The Muenster MR Centre

Coordinator:		Prof. Dr. med. Peter Wieacker
Institution:		Institut für Humangenetik, Universitätsklinikum Münster, Universität Münster
Homepage:		humangenetik.klinikum.uni-muenster.de/

Patients with syndromic and non-syndromic forms of mental retardation will be analysed by Array CGH to identify microdeletions and microduplications in order to search for new candidate genes. Furthermore, breakpoints of de novo-translocations/inversions in patients with mental retardation will be characterized to detect genes disrupted by these aberrations.

Beside the molecular karyotyping of patients with mental retardation there is an intensive exchange with other subprojects of the MRNET consortium to
1) delineate syndromes and identify patients with similar phenotypes,
2) functional analysis of candidate genes and
3) to standardize methods and quality parameters.

Goal of this project is a contribution for better medical management and therapeutic interventions of patients with mental retardation.



Additional relevant Internet link:
German Mental Retardation Network