Publications


2013

301 Binia A, Van Stiphout N, Liang L, Michel S, Bhavsar PK, Fan Chung K,Brightling CE, Barnes PJ, Kabesch M, Bush A, Cookson WO, Moffatt MF.  A Polymorphism Affecting MYB Binding within the Promoter of the PDCD4 Gene isAssociated with Severe Asthma in Children.  Hum Mutat. 2013 Apr 18. PMID: 23606399.

300 Buske-Kirschbaum A, Schmitt J, Plessow F, Romanos M, Weidinger S, Roessner V.  Psychoendocrine and psychoneuroimmunological mechanisms in the comorbidity of atopic eczema and attention deficit/hyperactivity disorder.  Psychoneuroendocrinology 2013; 38:12-23.

299 Couturier-Maillard A, Secher T, Rehman A, Normand S, De Arcangelis A, Haesler R, Huot L, Grandjean T, Bressenot A, Delanoye-Crespin A, Gaillot O, Schreiber S, Lemoine Y, Ryffel B, Hot D, Nùñez G, Chen G, Rosenstiel P*, Chamaillard M. NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer.  J Clin Invest. 2013 Jan 2. doi:pii: 62236. 10.1172/JCI62236. [Epub ahead of print] PubMed PMID: 23281400; PubMed Central PMCID: PMC3561825 * denotes shared senior authorship.

298 EEllinghaus D, Baurecht H, Esparza-Gordillo J, Rodríguez E, Matanovic A, Marenholz I, Hübner N, Schaarschmidt H, Novak N, Michel S, Maintz L, Werfel T, Meyer-Hoffert U, Hotze M, Prokisch H, Heim K, Herder C, Hirota T, Tamari M, Kubo M, Takahashi A, Nakamura Y, Tsoi LC, Stuart P, Elder JT, Sun L, Zuo X, Yang S, Zhang X, Hoffmann P, Nöthen MM, Fölster-Holst R, Winkelmann J, Illig T, Boehm BO, Duerr RH, Büning C, Brand S, Glas J, McAleer MA, Fahy CM, Kabesch M, Brown S, McLean WH, Irvine AD, Schreiber S, Lee YA, Franke A, Weidinger S.  High-density genotyping study identifies four new susceptibility loci for atopic dermatitis.  Nat Genet. 2013 Jun 2. doi: 10.1038/ng.2642.

297 Ellinghaus D, Zhang H, Zeissig S, Lipinski S, Till A, Jiang T, Stade B, Bromberg Y, Ellinghaus E, Keller A, Rivas MA, Skieceviciene J, Doncheva NT, Liu X, Liu Q, Jiang F, Forster M, Mayr G, Albrecht M, Hasler R, Boehm BO, Goodall J, Berzuini CR, Lee J, Andersen V, Vogel U, Kupcinskas L, Kayser M, Krawczak M, Nikolaus S, Weersma RK, Ponsioen CY, Sans M, Wijmenga C, Strachan DP, McArdle WL, Vermeire S, Rutgeerts P, Sanderson JD, Mathew CG, Vatn MH, Wang J, Nothen MM, Duerr RH, Buning C, Brand S, Glas J, Winkelmann J, Illig T, Latiano A, Annese V, Halfvarson J, Damato M, Daly MJ, Nothnagel M, Karlsen TH, Subramani S, Rosenstiel P, Schreiber S, Parkes M, Franke A (2013).  Association Between Variants of PRDM1 and NDP52 and Crohns Disease, Based on Exome Sequencing and Functional Studies.  Gastroenterology, Epub ahead of print.

296 Enciso-Mora V et al.  Deciphering the 8q24.21 association for glioma.  Hum Mol Genet. Epub 2013 Feb 20.

295 Esparza-Gordillo J, Schaarschmidt H, Liang L, Cookson WO, Bauerfeind A, Lee-Kirsch MA, Nemat K, Henderson J, Paternoster L, Harper JL, Mangold E, Nothen MM, Ruschendorf F, Kerscher T, Marenholz I, Matanovic A, Lau S, Keil T, Bauer CP, Kurek M, Ciechanowicz A, Macek M, Franke A, Kabesch M, Hubner N, Abecasis GR, Weidinger S, Moffatt MF, Lee YA.   A functional IL6R variant is a risk factor for persistent eczema. J Allergy Clin Immunol. 2013 Apr 9. doi:pii: S0091-6749(13)00322-9. 10.1016/j.jaci.2013.01.057.

294 Forster M, Forster P, Elsharawy A, Hemmrich G, Kreck B, Wittig M, Thomsen I, Stade B, Barann M, Ellinghaus D, Petersen BS, May S, Melum E, Schilhabel MB, Keller A, Schreiber S, Rosenstiel P, Franke A.  From next-generation sequencing alignments to accurate comparison and validation of single-nucleotide variants: the pibase software.  Nucleic Acids Res. 41(1): e16. Jan 2013.

293 Garding A, Bhattacharya N, Claus R, Ruppel M, Tschuch C, Zucknick M, Oakes C, Fleig V, Allegra D, Caudron-Herger M et al:  Epigenetic upregulation of lncRNAs at 13q14.3 in leukemia correlates with downregulation in cis of a gene cluster regulating NF-kB.  PLoS Genet. 2013 Apr;9(4):e1003373. doi: 10.1371/journal.pgen.1003373. Epub 2013 Apr 4.

292 Giatrakos S, Huse K, Kanni T, Tzanetakou V, Kramer M, Grech I, Papadavid E, Katoulis A, Stavrianeas N, Nothnagel M, Platzer M, Bauer M, Giamarellos-Bourboulis EJ (2013).  Haplotypes of IL-12R?1 impact on the clinical phenotype of hidradenitis suppurativa.  Cytokine 62(2):297-301.

291 Issa A, Gill JW, Heideman MR, Sahin O, Wiemann S, Dey JH, Hynes NE:  Combinatorial targeting of FGF and ErbB receptors blocks growth and metastatic spread of breast cancer models.  Breast Cancer Res 2013, 15(1):R8.

290 Kacprowski T, Doncheva NT, Albrecht M.  NetworkPrioritizer: A versatile tool for network-based prioritization of candidate disease genes or other molecules.  Bioinformatics. 2013 Jun 1;29(11):1471-3.

289 Keshav S, Va?ásek T, Niv Y, Petryka R, Howaldt S, Bafutto M, Rácz I, Hetzel D, Nielsen OH, Vermeire S, Reinisch W, Karlén P, Schreiber S, Schall TJ, Bekker P; Prospective Randomized Oral-Therapy Evaluation in Crohn?s Disease Trial-1 (PROTECT-1) Study Group A Randomized Controlled Trial of the Efficacy and Safety of CCX282-B, an Orally-Administered Blocker of Chemokine Receptor CCR9, for Patients with Crohn's Disease.<http://www.ncbi.nlm.nih.gov/pubmed/23527300>. PLoS One. 2013;8(3):e60094. doi: 10.1371/journal.pone.0060094. Epub 2013 Mar 20.

288 Körner C, Keklikoglou I, Bender C, Wörner A, Münstermann E, Wiemann S:  microRNA-31 sensitizes human breast cells to apoptosis by direct targeting of protein kinase C epsilon (PKC{varepsilon}).  J Biol Chem 2013:Epub.

287 Kreck B et al. (2013)   Base-pair resolution DNA methylome of the EBV-positive Endemic Burkitt lymphoma cell line DAUDI determined by SOLiD bisulfite-sequencing. Leukemia.doi: 10.1038/leu.2013.4. [Epub ahead of print].

286 Lal D et al. Rare exonic deletions of the RBFOX1 gene increase risk of idiopathic generalized epilepsy. Epilepsia. 2013;54:265-71.

285 Liedén A, Winge MC, Sääf A, Kockum I, Ekelund E, Rodriguez E, Fölster-Holst R, Franke A, Illig T, Tengvall-Linder M, Baurecht H, Weidinger S, Wahlgren CF, Nordenskjöld M, Bradley M.  Genetic variation in the epidermal transglutaminase genes is not associated with atopic dermatitis.  PLoS One 2012; 7:e49694.

284 Liu JZ, Hov JR, Folseraas T, Ellinghaus E, Rushbrook SM, Doncheva NT, Andreassen OA, Weersma RK, Weismüller TJ, Eksteen B, Invernizzi P, Hirschfield GM, Gotthardt DN, Pares A, Ellinghaus D, Shah T, Juran BD, Milkiewicz P, Rust C, Schramm C, Müller T, Srivastava B, Dalekos G, Nöthen MM, Herms S, Winkelmann J, Mitrovic M, Braun F, Ponsioen CY, Croucher PJ, Sterneck M, Teufel A, Mason AL, Saarela J, Leppa V, Dorfman R, Alvaro D, Floreani A, Onengut-Gumuscu S, Rich SS, Thompson WK, Schork AJ, Næss S, Thomsen I, Mayr G, König IR, Hveem K, Cleynen I, Gutierrez-Achury J, Ricaño-Ponce I, van Heel D, Björnsson E, Sandford RN, Durie PR, Melum E, Vatn MH, Silverberg MS, Duerr RH, Padyukov L, Brand S, Sans M, Annese V, Achkar JP, Boberg KM, Marschall HU, Chazouillères O, Bowlus CL, Wijmenga C, Schrumpf E, Vermeire S, Albrecht M; UK-PSCSC Consortium; International IBD Genetics Consortium, Rioux JD, Alexander G, Bergquist A, Cho J, Schreiber S, Manns MP, Färkkilä M, Dale AM, Chapman RW, Lazaridis KN; International PSC Study Group, Franke A, Anderson CA, Karlsen TH.  Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis.  Nat Genet. 2013 Apr 21;45(6):670-5.

283 Melén E, Granell R, Kogevinas M, Strachan D, Gonzalez JR, Wjst M, Jarvis D,Ege M, Braun-Fahrländer C, Genuneit J, Horak E, Bouzigon E, Demenais F, KauffmannF, Siroux V, Michel S, von Berg A, Heinzmann A, Kabesch M, Probst-Hensch NM,Curjuric I, Imboden M, Rochat T, Henderson J, Sterne JA, McArdle WL, Hui J, JamesAL, William Musk A, Palmer LJ, Becker A, Kozyrskyj AL, Chan-Young M, Park JE,Leung A, Daley D, Freidin MB, Deev IA, Ogorodova LM, Puzyrev VP, Celedón JC,Brehm JM, Cloutier MM, Canino G, Acosta-Pérez E, Soto-Quiros M, Avila L,Bergström A, Magnusson J, Söderhäll C, Kull I, Scholtens S, Marike Boezen H,Koppelman GH, Wijga AH, Marenholz I, Esparza-Gordillo J, Lau S, Lee YA, Standl M,Tiesler CM, Flexeder C, Heinrich J, Myers RA, Ober C, Nicolae DL, Farrall M,Kumar A, Moffatt MF, Cookson WO, Lasky-Su J.  Genome-wide association study of body mass index in 23 000 individuals with and without asthma.  Clin Exp Allergy. 2013 Apr;43(4):463-74. doi: 10.1111/cea.12054. PubMed PMID: 23517042.

282 Michel S, Busato F, Genuneit J, Pekkanen J, Dalphin JC, Riedler J, Mazaleyrat N, Weber J, Karvonen AM, Hirvonen MR, Braun-Fahrländer C, Lauener R, von MutiusE, Kabesch M, Tost J; PASTURE study group. Farm exposure and time trends in earlychildhood may influence DNA methylation in genes related to asthma and allergy. Allergy. 2013 Mar;68(3):355-64. doi: 10.1111/all.12097. Epub 2013 Jan 25. PubMed PMID: 23346934.

281 Pandey RC, Michel S, Schieck M, Binia A, Liang L, Klopp N, Franke A, von Berg A, Bufe A, Rietschel E, Heinzmann A, Laub O, Simma B, Frischer T, Genuneit J,Illig T, Kabesch M.  Polymorphisms in extracellular signal-regulated kinase familyinfluence genetic susceptibility to asthma.  J Allergy Clin Immunol. 2013 Feb 2.doi:pii: S0091-6749(12)02676-0. 10.1016/j.jaci.2012.12.675. [Epub ahead of print]PubMed PMID: 23384682.

280 Pandey RC, Michel S, Tesse R, Binia A, Schedel M, Liang L, Klopp N, Franke A, von Berg A, Bufe A, Rietschel E, Heinzmann A, Laub O, Simma B, Frischer T,Genuneit J, Illig T, Kabesch M.  Genetic variation in the Toll-like receptorsignaling pathway is associated with childhood asthma.  J Allergy Clin Immunol.2013 Feb;131(2):602-5. doi: 10.1016/j.jaci.2012.10.061. Epub 2012 Dec 28. PubMed PMID: 23273951.

