2013
146 Deo M, Huang JL, Fuchs H, Hrabé de Angelis M, Van Raamsdonk CD. Differential effects of neurofibromin gene dosage on melanocyte development. J Invest Dermatol. 2013 Jan;133(1):49-58. doi: 10.1038/jid.2012.240.
145 Hauer K, Calzada-Wack J, Steiger K, Grunewald TG, Baumhoer D, Plehm S, Buch T, Prazeres da Costa O, Esposito I, Burdach S, Richter GH. DKK2 mediates osteolysis, invasiveness, and metastatic spread in Ewing sarcoma. Cancer Res. 2013 Jan 15;73(2):967-77. doi: 10.1158/0008-5472.
144 Hauer K., Julia Calzada?Wack, Frauke Neff, Annette Fasan, Irene Esposito, Stefan Burdach and Günther HS Richter. BRICHOS genes CHM1 and ITM2A control osteolysis and maintain an undifferentiated, invasive phenotype in Ewing sarcoma. Frontiers in Oncology ISSN: 2234-943X in press.
143 Hochrath K, Ehnert S, Ackert-Bicknell CL, Lau Y, Schmid A, Krawczyk M,Hengstler JG, Dunn J, Hiththetiya K, Rathkolb B, Micklich K, Hans W, Fuchs H,Gailus-Durner V, Wolf E, de Angelis MH, Dooley S, Paigen B, Wildemann B, Lammert F, Nüssler AK. Modeling hepatic osteodystrophy in Abcb4 deficient mice. Bone. 2013 Mar 29. doi:pii: S8756-3282(13)00129-4. 10.1016/j.bone.2013.03.012. [Epubahead of print] PubMed PMID: 23545228.
142 Ju L, Wing J, Taylor E, Brandt R, Slijepcevic P, Horsch M, Rathkolb B, Rácz I, Becker L, Hans W, Adler T, Beckers J, Rozman J, Klingenspor M, Wolf E, Zimmer A, Klopstock T, Busch DH, Gailus-Durner V, Fuchs H, de Angelis MH, van der Horst G, Lehmann AR. SMC6 is an essential gene in mice, but a hypomorphic mutant in the ATPase domain has a mild phenotype with a range of subtle abnormalities. DNA Repair (Amst). 2013 May 1;12(5):356-66. doi: 10.1016/j.dnarep.2013.02.006.
141 Kugler JE, Horsch M, Huang D, Furusawa T, Rochman M, Garrett L, Becker L,Bohla A, Holter SM, Prehn C, Rathkolb B, Racz I, Aguilar-Pimentel JA, Adler T,Adamski J, Beckers J, Busch DH, Eickelberg O, Klopstock T, Ollert M, Stoeger T,Wolf E, Wurst W, Yildirim AO, Zimmer A, Gailus-Durner V, Fuchs H, Hrabe deAngelis M, Garfinkel B, Orly J, Ovcherenko I, Bustin M. High mobility group N (HMGN) proteins modulate the fidelity of the cellular transcriptional profile in a tissue and variant specific manner. J Biol Chem. 2013 Apr 24. [Epub ahead of print] PubMed PMID:23620591.
140 Nordström V, Monja Willershäuser M, Herzer S, Rozman J, von Bohlen und Halbach O, Sascha Meldner S, Rothermel U, Kaden S, Roth F, Waldeck C, Gretz N, Hrabé de Angelis M, Draguhn A, Klingenspor M, Gröne HJ, Jennemann R. Neuronal expression of glucosylceramide synthase in centralnervous system regulates body weight and energy homeostasis. PLoS Biol 11(3): e1001506. doi:10.1371/journal.pbio.1001506.
139 Parzefall T, Shivatzki S, Lenz DR, Rathkolb B, Ushakov K, Karfunkel D, Shapira Y, Wolf M, Mohr M, Wolf E, Sabrautzki S, de Angelis MH, Frydman M, Brownstein Z, Avraham KB. (2013) Cytoplasmic Mislocalization of POU3F4 Due to Novel Mutations Leads to Deafness in Humans and Mice. Hum Mutat. doi: 10.1002/humu.22339. [Epub ahead of print].
138 Puk O, Hrabe de Angelis M, Graw J. Longitudinal fundus and retinal studies with SD-OCT - a comparison of five mouse inbred strains. Mamm Genome 2013, [Epub ahead of print]. doi 10.1007/s00335-013-9457-z.
137 Puk O, Yan X, Sabrautzki S, Fuchs H, Gailus-Durner V, Hrab? de Angelis M, Graw J. Novel small-eye allele in paired box gene 6 (Pax6) is caused by a pointmutation in intron 7 and creates a new exon. Mol Vis. 2013 Apr 12;19:877-84.Print 2013. PubMed PMID: 23592925; PubMed Central PMCID: PMC3626302.
136 Ried JS, Baurecht H, Stückler F, Krumsiek J, Gieger C, Heinrich J, Kabesch M, Prehn C, Peters A, Rodriguez E, Schulz H, Strauch K, Suhre K, Wang-Sattler R, Wichmann HE, Theis FJ, Illig T, Adamski J, Weidinger S. Integrative genetic and metabolite profiling analysis suggests altered phosphatidylcholine metabolism in asthma. Allergy. 2013 Mar 1. doi: 10.1111/all.12110.
135 Sabrautzki S, Janas E, Lorenz-Depiereux B, Calzada-Wack J, Aguilar-Pimentel JA, Rathkolb B, Diener S, Adler T, Busch DH, Fuchs H, Gailus-Durner V, Wolfe E, Ollert M, Strom TM, Höfler H, Neff F, Hrabe de Angelis M.? An ENU mutagenesis derived mouse model with a dominant Jak1 mutation resembling phenotypes of systemic autoimmune disease? Am J Pathol. 2013 Jun 18. pii: S0002-9440(13)00349-0. doi: 10.1016/j.ajpath.2013.04.027. [Epub ahead of print].
134 Serpi R, Klein-Rodewald T, Calzada-Wack J, Neff F, Schuster T, Gailus-Durner V, Fuchs H, Poutanen M, Hrabé de Angelis M, Esposito I: Inbred wild type mouse strains have distinct spontaneous morphological phenotypes. Histol Histopathol. 2013 Jan;28(1):79-88.
133 Thiele F, Cohrs CM, Przemeck GK, Wurst W, Fuchs H, Hrabé de Angelis M. In vitro analysis of bone phenotypes in Col1a1 and Jagged1 mutant mice using a standardized osteoblast cell culture system. J Bone Miner Metab. 2013 Jan 31 PMID: 23371561.
132 Venit T, Dzijak R, Kalendová A, Kahle M, Roho?ková J, Schmidt V, Rülicke T, Rathkolb B, Hans W, Bohla A, Eickelberg O, Stoeger T, Wolf E, Yildirim AÖ, Gailus-Durner V, Fuchs H, de Angelis MH, Hozák P. (2013) Mouse nuclear Myosin I knock-out shows interchangeability and redundancy of Myosin isoforms in the cell nucleus. PLoS One. 8(4):e61406. doi: 10.1371/journal.pone.0061406.
131 Wefers B, Meyer M, Ortiz O, Hrabé de Angelis M, Hansen J, Wurst W, Kühn R. Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides. Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3782-7.
2012
130 Breu J, Touma C, Hölter SM, Knapman A, Wurst W, Deussing JM. (2012) Urocortin 2 modulates aspects of social behaviour in mice. Behav Brain Res 233(2):331-336. doi: 10.1016/j.bbr.2012.05.031. Epub 2012 May 26.
129 Dalke C., Gabriele Hölzlwimmer, Julia Calzada-Wack, Leticia Quintanilla-Martinez, Michael J Atkinson and Michael Rosemann (2012): Differences in the Susceptibility to Iodine131-induced Thyroid Tumours amongst Inbred Mouse Strains. J Radiat Res. doi:10.1269/jrr.11182.
128 Donahue LR, Hrabe de Angelis M, Hagn M, Franklin C, Lloyd KC, Magnuson T, McKerlie C, Nakagata N, Obata Y, Read S, Wurst W, Hörlein A, Davisson MT. (2012) Centralized mouse repositories, Mamm Genome. 23(9-10):559-71. doi: 10.1007/s00335-012-9420-4.
