NGFN-PLUS
GWA studies in alcohol dependent patients and replication studies
| Coordinator: | Prof. Dr. Marcella Rietschel | |
| Institution: | ZI Mannheim | |
| Homepage: | www.zi-mannheim.de/genetische_epidemiol |
The aim of this subproject is to identify vulnerability genes underlying alcohol dependence in humans, and to study their relevance to clinical variations of the disease.
For this purpose, we will apply a muli-tiered strategy.
Firstly, we will extend our ongoing genome-wide association study (GWAS) to include a total of 1000 individuals with alcohol dependence, replicate the emergent findings in an independent case-control sample from the German population, and then validate the findings replicated in the German population through the investigation of an independent sample from the US-Australian population.
Secondly, we will characterize associated haploytes/variants through detailed molecular genetic studies.
Thirdly, we will investigate the impact of these associated haplotypes/variants on the clinical variability of the disease and on drinking behaviour in the general population through the use of well-defined patient samples.
Fourthly, in collaboration with mouse research projects, we will e.g. test genes influencing the glutamatergic neurotransmission in order to translate the findings from mice to humans.
Our group is open to all collaborations with clinicians and other research partners which would advance knowledge in this field.
Further Coordinators:
For this purpose, we will apply a muli-tiered strategy.
Firstly, we will extend our ongoing genome-wide association study (GWAS) to include a total of 1000 individuals with alcohol dependence, replicate the emergent findings in an independent case-control sample from the German population, and then validate the findings replicated in the German population through the investigation of an independent sample from the US-Australian population.
Secondly, we will characterize associated haploytes/variants through detailed molecular genetic studies.
Thirdly, we will investigate the impact of these associated haplotypes/variants on the clinical variability of the disease and on drinking behaviour in the general population through the use of well-defined patient samples.
Fourthly, in collaboration with mouse research projects, we will e.g. test genes influencing the glutamatergic neurotransmission in order to translate the findings from mice to humans.
Our group is open to all collaborations with clinicians and other research partners which would advance knowledge in this field.
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