279 Potaczek DP, Michel S, Sharma V, Zeilinger S, Vogelberg C, von Berg A, Bufe A,Heinzmann A, Laub O, Rietschel E, Simma B, Frischer T, Genuneit J, Illig T,Kabesch M.  Different FCER1A polymorphisms influence IgE levels in asthmatics and  non-asthmatics.  Pediatr Allergy Immunol. 2013 Jun 3. PMID: 23725541.

278 Ried JS, Baurecht H, Stückler F, Krumsiek J, Gieger C, Heinrich J, Kabesch M, Prehn C, Peters A, Rodriguez E, Schulz H, Strauch K, Suhre K, Wang-Sattler R, Wichmann HE, Theis FJ, Illig T, Adamski J, Weidinger S.  Integrative genetic and metabolite profiling analysis suggests altered phosphatidylcholine metabolism in asthma. Allergy 2013; in press .

277 Roewer L, Nothnagel M, Gusmão L, Gomes V, González M, Corach D, Sala A, Alechine E, Palha T, Santos N, Ribeiro-Dos-Santos A, Geppert M, Willuweit S, Nagy M, Zweynert S, Baeta M, Núñez C, Martínez-Jarreta B, González-Andrade F, Fagundes de Carvalho E, da Silva DA, Builes JJ, Turbón D, Lopez Parra AM, Arroyo-Pardo E, Toscanini U, Borjas L, Barletta C, Ewart E, Santos S, Krawczak M (2013).  Continent-wide decoupling of y-chromosomal genetic variation from language and geography in native South americans.  PLoS Genet 9(4):e1003460.

276 Schaefer AS, Bochenek G, Manke T, Nothnagel M, Graetz C, Thien A, Jockel-Schneider Y, Harks I, Staufenbiel I, Wijmenga C, Eberhard J, Guzeldemir-Akcakanat E, Cine N, Folwaczny M, Noack B, Meyle J, Eickholz P, Trombelli L, Scapoli C, Nohutcu R, Bruckmann C, Doerfer C, Jepsen S, Loos BG, Schreiber S (2013).  Validation of reported genetic risk factors for periodontitis in a large-scale replication study.  J Clin Periodontol 40(6):563-72.

275 Schmitt J, Apfelbacher C, Heinrich J, Weidinger S, Romanos M.  Association of atopic eczema and attention-deficit/hyperactivity disorder - meta-analysis of epidemiologic studies.  Z Kinder Jugendpsychiatr Psychother 2013; 41:35-44.

274 Siegert S, Hampe J, Schafmayer C, von Schönfels W, Egberts JH, Försti A, Chen B, Lascorz J, Hemminki K, Franke A, Nothnagel M, Nöthlings U, Krawczak M.  Genome-wide investigation of gene-environment interactions in colorectal cancer.  Hum Genet. 2013 Feb;132(2):219-31.

273 Ward A, Balwierz A, Zhang JD, Küblbeck M, Pawitan Y, Hielscher T, Wiemann S, Sahin O (2012)  Re-expression of microRNA-375 reverts both tamoxifen resistance and accompanied EMT-like properties in breast cancer.  Oncogene 2013, 32(9):1173-1182.

272 Zeisel A, Yitzhaky A, Koerner C, Lauriola M, Cohen-Dvashi H, Kostler WJ, Yarden Y, Wiemann S, Domany E:  qCMA: A Desktop Application for Quantitative Collective Cell Migration Analysis.  J Biomol Screen 2013, 18(3):356-360.

2012

271 Anagnostopoulou P, Riederer B, Duerr J, Michel S, Binia A, Agrawal R, Liu X,Kalitzki K, Xiao F, Chen M, Schatterny J, Hartmann D, Thum T, Kabesch M,Soleimani M, Seidler U, Mall MA.  SLC26A9-mediated chloride secretion preventsmucus obstruction in airway inflammation.  J Clin Invest. 2012 Oct1;122(10):3629-34. doi: 10.1172/JCI60429. Epub 2012 Sep 4. PubMed PMID: 22945630;PubMed Central PMCID: PMC3461899.

270 Arnold M, Hartsperger ML, Baurecht H, Rodríguez E, Wachinger B, Franke A,Kabesch M, Winkelmann J, Pfeufer A, Romanos M, Illig T, Mewes HW, Stümpflen V,Weidinger S.  Network-based SNP meta-analysis identifies joint and disjointgenetic features across common human diseases.  BMC Genomics. 2012 Sep 18;13:490. doi: 10.1186/1471-2164-13-490. PubMed PMID: 22988944.

269 Binia A, Kabesch M.  Respiratory medicine - genetic base for allergy andasthma.  Swiss Med Wkly. 2012 Aug 22;142:w13612. doi: 10.4414/smw.2012.13612.Review. PubMed PMID: 22915201.

268 Brosch M, von Schönfels W, Ahrens M, Nothnagel M, Krawczak M, Laudes M, Sipos B, Becker T, Schreiber S, Röcken C, Schafmayer C, Hampe J.  SFRS10--a splicing factor gene reduced in human obesity?  Cell Metab. 2012 Mar 7;15(3):265-6.

267 Casaca VI, Illi S, Suttner K, Schleich I, Ballenberger N, Klucker E, Turan E, von Mutius E, Kabesch M, Schaub B.  TBX21 and HLX1 polymorphisms influencecytokine secretion at birth.  PLoS One. 2012;7(1):e31069. Epub 2012 Jan 30. PubMedPMID: 22303482; PubMed Central PMCID: PMC3268767.

266 Cleynen I, González JR, Figueroa C, Franke A, McGovern D, Bortlík M, Crusius BJ, Vecchi M, Artieda M, Szczypiorska M, Bethge J, Arteta D, Ayala E, Danese S, van Hogezand RA, Panés J, Peña SA, Lukas M, Jewell DP, Schreiber S, Vermeire S, Sans M. Genetic factors conferring an increased susceptibility to develop Crohn's disease also influencedisease phenotype: results from the IBDchip European Project. <http://www.ncbi.nlm.nih.gov/pubmed/23263249> Gut. 2012 Dec 21. [Epub ahead of print].

265 Dizier MH, Margaritte-Jeannin P, Madore AM, Esparza-Gordillo J, Moffatt M, Corda E, Monier F, Guilloud-Bataille M, Franke A, Weidinger S, Annesi-Maesano I, Just J, Pin I, Kauffmann F, Cookson W, Lee YA, Laprise C, Lathrop M, Bouzigon E, Demenais F. The ANO3/MUC15 locus is associated with eczema in families ascertained through asthma.  J Allergy Clin Immunol 2012;129:1547-53.e3.

264 Doncheva NT, Assenov Y, Domingues FS, Albrecht M.   Topological analysis and interactive visualization of biological networks and protein structures. Nat Protoc. 2012 Mar 15;7(4):670-85.

263 Doncheva NT, Kacprowski T, Albrecht M. Recent approaches to the prioritization of candidate disease genes. Wiley Interdiscip Rev Syst Biol Med.  2012 Sep-Oct;4(5):429-42.

262 Ellinghaus D*, Folseraas T*, Holm K, Ellinghaus E, Melum E, Balschun T, Laerdahl JK, Shiryaev A, Gotthardt DN, Weismüller TJ, Schramm C, Wittig M, Bergquist A, Björnsson E, Marschall HU, Vatn M, Teufel A, Rust C, Gieger C, Wichmann HE, Runz H, Sterneck M, Rupp C, Braun F, Weersma RK, Wijmenga C, Ponsioen CY, Mathew CG, Rutgeerts P, Vermeire S, Schrumpf E, Hov JR, Manns MP, Boberg KM, Schreiber S, Franke A, Karlsen TH.  Genome-wide association analysis in Primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4.  Hepatology. 2012 Jul 23. doi: 10.1002/hep.25977. [Epub ahead of print] PMID: 22821403.

261 Ellinghaus D, Ellinghaus E, Nair RP, Stuart PE, Esko T, Metspalu A, Debrus S, Raelson JV, Tejasvi T, Belouchi M, West SL, Barker JN, Kõks S, Kingo K, Balschun T, Palmieri O, Annese V, Gieger C, Wichmann HE, Kabesch M, Trembath RC, Mathew CG, Abecasis GR, Weidinger S, Nikolaus S, Schreiber S, Elder JT, Weichenthal M, Nothnagel M, Franke A.  Combined analysis of genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci. Am J Hum Genet 2012; 90:636-47.

260 Elsharawy A, Forster M, Schracke N, Keller A, Thomsen I, Petersen BS, Stade B, Stähler P, Schreiber S, Rosenstiel P, Franke A.  Improving mapping and SNP-calling performance in multiplexed targeted next-generation sequencing.  BMC Genomics.  2012 Aug 22;13:417.

259 ElSharawy A, Warner J, Olson J, Forster M, Schilhabel MB, Link DR, Rose-John S, Schreiber S, Rosenstiel P, Brayer J, Franke A. Accurate variant detection across non-amplified and whole genome amplified DNA using targeted next generation sequencing.   BMC Genomics. 2012 Sep 20;13:500.

258 Emig D, Blankenburg H, Ramírez F, Albrecht M.  Functional characterization of human genes from exon expression and RNA interference results.  Methods Mol Biol. 2012;910:33-53.

257 Eyerich S, Onken AT, Weidinger S, Franke A, Nasorri F, Pennino D, Grosber M, Pfab F, Schmidt-Weber CB, Mempel M, Hein R, Ring J, Cavani A, Eyerich K (2011)  Mutual antagonism of T cells causing psoriasis and atopic eczema.  New England journal of medicine 365(3): 231-8.

256 Faria D, Schlicker A, Pesquita C, Bastos H, Ferreira AE, Albrecht M, Falcão AO.  Mining GO annotations for improving annotation consistency.  PLoS One. 2012;7(7):e40519..

255 Fischer A, Schmid B, Ellinghaus D, Nothnagel M, Gaede KI, Schürmann M, Lipinski S, Rosenstiel P, Zissel G, Höhne K, Petrek M, Kolek V, Pabst S, Grohé C, Grunewald J, Ronninger M, Eklund A, Padyukov L, Gieger C, Wichmann HE, Nebel A, Franke A, Müller-Quernheim J, Hofmann S, Schreiber S.  A novel sarcoidosis risk locus for Europeans on chromosome 11q13.1.   Am J Respir Crit Care Med. 2012 Nov 1;186(9):877-85.

254 Folseraas T, Melum E, Rausch P, Juran BD, Ellinghaus E, Shiryaev A, Laerdahl JK, Ellinghaus D, Schramm C, Weismüller TJ, Gotthardt DN, Hov JR, Clausen OP, Weersma RK, Janse M, Boberg KM, Björnsson E, Marschall HU, Cleynen I, Rosenstiel P, Holm K, Teufel A, Rust C, Gieger C, Wichmann HE, Bergquist A, Ryu E, Ponsioen CY, Runz H, Sterneck M, Vermeire S, Beuers U, Wijmenga C, Schrumpf E, Manns MP, Lazaridis KN, Schreiber S, Baines JF, Franke A, Karlsen TH.  Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci.  J Hepatol. 2012 Aug;57(2):366-75. doi: 0.1016/j.jhep.2012.03.031. Epub 2012 Apr 18. PMID: 22521342.

253 Fransen K, Mitrovic M, van Diemen CC, Thelma BK, Sood A, Franke A, Schreiber S, Midha V, Juyal G, Potocnik U, Fu J, Nolte I, Weersma RK. Limited evidence for parent-of-origin effects in inflammatory bowel disease associated loci.<http://www.ncbi.nlm.nih.gov/pubmed/23028907> PLoS One. 2012;7(9):e45287. doi: 10.1371/journal.pone.0045287. Epub 2012 Sep 27.

252 Fritsch C, Herrmann A, Nothnagel M, Szafranski K, Huse K, Schumann F, Schreiber S, Platzer M, Krawczak M, Hampe J, Brosch M.   Genome-wide search for novel human uORFs and N-terminal protein extensions using ribosomal footprinting. Genome Res. 2012 Nov;22(11):2208-18.

251 Garai Á, Zeke A, Gógl G, Tör? I, Förd?s F, Blankenburg H, Bárkai T, Varga J, Alexa A, Emig D, Albrecht M, Reményi A.  Specificity of linear motifs that bind to a common mitogen-activated protein kinase docking groove.  Sci Signal. 2012 Oct 9;5(245):ra74.