127 Eißmann M, Melzer IM, Fernández SB, Michel G, Hrab? de Angelis M, Hoefler G, Finkenwirth P, Jauch A, Schoell B, Grez M, Schmidt M, Bartholomae CC, Newrzela S, Haetscher N, Rieger MA, Zachskorn C, Mittelbronn M, Zörnig M. Overexpression of the anti-apoptotic protein AVEN contributes to increased malignancy in hematopoietic neoplasms. . Oncogene. 2012 Jul 2. doi: 10.1038/onc.2012.263.
126 Erkan M, Adler G, Apte MV, Bachem MG, Buchholz M, Detlefsen S, Esposito I, Friess H, Gress TM, Habisch HJ, Hwang RF, Jaster R, Kleeff J, Klöppel G, Kordes C, Logsdon CD, Masamune A, Michalski CW, Oh J, Phillips PA, Pinzani M, Reiser-Erkan C, Tsukamoto H, Wilson J. StellaTUM: current consensus and discussion on pancreatic stellate cell research. Gut. 2012 Feb;61(2):172-8. doi: 10.1136/gutjnl-2011-301220.
125 Finan B, Yang B, Ottaway N, Stemmer K, Müller TD, Yi CX, Habegger K, Schriever SC, García-Cáceres C, Kabra DG, Hembree J, Holland J, Raver C, Seeley RJ, Hans W, Irmler M, Beckers J, Hrabé de Angelis M, Tiano JP, Mauvais-Jarvis F, Perez-Tilve D, Pfluger P, Zhang L, Gelfanov V, DiMarchi RD, Tschöp MH. Targeted estrogen delivery reverses the metabolic syndrome. Nat Med. 2012 Dec;18(12):1847-56. doi: 10.1038/nm.3009.
124 Fuchs H, Gailus-Durner V, Neschen S, Adler T, Afonso L, Aguilar-Pimentel JA, Becker L, Bohla A, Calzada-Wack J, Cohrs C, Dewert A, Fridrich B, Garrett L, Glasl L, Götz A, Hans W, Hölter SM, Horsch M, Hurt A, Janas E, Janik D, Kahle M, Kistler M, Klein-Rodewald T, Lengger C, Ludwig T, Maier H, Marschall S, Micklich K, Möller G, Naton B, Prehn C, Puk O, Rácz I, Räß M, Rathkolb B, Rozman J, Scheerer M, Schiller E, Schrewe A, Steinkamp R, Stöger C, Sun M, Szymczak W, Treise I, Vargas Panesso IL, Vernaleken AM, Willershäuser M, Wolff-Muscate A, Zeh R, Adamski J, Beckers J, Bekeredjian R, Busch DH, Eickelberg O, Favor J, Graw J, Höfler H, Höschen C, Katus H, Klingenspor M, Klopstock T, Neff F, Ollert M, Schulz H, Stöger T, Wolf E, Wurst W, Yildirim AÖ, Zimmer A, Hrabé de Angelis M: Innovations in phenotyping of mouse models in the German Mouse Clinic. Mamm Genome. 2012 Oct;23(9-10):611-22. doi: 10.1007/s00335-012-9415-1.
123 Fuchs H, Sabrautzki S, Seedorf H, Rathkolb B, Rozman J, Hans W, Schneider R, Klaften M, Hölter SM, Becker L, Klempt M, Elvert R, Wurst W, Klopstock T, Klingenspor M, Wolf E, Gailus-Durner V, Hrabé de Angelis M: Does enamelin have pleiotropic effects on organs other than the teeth? Lessons from a phenotyping screen of two enamelin-mutant mouse lines. Eur J Oral Sci. 120, 269-77 (2012). DOI: 10.1111/j.1600-0722.2012.00966.
122 Galli GG, Honnens de Lichtenberg K, Carrara M, Hans W, Wuelling M, Mentz B, Multhaupt HA, Fog CK, Jensen KT, Rappsilber J, Vortkamp A, Coulton L, Fuchs H, Gailus-Durner V, Hrabé de Angelis M, Calogero RA, Couchman JR, Lund AH: Prdm5 regulates collagen gene transcription by association with RNA polymerase II in developing bone PLoS Genet. 8(5), e1002711 (2012) doi:10.1371/journal.pgen.1002711.
121 Garrett L, Lie DC, Hrabé de Angelis M, Wurst W, Hölter SM: Voluntary wheel running in mice increases the rate of neurogenesis without affecting anxiety-related behaviour in single tests. BMC Neurosci. 2012 Jun 8;13(1):61. http://www.biomedcentral.com/1471-2202/13/61.
120 Glasl L, Kloos K, Giesert F, Roethig A, Di Benedetto B, Kühn R, Zhang J, Hafen U, Zerle J, Hofmann A, Hrabé de Angelis M, Winklhofer KF, Hölter SM, Vogt Weisenhorn DM, Wurst W.(2012) Pink1-deficiency in mice impairs gait, olfaction and serotonergic innervation of the olfactory bulb. Exp Neurol. 2012 Jan 11. doi:10.1016/j.expneurol.2012.01.002.
119 Grunewald T. G. P. , A. Ranft, I. Esposito, P. da Silva-Buttkus, M. Aichler, D. Baumhoer, K. L. Schaefer, L. Ottaviano, C. Poremba, G. Jundt, H. Jürgens, U. Dirksen, G. H. S. Richter and S. Burdach. High STEAP1 expression is associated with improved outcome of Ewing's sarcoma patients. Annals of Oncology Volume 23, Issue 8 Pp. 2185-2190.
118 Guan M, Marschall S, Raspa M, Pickard AR, Fray MD (2012) Overview of new developments in and the future of cryopreservation in the laboratory mouse. Mamm Genome. 23(9-10):572-9. doi: 10.1007/s00335-012-9423-1.
117 Hochrath K, Krawczyk M, Goebel R, Langhirt M, Rathkolb B, Micklich K, Rozman J, Horsch M, Beckers J, Klingenspor M, Fuchs H, Gailus-Durner V, Wolf E, Acalovschi M, Volmer DA, Hrab? de Angelis M, Lammert F. The hepatic phosphatidylcholine transporter ABCB4 as modulator of glucose homeostasis. FASEB J. 2012 Dec;26(12):5081-91. doi: 10.1096/fj.12-209379.
116 Hüttemann M, Lee I, Gao X, Pecina P, Pecinova A, Liu J, Aras S, Sommer N, Sanderson TH, Tost M, Neff F, Aguilar-Pimentel JA, Becker L, Naton B, Rathkolb B, Rozman J, Favor J, Hans W, Prehn C, Puk O, Schrewe A, Sun M, Höfler H, Adamski J, Bekeredjian R, Graw J, Adler T, Busch DH, Klingenspor M, Klopstock T, Ollert M, Wolf E, Fuchs H, Gailus-Durner V, Hrabé de Angelis M, Weissmann N, Doan JW, Bassett DJ, Grossman LI.: Cytochrome c oxidase subunit 4 isoform 2 knockout mice show reduced enzyme activity, airway hyporeactivity, and lung pathology FASEB Journal, 2012 Sep;26(9):3916-30. doi: 10.1096/fj.11-203273.
115 Irmler M, Gentier RJ, Dennissen FJ, Schulz H, Bolle I, Hölter SM, Kallnik M, Cheng JJ, Klingenspor M, Rozman J, Ehrhardt N, Hermes DJ, Gailus-Durner V, Fuchs H, Hrabé de Angelis M, Meyer HE, Hopkins DA, Van Leeuwen FW, Beckers J: Long-term proteasomal inhibition in transgenic mice by UBB+1 expression results in dysfunction of central respiration control reminiscent of brainstem neuropathology in Alzheimer patients Acta Neuropathologica. 124, 187-97 (2012). doi:10.1007/s00401-012-1003-7.
114 Klymiuk I, Kenner L, Adler T, Busch DH, Boersma A, Irmler M, Gailus-Durner V, Fuchs H, Leitner N, Müller M, Kühn R, Schlederer M, Treise I, de Angelis MH, Beckers J. (2012): In vivo functional requirement of the mouse Ifitm1 gene for germ cell development, interferon mediated immune response and somitogenesis. PLoS One 7(10):e44609. doi: 10.1371/journal.pone.0044609.
113 Kollmus H, Post R, Brielmeier M, Fernandez J, Fuchs H, McKerlie C, Montoliu L, Otaegui PJ, Rebelo M, Riedesel H, Ruberte J, Sedla?ek R, Hrabé de Angelis M, Schughart K: Structural and functional concepts employed in current mouse phenotyping and archiving facilities. JAALAS. 51, 418-435 (2012) PMID: 23043807.
