NGFN-PLUS

High-throughput sequencing of functional and positional candidate genes for common forms of migraine and epilepsy

Coordinator:    Prof. Dr. Peter Nürnberg
Institution: Cologne Center for Genomics (CCG)
Homepage: http://www.ccg.uni-koeln.de/nuernberg.html
In addition to the well known role of common genetic variation, there is increasing evidence also for an involvement of rare coding variants in the etiology of complex inherited diseases. This type of variation can not be analyzed by association approaches but has to be investigated by systematic high-throughput sequencing studies in large patient and control samples. Whereas conventional sequencing technologies could not offer an affordable and fast solution for this urgent question, the so called next-generation sequencing technologies promise to fill this gap. This project provides a high-throughput sequencing platform (based on e. g. the 454 sequencing technology) for members of EMINet to systematically look for rare genetic variants in a large number of candidate genes for epilepsy and migraine, which are both common disorders of neuronal excitability. Members of the network will jointly define a list of functional candidate genes (coding e. g. for neuronal ion channels, neurotransmitters and receptors, synaptic proteins) as well as of positional candidate genes stemming from genome-wide linkage and association approaches performed in this network.


Additional relevant Internet link:
Cologne Center for Genomics
SEARCH
INTRANET (Members login)
login:
password:
KTT
MEDIA
NGFN-MEETING-2012
NGFN- MEETING
LINKS