250 Gerdes S, Osadtschy S, Rostami-Yazdi M, Buhles N, Weichenthal M, Mrowietz U (2012)  Leptin, adiponectin, visfatin and retinol-binding protein-4 - mediators of comorbidities in patients with psoriasis?  Exp Dermatol 21(1): 43-7.

249 Glas J, Seiderer J, Czamara D, Pasciuto G, Diegelmann J, Wetzke M, Olszak T, Wolf C, Müller-Myhsok B, Balschun T, Achkar JP, Kamboh MI, Franke A, Duerr RH, Brand S. PTGER4 expression-modulating polymorphisms in the 5p13.1 region predispose to Crohn's disease and affect NF-?B and XBP1 binding sites.<http://www.ncbi.nlm.nih.gov/pubmed/23300802> PLoS One. 2012;7(12):e52873. doi: 10.1371/journal.pone.0052873. Epub 2012 Dec 27.

248 Granada M, Wilk JB, Tuzova M, Strachan DP, Weidinger S, Albrecht E, Gieger C, Heinrich J, Himes BE, Hunninghake GM, Celedón JC, Weiss ST, Cruikshank WW, Farrer LA, Center DM, O'Connor GT. A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study. J Allergy Clin Immunol 2012; 129:840-845.

247 Gravel S et al. (2012).  Demographic history and rare allele sharing among human populations.  Proc Natl Acad Sci U S A. 108(29):11983-8.

246 Hashimoto T, Perlot T, Rehman A, Trichereau J, Ishiguro H, Paolino M, Sigl V, Hanada T, Hanada R, Lipinski S, Wild B, Camargo SM, Singer D, Richter A, Kuba K, Fukamizu A, Schreiber S, Clevers H, Verrey F, Rosenstiel P*, Penninger JM.  ACE2links amino acid malnutrition to microbial ecology and intestinal inflammation. Nature. 2012 Jul 25;487(7408):477-81. doi: 10.1038/nature11228. PubMed PMID:22837003.

245 Häsler R, Feng Z, Bäckdahl L, Spehlmann ME, Franke A, Teschendorff A, RakyanVK, Down TA, Wilson GA, Feber A, Beck S, Schreiber S, Rosenstiel P.  A functional methylome map of ulcerative colitis Genome Res. 2012 Nov;22(11):2130-7. doi:10.1101/gr.138347.112. Epub 2012 Jul 23. PubMed PMID: 22826509; PubMed CentralPMCID: PMC3483542.

244 Helbig KL, Nothnagel M, Hampe J, Balschun T, Nikolaus S, Schreiber S, Franke A, Nöthlings U.  A case-only study of gene-environment interaction between genetic susceptibility variants in NOD2 and cigarette smoking in Crohn's disease aetiology.  BMC Med Genet. 2012 Mar 14;13:14.

243 Henjes F, Bender C, von der Heyde S, Braun L, Mannsperger HA, Schmidt C, Wiemann S, Hasmann M, Aulmann S, Beissbarth T et al: Strong EGFR signaling in cell line models of ERBB2-amplified breast cancer attenuates response towards ERBB2-targeting drugs.  Oncogenesis 2012, 1(7):e16.

242 Hofmann S, Fischer A, Nothnagel M, Jacobs G, Schmid B, Wittig M, Franke A, Gaede KI, Schürmann M, Petrek M, Mrazek F, Pabst S, Grohé C, Grunewald J, Ronninger M, Eklund A, Rosenstiel P, Höhne K, Zissel G, Müller-Quernheim J, Schreiber S. Genome-wide association analysis reveals 12q13.3-q14.1 as new risk locus for sarcoidosis. Eur Respir J. 2012 Aug 30.

241 Huang J et al. (2012)  1000 Genomes-based imputation identifies novel and refined associations for the Wellcome Trust Case Control Consortium phase 1 Data.  Eur J Hum Genet.: EJHG (January):1-5.

240 Jones DT, Jager N, Kool M, Zichner T, Hutter B, Sultan M, Cho YJ, Pugh TJ, Hovestadt V, Stutz AM et al:  Dissecting the genomic complexity underlying medulloblastoma.  Nature 2012, 488(7409):100-105.

239 Jostins L et al.  Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.  Nature. 2012 Nov 1;491(7422):119-24. doi: 10.1038/nature11582.

238 Jürgensen C, Brand J, Nothnagel M, Arlt A, Neser F, Habeck JO, Schreiber S, Stölzel U, Zeitz M, Hampe J.  Prognostic relevance of gastric cancer staging by endoscopic ultrasound.  Surg Endosc. 2012 Oct 6.

237 Jurmeister S, Baumann M, Balwierz A, Keklikoglou I, Ward A, Uhlmann S, Zhang JD, Wiemann S, Sahin O (2012)  MicroRNA-200c Represses Migration and Invasion of Breast Cancer Cells by Targeting Actin-Regulatory Proteins FHOD1 and PPM1F.  Mol Cell Biol 32: 633-651.

236 Kabesch M, Adcock IM.  Epigenetics in asthma and COPD.  Biochimie. 2012Nov;94(11):2231-41. doi: 10.1016/j.biochi.2012.07.017. Epub 2012 Jul 31. Review. PubMed PMID: 22874820.

235 Keklikoglou I, Koerner C, Schmidt C, Zhang JD, Heckmann D, Shavinskaya A, Allgayer H, Guckel B, Fehm T, Schneeweiss A, Sahin O, Wiemann S, Tschulena U (2012)  MicroRNA-520/373 family functions as a tumor suppressor in estrogen receptor negative breast cancer by targeting NF-kappaB and TGF-beta signaling pathways.  Oncogene 2012, 31(37):4150-4163.

234 Keller A et al.  New insights into the Tyrolean Iceman's origin and phenotype as inferred by whole-genome sequencing.  Nat Commun. 2012 Feb 28;3:698. doi: 10.1038/ncomms1701.

233 Knuppel S, Esparza-Gordillo J, Marenholz I, Holzhutter H, Bauerfeind A, Ruether A, Weidinger S, Lee YA, Rohde K.  Multi-locus stepwise regression: a haplotype-based algorithm for finding genetic associations applied to atopic dermatitis.  BMC Med Genet 2012; 27;13:8.

232 Kreck Benjamin et al. (2012).  B-SOLANA: an approach for the analysis of two-base encoding bisulfite sequencing data.  Bioinformatics 28(3): 428-9.

231 Krueger F et al. (2012).  DNA methylome analysis using short bisulfite sequencing data.  Nat Methods 9(2):145-51.

230 Lipinski S, Grabe N, Jacobs G, Billmann-Born S, Till A, Häsler R, Aden K,Paulsen M, Arlt A, Kraemer L, Hagemann N, Erdmann KS, Schreiber S, Rosenstiel P.  RNAi screening identifies mediators of NOD2 signaling: implications for spatialspecificity of MDP recognition.  Proc Natl Acad Sci U S A. 2012 Dec26;109(52):21426-31. doi: 10.1073/pnas.1209673109. Epub 2012 Dec 3. PubMed PMID: 23213202; PubMed Central PMCID: PMC3535590.

229 Lisauskas T, Matula P, Claas C, Reusing S, Wiemann S, Erfle H, Lehmann L, Fischer P, Eils R, Rohr K et al:  Live-cell assays to identify regulators of ER-to-Golgi trafficking.  Traffic 2012, 13(3):416-432.

228 Mills RE et al. (2012).  Mapping copy number variation by population-scale genome sequencing.  Nature 470(7332):59-65.

227 Panaccione R, Hibi T, Peyrin-Biroulet L, Schreiber S. Implementing changes in clinical practice to improve the management of Crohn's disease.<http://www.ncbi.nlm.nih.gov/pubmed/22463930> J Crohns Colitis. 2012 Feb;6 Suppl 2:S235-42. doi: 10.1016/S1873-9946(12)60503-0.

226 Peyrin-Biroulet L, Billioud V, D'Haens G, Panaccione R, Feagan B, Panés J, Danese S, Schreiber S, Ogata H, Hibi T, Higgins PD, Beaugerie L, Chowers Y, Louis E, Steinwurz F, Reinisch W, Rutgeerts P, Colombel JF, Travis S, Sandborn WJ. Development of the Paris definition of early Crohn's disease for disease-modification trials: results of an international expert opinion process.<http://www.ncbi.nlm.nih.gov/pubmed/23211844> Am J Gastroenterol. 2012 Dec;107(12):1770-6. doi: 10.1038/ajg.2012.117.

225 Philipp EE, Kraemer L, Mountfort D, Schilhabel M, Schreiber S, Rosenstiel P.  The Transcriptome Analysis and Comparison Explorer--T-ACE: a platform-independent, graphical tool to process large RNAseq datasets of non-model organisms.  Bioinformatics. 2012 Mar 15;28(6):777-83. Epub 2012 Jan 27.

224 Potaczek DP, Kabesch M. Current concepts of IgE regulation and impact ofgenetic determinants. Clin Exp Allergy. 2012 Jan 30. doi:10.1111/j.1365-2222.2012.03953.x. [Epub ahead of print] PubMed PMID: 22417242.

223 Quednow BB, Brinkmeyer J, Mobascher A, Nothnagel M, Musso F, Gründer G, Savary N, Petrovsky N, Frommann I, Lennertz L, Spreckelmeyer KN, Wienker TF, Dahmen N, Thuerauf N, Clepce M, Kiefer F, Majic T, Mössner R, Maier W, Gallinat J, Diaz-Lacava A, Toliat MR, Thiele H, Nürnberg P, Wagner M, Winterer G.  Schizophrenia risk polymorphisms in the TCF4 gene interact with smoking in the modulation of auditory sensory gating.  Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6271-6.

222 Raedler D, Illi S, Pinto LA, von Mutius E, Illig T, Kabesch M, Schaub B.  IL10 polymorphisms influence neonatal immune responses, atopic dermatitis, and wheeze at age 3 years.  J Allergy Clin Immunol. 2013 Mar;131(3):789-96. doi:10.1016/j.jaci.2012.08.008. Epub 2012 Sep 27. PubMed PMID: 23021880.

221 Ramírez F, Lawyer G, Albrecht M.  Novel search method for the discovery of functional relationships.  Bioinformatics. 2012 Jan 15;28(2):269-76.

220 Rebane A, Zimmermann M, Aab A, Baurecht H, Koreck A, Karelson M, Abram K, Metsalu T, Pihlap M, Meyer N, Fölster-Holst R, Nagy N, Kemeny L, Kingo K, Vilo J, Illig T, Akdis M, Franke A, Novak N, Weidinger S, Akdis CA.  Mechanisms of IFN-?-induced apoptosis of human skin keratinocytes in patients with atopic dermatitis.  J Allergy Clin Immunol 2012; 129:1297-306.

219 Reinisch W, Van Assche G, Befrits R, Connell W, D'Haens G, Ghosh S, Michetti P, Ochsenkühn T, Panaccione R, Schreiber S, Silverberg MS, Sorrentino D, van der Woude CJ, Vermeire S, Panes J.  Recommendations for the treatment of ulcerative colitis with infliximab: a gastroenterology expert group consensus.  J Crohns Colitis. 2012 Mar;6(2):248-58. Epub 2012 Jan 10.

218 Richter GM, Graetz C, Pohler P, Nothnagel M, Dommisch H, Laine ML, Folwaczny M, Noack B, Eickholz P, Groessner-Schreiber B, Jepsen S, Loos BG, Schreiber S, Schaefer AS.  Common genetic risk variants of TLR2 are not associated with periodontitis in large European case-control populations. J Clin Periodontol. 2012 Apr;39(4):315-22.

217 Ring J, Möhrenschlager M, Weidinger S.  Molecular genetics of atopic eczema.  Chem Immunol Allergy 2012;96:24-9.

216 Rubin D, Helwig U, Pfeuffer M, Auinger A, Ruether A, Matusch D, Darabaneanu S, Freitag-Wolf S, Nothnagel M, Schreiber S, Schrezenmeir J.  The effect of FABP2 promoter haplotype on response to a diet with medium-chain triacylglycerols.  Genes Nutr. 2012 Jul;7(3):437-45..

215 Sandborn WJ, Colombel JF, Sands BE, Rutgeerts P, Targan SR, Panaccione R, Bressler B, Geboes K, Schreiber S, Aranda R, Gujrathi S, Luo A, Peng Y, Salter-Cid L, Hanauer SB. Abatacept for Crohn's disease and ulcerative colitis.<http://www.ncbi.nlm.nih.gov/pubmed/22504093> Gastroenterology. 2012 Jul;143(1):62-69.e4. doi: 10.1053/j.gastro.2012.04.010. Epub 2012 Apr 12.

