NGFN-PLUS
Mouse disease models
| Coordinator: | Prof. Dr. Bernhard Herrmann | |
| Institution: | Max-Planck Institut für molekulare Genetik | |
| Homepage: | www.molgen.mpg.de |
The aim of our subproject is to determine the effect of selected disease-related mutations in-vivo, using advanced mouse tumor models. We employ Recombination-Mediated Cassette Exchange (RMCE) to integrate mutant versions of oncogenes, tumor suppressors, and other disease-related genes into the genome in a controlled manner.
Mice containing such inducible transgenes can be crossed to existing tumor models, for instance to APCmin mice.
The possibility of systematic in-vivo analysis of the roles of selected mutations in the mouse will likely unravel important aspects of tumor biology that cannot be assessed in cell culture or in retrospective analysis of human tumor samples. Our studies thus provide an essential link between the cell-based assays and future clinical studies.
Additional relevant Internet link:
The Mutanom project
Further Coordinators:
Mice containing such inducible transgenes can be crossed to existing tumor models, for instance to APCmin mice.
The possibility of systematic in-vivo analysis of the roles of selected mutations in the mouse will likely unravel important aspects of tumor biology that cannot be assessed in cell culture or in retrospective analysis of human tumor samples. Our studies thus provide an essential link between the cell-based assays and future clinical studies.
Additional relevant Internet link:
The Mutanom project
KTT
MEDIA
CURRENT
NGFN-MEETING-2012
NGFN- MEETING
NGFN1&2
LINKS