112 Kühne C, Puk O, Graw J, Hrab? de Angelis M, Schütz G, Wurst W, Deussing JM. Visualizing corticotropin-releasing hormone receptor type 1 expression and neuronal connectivities in the mouse using a novel multifunctional allele. J Comp Neurol. 2012 Oct 1;520(14):3150-80. doi: 10.1002/cne.23082.
111 Kumar S, Rathkolb B, Budde BS, Nürnberg P, Hrab? de Angelis M, Aigner B, Schneider MR. Gsdma3(I359N) is a novel ENU-induced mutant mouse line for studying the function of Gasdermin A3 in the hair follicle and epidermis. J Dermatol Sci. 2012 Sep;67(3):190-2. doi: 10.1016/j.jdermsci.2012.05.001.
110 Lee AW, Hengstler H, Schwald K, Berriel-Diaz M, Loreth D, Kirsch M, Kretz O, Haas CA, Hrabé de Angelis M, Herzig S, Brümmendorf T, Klingenspor M, Rathjen FG, Rozman J, Nicholson G, Cox RD, Schäfer MK. Functional inactivation of the genome-wide association study obesity gene neuronal growth regulator 1 in mice causes a body mass phenotype. PLoS ONE. 7(7), e41537 (2012) doi: 10.1371/journal.pone.0041537.
109 Meyer D, Voigt A, Widmayer P, Borth H, Huebner S, Breit A, Marschall S, Hrabé de Angelis M, Boehm U, Meyerhof W, Gudermann T, Boekhoff I. Expression of Tas1 taste receptors in mammalian spermatozoa: functional role of Tas1r1 in regulating basal Ca²? and cAMP concentrations in spermatozoa. PLoS One. 2012;7(2):e32354. doi: 10.1371/journal.pone.0032354.
108 Meyer M, Ortiz O, Hrabé de Angelis M, Wurst W, Kühn R. Modeling disease mutations by gene targeting in one-cell mouse embryos. Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9354-9. doi: 10.1073/pnas.1121203109.
107 Olszewski PK, Rozman J, Jacobsson JA, Rathkolb B, Strömberg S, Hans W, Klockars A, Alsiö J, Risérus U, Becker L, Hölter SM, Elvert R, Erhardt N, Gailus-Durner V, Fuchs H, Fredriksson R, Wolf E, Klopstock T, Wurst W, Levine AS, Marcus C, Hrabé de Angelis M, Klingenspor M, Schiöth HB, Kilimann MW (2012): Neurobeachin, a regulator of synaptic protein targeting, is associated with body fat mass and feeding behavior in mice and body-mass index in humans. PLoS Genet. 8(3), e1002568 doi:10.1371/journal.pgen.1002568.
106 Pozzi B, Amodio S, Lucano C, Sciullo A, Ronzoni S, Castelletti D, Adler T, Treise I, Betsholtz IH, Rathkolb B, Busch DH, Wolf E, Fuchs H, Gailus-Durner V, de Angelis MH, Betsholtz C, Casola S, Di Fiore PP, Offenhäuser N. The endocytic adaptor Eps15 controls marginal zone B cell numbers. PLoS One. 2012;7(11):e50818. doi: 10.1371/journal.pone.0050818.
105 Radermacher KA, Wingler K, Langhauser F, Altenhöfer S, Kleikers P, Hermans JJ, Hrabe de Angelis M, Kleinschnitz C, Schmidt HH. Neuroprotection After Stroke by Targeting NOX4 As a Source of Oxidative Stress. Antioxid Redox Signal. 2012 Oct 16. PMID: 22937798.
104 Sabrautzki S, Eva Janas, , Bettina Lorenz-Depiereux, Julia Calzada- Wack, Juan A. Aguilar-Pimentel, Birgit Rathkolb, Thure Adler, Christian 7 Cohrs, Wolfgang Hans, Susanne Diener, Helmut Fuchs, Valerie Gailus-Durner, Dirk H. Busch, Heinz Höfler, Markus Ollert, Tim Matthias Strom, Eckhard Wolf, Frauke Neff, Martin Hrabe de Angelis. An ENU mutagenesis derived mouse model with a dominant Jak1 mutation 1 resembling phenotypes of systemic autoimmune disease. Short title: New mouse model for systemic autoimmune disease. Am J Pathology manuscript#AJP12_0541 In press.
103 Sabrautzki S, Rubio-Aliaga I, Hans W, Fuchs H, Rathkolb B, Calzada-Wack J, Cohrs CM, Klaften M, Seedorf H, Eck S, Benet-Pagès A, Favor J, Esposito I, Strom TM, Wolf E, Lorenz-Depiereux B, Hrabé de Angelis M: New mouse models for metabolic bone diseases generated by genome-wide ENU mutagenesis. Mamm Genome. 23, 416-30 (2012) DOI 10.1007/s00335-012-9397-z.
102 Spyroglou A, Sabrautzki S, Rathkolb B, Bozoglu T, Hrabé de Angelis M, Reincke M, Bidlingmaier M, Beuschlein F. Gender-, strain-, and inheritance-dependent variation in aldosterone secretion in mice. J Endocrinol. 2012 Dec;215(3):375-81. doi: 10.1530/JOE-12-0429.
101 Staropoli JF, Haliw L, Biswas S, Garrett L, Hölter SM, Becker L, Skosyrski S, Da Silva-Buttkus P, Calzada-Wack J, Neff F, Rathkolb B, Rozman J, Schrewe A, Adler T, Puk O, Sun M, Favor J, Racz I, Bekeredjian R, Busch DH, Graw J, Klingenspor M, Klopstock T, Wolf E, Wurst W, Zimmer A, Lopez E, Harati H, Hill E, Krause DS, Guide J, Dragileva E, Gale E, Wheeler VC, Boustany RM, Brown DE, Breton S, Ruether K, Gailus-Durner V, Fuchs H, Hrabé de Angelis M, Cotman SL: Large-scale phenotyping of an accurate genetic mouse model of JNCL identifies novel early pathology outside the central nervous system. PLoS ONE. 7(6), e38310 (2012) doi:10.1371/journal.pone.0038310.
100 Stein C, Kling L, Proetzel G, Roopenian DC, Hrabé de Angelis M, Wolf E, Rathkolb B: Clinical chemistry of human FcRn transgenic mice. Mamm Genome 23, 259-269 (2012) DOI 10.1007/s00335-011-9379-6.
99 Thiele F, Cohrs CM, Flor A, Lisse TS, Przemeck GK, Horsch M, Schrewe A, Gailus-Durner V, Ivandic B, Katus HA, Wurst W, Reisenberg C, Chaney H, Fuchs H, Hans W, Beckers J, Marini JC, Hrabé de Angelis M: Cardiopulmonary dysfunction in the Osteogenesis imperfecta mouse model Aga2 and human patients are caused by bone-independent mechanisms. Hum Mol Genet. 21(16):3535-45 (2012) doi:10.1093/hmg/dds183.
98 van Buerck L, Schuster M, Rathkolb B, Sabrautzki S, Hrabé de Angelis M, Wolf E, Aigner B, Wanke R, Herbach N: Enhanced oxidative stress and endocrine pancreas alterations are linked to a novel glucokinase missense mutation in ENU-derived Munich Gck(D217V) mutants. Mol Cell Endocrinol. 2012 Oct 15;362(1-2):139-48. doi: 10.1016/j.mce.2012.06.001.
97 Wahl S, Yu Z, Kleber M, Singmann P, Holzapfel C, He Y, Mittelstrass K, Polonikov A, Prehn C, Römisch-Margl W, Adamski J, Suhre K, Grallert H, Illig T, Wang-Sattler R, Reinehr T. Childhood obesity is associated with changes in the serum metabolite profile. Obes Facts. 2012;5(5):660-70. doi: 10.1159/000343204. Epub 2012 Oct 4.
96 Waltereit R, Leimer U, von Bohlen und Halbach O, Panke J, Hölter SM, Garrett L, Wittig K, Schneider M, Schmitt C, Calzada-Wack J, Neff F, Becker L, Prehn C, Kutscherjawy S, Endris V, Bacon C, Fuchs H, Gailus-Durner V, Berger S, Schönig K, Adamski J, Klopstock T, Esposito I, Wurst W, Hrabé de Angelis M, Rappold G, Wieland T, Bartsch D: Srgap3-/- mice present a neurodevelopmental disorder with schizophrenia-related intermediate phenotypes. FASEB J. 2012 Nov;26(11):4418-28. doi: 10.1096/fj.11-202317.