214 Sandborn WJ, Gasink C, Gao LL, Blank MA, Johanns J, Guzzo C, Sands BE, Hanauer SB, Targan S, Rutgeerts P, Ghosh S, de Villiers WJ, Panaccione R, Greenberg G, Schreiber S, Lichtiger S, Feagan BG; CERTIFI Study Group. Ustekinumab induction and maintenance therapy in refractory Crohn's disease.<http://www.ncbi.nlm.nih.gov/pubmed/23075178> N Engl J Med. 2012 Oct 18;367(16):1519-28. doi: 10.1056/NEJMoa1203572.

213 Schmid MW, Schmidt A, Klostermeier UC, Barann M, Rosenstiel P, Grossniklaus U.  A powerful method for transcriptional profiling of specific cell types in eukaryotes: laser-assisted microdissection and RNA sequencing.  PLoS One. 2012;7(1):e29685. Epub 2012 Jan 26.

212 Schreiber S, Reinisch W, Colombel JF, Sandborn WJ, Hommes DW, Robinson AM, Huang B, Lomax KG, Pollack PF. Subgroup analysis of the placebo-controlled CHARM trial: increased remission rates through 3 years for adalimumab-treated patients with early Crohn's disease.<http://www.ncbi.nlm.nih.gov/pubmed/22704916> J Crohns Colitis. 2013 Apr 1;7(3):213-21. doi: 10.1016/j.crohns.2012.05.015. Epub 2012 Jun 16.

211 Shamu C, Wiemann S, Boutros M (2012) On target: A public repository for large-scale RNAi experiments.  Nat Cell Biology 14: 115.

210 Simpson JC, Joggerst B, Laketa V, Verissimo F, Cetin C, Erfle H, Bexiga MG, Singan VR, Heriche JK, Neumann B et al:  Genome-wide RNAi screening identifies human proteins with a regulatory function in the early secretory pathway.  Nat Cell Biol 2012, 14(7):764-774.

209 Sina C, Lipinski S, Gavrilova O, Aden K, Rehman A, Till A, Rittger A, PodschunR, Meyer-Hoffert U, Haesler R, Midtling E, Pütsep K, McGuckin MA, Schreiber S,Saftig P, Rosenstiel P.  Extracellular cathepsin K exerts antimicrobial activityand is protective against chronic intestinal inflammation in mice.  Gut. 2012 Mar 22. [Epub ahead of print] PubMed PMID: 22442160.

208 Spaich S, Will RD, Just S, Spaich S, Kuhn C, Frank D, Berger IM, Wiemann S, Korn B, Koegl M et al:  F-box and leucine-rich repeat protein 22 is a cardiac-enriched F-box protein that regulates sarcomeric protein turnover and is essential for maintenance of contractile function in vivo.  Circ Res 2012, 111(12):1504-1516.

207 Spehlmann ME, Begun AZ, Saroglou E, Hinrichs F, Tiemann U, Raedler A, Schreiber S.  Risk factors in German twins with inflammatory bowel disease: results of a questionnaire-based survey.  J Crohns Colitis. 2012 Feb;6(1):29-42.

206 Srivastava B, Mells GF, Cordell HJ, Muriithi A, Brown M, Ellinghaus E, Franke A, Consortium UP, Karlsen TH, Sandford RN, Alexander GJ, Chapman RW, Rushbrook SM, Melum E.  Fine mapping and replication of genetic risk loci in primary sclerosing cholangitis.  Scand J Gastroenterol. 2012 Jul;47(7):820-6. doi: 10.3109/00365521.2012.682090. Epub 2012 May 4. PMID: 22554193.

205 Taudien S, Gäbel G, Kuss O, Groth M, Grützmann R, Huse K, Kluttig A, Wolf A, Nothnagel M, Rosenstiel P, Greiser KH, Werdan K, Krawczak M, Pilarsky C, Platzer M. Association studies of the copy-number variable ß-defensin cluster on 8p23.1 in adenocarcinoma and chronic pancreatitis.  BMC Res Notes. 2012 Nov 13;5:629.

204 Thier S, Lorenz D, Nothnagel M, Poremba C, Papengut F, Appenzeller S, Paschen S, Hofschulte F, Hussl AC, Hering S, Poewe W, Asmus F, Gasser T, Schöls L, Christensen K, Nebel A, Schreiber S, Klebe S, Deuschl G, Kuhlenbäumer G.  Polymorphisms in the glial glutamate transporter SLC1A2 are associated with essential tremor.  Neurology. 2012 Jul 17;79(3):243-8.

203 Thye T, Owusu-Dabo E, Vannberg FO, van Crevel R, Curtis J, Sahiratmadja E, Balabanova Y, Ehmen C, Muntau B, Ruge G, Sievertsen J, Gyapong J, Nikolayevskyy V, Hill PC, Sirugo G, Drobniewski F, van de Vosse E, Newport M, Alisjahbana B, Nejentsev S, Ottenhoff TH, Hill AV, Horstmann RD, Meyer CG. Common variants at 11p13 are associated with susceptibility to tuberculosis. Nat Genet. 2012 Feb 5;44(3):257-9. doi: 10.1038/ng.1080.

202 Thyssen JP, Thuesen B, Huth C, Standl M, Carson CG, Heinrich J, Krämer U, Kratzsch J, Berg ND, Menné T, Johansen JD, Carlsen BC, Schwab S, Thorand B, Munk M, Wallaschofski H, Heickendorff L, Meldgaard M, Szecsi PB, Stender S, Bønnelykke K, Weidinger S, Bisgaard H, Linneberg A.  Skin barrier abnormality caused by filaggrin (FLG) mutations is associated with increased serum 25-hydroxyvitamin D concentrations.  J Allergy Clin Immunol 2012; 130:1204-1207.e2.

201 Timmann C et al.  Genome-wide association study indicates two novel resistance loci for severe malaria.  Nature. 2012 Sep 20;489(7416):443-6. doi: 10.1038/nature11334.

200 Toncheva AA, Suttner K, Michel S, Klopp N, Illig T, Balschun T, Vogelberg C,von Berg A, Bufe A, Heinzmann A, Laub O, Rietschel E, Simma B, Frischer T,Genuneit J, von Mutius E, Kabesch M.  Genetic variants in Protocadherin-1,bronchial hyper-responsiveness, and asthma subphenotypes in German children. Pediatr Allergy Immunol. 2012 Nov;23(7):636-41. doi:10.1111/j.1399-3038.2012.01334.x. Epub 2012 Oct 11. PubMed PMID: 23050600.

199 Tsoi LC et al. Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.  Nat Genet. 2012 Dec;44(12):1341-8. doi: 10.1038/ng.2467.

198 Uhlmann S, Mannsperger H, Zhang JD, Horvat E-A, Schmidt C, Küblbeck M, Henjes F, Ward A, Tschulena U, Zweig K, Korf U, Wiemann S, Sahin O (2012)  Global microRNA level regulation of EGFR-driven cell cycle protein network in breast cancer.  Mol Syst Biol 8: 570.

197 Visser MJ, Landeck L, Campbell LE, McLean WH, Weidinger S, Calkoen F, John SM, Kezic S.  Impact of atopic dermatitis and loss-of-function mutations in the filaggrin gene on the development of occupational irritant contact dermatitis.  Br J Dermatol 2013; 168:326-332.

196 vvon Kampen O, Buch S, Nothnagel M, Azocar L, Molina H, Brosch M, Erhart W, von Schönfels W, Egberts J, Seeger M, Arlt A, Balschun T, Franke A, Lerch MM, Mayerle J, Kratzer W, Boehm BO, Huse K, Schniewind B, Tiemann K, Jiang ZY, Han TQ, Mittal B, Srivastava A, Fenger M, Jørgensen T, Schirin-Sokhan R, Tönjes A, Wittenburg H, Stumvoll M, Kalthoff H, Lammert F, Tepel J, Puschel K, Becker T, Schreiber S, Platzer M, Völzke H, Krawczak M, Miquel JF, Schafmayer C, Hampe J.  Genetic and functional identification of the likely causative variant for cholesterol gallstone disease at the ABCG5/8 lithogenic locus.  Hepatology. 2012 Aug 16.

195 Walde S, Thakar K, Hutten S, Spillner C, Nath A, Rothbauer U, Wiemann S, Kehlenbach RH (2012)  The Nucleoporin Nup358/RanBP2 Promotes Nuclear Import in a Cargo- and Transport Receptor-Specific Manner.  Traffic 13: 218-233.

194 Ward A, Balwierz A, Zhang JD, Küblbeck M, Pawitan Y, Hielscher T, Wiemann S, Sahin O (2012)  Re-expression of microRNA-375 reverts both tamoxifen resistance and accompanied EMT-like properties in breast cancer.  Oncogene:  in press .

193 Yu W, Hegarty JP, Berg A, Kelly AA, Wang Y, Poritz LS, Franke A, Schreiber S, Koltun WA, Lin Z.  PTPN2 is associated with Crohn's disease and its expression is regulated by NKX2-3.  Dis Markers. 2012;32(2):83-91. doi: 10.3233/DMA-2011-086

192 Zirbs M, Pürner C, Buters JT, Effner R, Weidinger S, Ring J, Eberlein B. GSTM1, GSTT1 and GSTP1 gene polymorphism in polymorphous light eruption. J Eur Acad Dermatol Venereol 2012; in press.


 

2011

191 Andersen V, Ernst A, Sventoraityte J, Kupcinskas L, Jacobsen BA, Krarup HB, Vogel U, Jonaitis L, Denapiene G, Kiudelis G, Balschun T, Franke A. Assessment of heterogeneity between European Populations: a Baltic and Danish replication case-control study of SNPs from a recent European ulcerative colitis genome wide association study. BMC Med Genet 2011;12(1):139

190 Anderson CA, Boucher G, Lees CW, Franke A, D'Amato M, Taylor KD, Lee JC,Goyette P, Imielinski M, Latiano A, Lagacé C, Scott R, Amininejad L, Bumpstead S, Baidoo L, Baldassano RN, Barclay M, Bayless TM, Brand S, Büning C, Colombel JF, Denson LA, De Vos M, Dubinsky M, Edwards C, Ellinghaus D, Fehrmann RS, Floyd JA, Florin T, Franchimont D, Franke L, Georges M, Glas J, Glazer NL, Guthery SL, Haritunians T, Hayward NK, Hugot JP, Jobin G, Laukens D, Lawrance I, Lémann M, Levine A, Libioulle C, Louis E, McGovern DP, Milla M, Montgomery GW, Morley KI, Mowat C, Ng A, Newman W, Ophoff RA, Papi L, Palmieri O, Peyrin-Biroulet L, Panés J, Phillips A, Prescott NJ, Proctor DD, Roberts R, Russell R, Rutgeerts P,Sanderson J, Sans M, Schumm P, Seibold F, Sharma Y, Simms LA, Seielstad M, Steinhart AH, Targan SR, van den Berg LH, Vatn M, Verspaget H, Walters T, Wijmenga C, Wilson DC, Westra HJ, Xavier RJ, Zhao ZZ, Ponsioen CY, Andersen V, Torkvist L, Gazouli M, Anagnou NP, Karlsen TH, Kupcinskas L, Sventoraityte J, Mansfield JC, Kugathasan S, Silverberg MS, Halfvarson J, Rotter JI, Mathew CG, Griffiths AM, Gearry R, Ahmad T, Brant SR, Chamaillard M, Satsangi J, Cho JH, Schreiber S, Daly MJ, Barrett JC, Parkes M, Annese V, Hakonarson H, Radford-Smith G, Duerr RH, Vermeire S, Weersma RK, Rioux JD. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet. 2011 Mar;43(3):246-52. Epub 2011 Feb 6

189 Angelova-Fischer I, Mannheimer AC, Hinder A, Ruether A, Franke A, Neubert RH, Fischer TW, Zillikens D. Distinct barrier integrity phenotypes in filaggrin-related atopic eczema following sequential tape stripping and lipid profiling. Exp Dermatol. 2011 Apr;20(4):351-6. doi: 10.1111/j.1600-0625.2011.01259.x.

188 Aranda B, Blankenburg H, Kerrien S, Brinkman FS, Ceol A, Chautard E, Dana JM, De Las Rivas J, Dumousseau M, Galeota E, Gaulton A, Goll J, Hancock RE, Isserlin R, Jimenez RC, Kerssemakers J, Khadake J, Lynn DJ, Michaut M, O'Kelly G, Ono K, Orchard S, Prieto C, Razick S, Rigina O, Salwinski L, Simonovic M, Velankar S, Winter A, Wu G, Bader GD, Cesareni G, Donaldson IM, Eisenberg D, Kleywegt GJ, Overington J, Ricard-Blum S, Tyers M, Albrecht M, Hermjakob H. PSICQUIC and PSISCORE: accessing and scoring molecular interactions. Nat Methods. 2011 Jun 29;8(7):528-9.

