Alterations of the mouse brain proteome associated with the early development of diet-induced obesity in the mouse

Coordinator:		Prof. Dr. Martin Klingenspor, Dr. Kai Stühler
Institution:		Technische Universität München
Homepage:		www.molekulare-ernaehrungsmedizin.de/

The IG „Molecular Mechanisms of Obesity“ aims to identify genes and alleles that predispose individuals to become obese and to validate the epidemiological, functional, clinical and therapeutical implications for the development of obesity. In subproject 3 „Alterations of the proteome associated with the development of diet-induced obesity“ (workblock 1) Prof. Martin Klingenspor (Molecular Nutritional Medicine, Technische Universität München) and Dr. Kai Stühler (Prof. Helmut Meyer, Medical Proteom Center, Ruhr Universität Bochum) collaborate to study proteome alterations in selected tissues associated with the development obesity in response to high-fat diets. This subproject combines expertise in the physiology of the energy balance control system with state-of-the-art proteome analysis technology. Proteomics aims at describing all the proteins expressed by a genome in a given cell at a given time. In proteomics, the proteins of an organism or a specific tissue type are studied by differential analysis. This technology is widely applied to the comparative study of protein expression patterns in diseased versus normal tissues. The experiments can be referred to as unbiased or discovery-oriented proteomics. Here, the application of this technology will increase our understanding of the molecular mechanisms favouring the development of diet-induced obesity.


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The Center of Diet and Disease (CDD):