95 Wang-Sattler R, Yu Z, Herder C, Messias AC, Floegel A, He Y, Heim K, Campillos M, Holzapfel C, Thorand B, Grallert H, Xu T, Bader E, Huth C, Mittelstrass K, Döring A, Meisinger C, Gieger C, Prehn C, Roemisch-Margl W, Carstensen M, Xie L, Yamanaka-Okumura H, Xing G, Ceglarek U, Thiery J, Giani G, Lickert H, Lin X, Li Y, Boeing H, Joost HG, de Angelis MH, Rathmann W, Suhre K, Prokisch H, Peters A, Meitinger T, Roden M, Wichmann HE, Pischon T, Adamski J, Illig T. Novel biomarkers for pre-diabetes identified by metabolomics. Mol Syst Biol. 2012;8:615. doi: 10.1038/msb.2012.43.
94 Wefers B, Hitz C, Hölter SM, Trümbach D, Hansen J, Weber P, Pütz B, Deussing J, Hrabé de Angelis M, Roenneberg T, Zheng F, Alzheimer C, Silva A, Wurst W, Kühn R: MAPK signalling determines anxiety in the juvenile mouse brain but depression-like behavior in adults. PLoS One. 7(4), e350352012 (2012) doi:10.1371/journal.pone.0035035.
93 Yeritsyan N, Lehmann K, Puk O, Graw J, Löwel S. Visual capabilities and cortical maps in BALB/c mice. Eur J Neurosci. 2012 Sep; 36:2801-2811. doi10.1111/j.1460-9568.2012.08195.
2011
92 Abe K, Fuchs H, Boersma A, Hans W, Yu P, Kalaydjiev S, Klaften M, Adler T, Calzada-Wack J, Mossbrugger I, Rathkolb B, Rozman J, Prehn C, Maraslioglu M, Kametani Y, Shimada S, Adamski J, Busch DH, Esposito I, Klingenspor M, Wolf E, Wurst W, Gailus-Durner V, Katan M, Marschall S, Soewarto D, Wagner S, de Angelis MH. A novel ENU-induced mutation in Phospholipase C gamma 2 causes inflammatory arthritis, metabolic defects, and in vitro male infertility in the mouse. Arthritis Rheum. 2011 Feb 4. doi: 10.1002/art.30280. [Epub ahead of print].
91 Aigner B, Rathkolb B, Klempt M, Wagner S, Michel D, Klaften M, Laufs J, Schneider B, Sedlmeier R, Hrabé de Angelis M, Wolf E. Generation of N-ethyl-N-nitrosourea-induced mouse mutants with deviations in hematological parameters. Mamm Genome. 22(9-10):495-505. DOI:10.1007/s00335-011-9328-4
90 Bucher K, Dietz K, Lackner P, Pasche B, Fendel R, Mordmüller B, Ben-Smith A, Hoffmann WH. Schistosoma co-infection protects against brain pathology but does not prevent severe disease and death in a murine model of cerebral malaria. Int J Parasitol. 2011 Jan;41(1):21-31. PMID: 20708623
89 Fuchs H, Gailus-Durner V, Adler T, Aguilar-Pimentel JA, Becker L, Calzada-Wack J, Da Silva-Buttkus P, Neff F, Götz A, Hans W, Hölter SM, Horsch M, Kastenmüller G, Kemter E, Lengger C, Maier H, Matloka M, Möller G, Naton B, Prehn C, Puk O, Rácz I, Rathkolb B, Römisch-Margl W, Rozman J, Wang-Sattler R, Schrewe A, Stöger C, Tost M, Adamski J, Aigner B, Beckers J, Behrendt H, Busch DH, Esposito I, Graw J, Illig T, Ivandic B, Klingenspor M, Klopstock T, Kremmer E, Mempel M, Neschen S, Ollert M, Schulz H, Suhre K, Wolf E, Wurst W, Zimmer A, Hrabé de Angelis M: Mouse phenotyping. Methods. 53, 120-135 (2011) doi:10.1016/j.ymeth.2010.08.006
88 Ganguly K, Upadhyay S, Irmler M, Takenaka S, Pukelsheim K, Beckers J, De Angelis MH, Hamelmann E, Stoeger T, Schulz H. Impaired resolution of inflammatory response in the lungs of JF1/Msf mice following carbon nanoparticle instillation. Respir Res. 2011 Jul 15;12:94. DOI: 10.1186/1465-9921-12-94
87 Götz AA, Rozman J, Rödel HG, Fuchs H, Gailus-Durner V, Hrab? de Angelis M, Klingenspor M and Stöger T. Comparison of particle-exposure triggered pulmonary and systemic inflammation in mice fed with three different diets. Particle and Fibre Toxicology Volume: 8:30. DOI:10.1186/1743-8977-8-30
86 Götz AA, Vidal-Puig A, Rödel HG, Hrabé de Angelis M, Stoeger T. Carbon-nanoparticle-triggered acute lung inflammation and its resolution are not altered in PPARg-defective (P465L) mice. Particle and Fibre Toxicology 2011, 8:28 DOI:10.1186/1743-8977-8-28
85 Horsch M, Seeburg PH, Adler T, Aguilar-Pimentel JA, Becker L, Calzada-Wack J, Garrett L, Götz A, Hans W, Higuchi M, Hölter SM, Naton B, Prehn C, Puk O, Rácz I, Rathkolb B, Rozman J, Schrewe A, Adamski J, Busch DH, Esposito I, Graw J, Ivandic B, Klingenspor M, Klopstock T, Mempel M, Ollert M, Schulz H, Wolf E, Wurst W, Zimmer A, Gailus-Durner V, Fuchs H, Hrabé de Angelis M, Beckers J. Requirement of the RNA-editing enzyme ADAR2 for normal physiology in mice. J Biol Chem. 286(21):18614-22. DOI 10.1074/jbc.M110.200881
84 Jeub M, Emrich M, Pradier B, Taha O, Gailus-Durner V, Fuchs H, Hrabé de Angelis M, Huylebroeck D, Zimmer A, Beck H, Racz I. The transcription factor Smad-interacting protein 1 controls pain sensitivity via modulation of DRG neuron excitability. Pain. 152(10):2384-98. DOI:10.1016/j.pain.2011.07.006
83 Lückerath K, Kirkin V, Melzer IM, Thalheimer FB, Siele D, Milani W, Adler T, Aguilar-Pimentel A, Horsch M, Michel G, Beckers J, Busch DH, Ollert M, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Staal FJ, Rajalingam K, Hueber AO, Strobl LJ, Zimber-Strobl U, Zörnig M. Immune modulation by Fas ligand reverse signaling: lymphocyte proliferation is attenuated by the intracellular Fas ligand domain. Blood. 13;117(2):519-29.
82 Puk O, Ahmad N, Wagner S, Hrabé de Angelis M, Graw J. First mutation in the ?A2-crystallin encoding gene is associated with small lenses and age-related cataracts. Invest Ophthalmol Vis Sci. 52(5):2571-6. doi: 10.1167/iovs.10-6443
81 Puk O, Ahmad N, Wagner S, Hrabé de Angelis M, Graw J. Microphakia and congenital cataract formation in a novel Lim2C51R mutant mouse. Mol Vis. 17:1164-1171. PMID: 21617753 http://www.molvis.org/molvis/v17/a131
80 Puk O, Möller G, Geerlof A, Krowiorz K, Ahmad N, Wagner S, Adamski J, Hrabé de Angelis M, Graw J. The pathologic effect of a novel neomorphic Fgf9(Y162C) allele is restricted to decreased vision and retarded lens growth. PLoS One. 6(8):e23678. doi:10.1371/journal.pone.0023678
79 Raab M, Kappel S, Krämer A, Sanhaji M, Matthess Y, Kurunci-Csacsko E, Calzada-Wack J, Rathkolb B, Rozman J, Adler T, Busch DH, Esposito I, Fuchs H, Gailus-Durner V, Klingenspor M, Wolf E, Sänger N, Prinz F, Angelis MH, Seibler J, Yuan J, Bergmann M, Knecht R, Kreft B, Strebhardt K. Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells. Nat Commun. 2:395. doi: 10.1038/ncomms1395.