187 Autran D et al. (2011). Maternal epigenetic pathways control parental contributions to Arabidopsis early embryogenesis. Cell 145(5):707-19

186 Bai SW, Herrera-Abreu MT, Rohn J, Racine V, Tajadura V, Suryavanshi N, Bechtel S, Wiemann S, Baum B, Ridley AJ (2011). A novel strategy to identify and characterize a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration. BMC Biology 9: 54.

185 Barkhausen T, Tschernig T, Rosenstiel P, van Griensven M, Vonberg RP, DorschM, Mueller-Heine A, Chalaris A, Scheller J, Rose-John S, Seegert D, Krettek C,Waetzig GH. Selective blockade of interleukin-6 trans-signaling improves survivalin a murine polymicrobial sepsis model*. Crit Care Med. 2011 Mar 14. [Epub ahead of print] PubMed PMID: 21336117.

184 Bender C, von der Heyde S, Henjes F, Wiemann S, Korf U, Beissbarth T (2011). Inferring signalling networks from longitudinal data using sampling based approaches in the R-package 'ddepn'. BMC Bioinformatics 12: 291.

183 Billmann-Born S, Till A, Arlt A, Lipinski S, Sina C, Latiano A, Annese V, Häsler R, Kerick M, Manke T, Seegert D, Hanidu A, Schäfer H, van Heel D, Li J, Schreiber S, Rosenstiel P. Genome-wide expression profiling identifies an impairment of negative feedback signals in the Crohn's disease-associated NOD2 variant L1007fsinsC. J Immunol. 2011 Apr 1;186(7):4027-38. Epub 2011 Feb 18.

182 Bussmann C, Weidinger S, Novak N. Genetics of atopic dermatitis. J Dtsch Dermatol Ges 2011; 9:670-6

181 Däbritz J, Friedrichs F, Weinhage T, Hampe J, Kucharzik T, Lügering A, Broeckel U, Schreiber S, Spieker T, Stoll M, Foell D. The functional -374T/A polymorphism of the receptor for advanced glycation end products may modulate Crohn's disease. Am J Physiol Gastrointest Liver Physiol. 2011 May;300(5):G823-32. Epub 2011 Feb 10

180 Del Greco MF et al. (2011). Genome-wide association analysis and fine mapping of NT-proBNP level provide novel insight into the role of the MTHFR-CLCN6-NPPA-NPPB gene cluster. Hum Mol Genet 20(8):1660-1671.

179 D'Haens GR, Panaccione R, Higgins PD, Vermeire S, Gassull M, Chowers Y, Hanauer SB, Herfarth H, Hommes DW, Kamm M, Löfberg R, Quary A, Sands B, Sood A, Watermeyer G, Lashner B, Lémann M, Plevy S, Reinisch W, Schreiber S, Siegel C, Targan S, Watanabe M, Feagan B, Sandborn WJ, Colombel JF, Travis S. The London Position Statement of the World Congress of Gastroenterology on Biological Therapy for IBD with the European Crohn's and Colitis Organization: when to start, when to stop, which drug to choose, and how to predict response? Am J Gastroenterol. 2011 Feb;106(2):199-212; quiz 213. Epub 2010 Nov

178 Dignass A, Preiss JC, Aust DE, Autschbach F, Ballauff A, Barretton G, Bokemeyer B, Fichtner-Feigl S, Hagel S, Herrlinger KR, Jantschek G, Kroesen A, Kruis W, Kucharzik T, Langhorst J, Reinshagen M, Rogler G, Schleiermacher D, Schmidt C, Schreiber S, Schulze H, Stange E, Zeitz M, Hoffmann JC, Stallmach A. [Updated German guideline on diagnosis and treatment of ulcerative colitis, 2011] Z Gastroenterol. 2011 Sep;49(9):1276-341. Epub 2011 Aug 24. German.

177 Dolmans GH, Werker PM, Hennies HC, Furniss D, Festen EA, Franke L, Becker K, van der Vlies P, Wolffenbuttel BH, Tinschert S, Toliat MR, Nothnagel M, Franke A, Klopp N, Wichmann HE, Nürnberg P, Giele H, Ophoff RA, Wijmenga C; Dutch Dupuytren Study Group; German Dupuytren Study Group; LifeLines Cohort Study; BSSH-GODD Consortium (2011). Wnt signaling and Dupuytren's disease. N Engl J Med, 365(4):307-17.

176 Doncheva NT, Klein K, Domingues FS, Albrecht M. Analyzing and visualizing residue networks of protein structures. Trends Biochem Sci. 2011 Apr;36(4):179-82.

175 Emig D, Albrecht M. Tissue-specific proteins and functional implications. J Proteome Res. 2011 Apr 1;10(4):1893-903.
174 Emig D, Sander O, Mayr G, Albrecht M. Structure collisions between interacting proteins. PLoS One. 2011;6(6):e19581.

173 Eyerich S, Onken AT, Weidinger S, Franke A, Nasorri F, Pennino D, Grosber M, Pfab F, Schmidt-Weber CB, Mempel M, Hein R, Ring J, Cavani A, Eyerich K. Mutual antagonism of T cells causing psoriasis and atopic eczema. N Engl J Med 2011; 365:231-8

172 Feagan BG, Hanauer SB, Coteur G, Schreiber S. Evaluation of a daily practice composite score for the assessment of Crohn's disease: the treatment impact of certolizumab pegol. Aliment Pharmacol Ther. 2011 May;33(10):1143-51. doi: 10.1111/j.1365-2036.2011.04636.x. Epub 2011 Mar 28

171 Filipiak-Pittroff B, Schnopp C, Berdel D, Naumann A, Sedlmeier S, Onken A, Rodriguez E, Fölster-Holst R, Baurecht H, Ollert M, Ring J, Cramer C, von Berg A, Bauer CP, Herbarth O, Lehmann I, Schaaf B, Koletzko S,Wichmann HE, Heinrich J, Weidinger S. Predictive value of food sensitization and filaggrin mutations in children with eczema. J Allergy Clin Immunol 2011; 128:1235-1241

170 Freiwald A, Mao L, Kodelja V, Kliem M, Schuldt D, Schreiber S, Franke A, Sauer S. Differential analysis of Crohn?s disease and ulcerative colitis by mass spectrometry. Inflamm Bowel Dis 2011 Apr;17(4):1051-1052.

169 German IBD Study Group. [Adherence to the H1N1 vaccination recommendation in patients with Crohn's disease or ulcerative colitis]. Dtsch Med Wochenschr. 2011 May;136(18):939-43. Epub 2011 May 2.

168 Gieger C et al. (2011). New gene functions in megakaryopoiesis and platelet formation. Nature 480(7376):201-208.

167 Häsler R, Kerick M, Mah N, Hultschig C, Richter G, Bretz F, Sina C, Lehrach H, Nietfeld W, Schreiber S, Rosenstiel P. Alterations of pre-mRNA splicing in human inflammatory bowel disease. Eur J Cell Biol. 2011 Feb 14. [Epub ahead of print]PubMed PMID: 21324547.

166 Herrmann A, Haake A, Ammerpohl O, Martin-Guerrero I, Szafranski K, Stemshorn K, Nothnagel M, Kotsopoulos SK, Richter J, Warner J, Olson J, Link DR, Schreiber S, Krawczak M, Platzer M, Nürnberg P, Siebert R, Hampe J. Pipeline for large-scale microdroplet bisulfite PCR-based sequencing allows the tracking of hepitype evolution in tumors. PLoS One. 2011;6(7):e21332. Epub 2011 Jul 5.

165 Hofmann S, Fischer A, Till A*, Müller-Quernheim J, Häsler R, Franke A, Gäde K, GenPhenReSa Consortium, Schaarschmidt H, Rosenstiel P, Nebel A, Schürmann M, Nothnagel M, Schreiber S (2011). A genome-wide association study reveals evidence of association with sarcoidosis at 6p12.1.Eur Respir J, 38(5):1127-35.

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109 Ellinghaus E, Ellinghaus D, Stuart PE, Nair RP, Debrus S, Raelson JV, Belouchi M, Fournier H, Reinhard C, Ding J, Li Y, Tejasvi T, Gudjonsson J, Stoll SW, Voorhees JJ, Lambert S, Weidinger S, Eberlein B, Kunz M, Rahman P, Gladman DD, Gieger C, Wichmann HE, Karlsen TH, Mayr G, Albrecht M, Kabelitz D, Mrowietz U, Abecasis GR, Elder JT, Schreiber S, Weichenthal M, Franke A. Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2. Nat Genet 2010;42(11):991-5.

108 Emig D, Salomonis N, Baumbach J, Lengauer T, Conklin BR, Albrecht M. AltAnalyze and DomainGraph: analyzing and visualizing exon expression data.Nucleic Acids Res. 2010 Jul 1;38 Suppl:W755-62.

107 Esparza-Gordillo J, Marenholz I, Lee YA. Genome-wide approaches to the etiology of eczema. Curr Opin All Clin Immunol. 2010.

106 Festen EA, Stokkers PC, van Diemen CC, van Bodegraven AA, Boezen HM, Crusius BJ, Hommes DW, van der Woude CJ, Balschun T, Verspaget HW, Schreiber S, de Jong DJ, Franke A, Dijkstra G, Wijmenga C, Weersma RK. Genetic analysis in a Dutch study sample identifies more ulcerative colitis susceptibility loci and shows their additive role in disease risk.  .Am J Gastroenterol. 2010 Feb;105(2):395-402. Epub 2009 Oct 27. Erratum in: Am J Gastroenterol. 2010 Feb;105(2):479. van der Woude, Janneke C [corrected to van der Woude, C Janneke].

105 Fischer A, Nothnagel M, Franke A, Jacobs G, Saadati HR, Gaede KI, Rosenstiel P, Schurmann M, Muller-Quernheim J, Schreiber S, Hofmann S. Association of IBD Risk Loci with Sarcoidosis and its Acute and Chronic Subphenotypes. Eur Respir J 2010.

104 Fischer A, Nothnagel M, Schürmann M, Müller-Quernheim J, Schreiber S, Hofmann S. A genome-wide linkage analysis in 181 German sarcoidosis families using clustered bi-allelic markers. Chest. 2010 Jul;138(1):151-7. Epub 2010 Feb 26. PMID: 20190003

103 Flachsbart F, Caliebe A, Nothnagel M, Kleindorp R, Nikolaus S, Schreiber S, Nebel A. Depletion of potential A2M risk haplotype for Alzheimer's disease in long-lived individuals. Eur J Hum Genet. 2010 Jan;18(1):59-61. Epub. PMID: 19639019

102 Franke A, Balschun T, Sina C, Ellinghaus D, Hasler R, Mayr G, Albrecht M, Wittig M, Buchert E, Nikolaus S, Gieger C, Wichmann HE, Sventoraityte J, Kupcinskas L, Onnie CM, Gazouli M, Anagnou NP, Strachan D, McArdle WL, Mathew CG, Rutgeerts P, Vermeire S, Vatn MH, Krawczak M, Rosenstiel P, Karlsen TH, Schreiber S. Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL). Nat Genet 2010;42:292-4.

101 Franke A, McGovern DP, Barrett JC, Wang K, Radford-Smith GL, Ahmad T, Lees CW, Balschun
T, Lee J, Roberts R, Anderson CA, Bis JC, Bumpstead S, Ellinghaus D, Festen EM, Georges M, Green T, Haritunians T, Jostins L, Latiano A, Mathew CG, Montgomery GW, Prescott NJ, Raychaudhuri S, Rotter JI, Schumm P, Sharma Y, Simms LA, Taylor KD, Whiteman D, Wijmenga C, Baldassano RN, Barclay M, Bayless TM, Brand S, Buning C, Cohen A, Colombel JF, Cottone M, Stronati L, Denson T, De Vos M, D'Inca R, Dubinsky M, Edwards C, Florin T, Franchimont D, Gearry R, Glas J, Van Gossum A, Guthery SL, Halfvarson J, Verspaget HW, Hugot JP, Karban A, Laukens D, Lawrance I, Lemann M, Levine A, Libioulle C, Louis E, Mowat C, Newman W, Panes J, Phillips A, Proctor DD, Regueiro M, Russell R, Rutgeerts P, Sanderson J, Sans M, Seibold F, Steinhart AH, Stokkers PC, Torkvist L, Kullak-Ublick G, Wilson D, Walters T, Targan SR, Brant SR, Rioux JD, D'Amato M, Weersma RK, Kugathasan S, Griffiths AM, Mansfield JC, Vermeire S, Duerr RH, Silverberg MS, Satsangi J, Schreiber S, Cho JH, Annese V, Hakonarson H, Daly MJ, Parkes M. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet 2010;42:1118-25.

