Classification of phenotype-to-genotype relationships for neurodegenerative diseases

Coordinator:		Prof. Dr. Josef Priller
Institution:		Neuropsychiatry, Charité-Universitätsmedizin Berlin
Homepage:		http://www.charite.de/psychiatrie/

This subproject complements the basic science approach of the NeuroNet by providing a clinical platform. The aim of the subproject is to establish clinical syndrom families for Parkinson’s disease (PD), Alzheimer’s disease (AD), Huntington’s disease (HD), amyotrophic lateral sclerosis (ALS) and spinocerebeallar ataxias (SCA), which should reveal new links between genes, proteins and protein-protein interactions (interactome). The diversity of clinical information on neurodegenerative diseases will be standardized and weighted based on data mining results using Medline and clinical expertise. The aim is to establish phenotype-interactome-networks by combining phenotype similarity scores with genome, proteome and interactome data. In addition, a lymphoblastoid cell line repository will be established from individuals with phenotypically defined neurodegenerative diseases, and provided to the other subprojects of the NeuroNet for gene expression profiling and drug testing.





Heat map visualization of a phenotype network for neurodegenerative diseases (perfomed in collaboration with SP 8: Andrade, Fontaine).