78 Rolyan H, Scheffold A, Heinrich A, Begus-Nahrmann Y, Langkopf BH, Hölter SM, Vogt Weisenhorn DM, Liss B, Wurst W, Lie DC, Thal DR, Biber K, Rudolph KL. Telomere shortening reduces Alzheimer?s disease amyloid pathology in mice. Brain 134(Pt7):2044-56. DOI:10.1093/brain/awr133
77 Saarikangas J, Mattila PK, Varjosalo M, Bovellan M, Hakanen J, Calzada-Wack J, Tost M, Jennen L, Rathkolb B, Hans W, Horsch M, Hyvönen ME, Perälä N, Fuchs H, Gailus-Durner V, Esposito I, Wolf E, Hrabé de Angelis M, Frilander MJ, Savilahti H, Sariola H, Sainio K, Lehtonen S, Taipale J, Salminen M, Lappalainen P. Missing-in metastasis MIM/MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia. J Cell Science 124, 1245-1255 DOI:10.1242/jcs.082610
76 Spyroglou A, Wagner S, Gomez-Sanchez C, Rathkolb B, Wolf E, Manolopoulou J, Reincke M, Bidlingmaier M, Hrabé de Angelis M, Beuschlein F. Utilization of a mutagenesis screen to generate mouse models of hyperaldosteronism. Endocrinology. 152(1):326-31. DOI: 10.1210/en.2010-1081
75 Wirth EK, Sheu SY, Chiu-Ugalde J, Sapin R, Klein MO, Moßbrugger I, Quintanilla-Martinez L, Hrabé de Angelis M, Krude H, Riebel T, Rothe K, Köhrle J, Schmid KW, Schweizer U, Grüters A. Monocarboxylate transporter 8 deficiency: altered thyroid morphology and persistent high triiodothyronine/thyroxine ratio after thyroidectomy. Eur J Endocrinol. 165(4):555-61. DOI: 10.1530/EJE-11-0369
2010
74 Aguilar-Pimentel JA, Alessandrini F, Huster KM, Jakob T, Schulz H, Behrendt H, Ring J, Hrab? de Angelis M, Busch DH, Mempel M, Ollert M. Specific CD8 T cells in IgE-mediated allergy correlate with allergen dose and allergic phenotype. Am J Resp Crit Care Med 181:7-16. DOI: 10.1164/rccm.200902-0190OC
73 Alberts, R., Srivastava, B., Wu, H., Viegas, N., Geffers, R., Klawonn, F., Novoselova, N., Zaverucha do Valle, T., Panthier, J. J., and Schughart, K. Gene expression changes in the host response between resistant and susceptible inbred mouse strains after influenza A infection. Microbes Infect. 2010 April;12(4):309-18 doi:10.1016/j.micinf.2010.01.008
72 Bilkei-Gorzo A, Berner J, Zimmermann J, Wickström R, Racz I, Zimmer A. Increased morphine analgesia and reduced side-effects in mice lacking the tac1-gene Br. J Pharmacol. Accepted
71 Deussing JM, Breu J, Kühne C, Kallnik M, Bunck M, Glasl L, Yen YC, Vogl AM, Gailus-Durner V, Fuchs H, Hölter SM, Wotjak CT, Landgraf R, Hrabé de Angelis M, Holsboer F, Wurst W. Urocortin 3 modulates social discrimination abilities via corticotrophin-releasing hormone receptor 2. J Neurosci 30(27):9103-16 DOI:10.1523/JNEUROSCI.1049-10.2010
70 Dror AA, Politi Y, Shahin H, Lenz DR, Dossena S, Nofziger C, Fuchs H, Hrabé de Angelis M, Paulmichl M, Weiner S, Avraham KB. Calcium oxalate stone formation in the inner ear as a result of an Slc26a4 mutation. J Biol Chem. 285(28):21724-35. doi:10.1074/jbc.M110.120188.
69 Kemter E, Rathkolb B, Bankir L, Schrewe A, Hans W, Landbrecht C, Klaften M, Ivandic B, Fuchs H, Gailus-Durner V, Hrabé de Angelis M, Wolf E, Wanke R, Aigner B. Mutation of the Na(+)-K(+)-2Cl(-) cotransporter NKCC2 in mice is associated with severe polyuria and a urea-selective concentrating defect without hyperreninemia. Am J Physiol Renal Physiol 2010 Jun;298(6):F1405-15. Epub 2010 Mar 10. PMID: 20219826
68 Kleinschnitz C, Grund H, Wingler K, Armitage ME, Jones E, Mittal M, Barit D, Schwarz T, Geis C, Kraft P, Barthel K, Schuhmann MK, Herrmann AM, Meuth SG, Stoll G, Meurer S, Schrewe A, Becker L, Gailus-Durner V, Fuchs H, Klopstock T, Hrabé de Angelis M, Jandeleit-Dahm K, Shah AM, Weissmann N, Schmidt HH. Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration. PLoS Biol. 8(9): e1000479. doi:10.1371/journal.pbio.1000479
67 Meyer M, Hrabé de Angelis M, Wurst W, Kühn R. Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases. Proc Natl Acad Sci U S A. 107(34):15022-6. doi:10.1073/pnas.1009424107
66 Morgan H, Beck T, Blake A, Gates H, Adams N, Debouzy G, Leblanc S, Lengger C, Maier H, Melvin D, Meziane H, Richardson D, Wells S, White J,Wood J, The EUMODIC Consortiumy, Hrabé de Angelis M, Brown SDM,Hancock JM and Mallon A-M. EuroPhenome: a repository for high-throughputmouse phenotyping data. Nucleic Acids Res. 2010 Jan;38 (Database issue):D577-85. doi:10.1093/nar/gkp1007
65 Pham TT, Giesert F, Röthig A, Floss T, Kallnik M, Weindl K, Hölter SM, Ahting U, Prokisch H, Becker L, Klopstock T, Hrabé de Angelis M, Beyer K, Görner K, Kahle PJ, Vogt Weisenhorn DM, Wurst W. DJ-1-deficient mice show less TH-positive neurons in the ventral tegmental area and exhibit non-motoric behavioural impairments. Genes Brain Behav. 2009 (epub) Dec 17. doi: 10.1111/j.1601-183X.2009.00559.x
64 Rosemann M, Ivashkevich A, Favor J, Dalke C, Hölter SM, Becker L, Racz I, Bolle I, Klempt M, Rathkolb B, Kalaydjiev S, Adler T, Aguilar A, Hans W, Horsch M, Rozman J, Calzada-Wack J, Kunder S, Gailus-Durner V, Fuchs H, Naton B, Schulz H, Beckers J, Busch DH, Burbach JPH, Smidt MP, Quintanilla-Martinez L, Esposito I, Klopstock T, Klingenspor M, Ollert M, Wolf E, Wurst W, Zimmer A, Hrabé de Angelis M, Atkinson M, Heinzmann U, Graw J. Microphthalmia, parkinsonism and enhanced nociception in Pitx3416insG mice. Mamm Genome 21:13-27. doi:10.1007/s00335-009-9235-0 ( Published online: 22 December 2009)
63 Shimokawa N, Haglund K, Hölter SM, Grabbe C, Kirkin V, Koibuchi N, Schulz C, Rozman J, Höller D, Qiu CH, Londono MB, Jedlicka P, Schwarzacher SW, Wolfer DP, Ehrhardt N, Heuchel R, Nezis I, Brech A, Schmidt MHH, Fuchs H, Gailus-Durner V, Klingenspor M, Bogler O, Wurst W, Deller T, Hrab? de Angelis M, Dikic I. CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice. EMBO J 29(14):2421-32 doi:10.1038/emboj.2010.120
62 Tocchetti A, Soppo CB, Zani F, Bianchi F, Gagliani MC, Pozzi B, Rozman J, Elvert R, Ehrhardt N, Rathkolb B, Moerth C, Horsch M, Fuchs H, Gailus-Durner V, Beckers J, Klingenspor M, Wolf E, Hrabé de Angelis M, Scanziani E, Tacchetti C, Scita G, Di Fiore PP, Offenhäuser N. Loss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in mice. PLoS One. 2010 Mar 2;5(3):e9468. PMID: 20209148
61 van Bürck L, Blutke A, Kautz S, Rathkolb B, Klaften M, Wagner S, Kemter E, Hrabé de Angelis M, Wolf E, Aigner B, Wanke R, Herbach N. Phenotypic and pathomorphological characteristics of a novel mutant mouse model for maturity-onset diabetes of the young type 2 (MODY 2). Am J Physiol Endocrinol Metab. 298(3):E512-23. doi:10.1152/ajpendo.00465.2009
60 Vegiopoulos A, Müller-Decker K, Strzoda D, Schmitt I, Chichelnitskiy E, Ostertag A, Berriel Diaz M, Rozman J, Hrabe de Angelis M, Nüsing RM, Meyer CW, Wahli W, Klingenspor M, Herzig S. Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes. Science. 2010 May 28;328(5982):1158-61. Epub 2010 May 6. PMID: 20448152 [PubMed - indexed for MEDLINE]. DOI: 10.1126/science.1186034
59 Wagner S, Calzada-Wack J, Rosemann M, Becker L, Tost M, Silva-Buttkus P, Klein-Rodewald T, Fuchs H, Neff F, Hrabé de Angelis M, Esposito I. Characterization of ENU-mutant mice. Animal models for human diseases using morphological and molecular methods. Pathologe. 2010 Oct;31 Suppl 2:147-52. German. doi 10.1007/s00292-010-1347-5
58 Wu H, Haist V, Baumgärtner W, Schughart K. Sustained viral load and late death in Rag2-/- mice after influenza A virus infection. Virol J. 2010 Jul 28;7:172-77. PMID: 20667098
57 Wurst W, Hrabe de Angelis M. Systematic phenotyping of mouse mutants. Nat Biotechnol. 28(7):684-5. doi:10.1038/nbt0710-684
56 Yin R, Tian F, Frankenberger B, de Angelis MH, Stoeger T. Selection and evaluation of stable housekeeping genes for gene expression normalization in carbon nanoparticle-induced acute pulmonary inflammation in mice. Biochem Biophys Res Commun. 2010 Sep 3;399(4):531-6. Epub 2010 Aug 1.
