Cancer-promoting effect of a protein elucidated: LIN28B induces growth of neuroblastoma

Neuroblastomas are the most common solid tumors in children and account for 15% of pediatric cancer deaths. Therefore the search of new therapeutic strategies for targeting neuroblastoma is of great relevance. An international research team led by Prof. Dr. med. Johannes H. Schulte from the National Genome Research Network (NGFN) now successfully found a potential opportunity for such novel therapeutic strategies. The team proved the tumor promoting effect of the protein LIN28B in the development of neuroblastomas. The results of this work have been published in the journal Nature Genetics.


Publication:
Nature Genetics (2012). LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression. Molenaar JJ, Domingo-Fernández R, Ebus ME, Lindner S, Koster J, Drabek K, Mestdagh P, van Sluis P, Valentijn LJ, van Nes J, Broekmans M, Haneveld F, Volckmann R, Bray I, Heukamp L, Sprüssel A, Thor T, Kieckbusch K, Klein-Hitpass L, Fischer M, Vandesompele J, Schramm A, van Noesel MM, Varesio  L, Speleman F, Eggert A, Stallings RL, Caron HN, Versteeg R, Schulte JH. Publikation am 07. Oktober 2012, doi:10.1038/ng.2436