NGFN-PLUS
DiGTOP bioinformatics: resource development and application in comparative network analysis
| Coordinator: | Prof. Dr. Toby Gibson | |
| Institution: | European Molecular Biology Laboratory Heidelberg (EMBL) | |
| Homepage: | www.embl-heidelberg.de/~gibson/ |
The aims of this subproject are two-fold: firstly to build up a resource to store and disseminate data generated by the IG and secondly to analyse the data to extract insight into the regulatory networks and their differences.
We will provide a web-based electronic platform which makes the results and resources generated by the IG accessible to the members of the IG and to the scientific community. A web-based platform is the best way to coordinate the results and resources of the different DiGTOP groups. The platform will also be used to disseminate management details, experimental protocols, SOPs (standard operating procedures) and secure efficiency in decision making. At the heart of the data storage will be a custom designed relational database. In order to disseminate the results to other NGFN IGs and to the scientific community, the information content of the DiGTOP database will be dynamically linked to the NGFNplus portal that integrates
NGFN and NGFN-related data. This will allow a deeper exploration and further analysis of the data in a larger context, particularly with regard to human diseases as NGFNplus focuses on disease-related research. As the data accumulates in DiGTOP, the complexes and interaction data will become amenable to bioinformatics analysis. Probabilistic networks will be constructed with the aid of “Socio- Affinity Indexes” and these will be analysed and compared, seeking to gain insight into cell regulatory processes. Additionaly, these results serve as a feedback to the members of the IG to project future experiments.
Additional relevant Internet links:
DiGTOP
We will provide a web-based electronic platform which makes the results and resources generated by the IG accessible to the members of the IG and to the scientific community. A web-based platform is the best way to coordinate the results and resources of the different DiGTOP groups. The platform will also be used to disseminate management details, experimental protocols, SOPs (standard operating procedures) and secure efficiency in decision making. At the heart of the data storage will be a custom designed relational database. In order to disseminate the results to other NGFN IGs and to the scientific community, the information content of the DiGTOP database will be dynamically linked to the NGFNplus portal that integrates
NGFN and NGFN-related data. This will allow a deeper exploration and further analysis of the data in a larger context, particularly with regard to human diseases as NGFNplus focuses on disease-related research. As the data accumulates in DiGTOP, the complexes and interaction data will become amenable to bioinformatics analysis. Probabilistic networks will be constructed with the aid of “Socio- Affinity Indexes” and these will be analysed and compared, seeking to gain insight into cell regulatory processes. Additionaly, these results serve as a feedback to the members of the IG to project future experiments.
Additional relevant Internet links:
DiGTOP
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