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100 Antonchick A.P, S. López-Tosco, J. Parga, S. Sievers, M. Schürmann, H. Preut, S. Höing, H.R. Schöler, J. Sterneckert, D. Rauh, H. Waldmann. Highly Enantioselective Catalytic Synthesis of Neurite Growth-Promoting Secoyohimbanes Chemistry & Biology, 2013, 20(4):500-9.
99 Becker Kerstin, Claudia Vollbrecht, Ulrike Koitzsch, Katharina Koenig,Jana Fassunke, Sebastian Huss, Peter Nuernberg, Lukas C Heukamp,Reinhard Buettner, Margarete Odenthal, Janine Altmueller, Sabine Merkelbach-Bruse. Deep ion sequencing of amplicon adapter ligated libraries: a novel tool in molecular diagnostics of formalin fixed and paraffin embedded tissues. Journal of Clinical Pathology, jclinpath-2013-201549, in press.
98 Bos M, Gardizi M, Schildhaus HU, Heukamp LC, Geist T, Kaminsky B, Zander T, Nogova L, Scheffler M, Dietlein M, Kobe C, Holstein A, Maintz D, Büttner R, Wolf J. Complete metabolic response in a patient with repeatedly relapsed non-small cell lung cancer harboring ros1 gene rearrangement after treatment with crizotinib. Lung Cancer 2013.
97 Büttner R, Wolf J, Thomas RK. Lessons learned from lung cancer genomics: The emerging concept of individualized diagnostics and treatment. J Clin Oncol 2013.
96 Chatterjee S, Heukamp LC, Siobal M, Schöttle J, Wieczorek C, Peifer M, Frasca D, Koker M, König K, Meder L, Rauh D, Buettner R, Wolf J, Brekken RA, Neumaier B, Christofori G, Thomas RK, Ullrich RT. Tumor VEGF:VEGFR2 autocrine feed-forward loop triggers angiogenesis in lung cancer. J Clin Invest. 2013 Apr 1;123(4):1732-40.
95 Fang Z., C. Grütter, D. Rauh. Strategies for the Selective Regulation of Kinases with Allosteric Modulators - Exploiting Exclusive Structural Features. ACS Chem Biol, 2013, 8(1):58-70.
94 Jaiswal M, Dvorsky R, Ahmadian MR. Deciphering the Molecular and Functional Basis of Dbl Family Proteins: A NOVEL SYSTEMATIC APPROACH TOWARD CLASSIFICATION OF SELECTIVE ACTIVATION OF THE Rho FAMILY PROTEINS. J Biol Chem 288, 4486-4500. PMID: 23255595.
93 Over, B., S. Wetzel, C. Grütter, Y. Nakai, S. Renner, D. Rauh, H. Waldmann. Natural product derived fragments for fragment-based ligand discovery. Nat Chemistry, 2013, 5(1):21-8.
92 Rauh, D. Chemical Biology ? current and next challenges. ACS Chem Biol, 2013, 8(1):1-2.
91 Scheffler M, Zander T, Nogova L, Kobe C, Kahraman D, Dietlein M, Papachristou I, Heukamp L, Büttner R, Boellaard R, Lammertsma AA, Querings S, Stoelben E, Engel-Riedel W, Neumaier B, Wolf J: Prognostic impact of [18f]fluorothymidine and [18f]fluoro-d-glucose baseline uptakes in patients with lung cancer treated first-line with erlotinib. PLoS One 2013;8:e53081.
90 Schelhorn, S.E. et al. Sensitive Detection of Viral Transcripts in Human Tumor Transcriptomes, erscheint in PLOS Comput Biol 2013.
89 Schneider R., A. Gohla, J.R. Simard, D.B. Yadav, Z. Fang, W.A.L. van Otterlo, D. Rauh. Overcoming compound fluorescence in the FLiK screening assay with red-shifted fluorophores. J Am Chem Soc, 2013, in press.
88 Schneider R., C. Beumer, J.R. Simard, C. Grütter, D. Rauh. Selective Detection of Allosteric Phosphatase Inhibitors. J Am Chem Soc, 2013, 135(18):6838-41.