100 Freiwald A, Mao L, Kodelja V, Kliem M, Schuldt D, Schreiber S, Franke A, Sauer S. Differential analysis of Crohn's disease and ulcerative colitis by mass spectrometry. Inflamm Bowel Dis 2010.

99 Gerdes S, Zahl VA, Weichenthal M, Mrowietz U. Smoking and alcohol intake in severely affected patients with psoriasis in Germany. Dermatology 2010; 220(1):38-43. PMID: 19996578

98 Groth M, Wiegand C, Szafranski K, Huse K, Kramer M, Rosenstiel P, Schreiber S, Norgauer J, Platzer M. Both copy number and sequence variations affect expression of human DEFB4. Genes Immun. 2010 Sep;11(6):458-66.

97 Haller, F., Von Heydebreck, A., Zhang, J., Gunawan, B., Langer, C., Ramadori, G., Wiemann, S. and Sahin, O. Localisation- and mutation-dependent microRNA (miRNA) expression signatures in gastrointestinal stromal tumors (GISTs), with a cluster of coexpressed miRNAs located at 14q32.31. J Pathol 220(1), 71-86.

96 Holm K, Melum E, Franke A, Karlsen TH. SNPexp - A web tool for calculating and visualizing correlation between HapMap genotypes and gene expression levels. BMC Bioinformatics 2010;11:600.

95 Homolka S, Meyer CG, Hillemann D, Owusu-Dabo E, Adjei O, Horstmann RD, Browne EN, Chinbuah A, Osei I, Gyapong J, Kubica T, Ruesch-Gerdes S, Niemann S. Unequal distribution of resistance-conferring mutations among Mycobacterium tuberculosis and Mycobacterium africanum strains from Ghana. Int J Med Microbiol. 2010 Nov;300(7):489-95.

94 Hov JR, Keitel V, Laerdahl JK, Spomer L, Ellinghaus E, ElSharawy A, Melum E,Boberg KM, Manke T, Balschun T, Schramm C, Bergquist A, Weismüller T, Gotthardt D, Rust C, Henckaerts L, Onnie CM, Weersma RK, Sterneck M, Teufel A, Runz H, Stiehl A, Ponsioen CY, Wijmenga C, Vatn MH; IBSEN Study Group, Stokkers PC, Vermeire S, Mathew CG, Lie BA, Beuers U, Manns MP, Schreiber S, Schrumpf E, Häussinger D, Franke A, Karlsen TH. Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis. PLoS One. 2010 Aug 25;5(8):e12403

93 Jacobsen M, Repsilber D, Kleinsteuber K, Gutschmidt A, Schommer-Leitner S, Black G, Walzl G, Kaufmann SH. Suppressor of cytokine signaling (SOCS)-3 is affected in T cells from TB patients. Clin Microbiol Infect. 2010 Jul 29.

92 Joecker A et al. Quantitative Analysis of Microspot Immunoassays. Bioinformatics 26: 2480-2481.

91 Jungersted JM, Scheer H, Mempel M, Baurecht H, Cifuentes L, Høgh JK, Hellgren LI, Jemec GB, Agner T, Weidinger S. Stratum corneum lipids, skin barrier function and filaggrin mutations in patients with atopic eczema. Allergy. 2010 Feb 4

90 Juran BD, Atkinson EJ, Schlicht EM, Larson JJ, Ellinghaus D, Franke A,Lazaridis KN. Genetic polymorphisms of matrix metalloproteinase 3 in primary sclerosing cholangitis. Liver Int. 2010 Dec 7. doi: 10.1111/j.1478-3231.2010.02420.x. [Epub ahead of print] PubMed PMID: 21134112.

89 Karlsen TH, Franke A, Melum E, Kaser A, Hov JR, Balschun T, Lie BA, Bergquist A, Schramm C, Weismüller TJ, Gotthardt D, Rust C, Philipp EE, Fritz T, Henckaerts L, Weersma RK, Stokkers P, Ponsioen CY, Wijmenga C, Sterneck M, Nothnagel M, Hampe J, Teufel A, Runz H, Rosenstiel P, Stiehl A, Vermeire S, Beuers U, Manns MP, Schrumpf E, Boberg KM, Schreiber S. Genome-wide association analysis in primary sclerosing cholangitis. Gastroenterology. 2010 Mar;138(3):1102-11. Epub 2009 Nov 26.

88 Karlsen TH, Melum E, Franke A. The utility of genome-wide associationstudiesin hepatology. Hepatology. 2010 Jan 28. [Epub ahead of print] PubMed PMID:20232293.

87 Kielbasa SM, Blüthgen N, Fähling M, Mrowka R. Targetfinder.org: a resource for systematic discovery of transcription factor target genes.Nucleic Acids Res. 2010:W233-8

86 Kielbasa SM, Klein H, Roider HG, Vingron M, Blüthgen N. TransFind--predicting transcriptional regulators for gene sets.Nucleic Acids Res. 2010:W275-80.

85 Kramer M, Backhaus O, Rosenstiel P, Horn D, Klopocki E, Birkenmeier G, Schreiber S, Platzer M, Hampe J, Huse K. Analysis of relative gene dosage and expression differences of the paralogs RABL2A and RABL2B by Pyrosequencing. Gene. 2010 Feb 4. [Epub ahead of print]

84 Kramer M, Huse K, Menzel U, Backhaus O, Rosenstiel P, Schreiber S, Hampe J, Platzer M. Constant Splice Isoform Ratios in Human Lymphoblastoid Cells Support the Concept of a Splico-Stat. Genetics. 2011 Jan 10. [Epub ahead of print]

83 Kuenzel S, Till A, Winkler M, Häsler R, Lipinski S, Jung S, Grötzinger J, Fickenscher H, Schreiber S, Rosenstiel P. The nucleotide-binding oligomerization domain-like receptor NLRC5 is involved in IFN-dependent antiviral immune responses. J Immunol. 2010 Feb 15;184(4):1990-2000.

82 Lin Z, Nelson L, Franke A, Poritz L, Li TY, Wu R, Wang Y, MacNeill C, Thomas NJ, Schreiber S, Koltun WA. OCTN1 variant L503F is associated with familial and sporadic inflammatory bowel disease. J Crohns Colitis 2010;4:132-8

81 Lin Z, Poritz L, Franke A, Li TY, Ruether A, Byrnes KA, Wang Y, Gebhard AW, MacNeill C, Thomas NJ, Schreiber S, Koltun WA. Genetic association of nonsynonymous variants of the IL23R with familial and sporadic inflammatory bowel disease in women. . Dig Dis Sci. 2010 Mar;55(3):739-46. Epub 2009 Mar 18.

80 Lindner I, Hemdan NY, Buchold M, Huse K, Bigl M, Oerlecke I, Ricken A, Gaunitz F, Sack U, Naumann A, Hollborn M, Thal D, Gebhardt R, Birkenmeier G. Alpha2-macroglobulin inhibits the malignant properties of astrocytoma cells by impeding beta-catenin signaling. Cancer Res. 2010, 70:277.

79 Manke T, Heinig M, Vingron M. Quantifying the effect of sequence variation on regulatory interactions.Hum Mutat. 2010 Feb 2.

78 Mathias RA, Grant AV, Rafaels N, Hand T, Gao L, Vergara C, Tsai YJ, Yang M,Campbell M, Foster C, Gao P, Togias A, Hansel NN, Diette G, Adkinson NF, Liu MC, Faruque M, Dunston GM, Watson HR, Bracken MB, Hoh J, Maul P, Maul T, Jedlicka AE, Murray T, Hetmanski JB, Ashworth R, Ongaco CM, Hetrick KN, Doheny KF, Pugh EW, Rotimi CN, Ford J, Eng C, Burchard EG, Sleiman PM, Hakonarson H, Forno E, Raby BA, Weiss ST, Scott AF, Kabesch M, Liang L, Abecasis G, Moffatt MF, Cookson WO, Ruczinski I, Beaty TH, Barnes KC. A genome-wide association study on African-ancestry populations for asthma. J Allergy Clin Immunol. 2010 Feb;125(2):336-346.e4. Epub 2009 Nov 11. PubMed PMID: 19910028.

77 Melum E, May S, Schilhabel MB, Thomsen I, Karlsen TH, Rosenstiel P, Schreiber S, Franke A. SNP discovery performance of two second-generation sequencingplatforms in the NOD2 gene region. Hum Mutat. 2010 Jul;31(7):875-85. PubMed PMID:20506538

76 Michel S, Liang L, Depner M, Klopp N, Ruether A, Kumar A, Schedel M, Vogelberg C, von Mutius E, von Berg A, Bufe A, Rietschel E, Heinzmann A, Laub O, Simma B, Frischer T, Genuneit J, Gut IG, Schreiber S, Lathrop M, Illig T, Kabesch M. Unifying candidate gene and GWAS Approaches in Asthma. PLoS One. 2010 Nov 12;5(11):e13894.

75 Möller M, Flachsbart F, Till A, Thye T, Horstmann RD, Meyer CG, Osei I, van Helden PD, Hoal EG, Schreiber S, Nebel A, Franke A. A functional haplotype in the 3'untranslated region of TNFRSF1B is associated with tuberculosis in two African populations.Am J Respir Crit Care Med. 2010 Feb 15;181(4):388-93.

74 Nothnagel M, Lu TT, Kayser M, Krawczak M. Genomic and geographic distribution of SNP-defined runs of homozygosity in Europeans. Hum Mol Genet. 2010 Aug 1;19(15):2927-35. Epub 2010 May 12. PMID: 20462934

73 Pinto LA, Depner M, Klopp N, Illig T, Vogelberg C, von Mutius E, Kabesch M. MMP-9 gene variants increase the risk for non-atopic asthma in children. Respir Res. 2010 Feb 24;11:23. PubMed PMID: 20181264;

72 Ramírez F, Albrecht M. Finding scaffold proteins in interactomes. Trends Cell Biol. 2010 Jan;20(1):2-4.

71 Rubin D, Helwig U, Nothnagel M, Fölsch UR, Schreiber S, Schrezenmeir J. Association of postprandial and fasting triglycerides with traits of the metabolic syndrome in the Metabolic Intervention Cohort Kiel. Eur J Endocrinol. 2010 Apr;162(4):719-27. Epub 2010 Jan 14.

70 Rzehak P, Scherag A, Grallert H, Sausenthaler S, Koletzko S, Bauer CP, Schaaf B, von Berg A, Berdel D, Borte M, Herbarth O, Krämer U, Illig T, Wichmann HE, Hebebrand J, Heinrich J. GINI and LISA Study Group. Associations between BMI and the FTO gene are age dependent: results from the GINI and LISA birth cohort studies up to age 6 years. Obes Facts. 2010 Jun;3(3):173-80

69 Schaefer AS, Richter GM, Nothnagel M, Laine ML, Noack B, Glas J, Schrezenmeir J, Groessner-Schreiber B, Jepsen S, Loos BG, Schreiber S. COX-2 is associated with periodontitis in Europeans. J Dent Res. 2010 Apr;89(4):384-8. Epub 2010 Feb 22.

68 Schaefer AS, Richter GM, Nothnagel M, Manke T, Dommisch H, Jacobs G, Arlt A, Rosenstiel P, Noack B, Groessner-Schreiber B, Jepsen S, Loos BG, Schreiber S. A genome-wide association study identifies GLT6D1 as a susceptibility locus for periodontitis. Hum Mol Genet. 2010 Feb 1;19(3):553-62. Epub 2009 Nov 6.

67 Schlicker A, Albrecht M. FunSimMat update: new features for exploringfunctional similarity. Nucleic Acids Res. 2010 Jan;38(Database issue):D244-8.

66 Schlicker F, Lengauer T, Albrecht M. Improving disease gene prioritization using the semantic similarity of Gene Ontology terms. Bioinformatics. 2010 Sep 15;26(18):i561-7

65 Schulte JH, Marschall T, Martin M, Rosenstiel P, Mestdagh P, Schlierf S, Thor T, Vandesompele J, Eggert A, Schreiber S, Rahmann S, Schramm A. Deep sequencing reveals differential expression of microRNAs in favorable versus unfavorableneuroblastoma. Nucleic Acids Res. 2010 Sep 1;38(17):5919-28. Epub 2010 May 13.PubMed PMID: 20466808; PubMed Central PMCID: PMC2943620.

