Clinical Chemical Screen

Coordinator:		Prof. Dr. Eckhard Wolf
Institution:		Lehrstuhl für Molekulare Tierzucht und Biotechnologie, LMU München
Homepage:		www.lmb.uni-muenchen.de/groups/

Numerous genetic modifications exert a primary or secondary influence on essential metabolic processes or organ functions. This typically affects clinical-chemical and/or hematological blood parameters. The team of the clinical-chemistry screen at the German Mouse Clinic has established a broad spectrum of diagnostic methods. Their application allows the determination of a wide variety of essential laboratory diagnostic parameters with high precision and high throughput and is therefore a central part of the comprehensive phenotypic characterization of mutant mouse lines at the German Mouse Clinic. We have been involved in the generation of new knowledge about uromodulin-associated kidney disease (Kemter et al. 20009, Kemter et al. 2013), in the establishment and characterization of a new mouse model for systemic autoimmune disease (Sabrautzki et al. 2013) and in the discovery of hitherto unknown factors influencing body mass gain (Olszewski et al. 2012). We characterized FcRn-transgenic mice, which are used for studies on pharmacokinetics (Stein et al. 2012) and investigated the effects of trypanosome infection on different mouse inbred strains and selected congenic lines (Noyes et al. 2009, Rathkolb et al. 2009). By participating in European and international projects for the characterization of mouse knockout lines (EUMODIC, IMPC) we have been and will be involved in the generation of a database providing freely accessible data on the phenotypic consequences of single-gene-knockouts in mice.