87 Schultheis A, Wolf J, Büttner R. Lung cancer. Molecular pathology and personalized therapy. Internist (Berl) 2013;54:179-180, 182-177..
86 Tolosi, L., et al. A method for finding consensus breakpoints in the cancer genome from copy number data. Bioinformatics. 2013 Jun 19. [Epub ahead of print].
85 Urich R., G. Wishart, M. Kiczun, A. Richters, N. Tidten-Luksch, D. Rauh, B. Sherborne, P.G. Wyatt and R. Brenk. De novo design of protein kinase inhibitors by in silico identification of hinge region-binding fragments. ACS Chem Biol, 2013, in press.
2012
84 Bock, C. and T. Lengauer Managing drug resistance in cancer: lessons from HIV therapy. Nat Rev Cancer, 2012. 12(7): p. 494-501.
83 Brenk R., D. Rauh. Change or be changed: Reflections of the workshop 'Future in Medicinal Chemistry'. Bioorg Med Chem, 2012, 20(12):3695-7.
82 Cancer Genome Atlas Research Network. Comprehensive genomic characterization of squamous cell lung cancers. Nature. 2012 Sep 27;489(7417):519-25. doi: 10.1038/nature11404. Epub 2012 Sep 9. Erratum in: Nature. 2012 Nov 8;491(7423):288. Rogers, Kristen [corrected to Rodgers, Kristen].
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70 Koeberle, S.C., S. Fischer, D. Schollmeyer, V. Schattel, C. Grütter, D. Rauh, S. A. Laufer. Design, Synthesis, and Biological Evaluation of Novel Disubstituted Dibenzosuberones as Highly Potent and Selective Inhibitors of p38 Mitogen Activated Protein Kinase J Med Chem, 2012, 55(12):5868-77.
69 Martz K., A. Dorn, B. Baur, V. Schattel, M. Goettert, S. Mayer-Wrangowski, D. Rauh, S.A. Laufer. Targeting the hinge glycine flip and the activation loop: novel approach to potent p38? inhibitors. J Med Chem, 2012, 55(17):7862-74.
68 Mayer-Wrangowski, S., D. Rauh. Symbiose aus Chemie und Medizin - Zielgerichtet gegen Krebs. BIOspektrum, 2012, 18(4):376:79.
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2011
58 Chmielecki J, Foo J, Oxnard GR, Hutchinson K, Ohashi K, Somwar R, Wang L, Amato KR, Arcila M, Sos ML, Socci ND, Viale A, de Stanchina E, Ginsberg MS, Thomas RK, Kris MG, Inoue A, Ladanyi M, Miller VA, Michor F, Pao W. Optimization of dosing for EGFR-mutant non-small cell lung cancer with evolutionary cancer modeling. Sci Transl Med. 2011 Jul 6;3(90):90ra59.
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55 Gaertner J, Wuerstlein R, Klein U, Scheicht D, Frechen S, Wolf J, Hellmich M, Mallmann P, Harbeck N, Voltz R. Integrating Palliative Medicine into Comprehensive Breast Cancer Therapy - a Pilot Project. Breast Care (Basel). 2011;6(3):215-220. Epub 2011 Jun 14.
54 Gremer L, Merbitz-Zahradnik T, Dvorsky R, Cirstea IC, Kratz CP, Zenker M, Wittinghofer A, Ahmadian MR. Impacts of germline mutations in KRAS on the GTPase cycle and effector interaction. Hum Mutat 32, 33-43. PMID: 20949621
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46 Rode, H., M.L. Sos, C. Grütter, S. Heynck, J.R. Simard, D. Rauh. Synthesis and biological evaluation of 7-substituted-1-(3-bromophenylamino) isoquinoline-4-carbonitriles as inhibitors of Myosine Light Chain Kinase and Epidermal Growth Factor Receptor. Bioorg Med Chem, 2011, 19(1):429-39.
45 Tolosi L, Lengauer T. Classification with correlated features: unreliability of feature ranking and solutions. Bioinformatics. 2011 Jul 15;27(14):1986-94. Epub 2011 May 16.
