann C, Herold-Mende C, Reifenberger G, von Deimling A, Boutros M. The Wnt secretion protein Evi/Gpr177 promotes glioma tumourigenesis. EMBO Mol Med. 2012 Jan;4(1):38-51. doi: 10.1002/emmm.201100186. Epub 2011 Dec 7.
61 Barbus S, Tews B, Karra D, Hahn M, Radlwimmer B, Delhomme N, Hartmann C, Felsberg J, Krex D, Schackert G, Martinez R, Reifenberger G, Lichter P. Differential retinoic acid signaling in tumors of long- and short-term glioblastoma survivors. J Natl Cancer Inst. 2011 Apr 6;103(7):598-606. Epub 2011 Feb 23.PMID: 21346226 [PubMed - indexed for MEDLINE]
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59 Brehmer S, Pusch S, Schmieder K, von Deimling A, Hartmann C.; Mutational analysis of D2HGDH and L2HGDH in brain tumors without IDH1 or IDH2 mutations. Neuropathol Appl Neurobiol. 2011 Apr;37(3):330-2.
58 Campos B., Centner F.S., Lorenzo Bermejo J., Ali R., Dorsch K., Wan F., Felsberg J., Ahmadi R., Grabe N., Reifenberger G., Unterberg A., Burhenne J., Herold-Mende C. Aberrant Expression of Retinoic Acid Signaling Molecules Influences Patient Survival in Astrocytic Gliomas. Am J Pathol. 2011 May;178(5):1953-64.
57 Campos B., Lorenzo Bermejo J., Han L., Felsberg J., Ahmadi R, Grabe N., Reifenberger G., Unterberg A., Herold-Mende C. Expression of Nuclear Receptor Corepressors and Class I Histone Deacetylases in Astrocytic Gliomas. Cancer Sci. 2011 Feb;102(2):387-92. doi: 10.1111/j.1349-7006.2010.01792.x. Epub 2010 Dec 10.
56 Campos B., Zeng L., DaoTrong P.H., Eckstein V., Unterberg A., Mairbäurl H., Herold-Mende C. Expression and Regulation of AC133 and CD133 in Glioblastoma. Glia. 2011 Dec;59(12):1974-86. doi: 10.1002/glia.21239. Epub 2011 Sep 7.
55 Cin H, Meyer C, Herr R, Janzarik WG, Lambert S, Jones DT, Jacob K, Benner A, Witt H, Remke M, Bender S, Falkenstein F, Van Anh TN, Olbrich H, von Deimling A, Pekrun A, Kulozik AE, Gnekow A, Scheurlen W, Witt O, Omran H, Jabado N, Collins VP, Brummer T, Marschalek R, Lichter P, Korshunov A, Pfister SM. Oncogenic FAM131B-BRAF fusion resulting from 7q34 deletion comprises an alternative mechanism of MAPK pathway activation in pilocytic astrocytoma. Acta Neuropathol. 2011 Jun;121(6):763-74. Epub 2011 Mar 20. PMID: 21424530 [PubMed - indexed for MEDLINE]
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53 Ernst A, Aigner M, Nakata S, Engel F, Schlotter M, Kloor M, Brand K, Schmitt S, Steinert G, Rahbari N, Koch M, Radlwimmer B, Weitz J, Lichter P. A gene signature distinguishing CD133hi from CD133- colorectal cancer cells: essential role for EGR1 and downstream factors. Pathology. 2011 Apr;43(3):220-7.
52 Garvalov B, Acker T.Cancer stem cells: a new framework for the design of tumor therapies. J Mol Med (Berl). 2011 Feb;89(2):95-107. Epub 2010 Oct 2.
51 Gessi M, Setty P, Bisceglia M, zur Muehlen A, Lauriola L, Waha A, Giangaspero F, Pietsch T. Supratentorial primitive neuroectodermal tumors of the central nervous system in adults: molecular and histopathologic analysis of 12 cases. Am J Surg Pathol. 2011 Apr;35(4):573-82.
50 Gessi M, Waha A, Setty P, Waha A, Pietsch T. Analysis of KIAA1549-BRAF fusion status in a case of rosette-forming glioneuronal tumor of the fourth ventricle (RGNT). Neuropathology. 2011 Apr 26. doi: 10.1111/j.1440-1789.2011.01220
49 Goidts V, Bageritz J, Puccio L, Nakata S, Zapatka M, Barbus S, Toedt G, Campos B, Korshunov A, Momma S, Van Schaftingen E, Reifenberger G, Herold-Mende C, Lichter P, Radlwimmer B. RNAi screening in glioma stem-like cells identifies PFKFB4 as a key molecule important for cancer cell survival. Oncogene. 2012 Jul 5;31(27):3235-43. doi: 10.1038/onc.2011.490. Epub 2011 Nov 7.