2009
55 Abe K, Klaften M, Narita A, Kimura T, Imai K, Kimura M, Rubio-Aliaga I, Wagner S, Jakob T, Hrabé de Angelis M. Genome-wide search for genes that modulate inflammatory arthritis caused by Ali18 mutation in mice. Mamm Genome. 2009 Mar;20(3):152-61. DOI 10.1007/s00335-009-9170-0
54 Ahting U, Floss T, Uez N, Schneider-Lohmar I, Becker L, Kling E, Iuso A, Bender A, Hrabé de Angelis M, Gailus-Durner V, Fuchs H, Meitinger T, Wurst W, Prokisch H, Klopstock T. Neurological phenotype and reduced lifespan in heterozygous Tim23 knockout mice, the first mouse model of defective mitochondrial import. Biochim Biophys Acta. 2009 May;1787(5):371-6. DOI:10.1016/j.bbabio.2008.12.001
53 Aigner B, Rathkolb B, Klaften M, Sedlmeier R, Klempt M, Wagner S, Michel D, Mayer U, Klopstock T, Hrabé de Angelis M, Wolf E. Generation of N-ethyl-N-nitrosourea-induced mouse mutants with deviations in plasma enzyme activities as novel organ-specific disease models. Exp Physiol. 2009 Apr;94(4):412-21. DOI: 10.1113/expphysiol.2008.045864
52 Aigner B, Rathkolb B, Klempt M, Wagner S, Michel D, Hrabé de Angelis M, Wolf E. N-ethyl-N-nitrosourea mutagenesis produced a small number of mice with altered plasma electrolyte levels. J Biomed Sci. 2009 Jun 8;16:53. doi:10.1186/1423-0127-16-53
51 Bazhin AV, Dalke C, Willner N, Abschütz O, Wildberger HGH, Philippov PP, Dummer R, Graw J, Hrabé de Angelis M, Schadendorf D, Umansky V, Eichmüller SB. Cancer-retina antigens as potential paraneoplastic antigens in melanoma-associated retinopathy. Int. J. Cancer. 2009 Jan; 124(1):140-49. PMID: 18814277
50 Beckers J, Wurst W, Hrabé de Angelis M. Towards better mouse models: enhanced genotypes, systemic phenotyping and envirotype modelling. Nat Rev Genet. 2009 Jun;10(6):371-80. doi:10.1038/nrg2578
49 Darvas M, Morsch M, Racz I, Ahmadi S, Swandulla D, Zimmer A (2009) Modulation of the Ca2+ conductance of nicotinic acetylcholine receptors by Lypd6. Eur Neuropsychopharmacol 19:670-681 doi:10.1016/j.euroneuro.2009.03.007
48 Di Benedetto B, Kallnik M, Vogt Weisenhorn DM, Falls WA, Wurst W, Hölter SM. (2009) Activation of ERK/MAPK in the lateral amygdala of the mouse is required for acquisition of a fear potentiated startle response. Neuropsychopharmacology 34:356-366
47 Enard W, Gehre S, Hammerschmidt K, Hölter SM, Blass T, Somel M, Brückner MK, Schreiweis C, Winter C, Sohr R, Becker L, Wiebe V, Nickel B, Giger T, Müller U, Groszer M, Adler T, Aguilar Pimentel JA, Bolle I, Calzada-Wack J, Dalke C, Ehrhardt N, Favor J, Fuchs H, Gailus-Durner V, Hans W, Hölzlwimmer G, Javaheri A, Kalaydjiev S, Kallnik M, Kling E, Kunder S, Mossbrugger I, Naton B, Racz I, Rathkolb B, Rozman J, Schrewe A, Busch DH, Graw J, Ivandic B, Klingenspor M, Klopstock T, Ollert M, Quintanilla-Martinez L, Schulz H, Wolf E, Wurst W, Zimmer A, Fisher SE, Morgenstern R, Arendt T, Hrabé de Angelis M, Fischer J, Schwarz J, Pääbo S. A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice. Cell. 2009 May 29;137(5):961-71. DOI 10.1016/j.cell.2009.03.041
46 Feil R, Hölter SM, Weindl K, Wurst W, Langmesser S, Gerling A, Feil S, Albrecht U. (2009) cGMP-dependent protein kinase I, the circadian clock, sleep, and learning. Commun Integr Biol 2:298-301
45 Filosa A, Paixão S, Honsek SD, Carmona MA, Becker L, Feddersen B, Gaitanos L, Rudhard Y, Schoepfer R, Klopstock T, Kullander K, Rose CR, Pasquale EB, Klein R. Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport. Nat Neurosci. 2009 Oct;12(10):1285-92. Epub 2009 Sep 6.PMID: 19734893
44 Fuchs H, Gailus-Durner V, Adler T, Aguilar Pimentel JA, Becker L, Bolle I, Brielmeier M, Calzada-Wack J, Dalke C, Ehrhardt N, Fasnacht N, Ferwagner B, Frischmann U, Hans W, Hölter SM, Hölzlwimmer G, Horsch M, Javaheri A, Kallnik M, Kling E, Lengger C, Maier H, Moßbrugger I, Mörth C, Naton B, Nöth U, Pasche B, Prehn C, Przemeck G, Puk O, Racz I, Rathkolb B, Rozman J, Schäble K, Schreiner R, Schrewe A, Sina C, Steinkamp R, Thiele F, Willershäuser M, Zeh R, Adamski J, Busch DH, Beckers J, Behrendt H, Daniel H, Esposito I, Favor J, Graw J, Heldmaier G, Höfler H, Ivandic B, Katus H, Klingenspor M, Klopstock T, Lengeling A, Mempel M, Müller W, Neschen S, Ollert M, Quintanilla-Martinez L, Rosenstiel P, Schmidt J, Schreiber S, Schughart K, Schulz H, Wolf E, Wurst W, Zimmer A, Hrabé de Angelis M. The German Mouse Clinic: a platform for systemic phenotype analysis of mouse models. Curr Pharm Biotechnol. 2009 Feb;10(2):236-43. PMID: 19199957
43 Ganguly K, Depner M, Fattman C, Bein K, Oury TD, Wesselkamper SC, Borchers MT, Schreiber M, Gao F, von Mutius E, Kabesch M, Leikauf GD, Schulz H. Superoxide dismutase 3, extracellular (SOD3) variants and lung function. Physiological Genomics. 2009 May 13;37(3):260-7. Epub 2009 Mar 24. doi:10.1152/physiolgenomics.90363.2008.
