NGFN-TRANSFER
Bioanalytic of chronic renal-failure patients
Coordinator: | Dr. Vera Jankowski | |
Institution: | Charite | Medizinische Klinik IV (CBF) | |
Homepage: | www.charite.de/kliphatox |
Several explanations of increased mortality of renal failure patients, including hypertriglycerid-emia, increased lipoprotein (a) levels, increased production of oxidised low-density lipoprotein, hypertension and hyperhomocysteinemia are discussed [Brenner, 1999 #196].
In addition to these known mechanisms, still other unknown factors may contribute to the markedly increased CVD in renal failure patients. Therefore, this subproject focused on mechanisms playing a central role in renal failure-associated CVD.
This subproject is divided into four parts:
dealing with the secretome endothelial and associated cells (1.1),
post-translational modification of proteins and peptides, particular importance for CVD of renal failure patients (1.2),
the molecular phenotyping as a highly promising strategy allowing a forward genomic approach (1.3),
and testing of the functional effect of known and yet unknown mediators on the cardiovascular status of renal fail-ure patients (1.4).
In addition to these known mechanisms, still other unknown factors may contribute to the markedly increased CVD in renal failure patients. Therefore, this subproject focused on mechanisms playing a central role in renal failure-associated CVD.
This subproject is divided into four parts:
dealing with the secretome endothelial and associated cells (1.1),
post-translational modification of proteins and peptides, particular importance for CVD of renal failure patients (1.2),
the molecular phenotyping as a highly promising strategy allowing a forward genomic approach (1.3),
and testing of the functional effect of known and yet unknown mediators on the cardiovascular status of renal fail-ure patients (1.4).
KTT
MEDIA
CURRENT
NGFN-MEETING-2012
NGFN- MEETING
NGFN1&2
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