Protein complex composition and function in disease

Coordinator:		PD Dr. Bodo Lange
Institution:		Max-Planck Institut für molekulare Genetik
Homepage:		www.molgen.mpg.de/

This subproject aims to analyse the effect of disease relevant mutations on the composition and function of protein complexes. The project will deliver biochemical and functional data on the effect of genetic changes identified in cancer tissue or cancer cell lines.

The goals of this subproject are:
(1) to characterize protein-protein interactions identified under “wild type” versus cancer-relevant “mutant” conditions, pertinent to cell proliferation, cell transformation and metastasis;
(2) to define the biochemical and functional consequences of “mutant” protein-protein interactions, using tissue culture systems of isogenic cancer cell lines;
(3) to define the consequence of physiological (cancer-relevant) cues (chemicals, stress) on protein-protein interactions and their posttranslational modifications.

The contribution of this project to the overall goal of the IG-Mutanom is the provision of bicochemical and functional data for the modelling of disease related signalling pathways. This, together with data from the other subprojects, will be used in the development of models predicting the consequences of genetic somatic aberrations in cells.



Additional relevant Internet link:
The Mutanom project