42 Ganguly K, Upadhyay S, Irmler M, Takenaka S, Pukelsheim K, Beckers J, Hamelmann E, Schulz H, Stoeger T. Pathway focused protein profiling indicates differential function for IL-1B, -18 and VEGF during initiation and resolution of lung inflammation evoked by carbon nanoparticle exposure in mice. Particl and Fibre Toxicology 2009 Dec 2;6:31. doi:10.1186/1743-8977-6-31
41 Grzmil P, Konietzko J, Boehm D, Hölter SM, Aguilar-Pimentel JA, Javaheri A, Kalaydjiev S, Adler T, Bolle I, Adham I, Dixkens C, Wolf S, Fuchs H, Gailus-Durner V, Wurst W, Ollert M, Busch DH, Schulz H, Hrabé de Angelis M, Burfeind P. Targeted disruption of the mouse Npal3 gene leads to deficits in behavior, increased IgE levels, and impaired lung function. Cytogenet Genome Res. 2009;125(3):186-200. DOI: 10.1159/000230003
40 Horsch M, Recktenwald CV, Schädler S, Hrabé de Angelis M, Seliger B, Beckers J. Overexpressed vs mutated Kras in murine fibroblasts: a molecular phenotyping study. Br J Cancer. 2009 Feb 24;100(4):656-62. doi:10.1038/sj.bjc.6604882
39 Isensee J, Meoli L, Zazzu V, Nabzdyk C, Witt H, Soewarto D, Effertz K, Fuchs H, Gailus-Durner V, Busch D, Adler T, Hrabé de Angelis M, Irgang M, Otto C, Ruiz-Noppinger P. Expression pattern of G protein-coupled receptor 30 in LacZ reporter mice. Endocrinology. 2009 Apr;150(4):1722-30. doi: 10.1210/en.2008-1488
38 Kemter E, Rathkolb B, Rozman J, Hans W, Schrewe A, Landbrecht C, Klaften M, Ivandic B, Fuchs H, Gailus-Durner V, Klingenspor M, Hrabé de Angelis M, Wolf E, Wanke R, Aigner B. Novel missense mutation of uromodulin in mice causes renal dysfunction with alterations in urea handling, energy, and bone metabolism. Am J Physiol Renal Physiol. 2009 Nov;297(5):F1391-8. doi:10.1152/ajprenal.00261.2009
37 Khasawneh J, Schulz MD, Walch A, Rozman J, Hrabe de Angelis M, Klingenspor M, Buck A, Schwaiger M, Saur D, Schmid RM, Klöppel G, Sipos B, Greten FR, Arkan MC. Inflammation and mitochondrial fatty acid ?-oxidation link obesity to early tumor promotion. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3354-9. doi: 10.1073/pnas.0802864106
36 Klonisch T, Glogowska A, Gratao AA, Grzech M, Nistor A, Torchia M, Weber E, Hrabé de Angelis M, Rathkolb B, Cuong HV, Wolf E, Schneider MR. The C-terminal cytoplasmic domain of human proEGF is a negative modulator of body and organ weights in transgenic mice. FEBS Lett. 2009 Apr 17;583(8):1349-57. doi:10.1016/j.febslet.2009.03.051
35 Lewis MA, Quint E, Glazier AM, Fuchs H, Hrabé de Angelis M, Langford C, van Dongen S, Abreu-Goodger C, Piipari M, Redshaw N, Dalmay T, Moreno-Pelayo MA, Enright AJ, Steel KP. An ENU-induced mutation of miR-96 associated with progressive hearing loss in mice. Nat Genet. 2009 May;41(5):614-8. doi:10.1038/ng.369
34 Markoullis K, Bulian D, Hölzlwimmer G, Quintanilla-Martinez L, Heiliger KJ, Zitzelsberger H, Scherb H, Mysliwietz J, Uphoff CC, Drexler HG, Adler T, Busch DH, Schmidt J, Mahabir E. Mycoplasma contamination of murine embryonic stem cells affects cell parameters, germline transmission and chimeric progeny.Transgenic research 2009 Feb; 18(1):71-87. PMID: 18819014
33 Noyes HA, Alimohammadian MH, Agaba M, Brass A, Fuchs H, Gailus-Durner V, Hulme H, Iraqi F, Kemp S, Rathkolb B, Wolf E, Hrabé de Angelis M, Roshandel D, Naessens J. Mechanisms controlling anaemia in Trypanosoma congolense infected mice. PLoS One. 2009;4(4):e5170. doi:10.1371/journal.pone.0005170
32 Peters DD, Lepikhov K, Rodenacker K, Marschall S, Boersma A, Hutzler P, Scherb H, Walter J, Hrabé de Angelis M. Effect of IVF and laser zona dissection on DNA methylation pattern of mouse zygotes. Mamm Genome. 2009 Sep-Oct;20(9-10):664-73. DOI 10.1007/s00335-009-9227-0
31 Pham TT, Giesert F, Röthig A, Floss T, Kallnik M, Weindl K, Hölter SM, Ahting U, Prokisch H, Becker L, Klopstock T, Hrabé de Angelis M, Beyer K, Görner K, Kahle PJ, Vogt Weisenhorn DM, Wurst W. DJ-1-deficient mice show less TH-positive neurons in the ventral tegmental area and exhibit non-motoric behavioural impairments. Genes Brain Behav. 2010 Apr;9(3):305-17. doi: 10.1111/j.1601-183X.2009.00559.x
30 Puk O, Dalke C, Calzada-Wack J, Ahmad N, Klaften M, Wagner S, Hrabé de Angelis M, Graw J. Reduced corneal thickness and enlarged anterior chamber in a novel ColVIIIa2G257D mutant mouse. Invest Ophthalmol Vis Sci. 2009 Dec;50(12):5653-61. PMID: 19578028
29 Puk O, Esposito I, Söker T, Löster J, Budde B, Nürnberg P, Michel-Soewarto D, Fuchs H, Wolf E, Hrabé de Angelis M, Graw J. A new Fgf10 mutation in the mouse leads to atrophy of the harderian gland and slit-eye phenotype in heterozygotes: a novel model for dry-eye disease? Invest Ophthalmol Vis Sci. 2009 Sep;50(9):4311-8. PMID: 19407009
28 Rathkolb B, Noyes HA, Brass A, Dark P, Fuchs H, Gailus-Durner V, Gibson J, Hrabé de Angelis M, Ogugo M, Iraqi F, Kemp SJ, Naessens J, Pope ME, Wolf E, Agaba M. Clinical chemistry of congenic mice with quantitative trait loci for predicted responses to Trypanosoma congolense infection. Infect Immun. 2009 Sep;77(9):3948-57. doi:10.1128/IAI.00658-09
27 Rubio-Aliaga I, Przemeck GK, Fuchs H, Gailus-Durner V, Adler T, Hans W, Horsch M, Rathkolb B, Rozman J, Schrewe A, Wagner S, Hölter SM, Becker L, Klopstock T, Wurst W, Wolf E, Klingenspor M, Ivandic BT, Busch DH, Beckers J, Hrabé de Angelis M. Dll1 haploinsufficiency in adult mice leads to a complex phenotype affecting metabolic and immunological processes. PLoS One. 2009 Jun 29;4(6):e6054. doi:10.1371/journal.pone.0006054
26 Srivastava B, P.Blazejewska, M. Heßmann, D. Bruder, R. Geffers, S. Mauel, A. D. Gruber, K. Schughart. (2009) Host genetic background strongly influences the response to influenza A virus infections. PLoSONE, 4, e4857.
25 van Bürck L, Blutke A, Kautz S, Rathkolb B, Klaften M, Wagner S, Kemter E, Hrabé de Angelis M, Wolf E, Aigner B, Wanke R, Herbach N. Phenotypic and pathomorphological characteristics of a novel mutant mouse model for maturity-onset diabetes of the young type 2 (MODY 2). Am J Physiol Endocrinol Metab. Epub 2009 Dec 1. doi:10.1152/ajpendo.00465.2009
24 Wirth EK, Roth S, Blechschmidt C, Hölter SM, Becker L, Racz I, Zimmer A, Klopstock T, Gailus-Durner V, Fuchs H, Wurst W, Naumann T, Bräuer A, de Angelis MH, Köhrle J, Grüters A, Schweizer U. Neuronal 3',3,5-triiodothyronine (T3) uptake and behavioral phenotype of mice deficient in Mct8, the neuronal T3 transporter mutated in Allan-Herndon-Dudley syndrome. J Neurosci. 2009 Jul 29;29(30):9439-49.
