NGFN-PLUS
DNA Platform
Coordinator: | Dr. Benjamin Meder | |
Institution: | Abteilung Innere Medizin III , Uniklinik Heidelberg | |
Homepage: | www.klinikum.uni-heidelberg.de |
Cardiomyopathies are one leading cause for the development of heart failure and arrhythmias. These primary diseases of the heart muscle are inherited in a monogenic or polygenic trait. The identification of new disease genes can be accomplished by analysis of affected pedigrees, animal models, yeast-two-hybrid screens, and genome wide association studies (GWAS).
The main focus of this subproject is to identify and confirm new candidate genes for the development of the following phenotypes: left ventricular hypertrophy, diastolic and systolic heart failure, and cardiac arrhythmias.
For the validation of sequence variances in novel disease candidate genes in patients, TP12 supplies a high throughput platform for SNP Taqman analysis and mutation screening of large patient cohorts. The aim is to identify novel disease causing or -modifying gene mutations responsible for the investigated phenotypes.
Further Coordinators:
The main focus of this subproject is to identify and confirm new candidate genes for the development of the following phenotypes: left ventricular hypertrophy, diastolic and systolic heart failure, and cardiac arrhythmias.
For the validation of sequence variances in novel disease candidate genes in patients, TP12 supplies a high throughput platform for SNP Taqman analysis and mutation screening of large patient cohorts. The aim is to identify novel disease causing or -modifying gene mutations responsible for the investigated phenotypes.
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