RNomics of viral infections
|Coordinator:||PD Dr. Lutz Walter|
|Institution:||Deutsches Primatenzentrum - Leibniz-Institut für Primatenforschung|
Subproject RNomics of viral infections aims at identification and selection of certain RNA transcripts, which play a fundamental role in the regulation of genes. These so-called npcRNA (non-protein coding ribonucleic acid) molecules will be tested for their potential to interfere with the pathogenesis of AIDS upon infection with human immunodeficiency virus (HIV) or simian immunodeficiency virus (SIV). These experiments will give us insights into how these viruses use the npcRNA molecules of the infected host for their own purposes. Experimental infections with HIV and SIV will be performed in vitro in appropriate cell culture systems, leading to the identification of candidate npcRNAs. The role of candidate npcRNAs in viral infection and latency will be evaluated in cell culture systems and in isolated blood cells from rhesus macaques. Highly promising and significant candidates will be used as putative targets for the development of anti-HIV therapies in close cooperation with an industrial partner.