64 Sina C, Arlt A, Gavrilova O, Midtling E, Kruse ML, Müerköster SS, Kumar R, Fölsch UR, Schreiber S, Rosenstiel P, Schäfer H. Ablation of gly96/immediate early gene-X1 (gly96/iex-1) aggravates DSS-induced colitis in mice: role for gly96/iex-1 in the regulation of NF-kappaB. Inflamm Bowel Dis. 2010 Feb;16(2):320-31.

63 Sinha R, Lenser T, Jahn N, Gausmann U, Friedel S, Szafranski K, Huse K, Rosenstiel P, Hampe J, Schuster S, Hiller M, Backofen R, Platzer M. TassDB2 - A comprehensive database of subtle alternative splicing events. BMC Bioinformatics. 2010 Apr 29;11:216.

62 Stuart PE, Nair RP, Ellinghaus E, Ding J, Tejasvi T, Gudjonsson JE, Li Y, Weidinger S, Eberlein B, Gieger C, Wichmann HE, Kunz M, Ike R, Krueger GG, Bowcock AM, Mrowietz U, Lim HW, Voorhees JJ, Abecasis GR, Weichenthal M, Franke A, Rahman P, Gladman DD, Elder JT. Genome-wide association analysis identifies three psoriasis susceptibility loci. Nat Genet. 2010 Nov;42(11):1000-4

61 Sun LD, Cheng H, Wang ZX, Zhang AP, Wang PG, Xu JH, Zhu QX, Zhou HS, Ellinghaus E, Zhang FR, Pu XM, Yang XQ, Zhang JZ, Xu AE, Wu RN, Xu LM, Peng L, Helms CA, Ren YQ, Zhang C, Zhang SM, Nair RP, Wang HY, Lin GS, Stuart PE, Fan X, Chen G, Tejasvi T, Li P, Zhu J, Li ZM, Ge HM, Weichenthal M, Ye WZ, Zhang C, Shen SK, Yang BQ, Sun YY, Li SS, Lin Y, Jiang JH, Li CT, Chen RX, Cheng J, Jiang X, Zhang P, Song WM, Tang J, Zhang HQ, Sun L, Cui J, Zhang LJ, Tang B, Huang F, Qin Q, Pei XP, Zhou AM, Shao LM, Liu JL, Zhang FY, Du WD, Franke A, Bowcock AM, Elder JT, Liu JJ, Yang S, Zhang XJ.  Association analyses identify six new psoriasis susceptibility loci in the Chinese population. Nat Genet 2010;42(11):1005-9.

60 Suttner K, Depner M, Wetzke M, Klopp N, von Mutius E, Illig T, Sparwasser T, Kabesch M. Genetic variants harbored in the forkhead box protein 3 locus increase hay fever risk. J Allergy Clin Immunol. 2010 Jun;125(6):1395-9. Epub 2010 Apr 15

59 Sventoraityte J, Zvirbliene A, Franke A, Kwiatkowski R, Kiudelis G, Kupcinskas L, Schreiber S. NOD2, IL23R and ATG16L1 polymorphisms in Lithuanian patients with inflammatory bowel disease.  World J Gastroenterol. 2010 Jan 21;16(3):359-64.

58 Taudien S, Groth M, Huse K, Petzold A, Szafranski K, Hampe J, Rosenstiel P, Schreiber S, Platzer M. Haplotyping and copy number estimation of the highly polymorphic human beta-defensin locus on 8p23 by 454 amplicon sequencing. BMC Genomics. 2010 Apr 19;11(1):252

57 The GABRIEL consortium (incl. Lee YA, Esparza-Gordillo J, Marenholz I). A GABRIEL Consortium Large-Scale Genome-Wide Association Study of Asthma. N Engl J Med. 2010.

56 Thier S, Lorenz D, Nothnagel M, Stevanin G, Dürr A, Nebel A, Schreiber S, Kuhlenbäumer G, Deuschl G, Klebe S. LINGO1 polymorphisms are associated with essential tremor in Europeans. Mov Disord. 2010 Mar 22. [Epub ahead of print]

55 Thye T, Ehmen C, Intemann CD, Chinbuah MA, Ziegler A, Horstmann RD, Meyer CG. Rare human IFNG variants. J Interferon Cytokine Res. 2010 Apr;30(4):219-22.

54 Thye T, Vannberg FO, Wong SH, Owusu-Dabo E, Osei I, Gyapong J, Sirugo G, Sisay-Joof F, Enimil A, Chinbuah MA, Floyd S, Warndorff DK, Sichali L, Malema S, Crampin AC, Ngwira B, Teo YY, Small K, Rockett K, Kwiatkowski D, Fine PE, Hill PC, Newport M, Lienhardt C, Adegbola RA, Corrah T, Ziegler A; African TB Genetics Consortium; Wellcome Trust Case Control Consortium, Morris AP, Meyer CG, Horstmann RD, Hill AV. Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.Nat Genet. 2010 Sep;42(9):739-41.

53 Uhlmann et al. miR-200bc/429 cluster targets PLCgamma1 and differentially regulates proliferation and EGF-driven invasion than miR-200a/141 in breast cancer. Oncogene 29: 4297-4306.

52 von Kampen O, Lipinski S, Till A, Martin SJ, Nietfeld W, Lehrach H, Schreiber S, Rosenstiel P. The caspase recruitment domain-containing protein 8 (CARD8) negatively regulates NOD2-mediated signaling. J Biol Chem. 2010 Apr 12. [Epub ahead of print]

51 Weidinger S, Baurecht H, Naumann A, Novak N. Genome-wide association studies on IgE regulation: are genetics of IgE also genetics of atopic disease? Curr Opin Allergy Clin Immunol. 2010 Oct;10(5):408-17

50 Wittig M, Helbig I, Schreiber S, Franke A. CNVineta: a data mining tool for large case-control copy number variation datasets. Bioinformatics. 2010 Sep 1;26(17):2208-9. Epub 2010 Jul 6.

49 Wittkop T, Emig D, Lange S, Rahmann S, Albrecht M, Morris JH, Böcker S, Stoye J, Baumbach J. Partitioning biological data with transitivity clustering. Nat Methods. 2010 Jun;7(6):419-20.

2009

48 Blankenburg H, Finn RD, Prli A, Jenkinson AM, Ramírez F, Emig D, SchelhornSE, Büch J, Lengauer T, Albrecht M. DASMI: exchanging, annotating and assessing molecular interaction data. Bioinformatics. 2009 May 15;25(10):1321-8.

47 Blankenburg H, Ramírez F, Büch J, Albrecht M. DASMIweb: online integration,analysis and assessment of distributed protein interaction data. Nucleic AcidsRes. 2009 Jul 1;37(Web Server issue):W122-8.

46 Brosbøl-Ravnborg A, Hvas CL, Agnholt J, Dahlerup JF, Vind I, Till A, Rosenstiel P, Höllsberg P. Toll-like receptor-induced granulocyte-macrophage colony-stimulating factor secretion is impaired in Crohn's disease by nucleotide oligomerization domain 2-dependent and -independent pathways. Clin Exp Immunol. 2009 Mar;155(3):487-95.

45 Ellinghaus D, Schreiber S, Franke A, Nothnagel M. Current software for genotype imputation. Hum Genomics. 2009 Jul;3(4):371-80

44 El Sharawy A, Hundrieser B, Brosch M, Wittig M, Huse K, Platzer M, Becker A, Simon M, Rosenstiel P, Schreiber S, Krawczak M, Hampe J. Systematic evaluation of the effect of common SNPs on pre-mRNA splicing. Hum Mutat. 2009 Apr;30(4):625-32.

43 End C, Bikker F, Renner M, Bergmann G, Lyer S, Blaich S, Hudler M, Helmke B, Gassler N, Autschbach F, Ligtenberg AJ, Benner A, Holmskov U, Schirmacher P, Nieuw Amerongen AV, Rosenstiel P, Sina C, Franke A, Hafner M, Kioschis P, Schreiber S, Poustka A, Mollenhauer J. DMBT1 functions as pattern-recognition molecule for poly-sulfated and poly-phosphorylated ligands. Eur J Immunol. 2009 Mar;39(3):833-42.

42 Esparza-Gordillo J, Weidinger S, Fölster-Holst R, Bauerfeind A, Ruschendorf F, Patone G, Rohde K, Marenholz I, Schulz F, Kerscher T, Hubner N, Wahn U, Schreiber S, Franke A, Vogler R, Heath S, Baurecht H, Novak N, Rodriguez E, Illig T, Lee-Kirsch MA, Ciechanowicz A, Kurek M, Piskackova T, Macek M, Lee YA, Ruether A. A common variant on chromosome 11q13 is associated with atopic dermatitis. Nat Genet. 2009 May;41(5):596-601. Epub 2009 Apr 6.

41 Helbig I, Mefford HC, Sharp AJ, Guipponi M, Fichera M, Franke A, Muhle H, de Kovel C, Baker C, von Spiczak S, Kron KL, Steinich I, Kleefuß-Lie AA, Leu C, Gaus V, Schmitz B, Kein KM, Reif PS, Rosenow F, Weber Y, Lerche H, Zimprich F, Urak L, Fuchs K, Feucht M, Genton P, Thomas P, Visscher1 F, de Haan GJ, Møller RS, Hjalgrim H, Luciano D, Wittig M, Nothnagel M, Elger CE, Nürnberg P, Romano C, Malafosse A, Koeleman BP, Lindhout D, Stephani U, Schreiber S, Eichler EE, Sander T. 15q13.3 microdeletions increase risk of idiopathic generalized epilepsy. Nat Genet. 2009 Feb;41(2):160-2. Epub 2009 Jan 11.

40 Lin Z, Poritz L, Franke A, Li TY, Ruether A, Byrnes KA, Wang Y, Gebhard AW, MacNeill C, Thomas NJ, Wu R, Schreiber S, Koltun WA. Genetic association of DLG5 R30Q with familial and sporadic inflammatory bowel disease in men. Dis Markers. 2009;27(5):193-201.

39 Lipinski S, Till A, Sina C, Arlt A, Grasberger H, Schreiber S, Rosenstiel P. DUOX2-derived reactive oxygen species are effectors of NOD2-mediated antibacterial responses. J Cell Sci. 2009 Oct 1;122(Pt 19):3522-30.

38 Loos BG, Fiebig A, Nothnagel M, Jepsen S, Groessner-Schreiber B, Franke A, Jervøe-Storm PM, Schenck K, van der Velden U, Schreiber S. NOD1 gene polymorphisms in relation to aggressive periodontitis. Innate Immun. 2009 Aug;15(4):225-32

37 Lu TT, Lao O, Nothnagel M, Junge O, Freitag-Wolf S, Caliebe A, Balascakova M, Bertranpetit J, Bindoff LA, Comas D, Holmlund G, Kouvatsi A, Macek M, Mollet I, Nielsen F, Parson W, Palo J, Ploski R, Sajantila A, Tagliabracci A, Gether U, Werge T, Rivadeneira F, Hofman A, Uitterlinden AG, Gieger C, Wichmann HE, Ruether A, Schreiber S, Becker C, Nürnberg P, Nelson MR, Kayser M, Krawczak M. An evaluation of the genetic-matched pair study design using genome-wide SNP data from the European population. Eur J Hum Genet. 2009 Jul;17(7):967-75

36 Mahachie JJM, Baurecht H, Rodríguez E, Naumann A, Wagenpfeil S, Klopp N, Mempel M, Novak N, Bieber T, Wichmann HE, Ring J, Illig T, Cattaert T, Van Steen K, Weidinger S. Analysis of the high affinity IgE receptor genes reveals epistatic effects of FCER1A variants on eczema risk. Allergy. 2009 Dec 21.

35 Marenholz I, Kerscher T, Bauerfeind A, Esparza-Gordillo J, Nickel R, Keil T, Lau S, Rohde K, Wahn U, Lee YA. An interaction between filaggrin mutations and early food sensitization improves the prediction of childhood asthma. J Allergy Clin Immunol 123, 911-916. 2009.

34 Marenholz I, Lee YA. Die Genetik des atopischen Ekzems ? Neue Gene und Pathomechanismen. Med Genetik 21, 493-497. 2009.

33 Melum E, Franke A, Karlsen TH. Genome-wide association studies--a summary for the clinical gastroenterologist. World J Gastroenterol. 2009 Nov 21;15(43):5377-96.