48 Gronych J, Korshunov A, Bageritz J, Milde T, Jugold M, Hambardzumyan D, Remke M, Hartmann C, Witt H, Jones DT, Witt O, Heiland S, Bendszus M, Holland EC, Pfister S, Lichter P. An activated mutant BRAF kinase domain is sufficient to induce pilocytic astrocytoma in mice.J Clin Invest. 2011 Apr 1;121(4):1344-1348. doi: 10.1172/JCI44656.
47 Küchler J, Hartmann W, Waha A, Koch A, Endl E, Wurst P, Kindler D, Mikeska T, Waha A, Goodyer CG, Büttner R, Schilling K, Pietsch T. p75(NTR) induces apoptosis in medulloblastoma cells. Int J Cancer. 2011 Apr 15;128(8):1804-12. doi: 10.1002/ijc.25508.
46 Lemke D, Pfenning PN, Sahm F, Klein AC, Kempf T, Warnken U, Schnölzer M, Tudoran R, Weller M, Platten M, Wick W. Costimulatory protein 4IgB7H3 drives the malignant phenotype of glioblastoma by mediating immune escape and invasiveness. Clin Cancer Res. 2012 Jan 1;18(1):105-17. Epub 2011 Nov 11
45 Opitz CA, Litzenburger UM, Sahm F, Ott M, Tritschler I, Trump S, Schumacher T, Jestaedt L, Schrenk D, Weller M, Jugold M, Guillemin GJ, Miller CL, Lutz C, Radlwimmer B, Lehmann I, von Deimling A, Wick W, Platten M. An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor. Nature. 2011 Oct 5;478(7368):197-203. doi: 10.1038/nature10491.
44 Ramm P, Bettscheider M, Beier D, Kalbitzer HR, Kremer W, Bogdahn U, Hau P, Aigner L, Beier CP. 1H-Nuclear Magnetic Resonance Spectroscopy of Glioblastoma Cancer Stem Cells. Stem Cells Dev. 2011 Mar 6. [Epub ahead of print] PubMed PMID: 21265608.
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41 Toedt G, Barbus S, Wolter M, Felsberg J, Tews B, Blond F, Sabel MC, Hofmann S, Becker N, Hartmann C, Ohgaki H, von Deimling A, Wiestler OD, Hahn M, Lichter P, Reifenberger G, Radlwimmer B. Molecular signatures classify astrocytic gliomas by IDH1 mutation status. Int J Cancer. 2011 Mar 1;128(5):1095-103. doi: 10.1002/ijc.25448.
40 Waha A, Felsberg J, Hartmann W, Hammes J, von dem Knesebeck A, Endl E, Pietsch T, Waha A. Frequent epigenetic inactivation of the chaperone SGNE1/7B2 in human gliomas. Int. J. Cancer (2011) Sep 7. doi: 10.1002/ijc.26416. [Epub ahead of print]
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2010
38 Andrulis M, Capper D, Luft T, Hartmann C, Zentgraf H, von Deimling A. Detection of isocitrate dehydrogenase 1 mutations R132H in myelodysplastic syndrome by mutation specific antibody and direct sequencing. Leuk Res. 2010 Mar 11
37 Campos B, Wan F, Farhadi M, Ernst A, Zeppernick F, Tagscherer KE, Ahmadi R, Lohr J, Dictus C, Gdynia G, Combs SE, Helmke BM, Roth W, Beckhove P, Lichter P, Unterberg A, Radlwimmer B, Herold-Mende C. Differentiation Therapy Exerts Anti-Tumorigenic, Anti-Angiogenic, Anti-Invasive and Proapoptotic Effects in Brain Tumor Stem Cell-Derived Tumors. Clin Cancer Res. 2010
36 Czwan E, Brors B, Kipling D. Modelling p-value distributions to improvetheme-driven survival analysis of cancer transcriptome datasets. BMC Bioinformatics. 2010 Jan 11;11:19.
35 Ernst A, Campos B, Meier J, Devens F, Liesenberg F, Wolter M, Reifenberger G, Herold-Mende C, Lichter P, Radlwimmer B. De-repression of CTGF via the miR-17-92 cluster upon differentiation of human glioblastoma spheroid cultures. Oncogene. 2010 Jun 10;29(23):3411-22.
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