Breast cancer cells get thwarted by miRNAs
Small regulating micro-RNAs of the miR-200 family are often down regulated during tumor growth. NGFN-scientists could recently show for the first time that this miRNA family can be divided into two clusters. Both have different effects on invasion and apoptosis of breast cancer cells and might be potential targets for future therapies.
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New insight into the pathogenesis of Parkinson disease
NGFN-scientists of the Hertie Institute for Clinical Brain Research
showed for the first time, that and how the removal of damaged
mitochondria is directed by the two proteins PINK1 and Parkin. A defect
in this removal mechanism might be crucial for the pathogenesis of
Parkinson disease.
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Genome-wide association studies – a research approach with guaranty for success
In Genome-wide association studies (GWAS) human geneticists identify
disease-associated genes and their variants that contribute to an
increasing risk of developing a disease. With this approach NGFN
scientists identified nine new gene variants, which predispose for
changes in the heart rhythm. This knowledge might provide insights into
atrial disease and lead to new opportunities for atrial fibrillation
prevention and therapy.
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