32 Möckelmann N, von Schönfels W, Buch S, von Kampen O, Sipos B, Egberts JH, Rosenstiel P, Franke A, Brosch M, Hinz S, Röder C, Kalthoff H, Fölsch UR, Krawczak M, Schreiber S, Bröring CD, Tepel J, Schafmayer C, Hampe J. Investigation of innate immunity genes CARD4, CARD8 and CARD15 as germline susceptibility factors for colorectal cancer. BMC Gastroenterol. 2009 20;9:79.

31 Muller S, Marenholz I, Lee YA, Sengler C, Zitnik SE, Griffioen RW, Meglio P, Wahn U, Nickel R. Association of Filaggrin loss-of-function-mutations with atopic dermatitis and asthma in the Early Treatment of the Atopic Child (ETAC) population. Pediatr Allergy Immunol 20, 358-361. 2009.

30 Nair RP, Duffin KC, Helms C, Ding J, Stuart PE, Goldgar D, Gudjonsson JE, Li Y, Tejasvi T, Feng BJ, Ruether A, Schreiber S, Weichenthal M, Gladman D, Rahman P, Schrodi SJ, Prahalad S, Guthery SL, Fischer J, Liao W, Kwok PY, Menter A, Lathrop GM, Wise CA, Begovich AB, Voorhees JJ, Elder JT, Krueger GG, Bowcock AM, Abecasis GR.  Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. Nat Genet 2009; 41(2):199-204. doi:10.1038/ng.311 PMCID: PMC2745122

29 Nothnagel M, Ellinghaus D, Schreiber S, Krawczak M, Franke A. Acomprehensive evaluation of SNP genotype imputation. Hum Genet. 2009Mar;125(2):163-71. Epub 2008 Dec 17.

28 Rodríguez E, Baurecht H, Herberich E, Wagenpfeil S, Brown SJ, Cordell HJ, Irvine AD, Weidinger S. Meta-analysis of filaggrin polymorphisms in eczema and asthma: robust risk factors in atopic disease. J Allergy Clin Immunol. 2009 Jun;123(6):1361-70.e7.

27 Rosenstiel P, Schreiber S. NOD-like receptors--pivotal guardians of the immunological integrity of barrier organs. Adv Exp Med Biol. 2009;653:35-47. Review.

26 Rosenstiel P, Sina C, Franke A, Schreiber S. Towards a molecular risk map--recent advances on the etiology of inflammatory bowel disease. Semin Immunol. 2009 Dec;21(6):334-45. Epub 2
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25 Sahin O, Wiemann S. Functional genomics and proteomics approaches to study the ERBB network in cancer. FEBS Lett. 2009 Jun 5;583(11):1766-71. Epub 2009 Mar 20.

24 Sahin, O. et al. (2009). Modeling of ERBB receptor-regulated G1/S transition to find novel targets for de novo trastuzumab resistance. BMC Systems Biology 2009, 3, 1.

23 Schaefer AS, Richter GM, Groessner-Schreiber B, Noack B, Nothnagel M, El Mokhtari NE, Loos BG, Jepsen S, Schreiber S. Identification of a shared genetic susceptibility locus for coronary heart disease and periodontitis. PLoS Genet. 2009 Feb;5(2):e1000378

22 Schedel M, Frei R, Bieli C, Cameron L, Adamski J, Lauener R, Kabesch M. AnIgE-associated polymorphism in STAT6 alters NF-kappaB binding, STAT6 promoter activity, and mRNA expression. J Allergy Clin Immunol. 2009 Sep;124(3):583-9, 589.e1-6. Epub 2009 Aug 8. PubMed PMID: 19665768.

21 Siddiqui RA, Sauermann U, Altmüller J, Fritzer E, Nothnagel M, Dalibor N, Fellay J, Kaup FJ, Stahl-Hennig C, Nürnberg P, Krawczak M, Platzer M. X chromosomal variation is associated with slow progression to AIDS in HIV-1-infected women. Am J Hum Genet. 2009 Aug;85(2):228-39.

20 Sina C, Gavrilova O, Förster M, Till A, Derer S, Hildebrand F, Raabe B, Chalaris A, Scheller J, Rehmann A, Franke A, Ott S, Häsler R, Nikolaus S, Fölsch UR, Rose-John S, Jiang HP, Li J, Schreiber S, Rosenstiel P. G protein-coupled receptor 43 is essential for neutrophil recruitment during intestinal inflammation. J Immunol. 2009 Dec 1;183(11):7514-22. Epub 2009 Nov 16.

19 Sinha R, Nikolajewa S, Szafranski K, Hiller M, Jahn N, Huse K, Platzer M, Backofen R. Accurate prediction of NAGNAG alternative splicing. Nucleic Acids Res. 2009 ,37:3569.

18 Steubesand N, Kiehne K, Brunke G, Pahl R, Reiss K, Herzig KH, Schubert S, Schreiber S, Fölsch UR, Rosenstiel P, Arlt A. The expression of the beta-defensins hBD-2 and hBD-3 is differentially regulated by NF-kappaB and MAPK/AP-1 pathways in an in vitro model of Candida esophagitis. BMC Immunol. 2009 Jun 12;10:36.

17 Suttner K, Rosenstiel P, Depner M, Schedel M, Pinto LA, Ruether A, Adamski J, Klopp N, Illig T, Vogelberg C, Schreiber S, von Mutius E, Kabesch M. TBX21 gene variants increase childhood asthma risk in combination with HLX1 variants. J Allergy Clin Immunol. 2009 May;123(5):1062-8, 1068.e1-8. Epub 2009 Apr 10.

16 Suttner K, Ruoss I, Rosenstiel P, Depner M, Pinto LA, Schedel M, Adamski J, Illig T, Schreiber S, von Mutius E, Kabesch M. HLX1 gene variants influence the development of childhood asthma. J Allergy Clin Immunol. 2009 Jan;123(1):82-88.e6.

15 Temple G, Gerhard DS, Rasooly R, Feingold EA, Good PJ, Robinson C, Mandich A, Derge JG, Lewis J, Shoaf D, Collins FS, Jang W, Wagner L, Shenmen CM, Misquitta L, Schaefer CF, Buetow KH, Bonner TI, Yankie L, Ward M, Phan L, Astashyn A, Brown G, Farrell C, Hart J, Landrum M, Maidak BL, Murphy M, Murphy T, Rajput B, Riddick L, Webb D, Weber J, Wu W, Pruitt KD, Maglott D, Siepel A, Brejova B, Diekhans M, Harte R, Baertsch R, Kent J, Haussler D, Brent M, Langton L, Comstock CL, Stevens M, Wei C, van Baren MJ, Salehi-Ashtiani K, Murray RR, Ghamsari L, Mello E, Lin C, Pennacchio C, Schreiber K, Shapiro N, Marsh A, Pardes E, Moore T, Lebeau A, Muratet M, Simmons B, Kloske D, Sieja S, Hudson J, Sethupathy P, Brownstein M, Bhat N, Lazar J, Jacob H, Gruber CE, Smith MR, McPherson J, Garcia AM, Gunaratne PH, Wu J, Muzny D, Gibbs RA, Young AC, Bouffard GG, Blakesley RW, Mullikin J, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Hirst M, Zeng T, Tse K, Moksa M, Deng M, Ma K, Mah D, Pang J, Taylor G, Chuah E, Deng A, Fichter K, Go A, Lee S, Wang J, Griffith M, Morin R, Moore RA, Mayo M, Munro S, Wagner S, Jones SJ, Holt RA, Marra MA, Lu S, Yang S, Hartigan J, Graf M, Wagner R, Letovksy S, Pulido JC, Robison K, Esposito D, Hartley J, Wall VE, Hopkins RF, Ohara O, Wiemann S. MGC Project Team.  The completion of the Mammalian Gene Collection (MGC). Genome Res. 2009 Dec;19(12):2324-33. Epub 2009 Sep 18.

14 Yu X, Wieczorek S, Franke A, Yin H, Pierer M, Sina C, Karlsen TH, Boberg KM, Bergquist A, Kunz M, Witte T, Gross WL, Epplen JT, Alarcón-Riquelme ME, Schreiber S, Ibrahim SM. Association of UCP2 -866 G/A polymorphism with chronic inflammatory diseases. Genes Immun. 2009 Sep;10(6):601-5. Epub 2009 Apr 23.

13 Zeilinger S, Pinto LA, Nockher WA, Depner M, Klopp N, Illig T, von Mutius E,Renz H, Kabesch M. The effect of BDNF gene variants on asthma in German children. Allergy. 2009 Dec;64(12):1790-4. PubMed PMID: 19895626.

12 Zhang, J. D. & Wiemann, S. KEGGgraph: a graph approach to KEGG PATHWAY in R and Bioconductor. Bioinformatics. 2009 Jun; 25(11):1470-1.

2008

11 Fiebig A, Jepsen S, Loos BG, Scholz C, Schäfer C, Rühling A, Nothnagel M, Eickholz P, van der Velden U, Schenck K, Schreiber S, Grössner-Schreiber B. Polymorphisms in the interleukin-1 (IL1) gene cluster are not associated with aggressive periodontitis in a large Caucasian population. Genomics. 2008 Nov;92(5):309-15. Epub 2008 Sep 18.PMID: 18723088

10 Franke A, Balschun T, Karlsen TH, Sventoraityte J, Nikolaus S, Mayr G,Domingues FS, Albrecht M, Nothnagel M, Ellinghaus D, Sina C, Onnie CM,Weersma RK, Stokkers PC, Wijmenga C, Gazouli M, Strachan D, McArdle WL,Vermeire S, Rutgeerts P, Rosenstiel P, Krawczak M, Vatn MH; IBSEN studygroup, Mathew CG, Schreiber S. Sequence variants in IL10, ARPC2 andmultiple other loci contribute to ulcerative colitis susceptibility. Nat Genet. 2008 Nov;40(11):1319-23. Epub 2008 Oct 5.

9 Hofmann S, Franke A, Fischer A, Jacobs G, Nothnagel M, Gaede KI, Schürmann M, Müller-Quernheim J, Krawczak M, Rosenstiel P, Schreiber S. Genome-wide association study identifies ANXA11 as a new susceptibility locus for sarcoidosis. Nat Genet. 2008 Sep;40(9):1103-6. PMID: 19165924

8 Lao O, Lu TT, Nothnagel M, Junge O, Freitag-Wolf S, Caliebe A, Balascakova M, Bertranpetit J, Bindoff LA, Comas D, Holmlund G, Kouvatsi A, Macek M, Mollet I, Parson W, Palo J, Ploski R, Sajantila A, Tagliabracci A, Gether U, Werge T, Rivadeneira F, Hofman A, Uitterlinden AG, Gieger C, Wichmann HE, Rüther A, Schreiber S, Becker C, Nürnberg P, Nelson MR, Krawczak M, Kayser M. Correlation between genetic and geographic structure in Europe. Curr Biol. 2008 Aug 26;18(16):1241-8. Epub 2008 Aug 7.

7 Mathivanan, S. et al. (2008). Human Proteinpedia enables sharing of human protein data. Nat Biotechnol 26, 164-7.

6 Nair RP, Ruether A, Stuart PE, Jenisch S, Tejasvi T, Hiremagalore R, Schreiber S, Kabelitz D, Lim HW, Voorhees JJ, Christophers E, Elder JT, Weichenthal M. Polymorphisms of the IL12B and IL23R genes are associated with psoriasis. J Invest Dermatol 2008;128(7):1653-61. PMID: 18219280

5 Nothnagel M, Lu TT, Krawczak M. Hypotheses in genome-wide association scans. Eur J Hum Genet. 2008 Oct;16(10):1174-5; author reply 1175. Epub 2008 May 14. PMID: 18478034

4 Pepperkok, R. and Wiemann, S. (2008). Integrating systems biology with clinical research. Genome Biol 9, 314.

3 Sansone, S.A. et al. (2008). The first RSBI (ISA-TAB) workshop: can a simple format work for complex studies? Omics 12, 143-9.

2 Taylor, C.F. et al. (2008). Promoting coherent minimum reporting guidelines for biological and biomedical investigations: the MIBBI project. Nat Biotechnol 26, 889-96.

1 Weidinger S, O'Sullivan M, Illig T, Baurecht H, Depner M, Rodriguez E, Ruether A, Klopp N, Vogelberg C, Weiland SK, McLean WH, von Mutius E, Irvine AD, Kabesch M. Filaggrin mutations, atopic eczema, hay fever, and asthma in children. J Allergy Clin Immunol. 2008 May;121(5):1203-1209.e1. Epub 2008 Apr 8.

   
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