44 Tückmantel, S., J.N. Greul, P. Janning, A. Brockmeyer, C. Grütter, J.R. Simard, O. Gutbrod, M.E. Beck, K. Tietjen, D. Rauh, P.H. Schreier. Identification of Ustilago maydis Aurora Kinase As a Novel Antifungal Target. ACS Chem Biol, 2011, 6(9):926-33.
43 Vansteenkiste J, Solomon B, Boyer M, Wolf J, Miller N, Di Scala L, Pylvaenaeinen I, Petrovic K, Dimitrijevic S, Anrys B, Laack E. Everolimus in Combination with Pemetrexed in Patients with Advanced Non-small Cell Lung Cancer Previously Treated with Chemotherapy: A Phase I Study Using a Novel, Adaptive Bayesian Dose-Escalation Model. J Thorac Oncol. 2011 Dec;6(12):2120-9.
42 Vintonyak, V.V., H. Waldmann, D. Rauh. Using small molecules to target protein phosphatases. Bioorg Med Chem, 2011, 19(7):2145-55.
41 Vintonyak, V.V., K. Warburg, B. Over, K. Hübel, D. Rauh, H. Waldmann. Identification and further development of thiazolidinones spiro-fused to indolin-2-ones as potent and selective inhibitors of Mycobacterium tuberculosis Protein Tyrosine Phosphatase B. Tetrahedron, 2011, 67(35):6713-29.
40 Zander T, Hofmann A, Staratschek-Jox A, Classen S, Debey-Pascher S, Maisel D, Ansén S, Hahn M, Beyer M, Thomas RK, Gathof B, Mauch C, Delank KS, Engel-Riedel W, Wichmann HE, Stoelben E, Schultze JL, Wolf J. Blood-based gene expression signatures in non-small cell lung cancer. Clin Cancer Res. 2011 May 15;17(10):3360-7. Epub 2011 May 10
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36 Antonchick, A. C. Gerding-Reimers, M. Catarinella, S. Ziegler, D. Rauh and H. Waldmann. Highly Enantioselective Synthesis and Cellular Evaluation of Natural Product-Inspired Spirooxindoles, Nature Chemistry, 2010, 2(9):735-40
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2009
16 Barbie DA, Tamayo P, Boehm JS, Kim SY, Moody SE, Dunn IF, Schinzel AC, Sandy P, Meylan E, Scholl C, Fröhling S, Chan EM, Sos ML, Michel K, Mermel C, Silver SJ, Weir BA, Reiling JH, Sheng Q, Gupta PB, Wadlow RC, Le H, Hoersch S, Wittner BS, Ramaswamy S, Livingston DM, Sabatini DM, Meyerson M, Thomas RK, Lander ES, Mesirov JP, Root DE, Gilliland DG, Jacks T, Hahn WC. Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1. Nature. 2009 Nov 5;462(7269):108-12
15 Getlik, M., Grutter, C., Simard, J.R., Kluter, S., Rabiller, M., Rode, H.B., Robubi, A., and Rauh, D. (2009). Hybrid compound design to overcome the gatekeeper T338M mutation in cSrc. J Med Chem, 2009, 52, 3915-3926.
14 Gong Y, Yao E, Shen R, Goel A, Arcila M, Teruya-Feldstein J, Zakowski MF, Frankel S, Peifer M, Thomas RK, Ladanyi M, Pao W. High expression levels of total IGF-1R and sensitivity of NSCLC cells in vitro to an anti-IGF-1R antibody (R1507). PLoS One. 2009 Oct 6;4(10):e7273.
13 LaFramboise T, Winckler W, Thomas RK. A flexible rank-based framework for detecting copy number aberrations from array data. Bioinformatics. 2009 Mar 15;25(6):722-8
12 Renner S., W. van Otterlo, M. Dominguez Seoane, S. Möcklinghoff, B. Hofmann, S. Wetzel, A. Schuffenhauer, P. Ertl, T. Oprea, D. Steinhilber, L. Brunsveld, D. Rauh, H. Waldmann. (2009). Bioactivity-Guided Mapping of and Navigation in Chemical Space. Nat Chem Biol, 2009, 5(8):585-92
11 Simard, J.R., and Rauh, D. (2009). Chemical and structural biology to direct the repurposing of sulindac. ChemMedChem 4, 2009, 1793-1795.
