Data integration and modelling

Coordinator:		Dr. Christoph Wierling
Institution:		Max-Planck-Institut für Molekulare Genetik
Homepage:		www.molgen.mpg.de/

TP10 delivers the computational framework for the IG, in particular an integrated framework for data analysis and correlation, a tool for comprehensive network annotations of reactions affected by mutated cancer genes and methods and tools for the kinetic modelling of relevant network modules.

In the course of this IG we plan:
1.) to integrate the heterogeneous project data types in an existing, XML-based data integration system by implementing new XML schemas and digesters for the indexing process for those data types not yet included into the system (for example functional assays),
2.) to extend the pathway database integration system ConsensusPathDB, CPDB, with information on gene mutations and their effects on the molecular interactions (for example loss-of-function) and
3.) to develop a predictive cancer net model for the prediction of mutation effects, associated cell phenotypes and potential effective therapies based on intensive parameter fitting with experimental data.




Additional relevant Internet link:
The Mutanom project