NGFN-PLUS

Mutational analysis

Coordinator:    Dr. Dr. Michal Schweiger
Institution: Max-Planck Institut für molkulare Genetik
Homepage: www.molgen.mpg.de
For the mutational profiling approach we are interested in fundamental cancer relevant pathways. Once matured, the developed technologies and models will be easily transferable and applicable to other genetic diseases. However, in this project we will focus on sequencing cancer relevant genes and regulatory sequences of a broad spectrum of different tumors and cell lines to detect common aberrations. We will perform sequence-specific enrichments of cancer relevant genes and regulatory regions followed by Solexa next-generation sequencing. The sequencing of established cancer cell lines will help to choose optimal cell lines for further proteomic and functional analyses. Different tumor tissues will be provided from our clinical partners. Based on the mutational profiles for each tumor we will develop a sequencing module which will be further on tested for its applicability in large prospective clinical studies.



Additional relevant Internet link:
The Mutanom project
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