NGFN-PLUS

Cancer Genome comparison

Coordinator:    Dr. Tim Strom
Institution: Helmholtz Zentrum München
Homepage: www.helmholtz-muenchen.de
We will develop a selection process for genomic elements that will allow HT sequencing of defined loci in cancer patients and respective cell lines. We will address exon and splice signal sequences as well as promoter sequences for up to 4000 loci in parallel. With respect to the methylation analysis of promoters, we will also develop a nano-bisulfite treatment method that will allow us to use subnanogram amounts of genomic DNA in bisulfite sequencing. As "Gold Standard" we will use sequence information of the same samples, generated by classical methods (established in NGFN2/NGFN plus Braintumor Net and SMP Epigenetics).
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