10 Simard, J.R., Getlik, M., Grutter, C., Pawar, V., Wulfert, S., Rabiller, M., and Rauh, D. (2009). Development of a fluorescent-tagged kinase assay system for the detection and characterization of allosteric kinase inhibitors. J Am Chem Soc 131, 2009, 13286-13296.
9 Simard, J.R., Grutter, C., Pawar, V., Aust, B., Wolf, A., Rabiller, M., Wulfert, S., Robubi, A., Kluter, S., Ottmann, C., et al. (2009). High-throughput screening to identify inhibitors which stabilize inactive kinase conformations in p38alpha. J Am Chem Soc 131, 2009, 18478-18488.
8 Simard, J.R., S. Klüter, C. Grütter, M. Rabiller, H.B. Rode, D. Rauh. (2009). A new screening assay for allosteric inhibitors of cSrc. Nat Chem Biol, 2009, 5(6):394-6
7 Soria JC, Shepherd FA, Douillard JY, Wolf J, Giaccone G, Crino L, Cappuzzo F, Sharma S, Gross SH, Dimitrijevic S, Di Scala L, Gardner H, Nogova L, Papadimitrakopoulou V. Efficacy of everolimus (RAD001) in patients with advanced NSCLC previously treated with chemotherapy alone or with chemotherapy and EGFR inhibitors. Ann Oncol. 2009 Oct;20(10):1674-81. Epub 2009 Jun 23.
6 Sos ML, Fischer S, Ullrich R, Peifer M, Heuckmann JM, Koker M, Heynck S, Stückrath I, Weiss J, Fischer F, Michel K, Goel A, Regales L, Politi KA, Perera S, Getlik M, Heukamp LC, Ansén S, Zander T, Beroukhim R, Kashkar H, Shokat KM, Sellers WR, Rauh D, Orr C, Hoeflich KP, Friedman L, Wong KK, Pao W, Thomas RK.Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer. Proc Natl Acad Sci U S A. 2009 Oct 27; 106(43):18351-6
5 Sos ML, Koker M, Weir BA, Heynck S, Rabinovsky R, Zander T, Seeger JM, Weiss J, Fischer F, Frommolt P, Michel K, Peifer M, Mermel C, Girard L, Peyton M, Gazdar AF, Minna JD, Garraway LA, Kashkar H, Pao W, Meyerson M, Thomas RK. PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFR. Cancer Res. 2009 Apr 15; 69(8):3256-61.
4 Sos ML, Michel K, Zander T, Weiss J, Frommolt P, Peifer M, Li D, Ullrich R, Koker M, Fischer F, Shimamura T, Rauh D, Mermel C, Fischer S, Stückrath I, Heynck S, Beroukhim R, Lin W, Winckler W, Shah K, LaFramboise T, Moriarty WF, Hanna M, Tolosi L, Rahnenführer J, Verhaak R, Chiang D, Getz G, Hellmich M, Wolf J, Girard L, Peyton M, Weir BA, Chen TH, Greulich H, Barretina J, Shapiro GI, Garraway LA, Gazdar AF, Minna JD, Meyerson M, Wong KK, Thomas RK. Predicting drug susceptibility of non-small cell lung cancers based on genetic lesions. J Clin Invest. 2009 Jun; 119(6): 1727-40. doi: 10.1172/JCI37127. Epub 2009 May 18.
3 Triola, G., Wetzel, S., Ellinger, B., Koch, M.A., Hubel, K., Rauh, D., and Waldmann, H. ATP competitive inhibitors of D-alanine-D-alanine ligase based on protein kinase inhibitor scaffolds. Bioorg Med Chem 2009, 17, 1079-1087.
2 Vintonyak, V.V., Antonchick, A.P., Rauh, D., and Waldmann, H. (2009). The therapeutic potential of phosphatase inhibitors. Curr Opin Chem Biol, 2009, 13, 272-283.
1 Wetzel S., K. Klein, S. Renner, D. Rauh, T. Oprea, P. Mutzel, H. Waldmann. (2009). Interactive Exploration of Chemical Space with Scaffold Hunter. Nat Chem Biol; 2009; 5(8):581-3