2008
23 Abe K, Wechs S, Kalaydjiev S, Franz TJ, Busch DH, Fuchs H, Soewarto D, Behrendt H, Wagner S, Jakob T, Hrabé de Angelis M.: Novel lymphocyte-independent mechanisms to initiate inflammatory arthritis via bone marrow-derived cells of Ali18 mutant mice. Rheumatology 2008 47(3):292-300 doi:10.1093/rheumatology/kem358
22 Aigner, B., Rathkolb, B., Herbach, N., Hrabé de Angelis, M., Wanke, R., Wolf, E.: Diabetes models by screen for hyperglycemia in phenotype-driven ENU mouse mutagenesis projects. Am. J. Physiol. Endocrinol. Metab. 2008 294(2):E232-40 doi:10.1152/ajpendo.00592.2007
21 Bender A, Beckers J, Schneider I, Hölter SM, Haack T, Ruthsatz T, Vogt-Weisenhorn DM, Becker L, Genius J, Rujescu D, Irmler M, Mijalski T, Mader M, Quintanilla-Martinez L, Fuchs H, Gailus-Durner V, Hrabé de Angelis M, Wurst W, Schmidt J, Klopstock T.: Creatine improves health and survival of mice. Neurobiol Aging 2008 Sep;29(9):1404-11. doi:10.1016/j.neurobiolaging.2007.03.001
20 Bode M, Irmler M, Friedenberger M, May C, Jung K, Stephan C, Meyer HE,Lach C, Hillert R, Krusche A, Beckers J, Marcus K, Schubert W. Interlocking transcriptomics, proteomics and toponomics technologies for brain tissue analysis in murine hippocampus. Proteomics 2008; 8(6):1170-8; doi 10.1002/pmic.200700742
19 Delic S, Streif S, Deussing JM, Weber P, Üffing M, Hölter SM, Wurst W, Kühn R. (2008) Genetic mouse models for behavioural analysis through transgenic RNAi technology. Genes Brain Behav 7(7):821-830
18 Fuchs H., Lisse, T., Hans, W., Abe, K., Thiele, F., Gailus-Durner, V., Hrabé de Angelis, M.: Phenotypic characterization of mouse models for bone-related diseases in the German Mouse Clinic. J. Musculoskelet. Neuronal. Interact. 2008 Jan-Mar;8(1):13-4. PMID: 18398253
17 Hartl D, Irmler M, Romer I, Mader MT, Mao L, Zabel C, Hrabe de Angelis M,Beckers J, Klose J. Transcriptome and proteome analysis of early embryonic mouse brain development. Proteomics 2008;8(6):1257-65. doi 10.1002/pmic.200700724
16 Hölter SM, Dalke C, Kallnik M, Becker L, Horsch M, Schrewe A, Favor J, Klopstock T, Beckers J, Ivandic B, Gailus-Durner V, Fuchs H, Hrabé de Angelis M, Graw J, Wurst W.: 'Sighted C3H' mice - a tool for analysing the influence of vision on mouse behaviour? Front. Biosci. 2008;13:5810-23. doi:10.2741/3118
15 Horsch M., Schädler, S., Gailus-Durner, V., Fuchs, H., Meyer, H., Hrabé de Angelis, M., Beckers, J.: Systematic gene expression profiling of mouse model series reveals coexpressed genes. Proteomics 2008 Mar;8(6):1248-56 doi:10.1002/pmic.200700725
14 Hübner MP, Pasche B, Kalaydjiev S, Soboslay PT, Lengeling A, Schulz-Key H, Mitre E, Hoffmann WH. Microfilariae of the filarial nematode Litomosoides sigmodontis exacerbate the course of LPS-induced sepsis in mice. Infect. Immun. 2008 Apr;76(4):1668-1677. doi:10.1128/IAI.01042-07
13 Irmler M, Hartl D, Schmidt T, Schuchhardt J, Lach C, Meyer HE, Hrabe de Angelis M, Klose J, Beckers J. An approach to handling and interpretation of ambiguous data in transcriptome and proteome comparisons. Proteomics 2008;8(6):1165-9. doi10.1002/pmic.200700741
12 Lisse TS, Thiele F, Fuchs H, Hans W, Przemeck GK, Abe K, Rathkolb B, Quintanilla-Martinez L, Hoelzlwimmer G, Helfrich M, Wolf E, Ralston SH, Hrabé de Angelis M.: ER Stress-Mediated Apoptosis in a New Mouse Model of Osteogenesis imperfecta. PLoS Genet. 2008 4(2):e7 doi:10.1371/journal.pgen.0040007
11 Maier H., Lengger, C., Simic, B., Fuchs, H., Gailus-Durner, V., Hrabé de Angelis, M.: MausDB: an open source application for phenotype data and mouse colony management in large-scale mouse phenotyping projects. BMC Bioinformatics 2008 26;9:169 doi: 10.1186/1471-2105-9-169
10 McGowan KA, Li JZ, Park CY, Beaudry V, Tabor HK, Sabnis AJ, Zhang W, Fuchs H, Hrabé de Angelis M, Myers RM, Attardi LD, Barsh GS.: Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects. Nat. Genet. 2008 Aug;40(8):963-70. Epub 2008 Jul 20; doi:10.1038/ng.188
9 Petropoulos K, Arseni N, Schessl C, Stadler CR, Rawat VP, Deshpande AJ, Heilmeier B, Hiddemann W, Quintanilla-Martinez L, Bohlander SK, Feuring-Buske M, Buske C. A novel role for Lef-1, a central transcription mediator of Wnt signaling in leukemogenesis. J Exp Med. 2008 Mar; 205(3):515-522. doi 10.1084/jem.20071875
8 Puk O., Dalke, C., Hrabé de Angelis, M., Graw, J.: Variation of the response to the optokinetic drum among various strains of mice. Front. Biosci. 2008 May 1;13:6269-75 PMID: 18508659
7 Racz I, Bilkei-Gorzo A, Markert A, Stamer F, Gothert M, Zimmer A (2008) Anandamide effects on 5-HT(3) receptors in vivo. Eur J Pharmacol 2008;596:98-101.doi:10.1016/ j.ejphar.2008.08.012
6 Racz I, Nadal X, Alferink J, Banos JE, Rehnelt J, Martin M, Pintado B, Gutierrez-Adan A, Sanguino E, Manzanares J, Zimmer A, Maldonado R (2008) Crucial role of CB(2) cannabinoid receptor in the regulation of central immune responses during neuropathic pain. J Neurosci 2008; 28:12125-12135. DOI:10.1523/JNEUROSCI.3400-08.2008
5 Racz I., X. Nadal, J. Alferink, J. E. Baños, J. Rehnelt, M. Martín, B. Pintado, A. Gutierrez-Adan, E. Sanguino, N. Bellora, J. Manzanares, A. Zimmer, R. Maldonado, Interferon-? is a critical modulator of CB2 cannabinoid receptor signaling during neuropathic pain. J of Neuroscience (2008) 28(46): 12136-45 DOI:10.1523/JNEUROSCI.3402-08.2008
4 Rawat VP, Thoene S, Naidu VM, Arseni N, Heilmeier B, Metzeler K, Petropoulos K, Deshpande A, Quintanilla-Martinez L, Bohlander SK, Speikermann K, Hiddemannn W, Feuring-Buske M, Buske C. Overexpression of CDX2 perturbs HOX gene expression in murine progenitors deoending on its N-terminal domain and is closely correlated with deregulated HOX gene expression in human acute myeloid leukemia. Blood. 2008 Jan; 111(1):309-319. doi 10.1182/blood.200704085407
3 Schmidt S, Gawlik V, Hölter SM, Augustin R, Scheepers A, Behrens M, Wurst W, Gailus-Durner V, Fuchs H, Hrabé de Angelis M, Kluge R, Joost HG, Schürmann A.: Deletion of glucose transporter GLUT8 in mice increases locomotor activity. Behav. Genet. 2008 Jul;38(4):396-406. doi:10.1007/s10519-008-9208-1
2 Schuchhardt J, Glintschert A, Hartl D, Irmler M, Beckers J, Stephan C, Marcus K, Klose J, Meyer HE, Malik A. BrainProfileDB - a platform for integration of functional genomics data. Proteomics 2008;8(6):1162-4. doi 10.1002/pmic.200700743
1 Söker T, Dalke C, Puk O, Floss T, Becker L, Bolle I, Favor J, Hans W, Hölter SM, Horsch M, Kallnik M, Kling E, Moerth C, Schrewe A, Stigloher C, Topp S, Gailus-Durner V, Naton B, Beckers J, Fuchs H, Ivandic B, Klopstock T, Schulz H, Wolf E, Wurst W, Bally-Cuif L, Hrabé de Angelis M, Graw J.: Pleiotropic effects in Eya3 knockout mice. BMC Dev. Biol. 2008 Dec 22;8:118; doi: 10.1186/1471-213X-8-118.
