NGFN-PLUS

Identification of clinical relevant protein markers of prostate carcinoma

Coordinator:    Prof. Dr. Tim Brümmendorf
Institution: Universitätsklinikum Hamburg Eppendorf, Onkologisches Zentrum, Klinik für Onkologie und Hämatologie
Homepage: www.uke.de/
This project expands the IG screening campaign to the protein level. Carcinogenesis is a complex process resulting not only from dysregulated gene and protein expression but also from posttranslational modification of expressed proteins. Posttranslational modifications have substantial impact on protein function. Proteomics screening for altered proteins – although still more labor-intensive than RNA- and DNA screening – may thus be the most promising procedure to identify relevant targets. The current proposal will especially benefit from a) almost unlimited availability of unfixed prostate cancer tissue and b) the possibility to link proteomics data with a gene amplification and RNA expression database.
Specific aims of this proposal are:
A) Intraindividual tumor progression: Identification of proteins that show distinct alterations during progression from histologically normal to prostatic intraepithelial neoplasia (PIN) and to invasive carcinoma.
B) Identification of early cancer predisposing marker: Identification of proteins that show distinct differences during progression from histologically normal tissue in prostate cancer patients and histologically normal tissue from non-cancer patients .
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